CA2372511A1 - Secreted and transmembrane polypeptides and nucleic acids encoding the same - Google Patents

Secreted and transmembrane polypeptides and nucleic acids encoding the same Download PDF

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Publication number
CA2372511A1
CA2372511A1 CA002372511A CA2372511A CA2372511A1 CA 2372511 A1 CA2372511 A1 CA 2372511A1 CA 002372511 A CA002372511 A CA 002372511A CA 2372511 A CA2372511 A CA 2372511A CA 2372511 A1 CA2372511 A1 CA 2372511A1
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Prior art keywords
seq
polypeptide
cell
acid sequence
fgfr
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CA002372511A
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French (fr)
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CA2372511C (en
Inventor
Avi J. Ashkenazi
Kevin P. Baker
David Botstein
Luc Desnoyers
Dan L. Eaton
Napoleone Ferrara
Sherman Fong
Wei-Qiang Gao
Hanspeter Gerber
Mary E. Gerritsen
Audrey Goddard
Paul J. Godowski
Austin L. Gurney
Ivar J. Kljavin
Jennie P. Mather
Mary A. Napier
James Pan
Nicholas F. Paoni
Margaret Ann Roy
Timothy A. Stewart
Daniel Tumas
Colin K. Watanabe
P. Mickey Williams
William I. Wood
Zemin Zhang
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Genentech Inc
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Individual
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Priority claimed from PCT/US1999/020111 external-priority patent/WO2000012708A2/en
Priority claimed from PCT/US1999/020594 external-priority patent/WO2000015666A2/en
Priority claimed from PCT/US1999/021547 external-priority patent/WO2000015797A2/en
Priority claimed from PCT/US1999/021090 external-priority patent/WO2000015796A2/en
Priority claimed from PCT/US1999/028313 external-priority patent/WO2000032221A2/en
Priority claimed from PCT/US1999/028301 external-priority patent/WO2000032776A2/en
Priority claimed from PCT/US1999/028565 external-priority patent/WO2000037638A2/en
Priority claimed from PCT/US2000/000219 external-priority patent/WO2000053753A2/en
Priority claimed from PCT/US2000/004342 external-priority patent/WO2000078961A1/en
Priority claimed from PCT/US2000/004341 external-priority patent/WO2000053756A2/en
Priority claimed from PCT/US2000/004414 external-priority patent/WO2001004311A1/en
Priority claimed from PCT/US2000/005601 external-priority patent/WO2000056889A2/en
Priority claimed from PCT/US2000/005841 external-priority patent/WO2000053758A2/en
Priority claimed from PCT/US2000/007377 external-priority patent/WO2001019991A1/en
Priority claimed from PCT/US2000/008439 external-priority patent/WO2000073454A1/en
Priority claimed from PCT/US2000/013358 external-priority patent/WO2000075317A2/en
Priority claimed from PCT/US2000/013705 external-priority patent/WO2000073445A2/en
Application filed by Individual filed Critical Individual
Publication of CA2372511A1 publication Critical patent/CA2372511A1/en
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Publication of CA2372511C publication Critical patent/CA2372511C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims (39)

1. Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence that encodes an amino acid sequence selected from the group consisting of the amino acid sequence shown in Figure 2 (SEQ ID NO:4), Figure 4 (SEQ ID NO:9), Figure 6 (SEQ ID
NO:11), Figure 8 (SEQ ID
NO:13), Figure 10 (SEQ ID NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID
NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID NO:41), Figure 26 (SEQ ID NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID
NO:56), Figure 32 (SEQ ID NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID
NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID NO:86), Figure 48 (SEQ ID NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID
NO:104), Figure 54 (SEQ ID NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ
ID NO:110), Figure 60 (SEQ ID NO:115), Figure 62 (SEQ ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID
NO:128), Figure 68 (SEQ ID NO:130), Figure 70 (SEQ ID NO:132), Figure 72 (SEQ
ID NO:137) and Figure 74 (SEQ ID NO:139).
2. Isolated nucleic acid having at least 80 % nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the nucleotide sequence shown in Figure 1 (SEQ ID NO:3), Figure 3 (SEQ ID NO:8), Figure 5 (SEQ ID NO:10), Figure 7 (SEQ ID NO:12), Figure 9 (SEQ ID NO:14), Figure 11 (SEQ ID NO:16), Figure 13 (SEQ ID NO:21), Figure 15 (SEQ ID NO:23), Figure 17 (SEQ ID
NO:28), Figure 19 (SEQ ID NO:31), Figure 21 (SEQ ID NO:38), Figure 23 (SEQ ID
NO:40), Figure 25 (SEQ ID NO:51), Figure 27 (SEQ ID NO:53), Figure 29 (SEQ ID NO:55), Figure 31 (SEQ ID NO:57), Figure 33 (SEQ ID NO:62), Figure 35 (SEQ ID NO:64), Figure 37 (SEQ ID NO:72), Figure 39 (SEQ ID
NO:77), Figure 41 (SEQ ID NO:79), Figure 43 (SEQ ID NO:83), Figure 45 (SEQ ID
NO:85), Figure 47 (SEQ ID NO:90), Figure 49 (SEQ ID NO:98), Figure 51 (SEQ ID NO:103), Figure 53 (SEQ ID NO:105), Figure 55 (SEQ ID NO:107), Figure 57 (SEQ ID NO:109), Figure 59 (SEQ ID
NO:114), Figure 61 (SEQ
ID NO:120), Figure 63 (SEQ ID NO:125), Figure 65 (SEQ ID NO:127), Figures 67A-B (SEQ ID NO:129), Figure 69 (SEQ ID NO:131), Figure 71 (SEQ ID NO:136) and Figure 73 (SEQ ID
NO:138).
3. Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the full-length coding sequence of the nucleotide sequence shown in Figure 1 (SEQ ID NO:3), Figure 3 (SEQ ID NO:8), Figure 5 (SEQ ID
NO:10), Figure 7 (SEQ ID
NO:12), Figure 9 (SEQ ID NO:14), Figure 11 (SEQ ID NO:16), Figure 13 (SEQ ID
NO:21), Figure 15 (SEQ
ID NO:23), Figure 17 (SEQ ID NO:28), Figure 19 (SEQ ID NO:31), Figure 21 (SEQ
ID NO:38), Figure 23 (SEQ ID NO:40), Figure 25 (SEQ ID NO:51), Figure 27 (SEQ ID NO:53), Figure 29 (SEQ ID NO:55), Figure 31 (SEQ ID NO:57), Figure 33 (SEQ ID NO:62), Figure 35 (SEQ ID NO:64), Figure 37 (SEQ ID
NO:72), Figure 39 (SEQ ID NO:77), Figure 41 (SEQ ID NO:79), Figure 43 (SEQ ID
NO:83), Figure 45 (SEQ ID NO:85), Figure 47 (SEQ ID NO:90), Figure 49 (SEQ ID NO:98), Figure 51 (SEQ ID NO:103), Figure 53 (SEQ ID NO:105), Figure 55 (SEQ ID NO:107), Figure 57 (SEQ ID
NO:109), Figure 59 (SEQ

ID NO:114), Figure 61 (SEQ ID NO:120), Figure 63 (SEQ ID NO:125), Figure 65 (SEQ ID NO:127), Figures 67A-B (SEQ ID NO:129), Figure 69 (SEQ ID NO:131), Figure 71 (SEQ ID
NO:136) and Figure 73 (SEQ ID NO:138).
4. Isolated nucleic acid having at least 80% nucleic acid sequence identity to the full-length coding sequence of the DNA deposited under any ATCC accession number shown in Table 10.
