CA2344591A1 - Methods for improving the function of heterologous g protein-coupled receptors - Google Patents

Methods for improving the function of heterologous g protein-coupled receptors Download PDF

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Publication number
CA2344591A1
CA2344591A1 CA002344591A CA2344591A CA2344591A1 CA 2344591 A1 CA2344591 A1 CA 2344591A1 CA 002344591 A CA002344591 A CA 002344591A CA 2344591 A CA2344591 A CA 2344591A CA 2344591 A1 CA2344591 A1 CA 2344591A1
Authority
CA
Canada
Prior art keywords
receptor
protein
yeast cell
cell according
coupled receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002344591A
Other languages
English (en)
French (fr)
Inventor
Mark Henry Pausch
Jurgen Wess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
US Government
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2344591A1 publication Critical patent/CA2344591A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002344591A 1998-09-01 1999-09-01 Methods for improving the function of heterologous g protein-coupled receptors Abandoned CA2344591A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9870498P 1998-09-01 1998-09-01
US60/098,704 1998-09-01
PCT/US1999/020013 WO2000012705A2 (en) 1998-09-01 1999-09-01 Methods for improving the function of heterologous g protein-coupled receptors

Publications (1)

Publication Number Publication Date
CA2344591A1 true CA2344591A1 (en) 2000-03-09

Family

ID=22270543

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002343046A Abandoned CA2343046A1 (en) 1998-09-01 1999-09-01 Enhanced functional expression of g protein-coupled receptors
CA002344591A Abandoned CA2344591A1 (en) 1998-09-01 1999-09-01 Methods for improving the function of heterologous g protein-coupled receptors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002343046A Abandoned CA2343046A1 (en) 1998-09-01 1999-09-01 Enhanced functional expression of g protein-coupled receptors

Country Status (5)

Country Link
EP (2) EP1123391A2 (de)
JP (2) JP2002523091A (de)
AU (2) AU756244B2 (de)
CA (2) CA2343046A1 (de)
WO (2) WO2000012705A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
NZ521696A (en) 2000-04-24 2004-06-25 Wyeth Corp Transgenic animal models for diseases that are regulated by G-protein signalling
WO2002035234A1 (en) * 2000-10-26 2002-05-02 The University Of British Columbia A functional assay for g-protein-coupled receptors based on insect cells
AU2002210982A1 (en) * 2000-11-01 2002-05-15 Yamanouchi Pharmaceutical Co..Ltd. Method of screening antiplatelet
US7018812B2 (en) 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
US7163800B2 (en) 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
DE10056899A1 (de) * 2000-11-16 2002-05-29 Aventis Pharma Gmbh Promotor zur funktionellen Charakterisierung von G-Protein gekoppelten Rezeptoren in der Hefe Saccharomyces cerevisiae
WO2002045503A2 (en) * 2000-12-06 2002-06-13 Deltagen, Inc. Transgenic mice containing targeted gene disruptions
GB0030038D0 (en) * 2000-12-08 2001-01-24 Univ Warwick Yeast-based assay
US7279324B2 (en) 2001-01-23 2007-10-09 Duke University Nucleic acid encoding G-protein coupled receptor with modified DRY motif
EP1336655A1 (de) * 2002-01-12 2003-08-20 Aventis Pharma Deutschland GmbH Verfahren zur Identifikation von konstitutiv aktiven Mutanten
DE10233516A1 (de) * 2002-07-23 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Identifizierung von Substanzen
JP4977012B2 (ja) * 2005-03-29 2012-07-18 Ｂｉｏ−ｅｎｅｒｇｙ株式会社 レセプター結合性物質のスクリーニング方法
CN101166527A (zh) 2005-04-27 2008-04-23 艾尼纳制药公司 用于治疗肥胖症和糖尿病以及其相关病况和用于治疗可通过增加血液glp-1含量改善的病况的组合疗法
NZ564759A (en) 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
DK1971862T3 (da) 2006-04-11 2011-02-14 Arena Pharm Inc Fremgangsmåder til anvendelse af GPR119-receptor til identificering af forbindelser anvendelige til øgning af knoglemasse hos en person
EP2377863A1 (de) 2007-01-04 2011-10-19 Prosidion Limited Piperidin-GPCR-Agonisten
AR064735A1 (es) 2007-01-04 2009-04-22 Prosidion Ltd Agonistas de gpcr y composicion farmaceutica en base al compuesto
CL2008000017A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
CA2681415C (en) * 2007-03-22 2020-11-03 Heptares Therapeutics Limited Mutant g-protein coupled receptors and methods for selecting them
US20100286112A1 (en) 2007-09-10 2010-11-11 Oscar Barba Compounds for the treatment of metabolic disorders
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
EP2108960A1 (de) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Verfahren zur Verwendung eines A G Protein-gekoppelten Rezeptors zur Identifikation von Peptid YY (PYY) Sekretagoga und nützliche Verbindungen zur Behandlung von durch (PYY) Sekretagoga modulierten Zuständen und nützliche Verbindungen zur Behandlung von Zuständen durch PYY
GB0904285D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904287D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904284D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
JP7422498B2 (ja) * 2019-07-25 2024-01-26 芳武 村山 ペプチド、細胞遊走抑制剤、細胞浸潤抑制剤、がん細胞転移抑制剤、及び医薬

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
JPH10502245A (ja) * 1994-06-29 1998-03-03 メルク エンド カンパニー インコーポレーテッド 改変ｇ−蛋白質結合リセプタ
WO1998038217A1 (en) * 1997-02-27 1998-09-03 Milt Teitler Constitutively activated serotonin receptors

Also Published As

Publication number Publication date
AU5700999A (en) 2000-03-21
CA2343046A1 (en) 2000-03-09
WO2000012704A3 (en) 2000-11-30
WO2000012705A9 (en) 2000-07-13
AU5701199A (en) 2000-03-21
WO2000012705A3 (en) 2000-10-05
WO2000012704A9 (en) 2000-06-08
WO2000012705A2 (en) 2000-03-09
WO2000012704A2 (en) 2000-03-09
EP1123391A2 (de) 2001-08-16
EP1112359A2 (de) 2001-07-04
AU756244B2 (en) 2003-01-09
JP2002523091A (ja) 2002-07-30
JP2002523090A (ja) 2002-07-30

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Legal Events

Date Code Title Description
FZDE Discontinued