CH188317A - Process for the production of a sulfur-rich, water-soluble mixture of high molecular weight keratin breakdown products. - Google Patents
Process for the production of a sulfur-rich, water-soluble mixture of high molecular weight keratin breakdown products.Info
- Publication number
- CH188317A CH188317A CH188317DA CH188317A CH 188317 A CH188317 A CH 188317A CH 188317D A CH188317D A CH 188317DA CH 188317 A CH188317 A CH 188317A
- Authority
- CH
- Switzerland
- Prior art keywords
- sulfur
- water
- rich
- molecular weight
- production
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
- A61K38/015—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen from keratin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4741—Keratin; Cytokeratin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Description
Verfahren zur Herstellung eines schwefelreichen, wasserlöslichen Gemisches von höhermolekularen Keratinabbauprodukten. Die Hydrolyse von Keratinen mit Säuren ist bekannt. Bekannt ist auch, dass man durch Hydrolyse der Keratine mit Säuren bis zum gallertartigen Zustand und Isolie rung einer in Wasser unlöslichen Fraktion zu schwefelreichen, wasserunlöslichen Kera- tinabbauprodukten gelangen kann, während die wasserlöslichen Abbauprodukte schwe felärmer sind.
Es wurde nun gefunden, dass man ein schwefelreiches, wasserlösliches Gemisch von höhermolekularen Keratinabbauprodukten in der Weise erhalten kann, dass man Keratine durch Hydrolyse mit Säuren bis auf geringe, der Hydrolyse besonders lange widerstehende Anteile löst, das saure Reaktionsgemisch un mittelbar einer Dialyse unterwirft, filtriert. und zur Trockne bringt. Das erhaltene Pro dukt ist zur Verwendung als Kosmetikum und als Zwischenprodukt für pharmazeu tische Präparate bestimmt.
Versuche haben gezeigt, dass das durch Eindampfen des nichtdiffundierten Hydroly- sats gewonnene Produkt wesentlich reicher an Schwefel ist als die Ausgangskeratine. Verwendet man zum Beispiel Haar als Aus gangsmaterial, so gewinnt man ein Produkt, das einen Schwefelgehalt bis zu 7 % auf weist. Schon nach drei- bis fünftägiger Di alyse ist das Produkt so rein, dass es nur noch 0,5 bis<B>1,5%</B> Asche enthält.
<I>Beispiel Z:</I> 200 g Haar werden mit 800 cm' 25 % iger Salzsäure auf dem Wasserbad zunächst vor sichtig auf 40 C erhitzt, bis alles Haar von der Säure bedeckt ist. Dann wird die Tem peratur auf 70 bis 80 C erhöht und so lange weiter erhitzt, bis nur noch ein kleiner Rest ungelöst ist. Nach dem Abkühlen wird das Hydrolysat unmittelbar in einen Pergament beutel gebracht und drei bis fünf Tage gegen fliessendes Wasser dialysiert. Der Inhalt des Pergamentschlauches, der jetzt nur noch schwach sauer reagieren darf, wird filtriert und zur Trockne eingedampft. Man erhält ein gelbliches Pulver mit einem Gehalt von zirka 7 % Schwefel.
<I>Beispiel 2:</I> 1.00 g Wolle werden mit 400 am' 25 % iger Salzsäure auf dem Wasserbad so lange auf 40 C erhitzt, bis die gesamte Wolle von der Säure bedeckt ist. Hierauf wird bei 70 bis 80 C weiter hydrolisiert, bis die Wolle, bis auf einen geringen unlöslich bleibenden Anteil, eben in Lösung gegangen ist und das Hydrolysat, wie in Beispiel 1, weiterbehan- delt.
Process for the production of a sulfur-rich, water-soluble mixture of high molecular weight keratin breakdown products. The hydrolysis of keratins with acids is known. It is also known that hydrolysis of the keratins with acids to a gelatinous state and isolation of a water-insoluble fraction can lead to sulfur-rich, water-insoluble keratin breakdown products, while the water-soluble breakdown products are lower in sulfur.
It has now been found that a sulfur-rich, water-soluble mixture of higher molecular weight keratin degradation products can be obtained in such a way that keratins are dissolved by hydrolysis with acids except for small portions that resist hydrolysis for a particularly long time, the acidic reaction mixture is immediately subjected to dialysis, and filtered . and brings to dryness. The product obtained is intended for use as a cosmetic and as an intermediate for pharmaceutical preparations.
Tests have shown that the product obtained by evaporating the undiffused hydrolyzate is significantly richer in sulfur than the starting keratins. If, for example, hair is used as the starting material, a product is obtained that has a sulfur content of up to 7%. After just three to five days of analysis, the product is so pure that it only contains 0.5 to <B> 1.5% </B> ash.
<I> Example Z: </I> 200 g of hair are first carefully heated to 40 C on a water bath with 800 cm 'of 25% hydrochloric acid until all of the hair is covered by the acid. Then the temperature is increased to 70 to 80 C and continued to be heated until only a small residue remains undissolved. After cooling, the hydrolyzate is immediately placed in a parchment bag and dialyzed against running water for three to five days. The contents of the parchment tube, which are now only allowed to react slightly acidic, are filtered and evaporated to dryness. A yellowish powder is obtained with a content of approximately 7% sulfur.
<I> Example 2: </I> 1.00 g of wool is heated to 40 ° C. with 400 am '25% hydrochloric acid on a water bath until all of the wool is covered by the acid. This is followed by further hydrolysis at 70 to 80 C until the wool has just gone into solution, except for a small portion that remains insoluble, and the hydrolyzate is treated further as in Example 1.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH188317T | 1936-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH188317A true CH188317A (en) | 1936-12-31 |
Family
ID=4435538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH188317D CH188317A (en) | 1936-02-24 | 1936-02-24 | Process for the production of a sulfur-rich, water-soluble mixture of high molecular weight keratin breakdown products. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH188317A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985002120A1 (en) * | 1983-11-09 | 1985-05-23 | L'oreal | Medicament and medicinal composition for the treatment and/or prevention of skin diseases involving an inflammatory process |
-
1936
- 1936-02-24 CH CH188317D patent/CH188317A/en unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985002120A1 (en) * | 1983-11-09 | 1985-05-23 | L'oreal | Medicament and medicinal composition for the treatment and/or prevention of skin diseases involving an inflammatory process |
EP0147261A2 (en) * | 1983-11-09 | 1985-07-03 | L'oreal | Medicine and medicinal composition for the treatment and the prevention of skin affections involving an inflammation process |
EP0147261A3 (en) * | 1983-11-09 | 1985-08-07 | L'oreal | Medicine and medicinal composition for the treatment and the prevention of skin affections involving an inflammation process |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2128779A1 (en) | Process for obtaining tobacco flavorings | |
CH188317A (en) | Process for the production of a sulfur-rich, water-soluble mixture of high molecular weight keratin breakdown products. | |
DE490012C (en) | Process for the production of urea-formaldehyde condensation products | |
DE539101C (en) | Process for the preparation of compounds of agaricic acid | |
DE438199C (en) | Process for the preparation of tanning agents | |
AT159431B (en) | Process for the production of organic iodine compounds. | |
DE912398C (en) | Process for the production of products from formaldehyde, other carbonyl compounds, ammonium salts and urea | |
DE574101C (en) | Process for the production of novel lipoid preparations | |
DE730337C (en) | Process for the production of products from formaldehyde, other carbonyl compounds, ammonium salts and urea | |
DE573034C (en) | Process for the production of water-soluble preparations from diphenolisatin and its substitution products | |
DE434264C (en) | Method for the preparation of a therapeutically effective preparation from digitalis sheets | |
DE634033C (en) | Process for the preparation of dodecahydrotriphenyls | |
AT64086B (en) | Process for increasing the elasticity of bodies obtained from solutions of albumin in formic acid. | |
DE414813C (en) | Process for making clear and durable emulsions | |
DE970738C (en) | Core binder | |
AT61061B (en) | Process for the production of tanning agents. | |
DE630526C (en) | Process for the preparation of derivatives of higher alcohols | |
DE530309C (en) | Process for obtaining new products from yeast | |
DE129031C (en) | Process for the preparation of easily soluble in water, resistant alkali salts of the decomposition products resulting from the alkaline hydrolysis of the native protein | |
DE373849C (en) | Process for the production of an odorless naphthenic acid ester | |
DE577107C (en) | Process for the conversion of diacetyl monoxime into diacetyl | |
DE525821C (en) | Process for the preparation of pyrethrum extract emulsions | |
AT132707B (en) | Process for the preparation of organic bromine derivatives. | |
DE903624C (en) | Process for the preparation of durable, injectable solutions of 1-phenyl-2, 3-dialkyl-4-dialkylamino-5-pyrazolones | |
DE490400C (en) | Process for the preparation of alkaline earth salts of organic arsenic compounds |