5. A vector comprising the nucleic acid of any one of Claims 1 to 4.
6. The vector of Claim 5 operably linked to control sequences recognized by a host cell transformed with the vector.
7. A host cell comprising the vector of Claim 5.
8. The host cell of Claim 7, wherein said cell is a CHO cell.
9. The host cell of Claim 7, wherein said cell is an E. coli.
10. The host cell of Claim 7, wherein said cell is a yeast cell.
11. A process for producing a PRO polypeptides comprising culturing the host cell of Claim 7 under conditions suitable for expression of said PRO polypeptide and recovering said PRO polypeptide from the cell culture.
12. An isolated polypeptide having at least 80 % amino acid sequence identity to an amino acid sequence selected from the group consisting of the amino acid sequence shown in Figure 2 (SEQ ID NO:4), Figure 4 (SEQ ID NO:9), Figure 6 (SEQ ID NO:11), Figure 8 (SEQ ID NO:13), Figure 10 (SEQ ID NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID
NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID
NO:41), Figure 26 (SEQ ID NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID NO:56), Figure 32 (SEQ ID NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID
NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID
NO:86), Figure 48 (SEQ ID NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID NO:104), Figure 54 (SEQ ID NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ 1D NO:110), Figure 60 (SEQ ID
NO:115), Figure 62 (SEQ
ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID NO:128), Figure 68 (SEQ ID NO:130), Figure 70 (SEQ ID NO:132), Figure 72 (SEQ ID NO:137) and Figure 74 (SEQ ID NO:139).
13. An isolated polypeptide scoring at least 80% positives when compared to an amino acid sequence selected from the group consisting of the amino acid sequence shown in Figure 2 (SEQ ID NO:4), Figure 4 (SEQ ID NO:9), Figure 6 (SEQ ID NO:11), Figure 8 (SEQ ID NO:13), Figure 10 (SEQ ID NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID
NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID
NO:41), Figure 26 (SEQ ID NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID NO:56), Figure 32 (SEQ ID NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID
NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID
NO:86), Figure 48 (SEQ ID NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID NO:104), Figure 54 (SEQ 1D NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ ID NO:110), Figure 60 (SEQ ID
NO:115), Figure 62 (SEQ
ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID NO:128), Figure 68 (SEQ ID NO:130), Figure 70 (SEQ ID NO:132), Figure 72 (SEQ ID NO:137) and Figure 74 (SEQ ID NO:139).
14. An isolated polypeptide having at least 80% amino acid sequence identity to an amino acid sequence encoded by the full-length coding sequence of the DNA deposited under any ATCC accession number shown in Table 10.
15. A chimeric molecule comprising a polypeptide according to any one of Claims 12 to 14 fused to a heterologous amino acid sequence.
16. The chimeric molecule of Claim 15, wherein said heterologous amino acid sequence is an epitope tag sequence.
17. The chimeric molecule of Claim 15, wherein said heterologous amino acid sequence is a Fc region of an immunoglobulin.
18. An antibody which specifically binds to a polypeptide according to any one of Claims 12 to 14.
19. The antibody of Claim 18, wherein said antibody is a monoclonal antibody, a humanized antibody or a single-chain antibody.
