CH622286A5 - - Google Patents
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- Publication number
- CH622286A5 CH622286A5 CH822475A CH822475A CH622286A5 CH 622286 A5 CH622286 A5 CH 622286A5 CH 822475 A CH822475 A CH 822475A CH 822475 A CH822475 A CH 822475A CH 622286 A5 CH622286 A5 CH 622286A5
- Authority
- CH
- Switzerland
- Prior art keywords
- group
- hcl
- thrombin
- substrate
- arginine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/802—Chromogenic or luminescent peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH822475A CH622286A5 (fr) | 1975-06-23 | 1975-06-23 | |
IL49774A IL49774A (en) | 1975-06-23 | 1976-06-11 | Substrate for the quantitative determination of enzymes |
IT24281/76A IT1070002B (it) | 1975-06-23 | 1976-06-14 | Substrato cromogeno o fluorescente impiegabile come reagente per la determinazione quantitativa di enzimi proteolitici del gruppo e.c. 3.4.4. |
AU14952/76A AU511716B2 (en) | 1975-06-23 | 1976-06-16 | Substrate for quantitative determination of proteolytic enzymes ofthe classe. C. 3. 4. 4 |
US05/697,550 US4070245A (en) | 1975-06-23 | 1976-06-18 | Substrate for the quantitative determination of proteolytic enzymes |
CA255,304A CA1079167A (fr) | 1975-06-23 | 1976-06-21 | Substrat pour l'analyse quantitative des enzymes |
SU762373901A SU673165A3 (ru) | 1975-06-23 | 1976-06-21 | Способ получени пептидов |
DE19762627925 DE2627925A1 (de) | 1975-06-23 | 1976-06-22 | Chromogenes bzw. fluoreszierendes substrat |
GB25832/76A GB1553272A (en) | 1975-06-23 | 1976-06-22 | Substrate for the quantitative determination of enzymes |
NLAANVRAGE7606768,A NL183038C (nl) | 1975-06-23 | 1976-06-22 | Werkwijze voor het bereiden van een substraat voor de kwantitatieve bepaling van proteolytische enzymen uit de groep e.c.3.4.21. en werkwijze voor het kwantitatief bepalen van dergelijke enzymen. |
DK278576A DK149333C (da) | 1975-06-23 | 1976-06-22 | Tripeptidderivater samt salte deraf med mineralsyrer eller organiske syrer til anvendelse som substrater til kvantitativ bestemmelse af thrombin og thrombinlignende enzymer, ecarinthrombin, plasmin og plasminlignende enzymer samt proenzymer, proenzymaktivatorer og enzyminhibitorer herfor i legemsvaeskerfra mennesker og pattedyr samt i dyriske celleekstrakter |
LU75212A LU75212A1 (fr) | 1975-06-23 | 1976-06-22 | |
AT453876A AT349154B (de) | 1975-06-23 | 1976-06-22 | Verfahren zur bestimmung von proteolytischen enzymen der gruppe e.c. 3.4.4. |
FR7618995A FR2315695A1 (fr) | 1975-06-23 | 1976-06-22 | Substrat chromogene ou fluorescent |
SE7607173A SE430059B (sv) | 1975-06-23 | 1976-06-22 | Tripeptidderivat till anvendning som substrat for kvantitativ bestemning av proteolytiska enzymer samt anvendning av nemnda tripeptidderivat |
DE2661080A DE2661080C2 (fr) | 1975-06-23 | 1976-06-22 | |
NO762163A NO147213C (no) | 1975-06-23 | 1976-06-22 | Tripeptider for anvendelse som kromogene h.h.v. fluorescerende substrater ved enzymatiske bestemmelser |
BE168177A BE843245A (fr) | 1975-06-23 | 1976-06-22 | Substrat chromogene ou fluorescent |
JP51074273A JPS523494A (en) | 1975-06-23 | 1976-06-23 | Reagents and method of proteolytic enzyme determination |
SU772440347A SU1099839A3 (ru) | 1975-06-23 | 1977-01-21 | Способ определени тромбина, плазмина, трипсина и тромбиноподобных ферментов в биологических жидкост х |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH822475A CH622286A5 (fr) | 1975-06-23 | 1975-06-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH622286A5 true CH622286A5 (fr) | 1981-03-31 |
Family
ID=4337046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH822475A CH622286A5 (fr) | 1975-06-23 | 1975-06-23 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4070245A (fr) |
JP (1) | JPS523494A (fr) |
AT (1) | AT349154B (fr) |
AU (1) | AU511716B2 (fr) |
BE (1) | BE843245A (fr) |
CA (1) | CA1079167A (fr) |
CH (1) | CH622286A5 (fr) |
DE (2) | DE2627925A1 (fr) |
DK (1) | DK149333C (fr) |
FR (1) | FR2315695A1 (fr) |
GB (1) | GB1553272A (fr) |
IL (1) | IL49774A (fr) |
IT (1) | IT1070002B (fr) |
LU (1) | LU75212A1 (fr) |
