CA2443234A1 - Derives d'isoxaxole utilises comme inhibiteurs de proteines kinases src et d'autres proteines kinases - Google Patents

Derives d'isoxaxole utilises comme inhibiteurs de proteines kinases src et d'autres proteines kinases Download PDF

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CA2443234A1
CA2443234A1 CA002443234A CA2443234A CA2443234A1 CA 2443234 A1 CA2443234 A1 CA 2443234A1 CA 002443234 A CA002443234 A CA 002443234A CA 2443234 A CA2443234 A CA 2443234A CA 2443234 A1 CA2443234 A1 CA 2443234A1
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iia
disease
optionally substituted
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Edmund Harrington
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Vertex Pharmaceuticals Inc
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

La présente invention concerne des composés représentés par la formule I. Dans cette formule A est N ou CR et R¿1?, G et R¿2? sont tels que décrits dans les spécifications. Ces composés sont des inhibiteurs de protéine kinase, en particulier de protéine kinase Src de mammifère impliquée dans la prolifération cellulaire, dans la mort cellulaire et dans la réponse aux stimuli extracellulaires. Cette invention concerne aussi des techniques de production de ces inhibiteurs. Cette invention concerne enfin des compositions pharmaceutiques comprenant ces inhibiteurs et des techniques d'utilisation de ces compositions dans le traitement et la prévention de pathologies diverses.
CA002443234A 2001-04-10 2002-04-10 Derives d'isoxaxole utilises comme inhibiteurs de proteines kinases src et d'autres proteines kinases Abandoned CA2443234A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28293501P 2001-04-10 2001-04-10
US60/282,935 2001-04-10
PCT/US2002/011609 WO2002083668A1 (fr) 2001-04-10 2002-04-10 Derives d'isoxaxole utilises comme inhibiteurs de proteines kinases src et d'autres proteines kinases

Publications (1)

Publication Number Publication Date
CA2443234A1 true CA2443234A1 (fr) 2002-10-24

Family

ID=23083761

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002443234A Abandoned CA2443234A1 (fr) 2001-04-10 2002-04-10 Derives d'isoxaxole utilises comme inhibiteurs de proteines kinases src et d'autres proteines kinases

Country Status (5)

Country Link
EP (1) EP1377572A1 (fr)
JP (1) JP2005500261A (fr)
CA (1) CA2443234A1 (fr)
MX (1) MXPA03009257A (fr)
WO (1) WO2002083668A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030130209A1 (en) * 1999-12-22 2003-07-10 Cheresh David A. Method of treatment of myocardial infarction
DE60214198T2 (de) * 2001-07-03 2007-08-09 Vertex Pharmaceuticals Inc., Cambridge Isoxazolyl-pyrimidines als inhibitoren von src- und lck-protein-kinasen
DE10237883A1 (de) * 2002-08-19 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
CA2506773A1 (fr) 2002-11-04 2004-05-21 Vertex Pharmaceuticals Incorporated Derives d'heteroaryle pyrimidine utilises comme inhibiteurs de jak (janus kinase)
AR045595A1 (es) 2003-09-04 2005-11-02 Vertex Pharma Composiciones utiles como inhibidores de proteinas quinasas
MY144044A (en) * 2004-06-10 2011-07-29 Irm Llc Compounds and compositions as protein kinase inhibitors
KR20070084067A (ko) 2004-10-13 2007-08-24 와이어쓰 Ｎ-벤젠설포닐 치환 아닐리노-피리미딘 동족체
CA2591912C (fr) 2004-12-28 2013-06-25 Aska Pharmaceutical Co., Ltd. Derives de pyrimidinylisoxazole
CN1939910A (zh) * 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
KR101481872B1 (ko) * 2009-09-10 2015-01-12 에프. 호프만-라 로슈 아게 Ｊａｋ의 억제제
EP3194572B1 (fr) 2014-07-30 2023-10-25 Yeda Research and Development Co. Ltd. Milieux pour la culture de cellules souches pluripotentes
WO2020152686A1 (fr) 2019-01-23 2020-07-30 Yeda Research And Development Co. Ltd. Milieux de culture pour cellules souches pluripotentes
CN115677617B (zh) * 2022-11-04 2023-12-26 济南大学 一种靶向c-Src激酶SH3结构域的化合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL366110A1 (en) * 1999-08-13 2005-01-24 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases

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Publication number Publication date
WO2002083668A1 (fr) 2002-10-24
JP2005500261A (ja) 2005-01-06
EP1377572A1 (fr) 2004-01-07
MXPA03009257A (es) 2004-01-29

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