20. Isolated nucleic acid having at least 80% nucleic acid sequence identity to:
(a) a nucleotide sequence encoding the polypeptide shown in Figure 2 (SEQ ID
NO:4), Figure 4 (SEQ ID NO:9), Figure 6 (SEQ ID NO:11), Figure 8 (SEQ ID NO:13), Figure 10 (SEQ ID NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID NO:41), Figure 26 (SEQ ID

NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID NO:56), Figure 32 (SEQ ID
NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID NO:86), Figure 48 (SEQ ID
NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID NO:104), Figure 54 (SEQ ID
NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ ID NO:110), Figure 60 (SEQ ID NO:115), Figure 62 (SEQ ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID NO:128), Figure 68 (SEQ ID
NO:130), Figure 70 (SEQ
ID NO:132), Figure 72 (SEQ ID NO:137) or Figure 74 (SEQ ID NO:139), lacking its associated signal peptide;
(b) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in Figure 2 (SEQ ID NO:4), Figure 4 (SEQ ID NO:9), Figure 6 (SEQ ID NO:11), Figure 8 (SEQ ID NO:13), Figure (SEQ ID NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID
NO:41), Figure 26 (SEQ ID NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID
NO:56), Figure 32 (SEQ ID NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID
NO:86), Figure 48 (SEQ ID NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID
NO:104), Figure 54 (SEQ ID NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ ID NO:110), Figure 60 (SEQ ID NO:115), Figure 62 (SEQ ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID
NO:128), Figure 68 (SEQ
ID NO:130), Figure 70 (SEQ ID NO:132), Figure 72 (SEQ ID NO:137) or Figure 74 (SEQ ID NO:139), with its associated signal peptide; or (c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in Figure 2 (SEQ ID NO:4), Figure 4 (SEQ ID NO:9), Figure 6 (SEQ ID NO:11), Figure 8 (SEQ ID NO:13), Figure 10 (SEQ ID NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID
NO:41), Figure 26 (SEQ ID NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID
NO:56), Figure 32 (SEQ ID NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID
NO:86), Figure 48 (SEQ ID NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID
NO:104), Figure 54 (SEQ ID NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ ID NO:110), Figure 60 (SEQ ID NO:115), Figure 62 (SEQ ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID
NO:128), Figure 68 (SEQ
ID NO:130), Figure 70 (SEQ ID NO:132), Figure 72 (SEQ ID NO:137) or Figure 74 (SEQ ID NO:139), lacking its associated signal peptide.
21. An isolated polypeptide having at least 80% amino acid sequence identity to:
(a) the polypeptide shown in Figure 2 (SEQ ID NO:4), Figure 4 (SEQ ID NO:9), Figure 6 (SEQ
ID NO:11), Figure 8 (SEQ ID NO:13), Figure 10 (SEQ ID NO:15), Figure 12 (SEQ
ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID NO:41), Figure 26 (SEQ ID NO:52), Figure 28 (SEQ ID

NO:54), Figure 30 (SEQ ID NO:56), Figure 32 (SEQ ID NO:58), Figure 34 (SEQ ID
NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID NO:86), Figure 48 (SEQ ID NO:91), Figure 50 (SEQ ID
NO:99), Figure 52 (SEQ ID NO:104), Figure 54 (SEQ ID NO:106), Figure 56 (SEQ
ID NO:108), Figure 58 (SEQ ID NO:110), Figure 60 (SEQ ID NO:115), Figure 62 (SEQ ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID NO:128), Figure 68 (SEQ ID NO:130), Figure 70 (SEQ ID
NO:132), Figure 72 (SEQ
ID NO:137) or Figure 74 (SEQ ID NO:139), lacking its associated signal peptide;
