CA2344591A1 - Methods for improving the function of heterologous g protein-coupled receptors - Google Patents
Methods for improving the function of heterologous g protein-coupled receptors Download PDFInfo
- Publication number
- CA2344591A1 CA2344591A1 CA002344591A CA2344591A CA2344591A1 CA 2344591 A1 CA2344591 A1 CA 2344591A1 CA 002344591 A CA002344591 A CA 002344591A CA 2344591 A CA2344591 A CA 2344591A CA 2344591 A1 CA2344591 A1 CA 2344591A1
- Authority
- CA
- Canada
- Prior art keywords
- receptor
- protein
- yeast cell
- cell according
- coupled receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4722—G-proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9870498P | 1998-09-01 | 1998-09-01 | |
US60/098,704 | 1998-09-01 | ||
PCT/US1999/020013 WO2000012705A2 (en) | 1998-09-01 | 1999-09-01 | Methods for improving the function of heterologous g protein-coupled receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2344591A1 true CA2344591A1 (en) | 2000-03-09 |
Family
ID=22270543
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002343046A Abandoned CA2343046A1 (en) | 1998-09-01 | 1999-09-01 | Enhanced functional expression of g protein-coupled receptors |
CA002344591A Abandoned CA2344591A1 (en) | 1998-09-01 | 1999-09-01 | Methods for improving the function of heterologous g protein-coupled receptors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002343046A Abandoned CA2343046A1 (en) | 1998-09-01 | 1999-09-01 | Enhanced functional expression of g protein-coupled receptors |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP1123391A2 (de) |
JP (2) | JP2002523091A (de) |
AU (2) | AU756244B2 (de) |
CA (2) | CA2343046A1 (de) |
WO (2) | WO2000012705A2 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6528271B1 (en) | 1997-06-05 | 2003-03-04 | Duke University | Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia |
NZ521696A (en) | 2000-04-24 | 2004-06-25 | Wyeth Corp | Transgenic animal models for diseases that are regulated by G-protein signalling |
WO2002035234A1 (en) * | 2000-10-26 | 2002-05-02 | The University Of British Columbia | A functional assay for g-protein-coupled receptors based on insect cells |
AU2002210982A1 (en) * | 2000-11-01 | 2002-05-15 | Yamanouchi Pharmaceutical Co..Ltd. | Method of screening antiplatelet |
US7018812B2 (en) | 2000-11-03 | 2006-03-28 | Duke University | Modified G-protein coupled receptors |
US7163800B2 (en) | 2000-11-03 | 2007-01-16 | Molecular Devices Corporation | Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity |
DE10056899A1 (de) * | 2000-11-16 | 2002-05-29 | Aventis Pharma Gmbh | Promotor zur funktionellen Charakterisierung von G-Protein gekoppelten Rezeptoren in der Hefe Saccharomyces cerevisiae |
WO2002045503A2 (en) * | 2000-12-06 | 2002-06-13 | Deltagen, Inc. | Transgenic mice containing targeted gene disruptions |
GB0030038D0 (en) * | 2000-12-08 | 2001-01-24 | Univ Warwick | Yeast-based assay |
US7279324B2 (en) | 2001-01-23 | 2007-10-09 | Duke University | Nucleic acid encoding G-protein coupled receptor with modified DRY motif |
EP1336655A1 (de) * | 2002-01-12 | 2003-08-20 | Aventis Pharma Deutschland GmbH | Verfahren zur Identifikation von konstitutiv aktiven Mutanten |
DE10233516A1 (de) * | 2002-07-23 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Identifizierung von Substanzen |
JP4977012B2 (ja) * | 2005-03-29 | 2012-07-18 | Bio−energy株式会社 | レセプター結合性物質のスクリーニング方法 |
CN101166527A (zh) | 2005-04-27 | 2008-04-23 | 艾尼纳制药公司 | 用于治疗肥胖症和糖尿病以及其相关病况和用于治疗可通过增加血液glp-1含量改善的病况的组合疗法 |
NZ564759A (en) | 2005-06-30 | 2011-08-26 | Prosidion Ltd | GPCR agonists |
DK1971862T3 (da) | 2006-04-11 | 2011-02-14 | Arena Pharm Inc | Fremgangsmåder til anvendelse af GPR119-receptor til identificering af forbindelser anvendelige til øgning af knoglemasse hos en person |
EP2377863A1 (de) | 2007-01-04 | 2011-10-19 | Prosidion Limited | Piperidin-GPCR-Agonisten |
AR064735A1 (es) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr y composicion farmaceutica en base al compuesto |
CL2008000017A1 (es) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
CA2681415C (en) * | 2007-03-22 | 2020-11-03 | Heptares Therapeutics Limited | Mutant g-protein coupled receptors and methods for selecting them |
US20100286112A1 (en) | 2007-09-10 | 2010-11-11 | Oscar Barba | Compounds for the treatment of metabolic disorders |
GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
EP2108960A1 (de) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Verfahren zur Verwendung eines A G Protein-gekoppelten Rezeptors zur Identifikation von Peptid YY (PYY) Sekretagoga und nützliche Verbindungen zur Behandlung von durch (PYY) Sekretagoga modulierten Zuständen und nützliche Verbindungen zur Behandlung von Zuständen durch PYY |
GB0904285D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
GB0904287D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
GB0904284D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
JP7422498B2 (ja) * | 2019-07-25 | 2024-01-26 | 芳武 村山 | ペプチド、細胞遊走抑制剤、細胞浸潤抑制剤、がん細胞転移抑制剤、及び医薬 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5691188A (en) * | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
JPH10502245A (ja) * | 1994-06-29 | 1998-03-03 | メルク エンド カンパニー インコーポレーテッド | 改変g−蛋白質結合リセプタ |
WO1998038217A1 (en) * | 1997-02-27 | 1998-09-03 | Milt Teitler | Constitutively activated serotonin receptors |
-
1999
- 1999-09-01 AU AU57011/99A patent/AU756244B2/en not_active Ceased
- 1999-09-01 WO PCT/US1999/020013 patent/WO2000012705A2/en not_active Application Discontinuation
- 1999-09-01 JP JP2000567692A patent/JP2002523091A/ja not_active Withdrawn
- 1999-09-01 JP JP2000567691A patent/JP2002523090A/ja not_active Withdrawn
- 1999-09-01 AU AU57009/99A patent/AU5700999A/en not_active Abandoned
- 1999-09-01 CA CA002343046A patent/CA2343046A1/en not_active Abandoned
- 1999-09-01 WO PCT/US1999/020011 patent/WO2000012704A2/en not_active Application Discontinuation
- 1999-09-01 EP EP99944035A patent/EP1123391A2/de not_active Withdrawn
- 1999-09-01 CA CA002344591A patent/CA2344591A1/en not_active Abandoned
- 1999-09-01 EP EP99944033A patent/EP1112359A2/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU5700999A (en) | 2000-03-21 |
CA2343046A1 (en) | 2000-03-09 |
WO2000012704A3 (en) | 2000-11-30 |
WO2000012705A9 (en) | 2000-07-13 |
AU5701199A (en) | 2000-03-21 |
WO2000012705A3 (en) | 2000-10-05 |
WO2000012704A9 (en) | 2000-06-08 |
WO2000012705A2 (en) | 2000-03-09 |
WO2000012704A2 (en) | 2000-03-09 |
EP1123391A2 (de) | 2001-08-16 |
EP1112359A2 (de) | 2001-07-04 |
AU756244B2 (en) | 2003-01-09 |
JP2002523091A (ja) | 2002-07-30 |
JP2002523090A (ja) | 2002-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |