CA2427583A1 - Formulation d'une solution d'inhalation contenant un sel de tiotropium - Google Patents

Formulation d'une solution d'inhalation contenant un sel de tiotropium Download PDF

Info

Publication number: CA2427583A1
Authority: CA; Canada
Prior art keywords: solution containing; inhalable formulation; tiotropium salt; propellant; water
Prior art date: 2000-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002427583A

Other languages

English (en)

Other versions

CA2427583C (fr

Inventor

Karin Drechsel

Barbara Niklaus-Humke

Christel Schmelzer

Petra Barth

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-31

Filing date

2001-10-24

Publication date

2002-05-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7661727&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2427583(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-10-24 Application filed by Individual filed Critical Individual

2002-05-10 Publication of CA2427583A1 publication Critical patent/CA2427583A1/fr

2008-02-12 Application granted granted Critical

2008-02-12 Publication of CA2427583C publication Critical patent/CA2427583C/fr

2021-10-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract 3
238000009472 formulation Methods 0.000 title abstract 2
LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 abstract 1
239000000443 aerosol Substances 0.000 abstract 1
229960000257 tiotropium bromide Drugs 0.000 abstract 1
MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

CA002427583A 2000-10-31 2001-10-24 Formulation d'une solution d'inhalation contenant un sel de tiotropium Expired - Fee Related CA2427583C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10054042.2		2000-10-31
DE10054042		2000-10-31
PCT/EP2001/012296 WO2002036591A2 (fr)	2000-10-31	2001-10-24	Formulation d'une solution d'inhalation contenant un sel de tiotropium

Publications (2)

Publication Number	Publication Date
CA2427583A1 true CA2427583A1 (fr)	2002-05-10
CA2427583C CA2427583C (fr)	2008-02-12

Family

ID=7661727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002427583A Expired - Fee Related CA2427583C (fr)	2000-10-31	2001-10-24	Formulation d'une solution d'inhalation contenant un sel de tiotropium

Country Status (33)

Country	Link
EP (1)	EP1335729A2 (fr)
JP (1)	JP4559703B2 (fr)
KR (1)	KR100983208B1 (fr)
CN (1)	CN1237970C (fr)
AR (1)	AR038765A1 (fr)
AU (2)	AU2002221741B2 (fr)
BG (1)	BG66425B1 (fr)
BR (1)	BR0115016A (fr)
CA (1)	CA2427583C (fr)
CZ (1)	CZ305033B6 (fr)
DE (1)	DE10152369A1 (fr)
EA (1)	EA009068B1 (fr)
EC (1)	ECSP034570A (fr)
EE (1)	EE05343B1 (fr)
HK (1)	HK1060569A1 (fr)
HR (1)	HRP20030337A2 (fr)
HU (1)	HUP0301377A3 (fr)
IL (2)	IL155676A0 (fr)
ME (1)	ME00242B (fr)
MX (1)	MXPA03003750A (fr)
MY (1)	MY132777A (fr)
NO (1)	NO332524B1 (fr)
NZ (1)	NZ526024A (fr)
PE (1)	PE20020518A1 (fr)
PL (1)	PL361001A1 (fr)
SA (1)	SA01220503B1 (fr)
SK (1)	SK288031B6 (fr)
TW (1)	TWI296934B (fr)
UA (1)	UA76435C2 (fr)
UY (1)	UY26991A1 (fr)
WO (1)	WO2002036591A2 (fr)
YU (1)	YU33103A (fr)
ZA (1)	ZA200303045B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE309369T1 (de)	2000-04-28	2005-11-15	Kosan Biosciences Inc	Heterologe herstellung von polyketiden
US20030235538A1 (en)	2002-04-09	2003-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Method for the administration of an anticholinergic by inhalation
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
US9539221B2 (en) *	2003-10-09	2017-01-10	Egb Advisors, Llc	Method of treating airway diseases with β-adrenergic inverse agonists
SE0303269L (sv) *	2003-12-03	2005-06-04	Microdrug Ag	Medicinsk produkt
PL1863476T3 (pl) *	2005-03-16	2016-07-29	Meda Pharma Gmbh & Co Kg	Skojarzenie środków antycholinergicznych i antagonistów receptora leukotrienowego do leczenia chorób układu oddechowego
WO2007140285A2 (fr) *	2006-05-26	2007-12-06	Dey, L.P.	Compositions nébulisables d'ammoniums quaternaires antagonistes du récepteur muscarinique
CN100446770C (zh) *	2007-01-10	2008-12-31	上海现代药物制剂工程研究中心有限公司	丙酸培氯米松水雾剂
TR200907237A2 (tr) *	2009-09-23	2011-04-21	Bi̇lgi̇ç Mahmut	Tiotropyum kuru toz kombinasyonu
CN116173025A (zh) *	2018-07-26	2023-05-30	四川海思科制药有限公司	一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用
CN111971034A (zh) *	2018-07-26	2020-11-20	四川海思科制药有限公司	一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0504112A3 (en) *	1991-03-14	1993-04-21	Ciba-Geigy Ag	Pharmaceutical aerosol formulations
DE4203306A1 (de) *	1992-02-06	1993-08-12	Ig Spruehtechnik Gmbh	Asthma oder pulmonal-aerosolzubereitungen mit lecithin
IL122752A (en) *	1995-06-27	2001-07-24	Boehringer Ingelheim Kg	Stable preparations for creating propellant-free sprays
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
EP0954318A1 (fr) *	1996-06-04	1999-11-10	The Procter & Gamble Company	Aerosol nasal contenant un steroide intranasal et un antihistaminique
DE19653969A1 (de) *	1996-12-20	1998-06-25	Boehringer Ingelheim Kg	Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
JPH10298107A (ja) *	1997-04-25	1998-11-10	Taisho Pharmaceut Co Ltd	医薬組成物
ATE234604T1 (de) *	1998-08-04	2003-04-15	Jago Res Ag	Medizinische aerosolformulierungen
DE19847968A1 (de) *	1998-10-17	2000-04-20	Boehringer Ingelheim Pharma	Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen

2001
- 2001-10-24 EP EP01992710A patent/EP1335729A2/fr not_active Ceased
- 2001-10-24 NZ NZ526024A patent/NZ526024A/en not_active IP Right Cessation
- 2001-10-24 HU HU0301377A patent/HUP0301377A3/hu unknown
- 2001-10-24 JP JP2002539350A patent/JP4559703B2/ja not_active Expired - Lifetime
- 2001-10-24 UA UA2003054960A patent/UA76435C2/uk unknown
- 2001-10-24 EA EA200300483A patent/EA009068B1/ru not_active IP Right Cessation
- 2001-10-24 EE EEP200300202A patent/EE05343B1/xx unknown
- 2001-10-24 WO PCT/EP2001/012296 patent/WO2002036591A2/fr active IP Right Grant
- 2001-10-24 CN CNB018183271A patent/CN1237970C/zh not_active Expired - Lifetime
- 2001-10-24 KR KR1020037006001A patent/KR100983208B1/ko active IP Right Grant
- 2001-10-24 MX MXPA03003750A patent/MXPA03003750A/es active IP Right Grant
- 2001-10-24 ME MEP-2008-407A patent/ME00242B/fr unknown
- 2001-10-24 YU YU33103A patent/YU33103A/sh unknown
- 2001-10-24 AU AU2002221741A patent/AU2002221741B2/en not_active Expired
- 2001-10-24 DE DE10152369A patent/DE10152369A1/de not_active Withdrawn
- 2001-10-24 BR BR0115016-2A patent/BR0115016A/pt active Pending
- 2001-10-24 AU AU2174102A patent/AU2174102A/xx active Pending
- 2001-10-24 IL IL15567601A patent/IL155676A0/xx unknown
- 2001-10-24 CA CA002427583A patent/CA2427583C/fr not_active Expired - Fee Related
- 2001-10-24 CZ CZ2003-1487A patent/CZ305033B6/cs not_active IP Right Cessation
- 2001-10-24 SK SK526-2003A patent/SK288031B6/sk not_active IP Right Cessation
- 2001-10-24 PL PL01361001A patent/PL361001A1/xx not_active Application Discontinuation
- 2001-10-29 PE PE2001001072A patent/PE20020518A1/es active IP Right Grant
- 2001-10-29 MY MYPI20014987A patent/MY132777A/en unknown
- 2001-10-29 TW TW090126752A patent/TWI296934B/zh not_active IP Right Cessation
- 2001-10-29 UY UY26991A patent/UY26991A1/es not_active Application Discontinuation
- 2001-10-31 AR ARP010105088A patent/AR038765A1/es not_active Ceased/Invalidation/Refusal/Rejection/Nullification
- 2001-11-03 SA SA01220503A patent/SA01220503B1/ar unknown
2003
- 2003-04-16 BG BG107726A patent/BG66425B1/bg active Active
- 2003-04-17 ZA ZA200303045A patent/ZA200303045B/xx unknown
- 2003-04-28 EC EC2003004570A patent/ECSP034570A/es unknown
- 2003-04-28 HR HR20030337A patent/HRP20030337A2/hr not_active Application Discontinuation
- 2003-04-29 NO NO20031914A patent/NO332524B1/no not_active IP Right Cessation
- 2003-04-30 IL IL155676A patent/IL155676A/en active IP Right Grant
2004
- 2004-05-20 HK HK04103587A patent/HK1060569A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA200303045B (en)	2004-04-22
ME00242B (fr)	2011-05-10
WO2002036591A3 (fr)	2002-07-25
PL361001A1 (en)	2004-09-20
KR20040010552A (ko)	2004-01-31
JP4559703B2 (ja)	2010-10-13
EA009068B1 (ru)	2007-10-26
HRP20030337A2 (en)	2005-04-30
BR0115016A (pt)	2005-05-03
IL155676A (en)	2012-05-31
DE10152369A1 (de)	2002-05-08
NO20031914L (no)	2003-06-23
PE20020518A1 (es)	2002-07-12
NO20031914D0 (no)	2003-04-29
MEP40708A (en)	2011-02-10
CA2427583C (fr)	2008-02-12
HK1060569A1 (en)	2004-08-13
MXPA03003750A (es)	2004-10-15
SK5262003A3 (en)	2003-10-07
EE05343B1 (et)	2010-10-15
AU2002221741B2 (en)	2007-04-05
HUP0301377A3 (en)	2005-12-28
TWI296934B (en)	2008-05-21
AR038765A1 (es)	2005-01-26
MY132777A (en)	2007-10-31
SA01220503B1 (ar)	2007-03-10
EP1335729A2 (fr)	2003-08-20
HUP0301377A2 (hu)	2003-10-28
KR100983208B1 (ko)	2010-09-20
UY26991A1 (es)	2002-06-20
CN1237970C (zh)	2006-01-25
BG66425B1 (bg)	2014-04-30
UA76435C2 (en)	2006-08-15
IL155676A0 (en)	2003-11-23
EE200300202A (et)	2003-10-15
CZ20031487A3 (cs)	2003-09-17
NO332524B1 (no)	2012-10-08
YU33103A (sh)	2006-05-25
WO2002036591A2 (fr)	2002-05-10
CN1473044A (zh)	2004-02-04
EA200300483A1 (ru)	2003-12-25
BG107726A (bg)	2004-11-30
AU2174102A (en)	2002-05-15
JP2004523482A (ja)	2004-08-05
ECSP034570A (es)	2003-06-25
SK288031B6 (sk)	2012-12-03
NZ526024A (en)	2005-10-28
CZ305033B6 (cs)	2015-04-08