(b) an extracellular domain of the polypeptide shown in Figure 2 (SEQ ID
NO:4), Figure 4 (SEQ
ID NO:9), Figure 6 (SEQ ID NO:11), Figure 8 (SEQ ID NO:13), Figure 10 (SEQ ID
NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID NO:41), Figure 26 (SEQ ID
NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID NO:56), Figure 32 (SEQ ID
NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID NO:86), Figure 48 (SEQ ID
NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID NO:104), Figure 54 (SEQ ID
NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ ID NO:110), Figure 60 (SEQ ID NO:115), Figure 62 (SEQ ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID NO:128), Figure 68 (SEQ ID
NO:130), Figure 70 (SEQ
ID NO:132), Figure 72 (SEQ ID NO:137) or Figure 74 (SEQ ID NO:139), with its associated signal peptide;
or (c) an extracellular domain of the polypeptide shown in Figure 2 (SEQ ID
NO:4), Figure 4 (SEQ
ID NO:9), Figure 6 (SEQ ID NO:11), Figure 8 (SEQ ID NO:13), Figure 10 (SEQ ID
NO:15), Figure 12 (SEQ ID NO:17), Figure 14 (SEQ ID NO:22), Figure 16 (SEQ ID NO:24), Figure 18 (SEQ ID NO:29), Figure 20 (SEQ ID NO:32), Figure 22 (SEQ ID NO:39), Figure 24 (SEQ ID NO:41), Figure 26 (SEQ ID
NO:52), Figure 28 (SEQ ID NO:54), Figure 30 (SEQ ID NO:56), Figure 32 (SEQ ID
NO:58), Figure 34 (SEQ ID NO:63), Figure 36 (SEQ ID NO:65), Figure 38 (SEQ ID NO:73), Figure 40 (SEQ ID NO:78), Figure 42 (SEQ ID NO:80), Figure 44 (SEQ ID NO:84), Figure 46 (SEQ ID NO:86), Figure 48 (SEQ ID
NO:91), Figure 50 (SEQ ID NO:99), Figure 52 (SEQ ID NO:104), Figure 54 (SEQ ID
NO:106), Figure 56 (SEQ ID NO:108), Figure 58 (SEQ ID NO:110), Figure 60 (SEQ ID NO:115), Figure 62 (SEQ ID NO:121), Figure 64 (SEQ ID NO:126), Figure 66 (SEQ ID NO:128), Figure 68 (SEQ ID
NO:130), Figure 70 (SEQ
ID NO:132), Figure 72 (SEQ ID NO:137) or Figure 74 (SEQ ID NO:139), lacking its associated signal peptide.
22. A method of detecting a polypeptide designated as A, B, C, D, E, F, G, H, or I in a sample suspected of containing an A, B, C, D, E, F, G, H, or I polypeptide, said method comprising contacting said sample with a polypeptide designated herein as J, K, L, M, N, O, P, Q, R, S or T and determining the formation of a A/J, B/K, C/L, C/M, C/N, C/J, D/O, E/P, F/Q, G/R, H/S or I/T
polypeptide conjugate in said sample, wherein the formation of said conjugate is indicative of the presence of an A, B, C, D, E, F, G, H, or I polypeptide in said sample and wherein A is a PRO533 polypeptide, B is a PRO301 polypeptide, C is a PRO187 polypeptide, D is a PRO337 polypeptide, E is a PRO1411 polypeptide, F
is a PRO10096 polypeptide, G is a PRO246 polypeptide, H is a PRO6307 polypeptide, I is a PRO6003 polypeptide, J is an FGFR-4 polypeptide, K is a PRO301 polypeptide, L is an FGFR-3 polypeptide, M is an FGFR-1 polypeptide, N is an FGFR-2 polypeptide, O is a PRO6004 polypeptide, P is a PRO4356 polypeptide, Q
is a PRO2630 polypeptide, R is a PRO246 polypeptide, S is a PRO265 polypeptide and T is a PRO941 polypeptide.
23. The method according to Claim 22, wherein said sample comprises cells suspected of expressing said A, B, C, D, E, F, G, H, or I polypeptide.
24. The method according to Claim 22, wherein said J, K, L, M, N, O, P, Q, R, S or T
polypeptide is labeled with a detectable label.
25. The method according to Claim 22, wherein said J, K, L, M, N, O, P, Q, R, S or T
polypeptide is attached to a solid support.
