CH680570A5 - Allergen-free St. Johns wort extract prodn. to prevent skin tumour - by macerating mechanically comminuted St. Johns wort and camomile with a plant oil e.g. wheat germ, thistle, sunflower seed, etc. - Google Patents

Allergen-free St. Johns wort extract prodn. to prevent skin tumour - by macerating mechanically comminuted St. Johns wort and camomile with a plant oil e.g. wheat germ, thistle, sunflower seed, etc. Download PDF

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Publication number
CH680570A5
CH680570A5 CH3463/90A CH346390A CH680570A5 CH 680570 A5 CH680570 A5 CH 680570A5 CH 3463/90 A CH3463/90 A CH 3463/90A CH 346390 A CH346390 A CH 346390A CH 680570 A5 CH680570 A5 CH 680570A5
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CH
Switzerland
Prior art keywords
oil
prodn
johns wort
wheat germ
allergen
Prior art date
Application number
CH3463/90A
Other languages
German (de)
Inventor
Rolf Schaefer
Original Assignee
Flint Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flint Ag filed Critical Flint Ag
Priority to CH3463/90A priority Critical patent/CH680570A5/en
Publication of CH680570A5 publication Critical patent/CH680570A5/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

Prodn. of allergen-free St. John's wort oil extract comprises macerating together (i) a mixt. of mechanically comminuted St. John's wort with mechanically comminuted camomile in a wt. ratio of 1:20 to 20:1, esp. 10:1 and (ii) a plant oil in a ratio (i):(ii) of 1:1 to 1:50, esp. 1:10. The plant oil used is esp. wheat germ oil, thistle oil, maize germ oil, palm kernel oil, soya oil, sunflower seed oil, rape oil or groundnut oil. USE/ADVANTAGE - The prod. can be applied to the human skin without causing light-induced allergies. It is useful for prodn. of cosmetics and pharmaceutical agents, esp. for prophylaxis of ozone- and UV induced (via radical formation) skin tumors.

Description

1 1

CH 680 570 A5 CH 680 570 A5

Beschreibung description

Herkömmliche Extrakte aus Johanniskraut, welche als Hauptwirkstoff die Flavonoide Hypericin und ihre Derivate enthalten, rufen bei der Anwendung auf der menschlichen Haut lichtinduzierte Allergien hervor. Conventional extracts from St. John's wort, which contain the flavonoids hypericin and their derivatives as the main active ingredient, cause light-induced allergies when used on human skin.

Es wurde nun Überraschendenweise gefunden, dass Pflanzenölextrakte aus Mischungen von Johanniskraut und Kamille bei der Anwendung auf der menschlichen Haut keine lichtinduzierten Allergien mehr hervorrufen. Dies eröffnet eine neue breite Anwendung für Johanniskrautextrakte in der Kosmetik und in der Dermatologie, im speziellen zur Prophylaxe Ozon- und UV-induzierter (via Radikalbildung) Hauttumoren. It has now surprisingly been found that vegetable oil extracts from mixtures of St. John's wort and chamomile no longer cause light-induced allergies when used on human skin. This opens up a new broad application for St. John's wort extracts in cosmetics and dermatology, especially for the prophylaxis of ozone and UV-induced (via radical formation) skin tumors.

Beispiel: Eine Mischung von 100 kg mechanisch zerkleinertem Johanniskraut und 10 kg mechanisch zerkleinerter Kamille wird mit 890 I Weizenkeimöl bei Raumtemperatur 24 Stunden unter starkem Rühren extrahiert. Danach wird ein pflanzenteilchenfreier Extrakt durch Abpressen über eine Filtrationsanlage isoliert, welcher den Gegenstand der Erfindung darstellt. Example: A mixture of 100 kg mechanically crushed St. John's wort and 10 kg mechanically crushed chamomile is extracted with 890 l wheat germ oil at room temperature for 24 hours with vigorous stirring. A plant particle-free extract is then isolated by pressing through a filtration system, which is the subject of the invention.

Claims (5)

