CA2677001A1 - Composes a base de quinoleine et de naphtyridine a substitution thio en position 4 - Google Patents

Composes a base de quinoleine et de naphtyridine a substitution thio en position 4 Download PDF

Info

Publication number
CA2677001A1
CA2677001A1 CA002677001A CA2677001A CA2677001A1 CA 2677001 A1 CA2677001 A1 CA 2677001A1 CA 002677001 A CA002677001 A CA 002677001A CA 2677001 A CA2677001 A CA 2677001A CA 2677001 A1 CA2677001 A1 CA 2677001A1
Authority
CA
Canada
Prior art keywords
alkyl
aryl
aralkyl
cycloalkyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002677001A
Other languages
English (en)
Inventor
Zhen Yang
Reza Fathi
Qiang Zhu
Hyun Joon Cho
Yixin Liu
Anthony Sandrasagra
Richard C. Wobbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XTL Biopharmaceuticals Ltd
Original Assignee
Xtl Biopharmaceuticals Ltd.
Zhen Yang
Reza Fathi
Qiang Zhu
Hyun Joon Cho
Yixin Liu
Anthony Sandrasagra
Richard C. Wobbe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xtl Biopharmaceuticals Ltd., Zhen Yang, Reza Fathi, Qiang Zhu, Hyun Joon Cho, Yixin Liu, Anthony Sandrasagra, Richard C. Wobbe filed Critical Xtl Biopharmaceuticals Ltd.
Publication of CA2677001A1 publication Critical patent/CA2677001A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
CA002677001A 2006-08-23 2007-08-22 Composes a base de quinoleine et de naphtyridine a substitution thio en position 4 Abandoned CA2677001A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83992206P 2006-08-23 2006-08-23
US60/839,922 2006-08-23
PCT/US2007/018607 WO2008024423A2 (fr) 2006-08-23 2007-08-22 Composés à base de quinoléine et de naphtyridine à substitution thio en position 4

Publications (1)

Publication Number Publication Date
CA2677001A1 true CA2677001A1 (fr) 2008-02-28

Family

ID=39107397

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002677001A Abandoned CA2677001A1 (fr) 2006-08-23 2007-08-22 Composes a base de quinoleine et de naphtyridine a substitution thio en position 4

Country Status (5)

Country Link
EP (1) EP2061466A4 (fr)
JP (1) JP2010501570A (fr)
AU (1) AU2007288188A1 (fr)
CA (1) CA2677001A1 (fr)
WO (1) WO2008024423A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016333987A1 (en) 2015-10-05 2018-05-10 Ny State Psychiatric Institute Activators of autophagic flux and phospholipase D and clearance of protein aggregates including tau and treatment of proteinopathies
US11459340B2 (en) 2018-09-18 2022-10-04 Nikang Therapeutics, Inc. Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430153A (en) * 1991-04-03 1995-07-04 Korea Research Institute Of Chemical Technology 2-quinolinone derivatives
FR2737496B1 (fr) * 1995-07-31 1997-12-19 Centre Nat Rech Scient 4-aryl-thio-pyridin-2(1h)-ones, medicaments les contenant et leurs utilisations dans le traitement de maladies liees aux vih 1 et 2
CA2534649A1 (fr) * 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Derives de l'imidazole bicycliques diriges contre les flaviviridae

Also Published As

Publication number Publication date
WO2008024423A2 (fr) 2008-02-28
EP2061466A2 (fr) 2009-05-27
AU2007288188A1 (en) 2008-02-28
JP2010501570A (ja) 2010-01-21
WO2008024423A3 (fr) 2008-11-20
EP2061466A4 (fr) 2010-12-29

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