26. A method of detecting a polypeptide designated as J, K, L, M, N, O, P, Q, R, S or T in a sample suspected of containing a J, K, L, M, N, O, P, Q, R, S or T
polypeptide, said method comprising contacting said sample with a polypeptide designated herein as A, B, C, D, E, F, G, H, or I and determining the formation of a A/J, B/K, C/L, C/M, C/N, C/J, D/O, E/P, F/Q, G/R, H/S or I/T polypeptide conjugate in said sample, wherein the formation of said conjugate is indicative of the presence of a J, K, L, M, N, O, P, Q, R, S or T polypeptide in said sample and wherein A is a PRO533 polypeptide, B is a PRO301 polypeptide, C is a PRO187 polypeptide, D is a PRO337 polypeptide, E is a PRO1411 polypeptide, F is a PRO10096 polypeptide, G is a PRO246 polypeptide, H is a PRO6307 polypeptide, I
is a PRO6003 polypeptide, J is an FGFR-4 polypeptide, K is a PRO301 polypeptide, L is an FGFR-3 polypeptide, M is an FGFR-1 polypeptide, N is an FGFR-2 polypeptide, O is a PRO6004 polypeptide, P
is a PRO4356 polypeptide, Q is a PRO2630 polypeptide, R is a PRO246 polypeptide, S is a PRO265 polypeptide and T is a PRO941 polypeptide.
27. The method according to Claim 26, wherein said sample comprises cells suspected of expressing said J, K, L, M, N, O, P, Q, R, S or T polypeptide.
28. The method according to Claim 26, wherein said A, B, C, D, E, F, G, H, or I polypeptide is labeled with a detectable label.
29. The method according to Claim 26, wherein said A, B, C, D, E, F, G, H, or I polypeptide is attached to a solid support.
30. A method of linking a bioactive molecule to a cell expressing a polypeptide designated as A, B, C, D, E, F, G, H, or I, said method comprising contacting said cell with a polypeptide designated as J, K, L, M, N, O, P, Q, R, S or T that is bound to said bioactive molecule and allowing said A, B, C, D, E, F, G, H, or I and said J, K, L, M, N, O, P, Q, R, S or T polypeptides to bind to one another, thereby linking said bioactive molecules to said cell, wherein A is a PRO533 polypeptide, B is a PRO301 polypeptide, C is a PRO 187 polypeptide, D is a PRO337 polypeptide, E is a PRO1411 polypeptide, F
is a PRO10096 polypeptide, G is a PRO246 polypeptide, H is a PRO6307 polypeptide, I is a PRO6003 polypeptide, J is an FGFR-4 polypeptide, K is a PRO301 polypeptide, L is an FGFR-3 polypeptide, M is an FGFR-1 polypeptide, N is an FGFR-2 polypeptide, O is a PRO6004 polypeptide, P is a PRO4356 polypeptide, Q
is a PRO2630 polypeptide, R is a PRO246 polypeptide, S is a PRO265 polypeptide and T is a PRO941 polypeptide.
31. The method according to Claim 30, wherein said bioactive molecule is a toxin, a radiolabel or an antibody.
32. The method according to Claim 30, wherein said bioactive molecule causes the death of said cell.
33. A method of linking a bioactive molecule to a cell expressing a polypeptide designated as J, K, L, M, N, O, P, Q, R, S or T, said method comprising contacting said cell with a polypeptide designated as A, B, C, D, E, F, G, H, or I that is bound to said bioactive molecule and allowing said A, B, C, D, E, F, G, H, or I and said J, K, L, M, N, O, P, Q, R, S or T polypeptides to bind to one another, thereby linking said bioactive molecules to said cell, wherein A is a PRO533 polypeptide, B is a PRO301 polypeptide, C is a PRO187 polypeptide, D is a PRO337 polypeptide, E is a PRO1411 polypeptide, F
is a PRO10096 polypeptide, G is a PRO246 polypeptide, H is a PRO6307 polypeptide, I is a PRO6003 polypeptide, J is an FGFR-4 polypeptide, K is a PRO301 polypeptide, L is an FGFR-3 polypeptide, M
is an FGFR-1 polypeptide, N is an FGFR-2 polypeptide, O is a PRO6004 polypeptide, P is a PRO4356 polypeptide, Q is a PRO2630 polypeptide, R is a PRO246 polypeptide, S is a PRO265 polypeptide and T is a PRO941 polypeptide.
