CA2629468A1 - Derives de pyrazolyluree utilisables dans le traitement du cancer - Google Patents
Derives de pyrazolyluree utilisables dans le traitement du cancer Download PDFInfo
- Publication number
- CA2629468A1 CA2629468A1 CA002629468A CA2629468A CA2629468A1 CA 2629468 A1 CA2629468 A1 CA 2629468A1 CA 002629468 A CA002629468 A CA 002629468A CA 2629468 A CA2629468 A CA 2629468A CA 2629468 A1 CA2629468 A1 CA 2629468A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- pyrazol
- fluorophenyl
- oxy
- aminopyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73640005P | 2005-11-15 | 2005-11-15 | |
US60/736,400 | 2005-11-15 | ||
PCT/US2006/044322 WO2007059202A2 (fr) | 2005-11-15 | 2006-11-15 | Derives de pyrazolyluree utilisables dans le traitement du cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2629468A1 true CA2629468A1 (fr) | 2007-05-24 |
Family
ID=38016517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002629468A Abandoned CA2629468A1 (fr) | 2005-11-15 | 2006-11-15 | Derives de pyrazolyluree utilisables dans le traitement du cancer |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1960394A2 (fr) |
CA (1) | CA2629468A1 (fr) |
WO (1) | WO2007059202A2 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006029795A1 (de) * | 2006-06-27 | 2008-01-03 | Schebo Biotech Ag | Neue Harnstoff-Derivate und deren Verwendungen |
DK2229391T3 (da) | 2007-12-19 | 2014-10-13 | Cancer Res Inst Royal | Pyrido[2,3-B]pyrazin-8-substituerede forbindelser og deres anvendelse |
GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
PE20110598A1 (es) | 2008-10-02 | 2011-08-31 | Respivert Ltd | Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38 |
US8299073B2 (en) | 2008-12-11 | 2012-10-30 | Respivert Ltd. | P38 MAP kinase inhibitors |
JP2012516843A (ja) * | 2009-02-02 | 2012-07-26 | インドコ レメディーズ リミテッド | ニトロピリジン誘導体の調製方法 |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
CN102906090B (zh) | 2010-02-01 | 2015-06-24 | 癌症研究技术有限公司 | 1-(5-叔丁基-2-苯基-2h-吡唑-3-基)-3-[2-氟-4-(1-甲基-2-氧代-2,3-二氢-1h-咪唑并[4,5-b]吡啶-7-基氧基)-苯基]-脲和相关化合物及它们在治疗中的应用 |
WO2012003338A1 (fr) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet |
KR101960555B1 (ko) | 2011-05-13 | 2019-03-20 | 어레이 바이오파마 인크. | Trka 키나제 저해제로서의 피롤리디닐 유레아 및 피롤리디닐 티오유레아 화합물 |
US9809578B2 (en) | 2012-11-13 | 2017-11-07 | Array Biopharma Inc. | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors |
WO2014078408A1 (fr) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Composés d'hétéroaryle urée, thiourée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka |
DK2922844T3 (en) | 2012-11-13 | 2018-03-05 | Array Biopharma Inc | N-PYRROLIDINYL, N'-PYRAZOLYL-URINE, THIOURINE, GUANIDINE AND CYANOGUANIDE COMPOUNDS AS TRKA-KINASE INHIBITORS |
US9790178B2 (en) | 2012-11-13 | 2017-10-17 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
US9546156B2 (en) | 2012-11-13 | 2017-01-17 | Array Biopharma Inc. | N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors |
WO2014078331A1 (fr) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Composés de n-(arylalkyle)-n'-pyrazolyle-urée, de thiourée, de guanidine et de cyanoguanidine en tant qu'inhibiteurs de la kinase trka |
WO2014078322A1 (fr) * | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Composés de thiazolyl-urée, oxazolyl-urée, thio-urée, guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka |
WO2014078325A1 (fr) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Composés de n-aryle monocycliques, n'-pyrazolyl-urée, thiourée, guanidine et cyanoguanidine utiles comme inhibiteurs de trka kinase |
US9828360B2 (en) | 2012-11-13 | 2017-11-28 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
MX366761B (es) * | 2012-11-13 | 2019-07-23 | Array Biopharma Inc | Compuestos bíciclicos de urea, tiourea, guanidina y cianoguanidina útiles para el tratamiento del dolor. |
GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
MA40434B1 (fr) | 2014-05-15 | 2019-09-30 | Array Biopharma Inc | 1-((3s,4r)-4-(3-fluorophényl)-1-(2-méthoxyéthyl)pyrrolidin-3-yl)-3-(4-méthyl-3-(2-méthylpyrimidin-5-yl)-1-phényl-1h-pyrazol-5-yl)urée comme inhibiteur de la kinase trka |
EP3229836B1 (fr) | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Anticoprs monoclonaux contre 'axl' |
WO2016135041A1 (fr) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Protéines de fusion et anticorps les contenant pour favoriser l'apoptose |
CN107056653B (zh) * | 2017-06-09 | 2019-07-09 | 丽珠医药集团股份有限公司 | 布南色林中间体对氟苯甲酰乙腈的合成方法 |
US20230089368A1 (en) | 2019-07-19 | 2023-03-23 | Anagenesis Biotechnologies S.A.S. | Polyaromatic urea derivatives and their use in the treatment of muscle diseases |
EP4029501A1 (fr) | 2021-01-19 | 2022-07-20 | Anagenesis Biotechnologies | Combinaison de dérivés polyaromatiques de l'urée et d'inhibiteur glucocorticoïde ou hdac pour le traitement de maladies ou d'affections associées aux cellules musculaires et/ou aux cellules satellites |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100622138B1 (ko) * | 1997-12-22 | 2006-09-13 | 바이엘 코포레이션 | 아릴 및 헤테로아릴 치환 헤테로고리형 우레아를 사용한라프 키나제의 저해 |
CZ299156B6 (cs) * | 1997-12-22 | 2008-05-07 | Bayer Corporation | Substituované heterocyklické mocoviny, farmaceutické prípravky je obsahující a jejich použití |
JP2007535565A (ja) * | 2004-04-30 | 2007-12-06 | バイエル ファーマシューティカルス コーポレーション | 癌の治療に有用な置換ピラゾリル尿素誘導体 |
-
2006
- 2006-11-15 WO PCT/US2006/044322 patent/WO2007059202A2/fr active Application Filing
- 2006-11-15 CA CA002629468A patent/CA2629468A1/fr not_active Abandoned
- 2006-11-15 EP EP06837652A patent/EP1960394A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2007059202A3 (fr) | 2007-08-09 |
EP1960394A2 (fr) | 2008-08-27 |
WO2007059202A2 (fr) | 2007-05-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |