CA2650711A1 - Compositions et traitements utilisant des pyridazines et des inhibiteurs de cholinesterase - Google Patents

Compositions et traitements utilisant des pyridazines et des inhibiteurs de cholinesterase Download PDF

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Publication number
CA2650711A1
CA2650711A1 CA002650711A CA2650711A CA2650711A1 CA 2650711 A1 CA2650711 A1 CA 2650711A1 CA 002650711 A CA002650711 A CA 002650711A CA 2650711 A CA2650711 A CA 2650711A CA 2650711 A1 CA2650711 A1 CA 2650711A1
Authority
CA
Canada
Prior art keywords
compound
cholinesterase inhibitor
substituted
pyridazine compound
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002650711A
Other languages
English (en)
Inventor
Martin Watterson
Linda Van Eldik
Wenhui Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwestern University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2650711A1 publication Critical patent/CA2650711A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002650711A 2006-04-28 2007-04-27 Compositions et traitements utilisant des pyridazines et des inhibiteurs de cholinesterase Abandoned CA2650711A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79634806P 2006-04-28 2006-04-28
US60/796,348 2006-04-28
PCT/US2007/010463 WO2007127474A2 (fr) 2006-04-28 2007-04-27 Compositions et traitements utilisant des pyridazines et des inhibiteurs de cholinestérase

Publications (1)

Publication Number Publication Date
CA2650711A1 true CA2650711A1 (fr) 2007-11-08

Family

ID=38543765

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002650711A Abandoned CA2650711A1 (fr) 2006-04-28 2007-04-27 Compositions et traitements utilisant des pyridazines et des inhibiteurs de cholinesterase

Country Status (4)

Country Link
US (2) US8158627B2 (fr)
EP (1) EP2015750A2 (fr)
CA (1) CA2650711A1 (fr)
WO (1) WO2007127474A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011156901A2 (fr) * 2010-06-17 2011-12-22 Waratah Pharmaceuticals Inc. Composés, compositions et procédés pour traiter la sclérose en plaques
US8367672B2 (en) 2004-11-02 2013-02-05 Universite De Strasbourg Pyridazine compounds, compositions and methods

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EP2264014A1 (fr) 2001-08-31 2010-12-22 Université Louis Pasteur Pyridazines substitués comme anti-inflammatoirs et inhibiteurs de la protéine kinase
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
WO2006050359A2 (fr) 2004-11-02 2006-05-11 Northwestern University Composes pyridazine et methodes
EP2591784B1 (fr) 2005-05-10 2016-09-14 Intermune, Inc. Dérives de la Pyridin-2-one comme modulateur du système de proteine kinase activé par le stress
WO2007127375A2 (fr) 2006-04-28 2007-11-08 Northwestern University Formulations contenant un composé de pyridazine
WO2007127475A2 (fr) * 2006-04-28 2007-11-08 Northwestern University Compositions et traitements contre des maladies démyélinisantes et des troubles de type douleur
CA2650711A1 (fr) 2006-04-28 2007-11-08 Northwestern University Compositions et traitements utilisant des pyridazines et des inhibiteurs de cholinesterase
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
WO2010021993A1 (fr) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Procédés d'utilisation de cellules issues du tissu adipeux dans le traitement du système lymphatique et d'une maladie maligne
US20100227793A1 (en) * 2009-03-04 2010-09-09 Scott Thomas Brady Compositions and Methods for Treating Amyotrophic Lateral Sclerosis
CN109662964A (zh) 2010-02-09 2019-04-23 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
WO2012064923A2 (fr) * 2010-11-10 2012-05-18 Purdue Research Foundation Composés et procédés pour traiter la sclérose en plaques
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神***病を処置するための方法および組成物
WO2014144801A1 (fr) 2013-03-15 2014-09-18 Agenebio Inc. Procédés et compositions pour améliorer la fonction cognitive
EP3842424A1 (fr) 2013-03-15 2021-06-30 The Trustees of Columbia University in the City of New York Modulateurs de map kinase et leurs utilisations dans le traitement de tauopathies
EP3827820A1 (fr) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam pour améliorer la fonction cognitive
WO2015120388A1 (fr) * 2014-02-10 2015-08-13 Cytori Therapeutics, Inc. Thérapie cellulaire régénérative pour troubles du système nerveux central (snc) et espt
CA2943363A1 (fr) 2014-04-02 2015-10-08 Intermune, Inc. Pyridinones anti-fibrotiques
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam
US20220048913A1 (en) * 2017-07-12 2022-02-17 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
EP3697781B1 (fr) 2017-10-17 2023-06-07 Vanderbilt University Antagonistes du récepteur muscarinique de l'acétylcholine m4
WO2019126559A1 (fr) 2017-12-20 2019-06-27 Vanderbilt University Antagonistes du récepteur muscarinique de l'acétylcholine m4
TW202204323A (zh) * 2020-03-27 2022-02-01 日商安斯泰來製藥股份有限公司 經取代之嗒𠯤化合物
WO2023163951A1 (fr) * 2022-02-23 2023-08-31 Immunochem Therapeutics, Llc Traitement de l'hémorragie intracrânienne

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367672B2 (en) 2004-11-02 2013-02-05 Universite De Strasbourg Pyridazine compounds, compositions and methods
WO2011156901A2 (fr) * 2010-06-17 2011-12-22 Waratah Pharmaceuticals Inc. Composés, compositions et procédés pour traiter la sclérose en plaques
WO2011156901A3 (fr) * 2010-06-17 2012-02-02 Waratah Pharmaceuticals Inc. Composés, compositions et procédés pour traiter la sclérose en plaques

Also Published As

Publication number Publication date
WO2007127474A3 (fr) 2008-06-19
US20120157410A1 (en) 2012-06-21
WO2007127474A2 (fr) 2007-11-08
US8158627B2 (en) 2012-04-17
US20090197885A1 (en) 2009-08-06
EP2015750A2 (fr) 2009-01-21

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Effective date: 20110427