CA2643066A1 - Pyrazoles - Google Patents
Pyrazoles Download PDFInfo
- Publication number
- CA2643066A1 CA2643066A1 CA002643066A CA2643066A CA2643066A1 CA 2643066 A1 CA2643066 A1 CA 2643066A1 CA 002643066 A CA002643066 A CA 002643066A CA 2643066 A CA2643066 A CA 2643066A CA 2643066 A1 CA2643066 A1 CA 2643066A1
- Authority
- CA
- Canada
- Prior art keywords
- pyrazol
- pyrimidin
- chloro
- cycloheteroalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78278606P | 2006-03-16 | 2006-03-16 | |
| US60/782,786 | 2006-03-16 | ||
| US88656107P | 2007-01-25 | 2007-01-25 | |
| US60/886,561 | 2007-01-25 | ||
| PCT/IB2007/000561 WO2007105058A2 (fr) | 2006-03-16 | 2007-03-05 | Pyrazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2643066A1 true CA2643066A1 (fr) | 2007-09-20 |
Family
ID=38235169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002643066A Abandoned CA2643066A1 (fr) | 2006-03-16 | 2007-03-05 | Pyrazoles |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2024353A2 (fr) |
| JP (1) | JP2009530261A (fr) |
| CA (1) | CA2643066A1 (fr) |
| WO (1) | WO2007105058A2 (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008042639A1 (fr) | 2006-10-02 | 2008-04-10 | Irm Llc | Composés et compositions utilisés en tant qu'inhibiteurs de protéine kinase |
| CA2687931C (fr) * | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Antagonistes des recepteurs ccr2 et utilisations de ceux-ci |
| KR20100038119A (ko) | 2007-08-01 | 2010-04-12 | 화이자 인코포레이티드 | 피라졸 화합물 및 ｒａｆ 억제제로서 이의 용도 |
| MY152948A (en) * | 2007-11-16 | 2014-12-15 | Incyte Corp | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
| JP2011506277A (ja) * | 2007-11-28 | 2011-03-03 | トラガラ ファーマシューティカルズ，インク． | Ｃｏｘ−２阻害薬と代謝拮抗物質との組み合わせを使用する癌治療 |
| SI2324008T1 (sl) * | 2008-07-24 | 2012-08-31 | Nerviano Medical Sciences Srl | 3,4-diarilpirazoli kot protein-kinazni inhibitorji |
| PE20120061A1 (es) | 2008-12-19 | 2012-02-19 | Boehringer Ingelheim Int | Derivados de pirimidina como antagonistas del receptor ccr2 |
| JP5490137B2 (ja) * | 2008-12-19 | 2014-05-14 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | プロテインキナーゼ阻害薬としての二環式ピラゾール |
| KR101111247B1 (ko) * | 2009-07-17 | 2012-06-12 | 한국과학기술연구원 | Ｒｏｓ 카이네이즈 저해활성을 갖는 피라졸 화합물 |
| JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| EP2308866A1 (fr) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazoles et leur utilisation comme fongicides |
| KR101123071B1 (ko) * | 2009-10-23 | 2012-03-05 | 한국과학기술연구원 | 신규 이미다졸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 흑색종의 예방 및 치료용 약학적 조성물 |
| PT3091012T (pt) | 2009-12-17 | 2018-06-27 | Centrexion Therapeutics Corp | Antagonistas do receptor ccr2 e suas utilizações |
| WO2011092088A1 (fr) | 2010-01-27 | 2011-08-04 | Nerviano Medical Sciences S.R.L. | Dérivés sulfonamido des 3,4-diarylpyrazones comme inhibiteurs des protéines kinases |
| AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
| JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
| US8946218B2 (en) | 2010-05-12 | 2015-02-03 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| US8841313B2 (en) | 2010-05-17 | 2014-09-23 | Boehringer Ingelheim International Gmbh | CCR2 antagonists and uses thereof |
| JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| EP2576538B1 (fr) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | Nouveaux antagonistes de CCR2 |
| US9114137B2 (en) | 2010-08-03 | 2015-08-25 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
| CA2819215C (fr) * | 2010-12-01 | 2018-05-01 | Nissan Chemical Industries, Ltd. | Compose pyrazole ayant un effet therapeutique sur le myelome multiple |
| WO2012144463A1 (fr) | 2011-04-18 | 2012-10-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Agent thérapeutique pour les tumeurs |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| CN108542906A (zh) | 2011-11-11 | 2018-09-18 | 诺华股份有限公司 | 治疗增生性疾病的方法 |
| CN103945831A (zh) | 2011-11-23 | 2014-07-23 | 诺华股份有限公司 | 医药制剂 |
| CN105848682A (zh) | 2013-12-23 | 2016-08-10 | 诺华股份有限公司 | 药物组合 |
| MX2017017177A (es) | 2015-07-02 | 2018-11-09 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidi n-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-piran-2-il)m etilamino)pirimidin-4il) metanona. |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (fr) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Composés de pyrrolo[2,3-d]pyrimidinone en tant qu'inhibiteurs de cdk2 |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| MX2022001940A (es) | 2019-08-14 | 2022-05-10 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2. |
| PE20221905A1 (es) | 2019-10-11 | 2022-12-23 | Incyte Corp | Aminas biciclicas como inhibidoras de la cdk2 |
| WO2021120890A1 (fr) * | 2019-12-20 | 2021-06-24 | Novartis Ag | Dérivés pyrazolyle utiles en tant qu'agents anticancéreux |
| TW202233607A (zh) * | 2020-10-30 | 2022-09-01 | 瑞士商諾華公司 | Ｋｒａｓ ｇ１２ｃ抑制劑化合物之新結晶形式 |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA003925B1 (ru) * | 1997-05-22 | 2003-10-30 | Дж.Д.Сирл Энд Ко | ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ, КАК ИНГИБИТОРЫ p 38 КИНАЗЫ |
| AU7922100A (en) * | 1999-10-25 | 2001-05-08 | Basf Aktiengesellschaft | Agrochemical compositions containing pyrazoles as the active agents and use of said compositions as plant protection agents with a fungicidal action |
| AU2002356301A1 (en) * | 2001-12-21 | 2003-07-15 | Cancer Research Technology Ltd. | 3,4-diarylpyrazoles and their use in the therapy of cancer |
| EP1511743A1 (fr) * | 2002-06-05 | 2005-03-09 | Pharmacia Corporation | Derives de pyrazols utilises comme inhibiteurs de la p38 kinase |
| GB0215844D0 (en) * | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
| EP1841757B1 (fr) * | 2005-01-07 | 2010-06-30 | Pfizer Products Incorporated | Composes de quinoline heteroaromatiques et leur utilisation comme inhibiteurs de pde-10 |
-
2007
- 2007-03-05 EP EP07705682A patent/EP2024353A2/fr not_active Withdrawn
- 2007-03-05 JP JP2008558927A patent/JP2009530261A/ja not_active Withdrawn
- 2007-03-05 WO PCT/IB2007/000561 patent/WO2007105058A2/fr active Application Filing
- 2007-03-05 CA CA002643066A patent/CA2643066A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007105058A2 (fr) | 2007-09-20 |
| JP2009530261A (ja) | 2009-08-27 |
| EP2024353A2 (fr) | 2009-02-18 |
| WO2007105058A8 (fr) | 2008-10-16 |
| WO2007105058A3 (fr) | 2007-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |