CA2528095A1 - Compositions pour l'inactivation de micro-organismes pathogenes, procedes de fabrication de compositions, et leurs procedes d'utilisation - Google Patents

Compositions pour l'inactivation de micro-organismes pathogenes, procedes de fabrication de compositions, et leurs procedes d'utilisation Download PDF

Info

Publication number: CA2528095A1
Authority: CA; Canada
Prior art keywords: nanoemulsion; composition; species; oil; equal
Prior art date: 2003-06-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002528095A

Other languages

English (en)

Other versions

CA2528095C (fr

Inventor

James R. Baker

Ted C. Annis

Tarek Hamouda

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nanobio Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-04

Filing date

2004-06-03

Publication date

2005-03-31

2004-06-03 Application filed by Individual filed Critical Individual

2005-03-31 Publication of CA2528095A1 publication Critical patent/CA2528095A1/fr

2014-10-14 Application granted granted Critical

2014-10-14 Publication of CA2528095C publication Critical patent/CA2528095C/fr

2024-06-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 223
238000000034 method Methods 0.000 title claims abstract description 72
244000000010 microbial pathogen Species 0.000 title claims abstract description 28
230000000415 inactivating effect Effects 0.000 title claims abstract description 14
239000007908 nanoemulsion Substances 0.000 claims abstract description 393
244000005700 microbiome Species 0.000 claims abstract description 57
239000004094 surface-active agent Substances 0.000 claims abstract description 51
239000008346 aqueous phase Substances 0.000 claims abstract description 42
239000012071 phase Substances 0.000 claims abstract description 39
239000003960 organic solvent Substances 0.000 claims abstract description 26
239000002245 particle Substances 0.000 claims description 162
239000003921 oil Substances 0.000 claims description 96
235000019198 oils Nutrition 0.000 claims description 94
241000894006 Bacteria Species 0.000 claims description 63
241000700605 Viruses Species 0.000 claims description 47
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 43
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 38
241000233866 Fungi Species 0.000 claims description 29
210000004666 bacterial spore Anatomy 0.000 claims description 27
238000009472 formulation Methods 0.000 claims description 27
-1 squalene oil Substances 0.000 claims description 27
230000000694 effects Effects 0.000 claims description 23
241000894007 species Species 0.000 claims description 22
239000003795 chemical substances by application Substances 0.000 claims description 21
230000002163 immunogen Effects 0.000 claims description 20
241001465754 Metazoa Species 0.000 claims description 16
239000003814 drug Substances 0.000 claims description 16
239000003549 soybean oil Substances 0.000 claims description 16
235000012424 soybean oil Nutrition 0.000 claims description 16
239000003623 enhancer Substances 0.000 claims description 14
239000000422 germination enhancer Substances 0.000 claims description 13
230000003993 interaction Effects 0.000 claims description 13
241000193738 Bacillus anthracis Species 0.000 claims description 12
239000000654 additive Substances 0.000 claims description 11
229940124597 therapeutic agent Drugs 0.000 claims description 11
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 10
238000004519 manufacturing process Methods 0.000 claims description 10
241000700647 Variola virus Species 0.000 claims description 9
239000003599 detergent Substances 0.000 claims description 9
230000028993 immune response Effects 0.000 claims description 9
241000725303 Human immunodeficiency virus Species 0.000 claims description 8
229910019142 PO4 Inorganic materials 0.000 claims description 8
229920000136 polysorbate Polymers 0.000 claims description 8
235000002639 sodium chloride Nutrition 0.000 claims description 8
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 7
239000010452 phosphate Substances 0.000 claims description 7
230000000241 respiratory effect Effects 0.000 claims description 7
241000701806 Human papillomavirus Species 0.000 claims description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
239000003937 drug carrier Substances 0.000 claims description 6
239000003349 gelling agent Substances 0.000 claims description 6
241001480043 Arthrodermataceae Species 0.000 claims description 5
241000192125 Firmicutes Species 0.000 claims description 5
206010048461 Genital infection Diseases 0.000 claims description 5
241000712907 Retroviridae Species 0.000 claims description 5
229920004890 Triton X-100 Polymers 0.000 claims description 5
241000700618 Vaccinia virus Species 0.000 claims description 5
241000607734 Yersinia <bacteria> Species 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 5
229960003767 alanine Drugs 0.000 claims description 5
235000019270 ammonium chloride Nutrition 0.000 claims description 5
230000037304 dermatophytes Effects 0.000 claims description 5
230000000813 microbial effect Effects 0.000 claims description 5
STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical group CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims description 5
241000304886 Bacilli Species 0.000 claims description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 4
229930010555 Inosine Natural products 0.000 claims description 4
241000588748 Klebsiella Species 0.000 claims description 4
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 4
241000711408 Murine respirovirus Species 0.000 claims description 4
240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
241000710960 Sindbis virus Species 0.000 claims description 4
239000002671 adjuvant Substances 0.000 claims description 4
229940121375 antifungal agent Drugs 0.000 claims description 4
239000000427 antigen Substances 0.000 claims description 4
102000036639 antigens Human genes 0.000 claims description 4
108091007433 antigens Proteins 0.000 claims description 4
239000004599 antimicrobial Substances 0.000 claims description 4
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
229960003786 inosine Drugs 0.000 claims description 4
210000004877 mucosa Anatomy 0.000 claims description 4
230000003472 neutralizing effect Effects 0.000 claims description 4
239000002736 nonionic surfactant Substances 0.000 claims description 4
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
241000712461 unidentified influenza virus Species 0.000 claims description 4
241000701386 African swine fever virus Species 0.000 claims description 3
235000014469 Bacillus subtilis Nutrition 0.000 claims description 3
241000588807 Bordetella Species 0.000 claims description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
240000001817 Cereus hexagonus Species 0.000 claims description 3
241000222290 Cladosporium Species 0.000 claims description 3