PatentansprücheClaims 1) Verfahren zur Herstellung allergenfreier Jo-hanniskrautölextrakte, dadurch gekennzeichnet, dass mechanisch zerkleinertes Johanniskraut zusammen mit mechanisch zerkleinerter Kamille im Gewichtsverhältnis 1:20 bis 20:1 mit mindestens einem pflanzlichen Öl im Verhältnis Pflanzen/Öl von 1:1 bis 1:50 mazeriert werden.1) Process for the production of allergen-free jo-hanniskraut oil extracts, characterized in that mechanically crushed St. John's wort together with mechanically crushed chamomile in a weight ratio of 1:20 to 20: 1 with at least one vegetable oil in a plant / oil ratio of 1: 1 to 1:50 will. 2) Verfahren nach Anspruch 1, dadurch gekennzeichnet, dass das Gewichtsverhältnis Johanniskraut/Kamille im Verhältnis 10:1 und das Gewichtsverhältnis Pflanzen/Öl 1:10 beträgt.2) Method according to claim 1, characterized in that the weight ratio of St. John's wort / chamomile in a ratio of 10: 1 and the weight ratio of plants / oil is 1:10. 3) Verfahren nach Anspruch 2, dadurch gekennzeichnet, dass mindestens ein Öl ausgewählt aus der Gruppe, Weizenkeimöl, Distelöl, Maiskeimöl, Palmkernöl, Sojaöl, Sonnenblumenkernöl, Rapsöl und Erdnussöl verwendet wird.3) Method according to claim 2, characterized in that at least one oil selected from the group, wheat germ oil, safflower oil, corn oil, palm kernel oil, soybean oil, sunflower seed oil, rapeseed oil and peanut oil is used. 4) Verfahren nach Anspruch 3, dadurch gekennzeichnet, dass als Öl Weizenkeimöl verwendet wird.4) Method according to claim 3, characterized in that wheat germ oil is used as the oil. 5) Extrakte hergestellt nach dem Verfahren gemäss einem der Ansprüche 1-4, als Kosmetika und/oder als Arzneimittel.5) extracts prepared by the method according to any one of claims 1-4, as cosmetics and / or as a medicament. 55 1010th 1515 2020th 2525th 3030th 3535 4040 4545 5050 5555 6060 6565 22nd
CH3463/90A 1990-10-30 1990-10-30 Allergen-free St. Johns wort extract prodn. to prevent skin tumour - by macerating mechanically comminuted St. Johns wort and camomile with a plant oil e.g. wheat germ, thistle, sunflower seed, etc. CH680570A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH3463/90A CH680570A5 (en) 1990-10-30 1990-10-30 Allergen-free St. Johns wort extract prodn. to prevent skin tumour - by macerating mechanically comminuted St. Johns wort and camomile with a plant oil e.g. wheat germ, thistle, sunflower seed, etc.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH3463/90A CH680570A5 (en) 1990-10-30 1990-10-30 Allergen-free St. Johns wort extract prodn. to prevent skin tumour - by macerating mechanically comminuted St. Johns wort and camomile with a plant oil e.g. wheat germ, thistle, sunflower seed, etc.

Publications (1)

Publication Number Publication Date
CH680570A5 true CH680570A5 (en) 1992-09-30

Family

ID=4256489

Family Applications (1)

Application Number Title Priority Date Filing Date
CH3463/90A CH680570A5 (en) 1990-10-30 1990-10-30 Allergen-free St. Johns wort extract prodn. to prevent skin tumour - by macerating mechanically comminuted St. Johns wort and camomile with a plant oil e.g. wheat germ, thistle, sunflower seed, etc.

Country Status (1)

Country Link
CH (1) CH680570A5 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19700788A1 (en) * 1997-01-11 1998-07-16 Michael O Ruepp Use of a dry extract of St. John's wort
DE19712729A1 (en) * 1997-03-26 1998-10-01 Franz Marschall Medicament e.g. for healing wounds, infections or insect bites
WO1999021005A2 (en) * 1997-10-23 1999-04-29 Pharmaprint, Inc. Pharmaceutical grade st. john's wort
WO2000030660A2 (en) * 1998-11-25 2000-06-02 Universitätsklinikum Freiburg Hyperforin as cytostatic agent and hyperforin ointment or cream as application form
WO2007045854A2 (en) * 2005-10-20 2007-04-26 Roger Saul Natural oils and their use

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19700788A1 (en) * 1997-01-11 1998-07-16 Michael O Ruepp Use of a dry extract of St. John's wort
DE19712729A1 (en) * 1997-03-26 1998-10-01 Franz Marschall Medicament e.g. for healing wounds, infections or insect bites
WO1999021005A2 (en) * 1997-10-23 1999-04-29 Pharmaprint, Inc. Pharmaceutical grade st. john's wort
WO1999021005A3 (en) * 1997-10-23 2001-02-22 Pharmaprint Inc Pharmaceutical grade st. john's wort
WO2000030660A2 (en) * 1998-11-25 2000-06-02 Universitätsklinikum Freiburg Hyperforin as cytostatic agent and hyperforin ointment or cream as application form
WO2000030660A3 (en) * 1998-11-25 2001-03-01 Universitaetsklinikum Freiburg Hyperforin as cytostatic agent and hyperforin ointment or cream as application form
EP1275382A2 (en) * 1998-11-25 2003-01-15 Universitätsklinikum Freiburg Hyperforin as cytostatic agent and hyperforin ointment or cream as application form
EP1275382A3 (en) * 1998-11-25 2003-02-12 Universitätsklinikum Freiburg Hyperforin as cytostatic agent and hyperforin ointment or cream as application form
WO2007045854A2 (en) * 2005-10-20 2007-04-26 Roger Saul Natural oils and their use
WO2007045854A3 (en) * 2005-10-20 2009-09-24 Roger Saul Natural oils and their use
GB2445716B (en) * 2005-10-20 2010-10-20 Roger Saul Natural oils and their use

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