Legal Events

Date	Code	Title	Description
2003-11-19	EEER	Examination request
2020-12-07	MKLA	Lapsed	Effective date: 20201026

Publication	Publication Date	Title
AP1572A (en)	2006-02-13	Crystalline monohydrate, method for producing the same and use thereof in the production of a medicament.
CA2427583A1 (fr)	2002-05-10	Formulation d'une solution d'inhalation contenant un sel de tiotropium
CA2454328A1 (fr)	2003-01-30	Combinaisons pharmaceutiques d'oxycodone et naloxone
CA2359813A1 (fr)	2002-04-24	Vaporisateur de nicotine pour les muqueuses
WO2005030211A8 (fr)	2008-05-08	Formulations d'aerosols a inhaler, contenant un anticholinergique
CA2382919A1 (fr)	2001-04-19	Derives d'imidazo-3-yl-amine bicycliques
CA2426074A1 (fr)	2002-05-10	Formulation d'une solution d'inhalation contenant un sel de tiotropium
WO2001012202A3 (fr)	2001-11-15	Utilisation d'agents chimiques chelatants comme agents de neutralisation du blocage neuromusculaire provoque par des medicaments
GR3004148T3 (fr)	1993-03-31
AU2001246623A1 (en)	2001-10-03	Molecule of pharmaceutical interest comprising at its N-terminal a glutamic acid or a glutamine in the form of an addition salt to an acid
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