NL (1) | NL183038C (fr) |
NO (1) | NO147213C (fr) |
SE (1) | SE430059B (fr) |
SU (2) | SU673165A3 (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4169015A (en) * | 1975-07-11 | 1979-09-25 | Ab Kabi | Novel chromogenic thrombin substrates |
SE407571B (sv) * | 1975-07-11 | 1979-04-02 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
US4191808A (en) * | 1975-10-30 | 1980-03-04 | Ajinomoto Co., Inc. | Method of measuring dipeptidyl-amino-peptidase activity |
US4176009A (en) * | 1976-01-24 | 1979-11-27 | Ajinomoto Co., Inc. | Method of measuring collagenase activity |
CH634662A5 (de) * | 1976-05-28 | 1983-02-15 | Pentapharm Ag | Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren. |
US4167449A (en) * | 1976-07-29 | 1979-09-11 | American Hospital Supply Corporation | Composition and method for determining transferase and protease activity |
SE437153B (sv) * | 1976-12-01 | 1985-02-11 | Kabi Ab | Specifika kromogena enzymsubstrat for serinproteaser |
US4191809A (en) * | 1977-02-26 | 1980-03-04 | Ajinomoto Co., Inc. | Method of measuring enzymatic activity using novel peptide derivatives |
CA1087075A (fr) * | 1977-08-05 | 1980-10-07 | Robert J. Gargiulo | Produit et methode de dosage de l'activite de la transferase et de la protease |
DE2757992A1 (de) * | 1977-12-24 | 1979-06-28 | Boehringer Mannheim Gmbh | Verfahren zur prothrombin-bestimmung |
SE7801373L (sv) * | 1978-02-07 | 1979-08-08 | Kabi Ab | Lett spjelkbara substrat for kvantifiering av proteaser |
DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
US4275153A (en) * | 1978-08-03 | 1981-06-23 | American Hospital Supply Corporation | Analytical fluorogenic substrates for proteolytic enzymes |
US4336186A (en) * | 1978-08-03 | 1982-06-22 | Gargiulo Robert J | Analytical fluorogenic substrates for proteolytic enzymes |
US4216142A (en) * | 1978-12-18 | 1980-08-05 | Abbott Laboratories | Chromogenic substrates for the proteolytic enzymes |
US4217269A (en) * | 1979-03-23 | 1980-08-12 | Abbott Laboratories | Dipeptide chromogenic substrates |
US4219497A (en) * | 1979-04-06 | 1980-08-26 | Abbott Laboratories | Chromogenic substrates |
EP0018002B1 (fr) * | 1979-04-24 | 1983-02-09 | Marcel Jozefonvicz | Procédé pour la détermination de protéases et d'anti-protéases |
US4327178A (en) * | 1979-05-01 | 1982-04-27 | University Of Miami | Urinary kallikrein assay: specific substrates and assay method |
US4221706A (en) * | 1979-06-14 | 1980-09-09 | Abbott Laboratories | Chromogenic substrates |
US4244865A (en) * | 1979-12-03 | 1981-01-13 | Abbott Laboratories | α hydroxy tripeptide substrates |
CA1161432A (fr) * | 1980-02-12 | 1984-01-31 | Lars G. Svendsen | Derives de tripeptides et application pour le dosage des enzymes |
DE3108322A1 (de) | 1980-03-18 | 1981-12-24 | Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien | Chromogenes enzymsubstrat |
DE3164437D1 (en) * | 1980-08-25 | 1984-08-02 | Kabivitrum Ab | Peptide substrates for determination of protease activity |
US4496653A (en) * | 1980-10-09 | 1985-01-29 | Boehringer Mannheim Gmbh | Process for the determination of antithrombin-BM |
US4563305A (en) * | 1981-01-07 | 1986-01-07 | University Of Miami | Radiolabelled substrates for assaying mammalian enzymes |
DE3113350A1 (de) * | 1981-04-02 | 1982-10-21 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur optischen bestimmung des blutgerinnungsverhaltens |
US4434096A (en) | 1981-06-30 | 1984-02-28 | E. I. Du Pont De Nemours And Company | Substrates for the quantitative determination of proteolytic enzymes |
JPS5856695A (ja) * | 1981-09-28 | 1983-04-04 | Nitto Boseki Co Ltd | 新規なトロンビン測定用基質 |
JPS5863399A (ja) * | 1981-10-14 | 1983-04-15 | Nitto Boseki Co Ltd | 新規なプラスミン測定用基質 |
US4448715A (en) * | 1981-11-02 | 1984-05-15 | University Of Miami | Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein |
DE3211254A1 (de) * | 1982-03-26 | 1983-09-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
DE3244030A1 (de) * | 1982-11-27 | 1984-05-30 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