241000711573 Coronaviridae Species 0.000 claims description 3
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims description 3
241000196324 Embryophyta Species 0.000 claims description 3
241000711950 Filoviridae Species 0.000 claims description 3
241000710781 Flaviviridae Species 0.000 claims description 3
241000589989 Helicobacter Species 0.000 claims description 3
208000009889 Herpes Simplex Diseases 0.000 claims description 3
208000007514 Herpes zoster Diseases 0.000 claims description 3
QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims description 3
241000589248 Legionella Species 0.000 claims description 3
241000186781 Listeria Species 0.000 claims description 3
241000192041 Micrococcus Species 0.000 claims description 3
241000203736 Mobiluncus Species 0.000 claims description 3
241000588652 Neisseria gonorrhoeae Species 0.000 claims description 3
241000712464 Orthomyxoviridae Species 0.000 claims description 3
241000711504 Paramyxoviridae Species 0.000 claims description 3
241000228143 Penicillium Species 0.000 claims description 3
241000709664 Picornaviridae Species 0.000 claims description 3
241000193804 Planococcus <bacterium> Species 0.000 claims description 3
241000711931 Rhabdoviridae Species 0.000 claims description 3
241000316848 Rhodococcus <scale insect> Species 0.000 claims description 3
241000193985 Streptococcus agalactiae Species 0.000 claims description 3
241000710924 Togaviridae Species 0.000 claims description 3
239000003429 antifungal agent Substances 0.000 claims description 3
239000003443 antiviral agent Substances 0.000 claims description 3
239000001110 calcium chloride Substances 0.000 claims description 3
229910001628 calcium chloride Inorganic materials 0.000 claims description 3
235000011148 calcium chloride Nutrition 0.000 claims description 3
239000008103 glucose Substances 0.000 claims description 3
239000001103 potassium chloride Substances 0.000 claims description 3
235000011164 potassium chloride Nutrition 0.000 claims description 3
239000011780 sodium chloride Substances 0.000 claims description 3
XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 2
VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 2
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 2
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 2
108010001478 Bacitracin Proteins 0.000 claims description 2
235000008499 Canella winterana Nutrition 0.000 claims description 2
244000080208 Canella winterana Species 0.000 claims description 2
229930186147 Cephalosporin Natural products 0.000 claims description 2
241000606161 Chlamydia Species 0.000 claims description 2
241000193449 Clostridium tetani Species 0.000 claims description 2
DYDCUQKUCUHJBH-UWTATZPHSA-N D-Cycloserine Chemical compound N[C@@H]1CONC1=O DYDCUQKUCUHJBH-UWTATZPHSA-N 0.000 claims description 2
DYDCUQKUCUHJBH-UHFFFAOYSA-N D-Cycloserine Natural products NC1CONC1=O DYDCUQKUCUHJBH-UHFFFAOYSA-N 0.000 claims description 2
229930091371 Fructose Natural products 0.000 claims description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
239000005715 Fructose Substances 0.000 claims description 2
206010018612 Gonorrhoea Diseases 0.000 claims description 2
208000001688 Herpes Genitalis Diseases 0.000 claims description 2
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 2
BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 2
108091034117 Oligonucleotide Proteins 0.000 claims description 2
229930182555 Penicillin Natural products 0.000 claims description 2
235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 2
235000011613 Pinus brutia Nutrition 0.000 claims description 2
241000018646 Pinus brutia Species 0.000 claims description 2
235000019484 Rapeseed oil Nutrition 0.000 claims description 2
229930189077 Rifamycin Natural products 0.000 claims description 2
235000019485 Safflower oil Nutrition 0.000 claims description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
241000193998 Streptococcus pneumoniae Species 0.000 claims description 2
235000019486 Sunflower oil Nutrition 0.000 claims description 2
239000004098 Tetracycline Substances 0.000 claims description 2
208000005448 Trichomonas Infections Diseases 0.000 claims description 2
206010044620 Trichomoniasis Diseases 0.000 claims description 2
108010059993 Vancomycin Proteins 0.000 claims description 2
OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 claims description 2
RRDRHWJDBOGQHN-JWCTVYNTSA-N [2-[(2s,5r,8s,11s,14r,17s,22s)-17-[(1r)-1-hydroxyethyl]-22-[[(2s)-2-[[(2s,3r)-3-hydroxy-2-[[(2s)-2-[6-methyloctanoyl(sulfomethyl)amino]-4-(sulfomethylamino)butanoyl]amino]butyl]amino]-4-(sulfomethylamino)butanoyl]amino]-5,8-bis(2-methylpropyl)-3,6,9,12,15 Chemical compound CCC(C)CCCCC(=O)N(CS(O)(=O)=O)[C@@H](CCNCS(O)(=O)=O)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCNCS(O)(=O)=O)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCNCS(O)(=O)=O)NC(=O)[C@H](CCNCS(O)(=O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCNCS(O)(=O)=O)NC1=O RRDRHWJDBOGQHN-JWCTVYNTSA-N 0.000 claims description 2
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
229960004150 aciclovir Drugs 0.000 claims description 2
229940126575 aminoglycoside Drugs 0.000 claims description 2
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 2
229960003942 amphotericin b Drugs 0.000 claims description 2
229960001230 asparagine Drugs 0.000 claims description 2
235000009582 asparagine Nutrition 0.000 claims description 2
235000021302 avocado oil Nutrition 0.000 claims description 2
239000008163 avocado oil Substances 0.000 claims description 2
229960003071 bacitracin Drugs 0.000 claims description 2
229930184125 bacitracin Natural products 0.000 claims description 2
CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 claims description 2
229960000686 benzalkonium chloride Drugs 0.000 claims description 2
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 claims description 2
239000000828 canola oil Substances 0.000 claims description 2
235000019519 canola oil Nutrition 0.000 claims description 2
229940124587 cephalosporin Drugs 0.000 claims description 2
150000001780 cephalosporins Chemical class 0.000 claims description 2
229960005091 chloramphenicol Drugs 0.000 claims description 2
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 2
229940017545 cinnamon bark Drugs 0.000 claims description 2
229960002227 clindamycin Drugs 0.000 claims description 2
KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 2
229960004022 clotrimazole Drugs 0.000 claims description 2
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 2
239000003240 coconut oil Substances 0.000 claims description 2
235000019864 coconut oil Nutrition 0.000 claims description 2
229940108538 colistimethate Drugs 0.000 claims description 2
108700028201 colistinmethanesulfonic acid Proteins 0.000 claims description 2
235000005687 corn oil Nutrition 0.000 claims description 2
239000002285 corn oil Substances 0.000 claims description 2
