CA3083118A1 - Expansion de lymphocytes de sang peripherique (pbl) a partir de sang peripherique - Google Patents

Expansion de lymphocytes de sang peripherique (pbl) a partir de sang peripherique Download PDF

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Publication number
CA3083118A1
CA3083118A1 CA3083118A CA3083118A CA3083118A1 CA 3083118 A1 CA3083118 A1 CA 3083118A1 CA 3083118 A CA3083118 A CA 3083118A CA 3083118 A CA3083118 A CA 3083118A CA 3083118 A1 CA3083118 A1 CA 3083118A1
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CA
Canada
Prior art keywords
pbls
cells
cell
tils
culture medium
Prior art date
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Pending
Application number
CA3083118A
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English (en)
Inventor
Lavakumar KARYAMPUDI
Maria Fardis
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Iovance Biotherapeutics Inc
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Iovance Biotherapeutics Inc
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Publication date
Priority claimed from PCT/US2018/032109 external-priority patent/WO2018209115A1/fr
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of CA3083118A1 publication Critical patent/CA3083118A1/fr
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/30—Coculture with; Conditioned medium produced by tumour cells

Abstract

L'invention concerne des procédés d'expansion de lymphocytes infiltrant les tumeurs (TIL), dont les lymphocytes de sang périphérique (PBL) et de lymphocytes infiltrant la moelle (MIL), à partir de sang et/ou de moelle osseuse de patients porteurs de malignités hématologiques, telles que des tumeurs liquides, y compris les lymphomes et leucémies, et des modifications génétiques de TIL, PBL et MIL expansés pour incorporer des récepteurs d'antigènes chimériques, des récepteurs de lymphocytes T génétiquement modifiés, et autres modifications génétiques, et des utilisations de ces TIL, PBL, et MIL expansés et/ou modifiés dans le traitement de maladies telles que les cancers et les malignités hématologiques ci-décrites.
CA3083118A 2017-11-22 2018-11-09 Expansion de lymphocytes de sang peripherique (pbl) a partir de sang peripherique Pending CA3083118A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762590034P 2017-11-22 2017-11-22
US62/590,034 2017-11-22
US201862621462P 2018-01-24 2018-01-24
US62/621,462 2018-01-24
US201862621798P 2018-01-25 2018-01-25
US62/621,798 2018-01-25
US201862647367P 2018-03-23 2018-03-23
US62/647,367 2018-03-23
USPCT/US2018/032109 2018-05-10
PCT/US2018/032109 WO2018209115A1 (fr) 2017-05-10 2018-05-10 Expansion de lymphocytes infiltrant des tumeurs à partir de tumeurs liquides et leurs utilisations thérapeutiques
PCT/US2018/060183 WO2019103857A1 (fr) 2017-11-22 2018-11-09 Expansion de lymphocytes de sang périphérique (pbl) à partir de sang périphérique

Publications (1)

Publication Number Publication Date
CA3083118A1 true CA3083118A1 (fr) 2019-05-31

Family

ID=66631141

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3083118A Pending CA3083118A1 (fr) 2017-11-22 2018-11-09 Expansion de lymphocytes de sang peripherique (pbl) a partir de sang peripherique

Country Status (4)

Country Link
EP (1) EP3714041A1 (fr)
JP (2) JP2021503885A (fr)
CA (1) CA3083118A1 (fr)
WO (1) WO2019103857A1 (fr)

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CA3056630A1 (fr) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Immunotolerance ciblee
CA3064435A1 (fr) 2017-05-24 2018-11-29 Pandion Therapeutics, Inc. Immunotolerance ciblee
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
KR20210098485A (ko) * 2018-11-30 2021-08-10 윈드밀 테라퓨틱스, 인크. 키메라 항원 수용체(car)를 발현하는 골수 침윤성 림프구(mil), 이를 제조하는 방법 및 치료에 사용하는 방법
WO2020232029A1 (fr) * 2019-05-13 2020-11-19 Iovance Biotherapeutics, Inc. Procédés et compositions pour sélectionner des lymphocytes infiltrant les tumeurs et leurs utilisations en immunothérapie
BR112021023345A2 (pt) 2019-05-20 2022-02-01 Pandion Operations Inc Imunotolerância com alvo em madcam
WO2021123832A1 (fr) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Dispositifs et procédés d'isolement de lymphocytes infiltrant les tumeurs et leurs utilisations
BR112023021665A2 (pt) * 2021-04-19 2023-12-19 Iovance Biotherapeutics Inc Método para tratar um câncer, e, composição
CN116355845B (zh) * 2021-12-28 2024-03-26 北京永泰生物制品有限公司 一种质量稳定可控的扩增活化淋巴细胞的方法及其用于抗肿瘤用途

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