34. The method according to Claim 33, wherein said bioactive molecule is a toxin, a radiolabel or an antibody.
35. The method according to Claim 33, wherein said bioactive molecule causes the death of said cell.
36. A method of modulating at least one biological activity of a cell expressing a polypeptide designated as A, B, C, D, E, F, G, H, or I, said method comprising contacting said cell with a polypeptide designated as J, K, L, M, N, O, P, Q, R, S or T or an anti-A, B, C, D, E, F, G, H, or I polypeptide antibody, whereby said J, K, L, M, N, O, P, Q, R, S or T polypeptide or anti-A, B, C, D, E, F, G, H, or I polypeptide antibody binds to said A, B, C, D, E, F, G, H, or I polypeptide, thereby modulating at least one biological activity of said cell.
37. The method according to Claim 36, wherein said cell is killed.
38. A method of modulating at least one biological activity of a cell expressing a polypeptide designated as J, K, L, M, N, O, P, Q, R, S or T, said method comprising contacting said cell with a polypeptide designated as A, B, C, D, E, F, G, H, or I or an anti-J, K, L, M, N, O, P, Q, R, S or T
polypeptide antibody, whereby said anti-J, K, L, M, N, O, P, Q, R, S or T
polypeptide antibody or A, B, C, D, E, F, G, H, or I polypeptide antibody binds to said J, K, L, M, N, O, P, Q, R, S or T polypeptide, thereby modulating at least one biological activity of said cell.
39. The method according to Claim 36, wherein said cell is killed.
CA2372511A 1999-06-15 2000-05-22 Secreted and transmembrane polypeptides and nucleic acids encoding the same Expired - Lifetime CA2372511C (en)

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US14507099P 1999-07-20 1999-07-20
US60/145,070 1999-07-20
US14569899P 1999-07-26 1999-07-26
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USPCT/US99/21547 1999-09-15
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USPCT/US99/21090 1999-09-15
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USPCT/US99/28313 1999-11-30
USPCT/US99/28301 1999-12-01
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PCT/US2000/000219 WO2000053753A2 (en) 1999-03-08 2000-01-05 Promotion or inhibition of angiogenesis and cardiovascularization
USPCT/US00/00219 2000-01-05
PCT/US2000/004341 WO2000053756A2 (en) 1999-03-08 2000-02-18 Secreted and transmembrane polypeptides and nucleic acids encoding the same
PCT/US2000/004342 WO2000078961A1 (en) 1999-06-23 2000-02-18 Secreted and transmembrane polypeptides and nucleic acids encoding the same
USPCT/US00/04341 2000-02-18
USPCT/US00/04342 2000-02-18
PCT/US2000/004414 WO2001004311A1 (en) 1999-07-07 2000-02-22 Secreted and transmembrane polypeptides and nucleic acids encoding the same
USPCT/US00/04414 2000-02-22
USPCT/US00/05601 2000-03-01
PCT/US2000/005601 WO2000056889A2 (en) 1999-03-23 2000-03-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
USPCT/US00/05841 2000-03-02
PCT/US2000/005841 WO2000053758A2 (en) 1999-03-08 2000-03-02 Compositions and methods for the treatment of immune related diseases
PCT/US2000/007377 WO2001019991A1 (en) 1999-09-15 2000-03-20 Compositions and methods for the treatment of immune related diseases
USPCT/US00/07377 2000-03-20
USPCT/US00/08439 2000-03-30
PCT/US2000/008439 WO2000073454A1 (en) 1999-06-02 2000-03-30 Secreted and transmembrane polypeptides and nucleic acids encoding the same
USPCT/US00/13358 2000-05-15
PCT/US2000/013358 WO2000075317A2 (en) 1999-06-09 2000-05-15 Compositions and methods for the treatment of tumor
USPCT/US00/13705 2000-05-17
PCT/US2000/013705 WO2000073445A2 (en) 1999-06-02 2000-05-17 Interleukin-1-receptor associated kinase-3 (irak3)
PCT/US2000/014042 WO2000077037A2 (en) 1999-06-15 2000-05-22 Secreted and transmembrane polypeptides and nucleic acids encoding the same

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