CA2370884A1 - Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease - Google Patents

Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease Download PDF

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Publication number
CA2370884A1
CA2370884A1 CA002370884A CA2370884A CA2370884A1 CA 2370884 A1 CA2370884 A1 CA 2370884A1 CA 002370884 A CA002370884 A CA 002370884A CA 2370884 A CA2370884 A CA 2370884A CA 2370884 A1 CA2370884 A1 CA 2370884A1
Authority
CA
Canada
Prior art keywords
mitochondrial
disease
single nucleotide
alzheimer
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002370884A
Other languages
English (en)
French (fr)
Inventor
Corinna Herrnstadt
Robert E. Davis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Migenix Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2370884A1 publication Critical patent/CA2370884A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002370884A 1999-04-20 2000-04-19 Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease Abandoned CA2370884A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13044799P 1999-04-20 1999-04-20
US60/130,447 1999-04-20
US16090199P 1999-10-22 1999-10-22
US60/160,901 1999-10-22
PCT/US2000/010906 WO2000063441A2 (en) 1999-04-20 2000-04-19 Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease

Publications (1)

Publication Number Publication Date
CA2370884A1 true CA2370884A1 (en) 2000-10-26

Family

ID=26828492

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002370884A Abandoned CA2370884A1 (en) 1999-04-20 2000-04-19 Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease

Country Status (5)

Country Link
EP (1) EP1208225A2 (ja)
JP (1) JP2003521879A (ja)
AU (1) AU4368300A (ja)
CA (1) CA2370884A1 (ja)
WO (1) WO2000063441A2 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2364294C (en) * 2000-12-04 2013-04-02 Primagen B.V. Testing endosymbiont cellular organelles and compounds identifiable therewith
GB2380194B (en) * 2001-10-01 2005-06-22 Roger Michael Marchbanks A mitochondrial mutation associated with schizophrenia and increased oxidative stress
US6897025B2 (en) * 2002-01-07 2005-05-24 Perlegen Sciences, Inc. Genetic analysis systems and methods
CA2513191A1 (en) * 2003-01-30 2004-08-12 Research Development Foundation Methods and compositions for analysis of mitochondrial-related gene expression
ATE506437T1 (de) 2003-05-21 2011-05-15 Andes Biotechnologies S A Marker für präkanzeröse und kanzeröse zellen sowie verfahren zur störung der zellproliferation darin
EP1694695A4 (en) * 2003-12-11 2007-10-31 1304854 Ontario Ltd COMPLETE MITOCHONDRIAL GENOME SEQUENCES AS A DIAGNOSTIC TOOL FOR MEDICAL SCIENCES
US20130022979A1 (en) 2005-04-18 2013-01-24 Genesis Genomics Inc. 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER
SG2014011837A (en) 2005-04-18 2014-04-28 Mitomics Inc Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
EP2142923A2 (en) * 2007-03-23 2010-01-13 King's College London Altered mitochondrial activity in diseases resulting from oxidative stress
WO2012008839A2 (en) * 2010-07-16 2012-01-19 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of a disease marker
AU2012231884B2 (en) * 2011-03-18 2017-03-09 Stichting Vumc A method of analysing a blood sample of a subject for the presence of a disease marker
ES2482866B1 (es) * 2012-11-22 2015-05-12 Consejo Superior De Investigaciones Científicas (Csic) Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.
ES2546743B1 (es) * 2014-03-28 2016-07-07 Institut D'investigació Biomèdica De Bellvitge (Idibell) Marcadores mitocondriales de enfermedades neurodegenerativas
GB2566516A (en) 2017-09-15 2019-03-20 Univ Oxford Innovation Ltd Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria
WO2020111169A1 (ja) * 2018-11-28 2020-06-04 国立大学法人千葉大学 多因子遺伝疾患の遺伝子検査法、及び検査キット
CN113862346B (zh) * 2021-09-26 2023-07-07 北京大学 长链非编码rna在治疗阿尔茨海默病中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494794A (en) * 1992-10-20 1996-02-27 Emory University Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease
US6027883A (en) * 1994-03-30 2000-02-22 Mitokor Optimal procedure for isolation of mutant mitochondrial alleles
US5976798A (en) * 1994-03-30 1999-11-02 Mitokor Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid
US5565323A (en) * 1994-03-30 1996-10-15 Mitokor Cytochrome oxidase mutations aiding diagnosis of sporadic alzheimer's disease
JPH1099085A (ja) * 1996-05-16 1998-04-21 Affymetrix Inc ヒトミトコンドリアｄｎａの多形性

Also Published As

Publication number Publication date
WO2000063441A3 (en) 2002-03-14
AU4368300A (en) 2000-11-02
EP1208225A2 (en) 2002-05-29
WO2000063441A2 (en) 2000-10-26
JP2003521879A (ja) 2003-07-22

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