CA2493199A1 - Peroxynitrite rearrangement catalysts used for the treatment or prophylaxis of diseases caused by peroxynitrite-mediated reactions - Google Patents

Peroxynitrite rearrangement catalysts used for the treatment or prophylaxis of diseases caused by peroxynitrite-mediated reactions Download PDF

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Publication number
CA2493199A1
CA2493199A1 CA002493199A CA2493199A CA2493199A1 CA 2493199 A1 CA2493199 A1 CA 2493199A1 CA 002493199 A CA002493199 A CA 002493199A CA 2493199 A CA2493199 A CA 2493199A CA 2493199 A1 CA2493199 A1 CA 2493199A1
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CA
Canada
Prior art keywords
peroxynitrite
diseases
prophylaxis
treatment
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002493199A
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English (en)
French (fr)
Inventor
Gisbert Depke
Margrit Hillmann
Guenter Michl
Johannes Platzek
Detlev Suelzle
Roland Neuhaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
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Individual
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Filing date
Publication date
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Publication of CA2493199A1 publication Critical patent/CA2493199A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CA002493199A 2002-08-27 2003-07-12 Peroxynitrite rearrangement catalysts used for the treatment or prophylaxis of diseases caused by peroxynitrite-mediated reactions Abandoned CA2493199A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10240343A DE10240343A1 (de) 2002-08-27 2002-08-27 Peroxynitrit-Umlagerungskatalysatoren
DE10240343.0 2002-08-27
PCT/EP2003/007556 WO2004019936A1 (de) 2002-08-27 2003-07-12 Peroxynitrit-umlagerungskatalysatoren zur behandlung oder prophylaxe von krankheiten, die durch peroxynitrit-vermittelte reaktionen verursacht werden

Publications (1)

Publication Number Publication Date
CA2493199A1 true CA2493199A1 (en) 2004-03-11

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ID=31502240

Family Applications (1)

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CA002493199A Abandoned CA2493199A1 (en) 2002-08-27 2003-07-12 Peroxynitrite rearrangement catalysts used for the treatment or prophylaxis of diseases caused by peroxynitrite-mediated reactions

Country Status (6)

Country Link
EP (1) EP1531808A1 (de)
JP (1) JP2006500383A (de)
AU (1) AU2003246687A1 (de)
CA (1) CA2493199A1 (de)
DE (1) DE10240343A1 (de)
WO (1) WO2004019936A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2506083C2 (ru) * 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
US8946202B2 (en) 1999-01-25 2015-02-03 Aeolus Sciences, Inc. Substituted porphyrins

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005041885A2 (en) * 2003-10-31 2005-05-12 Metaphore Pharmaceuticals, Inc. Compositions and methods for treating, preventing, reversing and inhibiting pain
US20090149436A1 (en) * 2004-11-16 2009-06-11 Astellas Pharma Inc. Caspase inhibitor
US9102636B2 (en) * 2010-03-10 2015-08-11 Galleon Pharmaceuticals, Inc. Analgesic compounds, compositions, and uses thereof
CN111848656B (zh) * 2020-06-24 2023-03-14 天津大学 离子修饰的原卟啉镓化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827940A1 (de) * 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4232925A1 (de) * 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
WO1995031219A1 (en) * 1994-05-11 1995-11-23 Schering Aktiengesellschaft The use of porphyrin-complex or expanded porphyrin-complex compounds as localization diagnosticum for infarction or necrosis
US6245758B1 (en) * 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
PL317192A1 (en) * 1994-05-13 1997-03-17 Monsanto Co Methods of using pernitrite decomposition catalyst and their pharmaceutic compositions
DE19825512A1 (de) * 1998-06-02 1999-12-09 Schering Ag 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
DE19835082A1 (de) * 1998-07-24 2000-02-03 Schering Ag Paramagnetische 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung für das Nekrose- und Infarkt-MR-Imaging
US6448239B1 (en) * 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
AU1087401A (en) * 1999-10-13 2001-04-23 Uab Research Foundation Metalloporphyrin treatment of neurologic disease

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946202B2 (en) 1999-01-25 2015-02-03 Aeolus Sciences, Inc. Substituted porphyrins
US9289434B2 (en) 1999-01-25 2016-03-22 Aeolus Sciences, Inc. Substituted porphyrins
RU2506083C2 (ru) * 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species

Also Published As

Publication number Publication date
AU2003246687A1 (en) 2004-03-19
DE10240343A1 (de) 2004-03-11
JP2006500383A (ja) 2006-01-05
EP1531808A1 (de) 2005-05-25
WO2004019936A1 (de) 2004-03-11

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