235000012343 cottonseed oil Nutrition 0.000 claims description 2
239000002385 cottonseed oil Substances 0.000 claims description 2
229960003077 cycloserine Drugs 0.000 claims description 2
150000002009 diols Chemical class 0.000 claims description 2
229960003276 erythromycin Drugs 0.000 claims description 2
229940013317 fish oils Drugs 0.000 claims description 2
239000000796 flavoring agent Substances 0.000 claims description 2
235000019634 flavors Nutrition 0.000 claims description 2
201000004946 genital herpes Diseases 0.000 claims description 2
208000001786 gonorrhea Diseases 0.000 claims description 2
229960004125 ketoconazole Drugs 0.000 claims description 2
229960002509 miconazole Drugs 0.000 claims description 2
239000002480 mineral oil Substances 0.000 claims description 2
235000010446 mineral oil Nutrition 0.000 claims description 2
229940087419 nonoxynol-9 Drugs 0.000 claims description 2
229920004918 nonoxynol-9 Polymers 0.000 claims description 2
229960000988 nystatin Drugs 0.000 claims description 2
VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 2
239000004006 olive oil Substances 0.000 claims description 2
235000008390 olive oil Nutrition 0.000 claims description 2
239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
229960003415 propylparaben Drugs 0.000 claims description 2
235000005713 safflower oil Nutrition 0.000 claims description 2
239000003813 safflower oil Substances 0.000 claims description 2
239000010703 silicon Substances 0.000 claims description 2
229910052710 silicon Inorganic materials 0.000 claims description 2
229940038774 squalene oil Drugs 0.000 claims description 2
229940124530 sulfonamide Drugs 0.000 claims description 2
150000003456 sulfonamides Chemical class 0.000 claims description 2
239000002600 sunflower oil Substances 0.000 claims description 2
208000006379 syphilis Diseases 0.000 claims description 2
FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 claims description 2
235000019364 tetracycline Nutrition 0.000 claims description 2
150000003522 tetracyclines Chemical class 0.000 claims description 2
229940040944 tetracyclines Drugs 0.000 claims description 2
238000011200 topical administration Methods 0.000 claims description 2
IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims description 2
229960001082 trimethoprim Drugs 0.000 claims description 2
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 2
229960003165 vancomycin Drugs 0.000 claims description 2
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 2
229960003636 vidarabine Drugs 0.000 claims description 2
235000013343 vitamin Nutrition 0.000 claims description 2
239000011782 vitamin Substances 0.000 claims description 2
229940088594 vitamin Drugs 0.000 claims description 2
229930003231 vitamin Natural products 0.000 claims description 2
239000000341 volatile oil Substances 0.000 claims description 2
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims description 2
229960002555 zidovudine Drugs 0.000 claims description 2
241000228212 Aspergillus Species 0.000 claims 4
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
241000150452 Orthohantavirus Species 0.000 claims 3
241000710886 West Nile virus Species 0.000 claims 3
UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims 2
241000223600 Alternaria Species 0.000 claims 2
241000193752 Bacillus circulans Species 0.000 claims 2
241000193468 Clostridium perfringens Species 0.000 claims 2
241000588914 Enterobacter Species 0.000 claims 2
241001480036 Epidermophyton floccosum Species 0.000 claims 2
241000223218 Fusarium Species 0.000 claims 2
241000207201 Gardnerella vaginalis Species 0.000 claims 2
241000700739 Hepadnaviridae Species 0.000 claims 2
241000058827 Megasphaera hominis Species 0.000 claims 2
241000893980 Microsporum canis Species 0.000 claims 2
241000588621 Moraxella Species 0.000 claims 2
241000893976 Nannizzia gypsea Species 0.000 claims 2
241000187654 Nocardia Species 0.000 claims 2
241000588769 Proteus <enterobacteria> Species 0.000 claims 2
241000589516 Pseudomonas Species 0.000 claims 2
241000607720 Serratia Species 0.000 claims 2
241000193996 Streptococcus pyogenes Species 0.000 claims 2
241001045770 Trichophyton mentagrophytes Species 0.000 claims 2
241000223229 Trichophyton rubrum Species 0.000 claims 2
239000003093 cationic surfactant Substances 0.000 claims 2
241000193155 Clostridium botulinum Species 0.000 claims 1
241000223208 Curvularia Species 0.000 claims 1
241000606768 Haemophilus influenzae Species 0.000 claims 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
108010040201 Polymyxins Proteins 0.000 claims 1
XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims 1
241000607626 Vibrio cholerae Species 0.000 claims 1
230000000996 additive effect Effects 0.000 claims 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
229940049954 penicillin Drugs 0.000 claims 1
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
229960003292 rifamycin Drugs 0.000 claims 1
HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 claims 1
241001529453 unidentified herpesvirus Species 0.000 claims 1
230000002779 inactivation Effects 0.000 abstract description 6
231100000053 low toxicity Toxicity 0.000 abstract description 2
230000006806 disease prevention Effects 0.000 abstract 1
239000000839 emulsion Substances 0.000 description 97
238000000926 separation method Methods 0.000 description 36
239000004743 Polypropylene Substances 0.000 description 28
238000012360 testing method Methods 0.000 description 26
235000019441 ethanol Nutrition 0.000 description 21
238000010790 dilution Methods 0.000 description 20
239000012895 dilution Substances 0.000 description 20
238000011282 treatment Methods 0.000 description 18
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 17
238000002156 mixing Methods 0.000 description 17
238000005202 decontamination Methods 0.000 description 16
230000003588 decontaminative effect Effects 0.000 description 16
239000007788 liquid Substances 0.000 description 16
241001502050 Acis Species 0.000 description 14
208000015181 infectious disease Diseases 0.000 description 14
235000013305 food Nutrition 0.000 description 13
244000052769 pathogen Species 0.000 description 13
210000004215 spore Anatomy 0.000 description 13
150000001875 compounds Chemical class 0.000 description 12
239000000645 desinfectant Substances 0.000 description 12
235000011187 glycerol Nutrition 0.000 description 12
230000001717 pathogenic effect Effects 0.000 description 11
229920001213 Polysorbate 20 Polymers 0.000 description 10
230000001580 bacterial effect Effects 0.000 description 10
239000000969 carrier Substances 0.000 description 10
230000035784 germination Effects 0.000 description 10
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 10
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 10
229960005486 vaccine Drugs 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
230000000844 anti-bacterial effect Effects 0.000 description 9
238000011109 contamination Methods 0.000 description 9
101710194807 Protective antigen Proteins 0.000 description 8
239000002738 chelating agent Substances 0.000 description 8
230000002265 prevention Effects 0.000 description 8
239000007921 spray Substances 0.000 description 8
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 7
229960001927 cetylpyridinium chloride Drugs 0.000 description 7
239000003995 emulsifying agent Substances 0.000 description 7
239000006260 foam Substances 0.000 description 7
229910052736 halogen Inorganic materials 0.000 description 7
150000002632 lipids Chemical group 0.000 description 7
239000000463 material Substances 0.000 description 7
239000002904 solvent Substances 0.000 description 7
206010052428 Wound Diseases 0.000 description 6
208000027418 Wounds and injury Diseases 0.000 description 6
238000004140 cleaning Methods 0.000 description 6
230000007423 decrease Effects 0.000 description 6
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
239000012153 distilled water Substances 0.000 description 6
239000000499 gel Substances 0.000 description 6
208000006454 hepatitis Diseases 0.000 description 6
231100000283 hepatitis Toxicity 0.000 description 6
230000002147 killing effect Effects 0.000 description 6
239000002953 phosphate buffered saline Substances 0.000 description 6
239000003755 preservative agent Substances 0.000 description 6
230000009467 reduction Effects 0.000 description 6
230000003330 sporicidal effect Effects 0.000 description 6
201000008827 tuberculosis Diseases 0.000 description 6
241000193830 Bacillus <bacterium> Species 0.000 description 5
241000607142 Salmonella Species 0.000 description 5
241000191967 Staphylococcus aureus Species 0.000 description 5
239000000443 aerosol Substances 0.000 description 5
229940024606 amino acid Drugs 0.000 description 5
239000006071 cream Substances 0.000 description 5
210000004379 membrane Anatomy 0.000 description 5
239000012528 membrane Substances 0.000 description 5
239000002777 nucleoside Substances 0.000 description 5
125000003835 nucleoside group Chemical group 0.000 description 5
235000021317 phosphate Nutrition 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
238000004659 sterilization and disinfection Methods 0.000 description 5
238000003860 storage Methods 0.000 description 5
229920001817 Agar Polymers 0.000 description 4
239000013504 Triton X-100 Substances 0.000 description 4
150000001298 alcohols Chemical class 0.000 description 4
239000008365 aqueous carrier Substances 0.000 description 4
230000003115 biocidal effect Effects 0.000 description 4
230000003247 decreasing effect Effects 0.000 description 4
238000012545 processing Methods 0.000 description 4
238000011321 prophylaxis Methods 0.000 description 4
238000005507 spraying Methods 0.000 description 4
238000012430 stability testing Methods 0.000 description 4
230000001954 sterilising effect Effects 0.000 description 4
230000003612 virological effect Effects 0.000 description 4
208000035143 Bacterial infection Diseases 0.000 description 3
241000222120 Candida <Saccharomycetales> Species 0.000 description 3
239000004278 EU approved seasoning Substances 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
206010017533 Fungal infection Diseases 0.000 description 3
241000282412 Homo Species 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
208000031888 Mycoses Diseases 0.000 description 3
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
235000010419 agar Nutrition 0.000 description 3
239000008272 agar Substances 0.000 description 3
235000001014 amino acid Nutrition 0.000 description 3
150000001413 amino acids Chemical class 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
229940088710 antibiotic agent Drugs 0.000 description 3
208000022362 bacterial infectious disease Diseases 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000000872 buffer Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
230000000249 desinfective effect Effects 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
235000011194 food seasoning agent Nutrition 0.000 description 3
230000002538 fungal effect Effects 0.000 description 3
239000001963 growth medium Substances 0.000 description 3
150000004820 halides Chemical class 0.000 description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
230000001976 improved effect Effects 0.000 description 3
230000001965 increasing effect Effects 0.000 description 3
238000011534 incubation Methods 0.000 description 3
206010022000 influenza Diseases 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
235000013372 meat Nutrition 0.000 description 3
201000009240 nasopharyngitis Diseases 0.000 description 3
235000018102 proteins Nutrition 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
230000001568 sexual effect Effects 0.000 description 3
239000007787 solid Substances 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
239000000080 wetting agent Substances 0.000 description 3
KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
208000002874 Acne Vulgaris Diseases 0.000 description 2
208000004926 Bacterial Vaginosis Diseases 0.000 description 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
238000002965 ELISA Methods 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
241000588722 Escherichia Species 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
241000606790 Haemophilus Species 0.000 description 2
101710154606 Hemagglutinin Proteins 0.000 description 2
208000007764 Legionnaires' Disease Diseases 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
241000186365 Mycobacterium fortuitum Species 0.000 description 2
241000345052 Mycobates Species 0.000 description 2
102000005348 Neuraminidase Human genes 0.000 description 2
108010006232 Neuraminidase Proteins 0.000 description 2
101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
206010034133 Pathogen resistance Diseases 0.000 description 2
241000183024 Populus tremula Species 0.000 description 2
101710176177 Protein A56 Proteins 0.000 description 2
206010057190 Respiratory tract infections Diseases 0.000 description 2
206010040047 Sepsis Diseases 0.000 description 2
208000019802 Sexually transmitted disease Diseases 0.000 description 2
241000607768 Shigella Species 0.000 description 2
241000191940 Staphylococcus Species 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
206010000496 acne Diseases 0.000 description 2
230000009471 action Effects 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
230000002411 adverse Effects 0.000 description 2
230000032683 aging Effects 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
230000008901 benefit Effects 0.000 description 2
239000003139 biocide Substances 0.000 description 2
229920001400 block copolymer Polymers 0.000 description 2
239000006172 buffering agent Substances 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000006285 cell suspension Substances 0.000 description 2
210000002421 cell wall Anatomy 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
235000010980 cellulose Nutrition 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
230000008859 change Effects 0.000 description 2
238000010411 cooking Methods 0.000 description 2
230000002939 deleterious effect Effects 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000001493 electron microscopy Methods 0.000 description 2
229940096118 ella Drugs 0.000 description 2
DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000004744 fabric Substances 0.000 description 2
239000012530 fluid Substances 0.000 description 2
238000005187 foaming Methods 0.000 description 2
239000003897 fog Substances 0.000 description 2
238000007710 freezing Methods 0.000 description 2
230000008014 freezing Effects 0.000 description 2
210000004392 genitalia Anatomy 0.000 description 2
239000000185 hemagglutinin Substances 0.000 description 2
208000002672 hepatitis B Diseases 0.000 description 2
238000000265 homogenisation Methods 0.000 description 2
239000000017 hydrogel Substances 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
239000006210 lotion Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
108020004707 nucleic acids Proteins 0.000 description 2
102000039446 nucleic acids Human genes 0.000 description 2
150000007523 nucleic acids Chemical class 0.000 description 2
239000002304 perfume Substances 0.000 description 2
238000005191 phase separation Methods 0.000 description 2
238000002962 plaque-reduction assay Methods 0.000 description 2
229920001983 poloxamer Polymers 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229950008882 polysorbate Drugs 0.000 description 2
244000144977 poultry Species 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
230000000069 prophylactic effect Effects 0.000 description 2
238000001243 protein synthesis Methods 0.000 description 2
230000004044 response Effects 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
239000006152 selective media Substances 0.000 description 2
239000002210 silicon-based material Chemical class 0.000 description 2
239000000758 substrate Substances 0.000 description 2
229960004793 sucrose Drugs 0.000 description 2
239000000829 suppository Substances 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
238000012546 transfer Methods 0.000 description 2
230000014616 translation Effects 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 2
210000001215 vagina Anatomy 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
230000035899 viability Effects 0.000 description 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
241000701242 Adenoviridae Species 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241000712892 Arenaviridae Species 0.000 description 1
241001533362 Astroviridae Species 0.000 description 1
241000701412 Baculoviridae Species 0.000 description 1
241000702628 Birnaviridae Species 0.000 description 1
206010006326 Breath odour Diseases 0.000 description 1
238000009631 Broth culture Methods 0.000 description 1
241000589562 Brucella Species 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000714198 Caliciviridae Species 0.000 description 1
241000222122 Candida albicans Species 0.000 description 1
206010007134 Candida infections Diseases 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
241001115395 Caulimoviridae Species 0.000 description 1
241001533399 Circoviridae Species 0.000 description 1
241000193403 Clostridium Species 0.000 description 1
241001442234 Cosa Species 0.000 description 1
244000303965 Cyamopsis psoralioides Species 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
230000006820 DNA synthesis Effects 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
101710121417 Envelope glycoprotein Proteins 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
208000019331 Foodborne disease Diseases 0.000 description 1
241000206672 Gelidium Species 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
238000003794 Gram staining Methods 0.000 description 1
208000031886 HIV Infections Diseases 0.000 description 1
208000037357 HIV infectious disease Diseases 0.000 description 1
208000032139 Halitosis Diseases 0.000 description 1
208000005176 Hepatitis C Diseases 0.000 description 1
241000700586 Herpesviridae Species 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
206010021531 Impetigo Diseases 0.000 description 1
241000712431 Influenza A virus Species 0.000 description 1
241000701377 Iridoviridae Species 0.000 description 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
208000004852 Lung Injury Diseases 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
201000009906 Meningitis Diseases 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
239000004909 Moisturizer Substances 0.000 description 1
241000186359 Mycobacterium Species 0.000 description 1
241000204048 Mycoplasma hominis Species 0.000 description 1
231100000678 Mycotoxin Toxicity 0.000 description 1
241000701553 Myoviridae Species 0.000 description 1
241000588653 Neisseria Species 0.000 description 1
208000010195 Onychomycosis Diseases 0.000 description 1
241000701945 Parvoviridae Species 0.000 description 1
241000606860 Pasteurella Species 0.000 description 1
241000150350 Peribunyaviridae Species 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
241000701253 Phycodnaviridae Species 0.000 description 1
206010035664 Pneumonia Diseases 0.000 description 1
206010035718 Pneumonia legionella Diseases 0.000 description 1
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
241001533393 Potyviridae Species 0.000 description 1
241000700625 Poxviridae Species 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
241000702247 Reoviridae Species 0.000 description 1
241001138501 Salmonella enterica Species 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
239000005708 Sodium hypochlorite Substances 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
208000031650 Surgical Wound Infection Diseases 0.000 description 1
102100021696 Syncytin-1 Human genes 0.000 description 1
241000701521 Tectiviridae Species 0.000 description 1
229920002359 Tetronic® Polymers 0.000 description 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
239000004473 Threonine Substances 0.000 description 1
208000002474 Tinea Diseases 0.000 description 1
241000130764 Tinea Species 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
206010046865 Vaccinia virus infection Diseases 0.000 description 1
206010046914 Vaginal infection Diseases 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
108010003533 Viral Envelope Proteins Proteins 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
239000003070 absorption delaying agent Substances 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
108700010877 adenoviridae proteins Proteins 0.000 description 1
238000004378 air conditioning Methods 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
230000000172 allergic effect Effects 0.000 description 1
239000003945 anionic surfactant Substances 0.000 description 1
208000022338 anthrax infection Diseases 0.000 description 1
230000000340 anti-metabolite Effects 0.000 description 1
230000001775 anti-pathogenic effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
229940100197 antimetabolite Drugs 0.000 description 1
239000002256 antimetabolite Substances 0.000 description 1
238000011203 antimicrobial therapy Methods 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
230000002238 attenuated effect Effects 0.000 description 1
238000003287 bathing Methods 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
208000037815 bloodstream infection Diseases 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
201000003984 candidiasis Diseases 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
230000030833 cell death Effects 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
229940074979 cetyl palmitate Drugs 0.000 description 1
229960004830 cetylpyridinium Drugs 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
150000001805 chlorine compounds Chemical group 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
230000001332 colony forming effect Effects 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
230000002301 combined effect Effects 0.000 description 1
229940028617 conventional vaccine Drugs 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
239000002781 deodorant agent Substances 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000007933 dermal patch Substances 0.000 description 1
238000001784 detoxification Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
235000013681 dietary sucrose Nutrition 0.000 description 1
229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000002612 dispersion medium Substances 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
239000000975 dye Substances 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000003517 fume Substances 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000036541 health Effects 0.000 description 1
210000003709 heart valve Anatomy 0.000 description 1
208000005252 hepatitis A Diseases 0.000 description 1
PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
239000003906 humectant Substances 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000009851 immunogenic response Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
208000027866 inflammatory disease Diseases 0.000 description 1
208000037797 influenza A Diseases 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
235000015110 jellies Nutrition 0.000 description 1
235000021581 juice product Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
238000002356 laser light scattering Methods 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000000944 linseed oil Substances 0.000 description 1
235000021388 linseed oil Nutrition 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
244000144972 livestock Species 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
235000011147 magnesium chloride Nutrition 0.000 description 1
229910001425 magnesium ion Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000000693 micelle Substances 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000001333 moisturizer Effects 0.000 description 1
239000002991 molded plastic Substances 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
230000036457 multidrug resistance Effects 0.000 description 1
239000002636 mycotoxin Substances 0.000 description 1
229940097496 nasal spray Drugs 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229920002113 octoxynol Polymers 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
229940055577 oleyl alcohol Drugs 0.000 description 1
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
208000003154 papilloma Diseases 0.000 description 1
238000010951 particle size reduction Methods 0.000 description 1
239000006072 paste Substances 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
230000004260 plant-type cell wall biogenesis Effects 0.000 description 1
229960000502 poloxamer Drugs 0.000 description 1
229940051841 polyoxyethylene ether Drugs 0.000 description 1
229920000056 polyoxyethylene ether Polymers 0.000 description 1
239000013641 positive control Substances 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
150000003138 primary alcohols Chemical class 0.000 description 1
230000008569 process Effects 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000005086 pumping Methods 0.000 description 1
150000007660 quinolones Chemical class 0.000 description 1
238000005067 remediation Methods 0.000 description 1
238000009877 rendering Methods 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
210000004708 ribosome subunit Anatomy 0.000 description 1
BTVYFIMKUHNOBZ-QXMMDKDBSA-N rifamycin s Chemical class O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-QXMMDKDBSA-N 0.000 description 1
229940081192 rifamycins Drugs 0.000 description 1
150000003333 secondary alcohols Chemical class 0.000 description 1
239000003352 sequestering agent Substances 0.000 description 1
239000002911 sialidase inhibitor Substances 0.000 description 1
238000004513 sizing Methods 0.000 description 1
235000020183 skimmed milk Nutrition 0.000 description 1
206010040872 skin infection Diseases 0.000 description 1
239000000344 soap Substances 0.000 description 1
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
238000013112 stability test Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000009662 stress testing Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
201000004647 tinea pedis Diseases 0.000 description 1
201000005882 tinea unguium Diseases 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
150000004072 triols Chemical class 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229920001664 tyloxapol Polymers 0.000 description 1
MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
229960004224 tyloxapol Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
208000019206 urinary tract infection Diseases 0.000 description 1
238000002255 vaccination Methods 0.000 description 1
208000007089 vaccinia Diseases 0.000 description 1
239000004474 valine Substances 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
230000003253 viricidal effect Effects 0.000 description 1
238000004383 yellowing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dispersion Chemistry (AREA)
Biophysics (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2528095A 2003-06-04 2004-06-03 Compositions pour l'inactivation de micro-organismes pathogenes, procedes de fabrication de compositions, et leurs procedes d'utilisation Expired - Lifetime CA2528095C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US45763303P	2003-06-04	2003-06-04
US60/475,633		2003-06-04
PCT/US2004/017417 WO2005027872A2 (fr)	2003-06-04	2004-06-03	Compositions pour l'inactivation de micro-organismes pathogenes, procedes de fabrication de compositions, et leurs procedes d'utilisation

Publications (2)

Publication Number	Publication Date
CA2528095A1 true CA2528095A1 (fr)	2005-03-31
CA2528095C CA2528095C (fr)	2014-10-14

Family

ID=34375188

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2528095A Expired - Lifetime CA2528095C (fr)	2003-06-04	2004-06-03	Compositions pour l'inactivation de micro-organismes pathogenes, procedes de fabrication de compositions, et leurs procedes d'utilisation

Country Status (4)

Country	Link
EP (1)	EP1633322A2 (fr)
AU (1)	AU2004273779B2 (fr)
CA (1)	CA2528095C (fr)
WO (1)	WO2005027872A2 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7763663B2 (en)	2001-12-19	2010-07-27	University Of Massachusetts	Polysaccharide-containing block copolymer particles and uses thereof
WO2004100890A2 (fr)	2003-05-09	2004-11-25	The Trustees Of Columbia University In The City Of New York	Procedes lies a la fonction rage g82s et compositions destinees au traitement de troubles inflammatoires
CA2618655C (fr) *	2005-07-18	2015-12-22	University Of Massachusetts Lowell	Compositions et procedes de fabrication et d'utilisation de nanoemulsions
AU2016244292A1 (en) *	2005-07-18	2016-11-03	University Of Massachusetts Lowell	Compositions and methods for making and using nanoemulsions
WO2008051186A2 (fr)	2005-08-09	2008-05-02	Nanobio Corporation	Compositions de nano-émulsion ayant une activité anti-inflammatoire
DK3144013T3 (en)	2005-12-01	2019-03-04	Univ Massachusetts Lowell	Botulinum nanoemulsions
US9486408B2 (en)	2005-12-01	2016-11-08	University Of Massachusetts Lowell	Botulinum nanoemulsions
EP2010149A1 (fr) *	2006-04-07	2009-01-07	Novavax, Inc.	Compositions nanostructures aux proprietes antibacteriennes, antifongiques, anti-levures et/ou antivirales
CA2649457A1 (fr) *	2006-04-13	2007-10-25	The Regents Of The University Of Michigan	Vaccins a base d'une nanoemulsion
US10138279B2 (en)	2006-04-13	2018-11-27	Regents Of The University Of Michigan	Compositions and methods for Bacillus anthracis vaccination
US9839685B2 (en)	2006-04-13	2017-12-12	The Regents Of The University Of Michigan	Methods of inducing human immunodeficiency virus-specific immune responses in a host comprising nasally administering compositions comprising a naonemulsion and recombinant GP120 immunogen
FR2907012B1 (fr) *	2006-10-12	2012-09-21	Galderma Sa	Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation
BRPI0719732A2 (pt)	2006-12-01	2017-05-16	Anterios Inc	nanopartículas de peptídeo e usos para as mesmas
BRPI0719756A2 (pt)	2006-12-01	2014-01-21	Anterios Inc	Nanopartículas de entidades anfifílicas
EP1938801A1 (fr) *	2006-12-22	2008-07-02	Biofrontera Bioscience GmbH	Nanoémulsion
DE102007007698A1 (de) *	2007-02-09	2008-08-21	Exner, Heinrich, Dr.	Verwendung einer hochemulgierten Silikonöl-Emulsion (HSE)zur Herstellung eines Medikamentes
KR20100050443A (ko)	2007-05-31	2010-05-13	안테리오스, 인코퍼레이티드	핵산 나노입자 및 이의 용도
BRPI0705564B8 (pt) *	2007-10-10	2021-05-25	Embrapa Pesquisa Agropecuaria	sistema do tipo cristal líquido contínuo contendo co-solvente portador de substâncias fracamente solúveis em água, seu processo de obtenção e seus usos
EP3023107A1 (fr)	2008-04-21	2016-05-25	Nanobio Corporation	Vaccin contre la grippe à nanoémulsions
WO2009132343A1 (fr) *	2008-04-25	2009-10-29	Nanobio Corporation	Nanoemulsions destinées à traiter l'onychomycose
JP2011518844A (ja) *	2008-04-25	2011-06-30	ナノバイオコーポレーション	真菌、酵母および糸状菌感染症を治療するためのナノエマルション
US8877208B2 (en)	2008-05-23	2014-11-04	The Regents Of The University Of Michigan	Multivalent nanoemulsion vaccines
CN105147608B (zh) *	2008-06-26	2019-12-10	安特里奥公司	真皮递送
EP2349209A2 (fr)	2008-09-26	2011-08-03	Nanobio Corporation	Compositions thérapeutiques de nanoémulsion et procédés d'utilisation de celles-ci
EP2370057A1 (fr) *	2008-12-31	2011-10-05	Sunev Pharma Solution Limited Corporate	Nouvelles formules phytosanitaires topiques pour le traitement de l'acné et des troubles cutanés
US9345660B2 (en) *	2009-06-05	2016-05-24	Sunev Pharma Solution Limited	Micro-emulsions for the treatment of rheumatic disorders
DE102009056883B4 (de)	2009-12-03	2012-08-16	Novartis Ag	Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
US8895629B2 (en)	2009-12-03	2014-11-25	Novartis Ag	Circulation of components during homogenization of emulsions
DE102009056884B4 (de)	2009-12-03	2021-03-18	Novartis Ag	Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
WO2011067672A2 (fr) †	2009-12-03	2011-06-09	Novartis Ag	Chambres d'interaction d'agencement et de contre-pression pour la microfluidisation
JP5754860B2 (ja)	2009-12-03	2015-07-29	ノバルティスアーゲー	ワクチンアジュバントの製造の間の親水性濾過
CL2012001399A1 (es)	2009-12-03	2013-03-08	Novartis Ag	Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
AU2013213678B2 (en) *	2009-12-03	2016-06-23	Novartis Ag	Arranging interaction and back pressure chambers for microfluidization
DE102009056871A1 (de)	2009-12-03	2011-06-22	Novartis AG, 4056	Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE202010004750U1 (de) *	2010-04-09	2011-10-11	Biofrontera Bioscience Gmbh	Pharmazeutische oder/und kosmetische Zusammensetzung zur Behandlung der Haut
EP2841098A4 (fr)	2012-04-23	2016-03-02	Allertein Therapeutics Llc	Nanoparticules pour le traitement d'allergies
WO2014206857A1 (fr) *	2013-06-28	2014-12-31	Universitat Autonoma De Barcelona	Formulations huile-dans-l'eau de mycobacterium et utilisations associées
WO2015143444A1 (fr) *	2014-03-21	2015-09-24	University Of Florida Research Foundation, Inc.	Utilisation d'aldéhydes formulés avec des nanoparticules et/ou des nanoémulsions pour augmenter la résistance aux maladies de plantes vis-à-vis des liberibacters
CN104274405A (zh) *	2014-10-21	2015-01-14	河南牧翔动物药业有限公司	一种水包油型复方头孢噻呋纳米乳抗菌药物
WO2016127022A1 (fr) *	2015-02-06	2016-08-11	Foreman James Michael	Préparation d'une émulsion huile dans l'eau pour formulations pharmaceutiques stabilisées par un polymère
JP2019530737A (ja)	2016-08-23	2019-10-24	アコーオスインコーポレイテッド	ヒト対象において非加齢性聴力障害を治療するための組成物および方法
US11311496B2 (en)	2016-11-21	2022-04-26	Eirion Therapeutics, Inc.	Transdermal delivery of large agents
CN106924730B (zh) *	2017-02-14	2019-11-08	商丘美兰生物工程有限公司	猪伪狂犬病毒芦荟胶纳米乳佐剂灭活苗及其制备方法
JP7309720B2 (ja) *	2018-01-23	2023-07-18	ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ	ラウリン油を含む透明ナノエマルジョンの製造方法
CN111629705A (zh) *	2018-01-23	2020-09-04	荷兰联合利华有限公司	包含月桂油的透明纳米乳液
BR112022016596A2 (pt)	2020-02-21	2022-11-16	Akouos Inc	Composições e métodos para o tratamento de debilitação auditiva não associada à idade em um indivíduo humano
CN113662006B (zh) *	2021-06-30	2022-05-20	南京凯创协同纳米技术有限公司	一种可杀灭细菌灭活病毒的微纳锌的制备方法
WO2024005601A1 (fr) *	2022-06-30	2024-01-04	씨제이제일제당(주)	Composition médicale

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2912426B2 (ja) *	1990-06-15	1999-06-28	鐘紡株式会社	微細化エマルション組成物
US6506803B1 (en) *	1999-04-28	2003-01-14	Regents Of The University Of Michigan	Methods of preventing and treating microbial infections
WO2002051390A2 (fr) *	2000-12-27	2002-07-04	Ares Trading S.A.	Nanoparticules lipidiques amphiphiles destinees a l'incorporation de peptides et/ou proteines
AU2002367976B2 (en) *	2001-06-05	2007-06-21	The Regents Of The University Of Michigan	Nanoemulsion vaccines

2004
- 2004-06-03 WO PCT/US2004/017417 patent/WO2005027872A2/fr active Application Filing
- 2004-06-03 AU AU2004273779A patent/AU2004273779B2/en not_active Expired
- 2004-06-03 EP EP04809431A patent/EP1633322A2/fr not_active Withdrawn
- 2004-06-03 CA CA2528095A patent/CA2528095C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2005027872A3 (fr)	2006-03-09
AU2004273779B2 (en)	2009-10-22
WO2005027872A2 (fr)	2005-03-31
EP1633322A2 (fr)	2006-03-15
CA2528095C (fr)	2014-10-14
AU2004273779A1 (en)	2005-03-31
AU2004273779A2 (en)	2005-03-31

Legal Events

Date	Code	Title	Description
2009-06-02	EEER	Examination request

Publication	Publication Date	Title
US9131680B2 (en)	2015-09-15	Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof
AU2004273779B2 (en)	2009-10-22	Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof
CA2618974C (fr)	2014-01-28	Compositions de nanoemulsions possedant une activite anti-inflammatoire
CA2395678C (fr)	2012-06-26	Compositions antimicrobiennes et procedes d'utilisation
US7767216B2 (en)	2010-08-03	Antimicrobial compositions and methods of use
AU2002350587B2 (en)	2004-12-23	Antimicrobial nanoemulsion compositions and methods
US6559189B2 (en)	2003-05-06	Non-toxic antimicrobial compositions and methods of use
US8236335B2 (en)	2012-08-07	Antimicrobial nanoemulsion compositions and methods
US7655252B2 (en)	2010-02-02	Antimicrobial nanoemulsion compositions and methods
WO2005030172A1 (fr)	2005-04-07	Compositions antimicrobiennes en nanoemulsion et methodes associees
JP2010209109A (ja)	2010-09-24	抗微生物ナノエマルジョンの組成物および方法