JPS6061557A (ja) * | 1983-09-14 | 1985-04-09 | Nitto Boseki Co Ltd | アルギニル−p−ニトロアニリド化合物の製造方法 |
DE3413311A1 (de) * | 1984-04-09 | 1985-10-17 | Behringwerke Ag, 3550 Marburg | Reagenz zur bestimmung der thromboplastinzeit |
US4897444A (en) * | 1985-05-31 | 1990-01-30 | The Research Foundation Of The State University Of New York | Immobilized fluorogenic substrates for enzymes; and processes for their preparation |
JP2516365B2 (ja) * | 1987-05-09 | 1996-07-24 | サンスタ−株式会社 | 歯周疾患検査薬 |
DE3710937A1 (de) * | 1987-04-01 | 1988-10-13 | Boehringer Mannheim Gmbh | Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate |
JPH01112157A (ja) * | 1987-07-10 | 1989-04-28 | Yamanouchi Pharmaceut Co Ltd | 組織プラスミノーゲンアクチベーター活性の測定法,測定具及び測定用キット |
FR2689640B1 (fr) * | 1992-04-06 | 1997-08-08 | Bio Merieux | Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique. |
JP3368279B2 (ja) * | 1992-04-27 | 2003-01-20 | ベックマン コールター,インコーポレイティド | 血液凝固検定を行うためのテスト物品及び方法 |
NL1006429C2 (nl) * | 1997-06-27 | 1998-12-29 | Univ Maastricht | Werkwijze voor het bepalen van het heparinegehalte. |
DE19904674A1 (de) | 1999-02-04 | 2000-08-31 | Haemosys Gmbh | Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren |
EP1367135A1 (fr) * | 2002-05-29 | 2003-12-03 | Pentapharm AG | Procédé amélioré pour l'évaluation de formation de thrombin dans plasma sanguine |
KR100920297B1 (ko) | 2004-10-12 | 2009-10-08 | 에프. 호프만-라 로슈 아게 | 고상 펩티드 합성 방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL42124A (en) * | 1972-05-02 | 1977-02-28 | Kabi Ab | Substrate for the determination of proteolytic enzymes |
SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
-
1975
- 1975-06-23 CH CH822475A patent/CH622286A5/de not_active IP Right Cessation
-
1976
- 1976-06-11 IL IL49774A patent/IL49774A/xx unknown
- 1976-06-14 IT IT24281/76A patent/IT1070002B/it active
- 1976-06-16 AU AU14952/76A patent/AU511716B2/en not_active Expired
- 1976-06-18 US US05/697,550 patent/US4070245A/en not_active Expired - Lifetime
- 1976-06-21 CA CA255,304A patent/CA1079167A/fr not_active Expired
- 1976-06-21 SU SU762373901A patent/SU673165A3/ru active
- 1976-06-22 SE SE7607173A patent/SE430059B/xx not_active IP Right Cessation
- 1976-06-22 DE DE19762627925 patent/DE2627925A1/de active Granted
- 1976-06-22 GB GB25832/76A patent/GB1553272A/en not_active Expired
- 1976-06-22 NL NLAANVRAGE7606768,A patent/NL183038C/xx not_active IP Right Cessation
- 1976-06-22 BE BE168177A patent/BE843245A/fr not_active IP Right Cessation
- 1976-06-22 NO NO762163A patent/NO147213C/no unknown
- 1976-06-22 AT AT453876A patent/AT349154B/de not_active IP Right Cessation
- 1976-06-22 LU LU75212A patent/LU75212A1/xx unknown
- 1976-06-22 FR FR7618995A patent/FR2315695A1/fr active Granted
- 1976-06-22 DK DK278576A patent/DK149333C/da not_active IP Right Cessation
- 1976-06-22 DE DE2661080A patent/DE2661080C2/de not_active Expired - Lifetime
- 1976-06-23 JP JP51074273A patent/JPS523494A/ja active Granted
-
1977
- 1977-01-21 SU SU772440347A patent/SU1099839A3/ru active
Also Published As
Publication number | Publication date |
---|---|
IT1070002B (it) | 1985-03-25 |
JPS5622519B2 (fr) | 1981-05-26 |
SU673165A3 (ru) | 1979-07-05 |
AU511716B2 (en) | 1980-09-04 |
NO762163L (fr) | 1976-12-27 |
NO147213C (no) | 1983-02-23 |
SE430059B (sv) | 1983-10-17 |
FR2315695B1 (fr) | 1980-07-25 |
BE843245A (fr) | 1976-10-18 |
CA1079167A (fr) | 1980-06-10 |
GB1553272A (en) | 1979-09-26 |
US4070245A (en) | 1978-01-24 |
DE2627925A1 (de) | 1976-12-30 |
DK278576A (da) | 1976-12-24 |
AT349154B (de) | 1979-03-26 |
IL49774A (en) | 1979-11-30 |
DE2661080C2 (fr) | 1990-03-22 |
AU1495276A (en) | 1977-12-22 |
DK149333C (da) | 1986-10-20 |
SU1099839A3 (ru) | 1984-06-23 |
NL183038C (nl) | 1988-07-01 |
FR2315695A1 (fr) | 1977-01-21 |
DK149333B (da) | 1986-05-05 |
SE7607173L (sv) | 1976-12-24 |
NO147213B (no) | 1982-11-15 |
NL183038B (nl) | 1988-02-01 |
DE2627925C2 (fr) | 1987-07-16 |
IL49774A0 (en) | 1976-08-31 |
ATA453876A (de) | 1978-08-15 |
NL7606768A (nl) | 1976-12-27 |
LU75212A1 (fr) | 1977-02-17 |
JPS523494A (en) | 1977-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |