CA3136453A1 - Anticorps anti-pd-l1 humanises - Google Patents
Anticorps anti-pd-l1 humanises Download PDFInfo
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- CA3136453A1 CA3136453A1 CA3136453A CA3136453A CA3136453A1 CA 3136453 A1 CA3136453 A1 CA 3136453A1 CA 3136453 A CA3136453 A CA 3136453A CA 3136453 A CA3136453 A CA 3136453A CA 3136453 A1 CA3136453 A1 CA 3136453A1
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- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Abstract
La présente invention concerne des molécules de liaison isolées qui se lient à PD-L1 et le bloquent, des vecteurs comprenant une molécule d'acide nucléique codant pour une séquence d'acides aminés des molécules de liaison, des cellules hôtes contenant les vecteurs, des procédés de fabrication des molécules de liaison, des compositions pharmaceutiques contenant les molécules de liaison, et des procédés d'utilisation de ces anticorps, fragments d'anticorps et dérivés et polypeptides, y compris des méthodes de traitement d'une maladie nécessitant une stimulation des réponses immunitaires y compris le cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201962835764P | 2019-04-18 | 2019-04-18 | |
US62/835,764 | 2019-04-18 | ||
PCT/US2020/028862 WO2020215020A1 (fr) | 2019-04-18 | 2020-04-17 | Anticorps anti-pd-l1 humanisés |
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CA3136453A1 true CA3136453A1 (fr) | 2020-10-22 |
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CA3136453A Pending CA3136453A1 (fr) | 2019-04-18 | 2020-04-17 | Anticorps anti-pd-l1 humanises |
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US (2) | US11124572B2 (fr) |
EP (1) | EP3955925A4 (fr) |
JP (1) | JP2022529269A (fr) |
CN (1) | CN114025757A (fr) |
CA (1) | CA3136453A1 (fr) |
WO (1) | WO2020215020A1 (fr) |
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WO2022068894A1 (fr) * | 2020-09-30 | 2022-04-07 | 上海齐鲁制药研究中心有限公司 | Molécule bifonctionnelle ciblant simultanément pd-l1 et vegf et son utilisation médicale |
CA3191224A1 (fr) * | 2020-10-16 | 2022-04-21 | Shenda GU | Composes de liaison multispecifiques se liant a pd-l1 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
KR20210060670A (ko) * | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도 |
KR20220084444A (ko) * | 2012-05-31 | 2022-06-21 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Pd-l1에 결합하는 항원 결합 단백질 |
IL256245B (en) * | 2015-06-16 | 2022-09-01 | Merck Patent Gmbh | Treatments that combine a pd-l1 antagonist |
AU2017212717B2 (en) * | 2016-01-29 | 2023-11-16 | Yuhan Corporation | Antigen binding proteins that bind PD-L1 |
US20190106494A1 (en) * | 2016-06-13 | 2019-04-11 | Askgene Pharma Inc. | PD-L1 Specific Monoclonal Antibodies for Disease Treatment and Diagnosis |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
US11168144B2 (en) * | 2017-06-01 | 2021-11-09 | Cytomx Therapeutics, Inc. | Activatable anti-PDL1 antibodies, and methods of use thereof |
AU2018276140A1 (en) * | 2017-06-01 | 2019-12-19 | Compugen Ltd. | Triple combination antibody therapies |
US11498966B2 (en) * | 2017-08-09 | 2022-11-15 | Orionis Biosciences Inc. | PD-1 and PD-L1 binding agents |
-
2020
- 2020-04-17 WO PCT/US2020/028862 patent/WO2020215020A1/fr unknown
- 2020-04-17 EP EP20791195.9A patent/EP3955925A4/fr active Pending
- 2020-04-17 CA CA3136453A patent/CA3136453A1/fr active Pending
- 2020-04-17 US US16/852,313 patent/US11124572B2/en active Active
- 2020-04-17 JP JP2021561618A patent/JP2022529269A/ja active Pending
- 2020-04-17 CN CN202080029661.0A patent/CN114025757A/zh active Pending
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2021
- 2021-08-19 US US17/407,151 patent/US11643466B2/en active Active
Also Published As
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EP3955925A4 (fr) | 2023-03-22 |
JP2022529269A (ja) | 2022-06-20 |
US20220112290A1 (en) | 2022-04-14 |
WO2020215020A1 (fr) | 2020-10-22 |
US11124572B2 (en) | 2021-09-21 |
EP3955925A1 (fr) | 2022-02-23 |
CN114025757A (zh) | 2022-02-08 |
US20200332010A1 (en) | 2020-10-22 |
US11643466B2 (en) | 2023-05-09 |
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