CH414652A - Process for the preparation of 1,4-benzodiazepine derivatives - Google Patents

Process for the preparation of 1,4-benzodiazepine derivatives

Info

Publication number: CH414652A
Authority: CH; Switzerland
Prior art keywords: preparation; benzodiazepine derivatives; benzodiazepine; derivatives
Prior art date: 1959-12-10

Application number

CH1349460A

Other languages

German (de)

Inventor

Reeder Earl

Hendryk Sternbach Leo

Keller Oscar

Steiger Norbert

Stempel Arthur

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1959-12-10

Filing date

1960-12-02

Publication date

1966-06-15

1960-12-02 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1961-06-24 Priority to DK259661AA priority Critical patent/DK104746C/en

1961-06-26 Priority to ES0268604A priority patent/ES268604A1/en

1961-07-07 Priority to FR867221A priority patent/FR1397M/en

1961-11-02 Priority to US149527A priority patent/US3136815A/en

1961-11-20 Priority to US154921A priority patent/US3371085A/en

1966-06-15 Publication of CH414652A publication Critical patent/CH414652A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

CH1349460A 1959-12-10 1960-12-02 Process for the preparation of 1,4-benzodiazepine derivatives CH414652A (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
DK259661AA DK104746C (en)	1960-06-27	1961-06-24	Process for the preparation of 2-α-aminoalkanoylamido-benzophenone compounds or acid addition salts or quaternary ammonium compounds thereof.
ES0268604A ES268604A1 (en)	1960-06-27	1961-06-26	A procedure for the obtaining of benzofenone derivatives (Machine-translation by Google Translate, not legally binding)
FR867221A FR1397M (en)	1960-06-27	1961-07-07	Benzophenone derivatives.
US149527A US3136815A (en)	1959-12-10	1961-11-02	Amino substituted benzophenone oximes and derivatives thereof
US154921A US3371085A (en)	1959-12-10	1961-11-20	5-aryl-3h-1,4-benzodiazepin-2(1h)-ones

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US85856459A	1959-12-10	1959-12-10
US260560A	1960-01-15	1960-01-15
US2468660A	1960-04-26	1960-04-26
US3873260A	1960-06-27	1960-06-27

Publications (1)

Publication Number	Publication Date
CH414652A true CH414652A (en)	1966-06-15

Family

ID=27485190

Family Applications (9)

Application Number	Title	Priority Date	Filing Date
CH1230565A CH408045A (en)	1959-12-10	1960-12-02	Process for the preparation of benzophenone derivatives
CH1349460A CH414652A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepine derivatives
CH1349560A CH414653A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepine derivatives
CH1348960A CH408940A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepine derivatives
CH1349260A CH418341A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepines
CH1349060A CH411910A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepine derivatives
CH1349360A CH418342A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepines
CH1349160A CH408029A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepines
CH1389960A CH396016A (en)	1959-12-10	1960-12-13	Process for the preparation of fluorine-containing benzodiazepines

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CH1230565A CH408045A (en)	1959-12-10	1960-12-02	Process for the preparation of benzophenone derivatives

Family Applications After (7)

Application Number	Title	Priority Date	Filing Date
CH1349560A CH414653A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepine derivatives
CH1348960A CH408940A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepine derivatives
CH1349260A CH418341A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepines
CH1349060A CH411910A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepine derivatives
CH1349360A CH418342A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepines
CH1349160A CH408029A (en)	1959-12-10	1960-12-02	Process for the preparation of 1,4-benzodiazepines
CH1389960A CH396016A (en)	1959-12-10	1960-12-13	Process for the preparation of fluorine-containing benzodiazepines

Country Status (11)

Country	Link
BE (4)	BE598013A (en)
BR (1)	BR6024755D0 (en)
CH (9)	CH408045A (en)
CY (1)	CY324A (en)
DE (5)	DE1288610B (en)
ES (2)	ES263124A1 (en)
GB (13)	GB972976A (en)
MY (1)	MY6500178A (en)
NL (2)	NL6412250A (en)
OA (7)	OA00817A (en)
SE (2)	SE310887B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1795231C3 (en) *	1963-05-29	1978-07-13	American Home Products Corp., New York, N.Y. (V.St.A.)	Process for the preparation of 5-aryl-1,2-dihydro -3H-1,4-benzodiazepin-2-one-4-oxides
GB1333501A (en) *	1971-03-05	1973-10-10	Ravizza Spa	Process for the preparation of 7-chlorobenzodiazepine de rivatives
US4820834A (en) *	1984-06-26	1989-04-11	Merck & Co., Inc.	Benzodiazepine analogs
CA1332410C (en) *	1984-06-26	1994-10-11	Roger M. Freidinger	Benzodiazepine analogs
CA2446696A1 (en) *	2001-06-07	2002-12-12	Neuro3D	Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
CA2485681C (en) *	2002-05-24	2012-10-16	Millennium Pharmaceuticals, Inc.	Ccr9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2893992A (en) *		1959-07-07		I ii i i

1960
- 1960-12-02 CH CH1230565A patent/CH408045A/en unknown
- 1960-12-02 CH CH1349460A patent/CH414652A/en unknown
- 1960-12-02 CH CH1349560A patent/CH414653A/en unknown
- 1960-12-02 CH CH1348960A patent/CH408940A/en unknown
- 1960-12-02 CH CH1349260A patent/CH418341A/en unknown
- 1960-12-02 CH CH1349060A patent/CH411910A/en unknown
- 1960-12-02 CH CH1349360A patent/CH418342A/en unknown
- 1960-12-02 CH CH1349160A patent/CH408029A/en unknown
- 1960-12-07 BR BR124755/60A patent/BR6024755D0/en unknown
- 1960-12-07 DE DEH41139A patent/DE1288610B/en active Pending
- 1960-12-07 DE DEH41137A patent/DE1288609B/en active Pending
- 1960-12-07 DE DEH41138A patent/DE1290143B/en active Pending
- 1960-12-09 GB GB20071/63A patent/GB972976A/en not_active Expired
- 1960-12-09 GB GB42408/60A patent/GB972968A/en not_active Expired
- 1960-12-09 ES ES0263124A patent/ES263124A1/en not_active Expired
- 1960-12-09 GB GB42400/60A patent/GB972962A/en not_active Expired
- 1960-12-09 BE BE598013A patent/BE598013A/en unknown
- 1960-12-09 GB GB42401/60A patent/GB972963A/en not_active Expired
- 1960-12-09 GB GB42405/60A patent/GB972967A/en not_active Expired
- 1960-12-09 GB GB42399/60A patent/GB972961A/en not_active Expired
- 1960-12-09 BE BE598015A patent/BE598015A/en unknown
- 1960-12-09 GB GB42403/60A patent/GB972965A/en not_active Expired
- 1960-12-09 GB GB42402/60A patent/GB972964A/en not_active Expired
- 1960-12-09 BE BE598012A patent/BE598012A/en unknown
- 1960-12-09 GB GB42404/60A patent/GB972966A/en not_active Expired
- 1960-12-09 ES ES0263123A patent/ES263123A1/en not_active Expired
- 1960-12-09 GB GB40978/62A patent/GB972972A/en not_active Expired
- 1960-12-09 BE BE598008A patent/BE598008A/en unknown
- 1960-12-09 GB GB40979/62A patent/GB972973A/en not_active Expired
- 1960-12-13 CH CH1389960A patent/CH396016A/en unknown
- 1960-12-19 DE DE19601445073 patent/DE1445073A1/en active Pending
1961
- 1961-01-11 GB GB1168/61A patent/GB972969A/en not_active Expired
- 1961-01-11 GB GB29834/62A patent/GB972970A/en not_active Expired
1964
- 1964-09-10 DE DE19641445908 patent/DE1445908A1/en active Pending
- 1964-10-21 NL NL6412250A patent/NL6412250A/xx unknown
- 1964-10-21 NL NL6412251A patent/NL6412251A/xx unknown
- 1964-12-16 OA OA50896A patent/OA00817A/en unknown
- 1964-12-16 OA OA50895A patent/OA00816A/en unknown
- 1964-12-26 OA OA51048A patent/OA00953A/en unknown
- 1964-12-26 OA OA51053A patent/OA00958A/en unknown
- 1964-12-26 OA OA51054A patent/OA00959A/en unknown
1965
- 1965-09-17 SE SE12149/65A patent/SE310887B/xx unknown
- 1965-11-03 CY CY32465A patent/CY324A/en unknown
- 1965-12-31 MY MY1965178A patent/MY6500178A/en unknown
1967
- 1967-03-30 OA OA52850A patent/OA02385A/en unknown
- 1967-03-30 OA OA52849A patent/OA02384A/en unknown
- 1967-11-15 SE SE1570567A patent/SE318283B/xx unknown

Also Published As

Publication number	Publication date
OA02385A (en)	1970-05-05
DE1445908A1 (en)	1969-04-17
BR6024755D0 (en)	1973-05-24
GB972964A (en)	1964-10-21
GB972963A (en)	1964-10-21
CH418342A (en)	1966-08-15
GB972968A (en)	1964-10-21
OA00817A (en)	1967-11-15
DE1445073A1 (en)	1968-10-31
BE598015A (en)	1961-06-09
CH411910A (en)	1966-04-30
CH408045A (en)	1966-02-28
CY324A (en)	1965-11-03
CH408029A (en)	1966-02-28
OA00953A (en)	1968-03-22
CH414653A (en)	1966-06-15
SE318283B (en)	1969-12-08
GB972965A (en)	1964-10-21
MY6500178A (en)	1965-12-31
DE1288609B (en)	1969-02-06
DE1288610B (en)	1969-02-06
CH408940A (en)	1966-03-15
BE598008A (en)	1961-06-09
CH396016A (en)	1965-07-31
ES263123A1 (en)	1961-06-01
GB972973A (en)	1964-10-21
GB972967A (en)	1964-10-21
OA02384A (en)	1970-05-05
BE598013A (en)	1961-06-09
OA00958A (en)	1968-03-22
GB972976A (en)	1964-10-21
GB972966A (en)	1964-10-21
CH418341A (en)	1966-08-15
GB972961A (en)	1964-10-21
DE1290143B (en)	1969-03-06
BE598012A (en)	1961-06-09
NL6412250A (en)	1966-01-25
ES263124A1 (en)	1961-06-01
GB972972A (en)	1964-10-21
GB972969A (en)	1964-10-21
GB972962A (en)	1964-10-21
OA00959A (en)	1968-03-22
GB972970A (en)	1964-10-21
OA00816A (en)	1967-11-15
NL6412251A (en)	1966-01-25
SE310887B (en)	1969-05-19

Publication	Publication Date	Title
AT230379B (en)	1963-12-10	Process for the preparation of 2,4-diamino-5-arylmethylpyrimidines
CH393349A (en)	1965-06-15	Process for the preparation of pyrazolo- (1 ', 5': 3,2) -quinazolones
CH408030A (en)	1966-02-28	Process for the preparation of 1,4-benzodiazepine-4-oxides
CH393338A (en)	1965-06-15	Process for the preparation of 1-aryl-4,5-dihalopyridazonen- (6)
CH408940A (en)	1966-03-15	Process for the preparation of 1,4-benzodiazepine derivatives
CH385246A (en)	1964-12-15	Process for the preparation of 1,4-diaminoanthraquinone-2,3-dinitrile
CH462793A (en)	1968-09-30	Process for the preparation of 2,6-dimethyl-2,8-dihalo-octane
CH386420A (en)	1965-01-15	Process for the preparation of 16,17a-dioxy-pregnen-20-one derivatives
CH379488A (en)	1964-07-15	Process for the preparation of 1,4-dicyanobutenes
AT224121B (en)	1962-11-12	Process for the preparation of new 1,4-benzodiazepine derivatives
CH373026A (en)	1963-11-15	Process for the preparation of 2-methyl-2-propyl-propanediol-1,3
CH389628A (en)	1965-03-31	Process for the preparation of 2,4-diamino-quinazolines
CH387048A (en)	1965-01-31	Process for the preparation of 7-theophylline derivatives
CH380727A (en)	1964-08-15	Process for the preparation of 2,4-dioxyquinolines
CH440302A (en)	1967-07-31	Process for the preparation of 1,4-benzodiazepine derivatives
CH373045A (en)	1963-11-15	Process for the preparation of 2,4,5,6-tetrachloropyrimidine
AT209341B (en)	1960-05-25	Process for the preparation of 1,3,4-oxdiazoles
CH404624A (en)	1965-12-31	Process for the preparation of 2,6-dichlorobenzal chloride
CH394201A (en)	1965-06-30	Process for the preparation of N4, N4'-alkylene-N1, N1'-alkylene-bis-4-aminochinaldinium-dihalides
AT223621B (en)	1962-10-10	Process for the preparation of new 1,4-benzodiazepine derivatives
AT224124B (en)	1962-11-12	Process for the preparation of new 1,4-benzodiazepine derivatives
AT224123B (en)	1962-11-12	Process for the preparation of new 1,4-benzodiazepine derivatives
AT223620B (en)	1962-10-10	Process for the preparation of new 1,4-benzodiazepine derivatives
AT224645B (en)	1962-12-10	Process for the preparation of new 1,4-benzodiazepine derivatives
AT224120B (en)	1962-11-12	Process for the preparation of new 1,4-benzodiazepine derivatives