CA2331641A1 - Multivalent antibody constructs - Google Patents

Multivalent antibody constructs Download PDF

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Publication number
CA2331641A1
CA2331641A1 CA002331641A CA2331641A CA2331641A1 CA 2331641 A1 CA2331641 A1 CA 2331641A1 CA 002331641 A CA002331641 A CA 002331641A CA 2331641 A CA2331641 A CA 2331641A CA 2331641 A1 CA2331641 A1 CA 2331641A1
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CA
Canada
Prior art keywords
antibody construct
expression plasmid
construct according
namely
multivalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002331641A
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French (fr)
Other versions
CA2331641C (en
Inventor
Melvyn Little
Sergej Kipriyanov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
Melvyn Little
Sergej Kipriyanov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7866613&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2331641(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts, Melvyn Little, Sergej Kipriyanov filed Critical Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
Publication of CA2331641A1 publication Critical patent/CA2331641A1/en
Application granted granted Critical
Publication of CA2331641C publication Critical patent/CA2331641C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

The invention relates to a multivalent Fv antibody construct comprising at least four variable domains which are connected to one another via peptide linkers 1, 2 and 3. The invention also relates to expression plasmids which code for such an Fv antibody construct. In addition, the invention relates to a method for producing the Fv antibody constructs and to the use thereof.

Claims (21)

1. A multivalent F v antibody construct having at least four variable domains which are linked with one another via the peptide linkers 1, 2 and 3, wherein the peptide linkers 1 and 3 have 0 to 10 amino acids.
2. The F v antibody construct according to claim 1, wherein the peptide linkers 1 and 3 have the amino acid sequence GG.
3. The F v antibody construct according to claim 1 or 2, wherein the F v antibody construct is bivalent.
4. The F v antibody construct according to claim 3, wherein the peptide linker 2 has 11 to 20 amino acids.
5. The F v antibody construct according to claim 3 or 4, wherein the peptide linker 2 has the amino acid sequence (GQS)4.
6. The F v antibody construct according to claim 1 or 2, wherein the F v antibody construct is tetravalent.
7. The F v antibody construct according to claim 6, wherein the peptide linker 2 has 3 to 10 amino acids.
8. The F v antibody construct according to claim 6 or 7, wherein the peptide linker 2 comprises the amino acid sequence GGPGS.
9. The F v antibody construct according to any of claims 1 to 8, wherein the F v antibody construct is multispecific.
10. F v antibody construct according to claim 9, wherein the F v antibody construct is bispecific.
11. The F v antibody construct according to any of claims 1 to 8, wherein the F v antibody construct is monospecific.
12. A method of producing the multivalent F v antibody construct according to any of claims 1 to 11, wherein DNAs coding for the peptide linkers 1, 2 and 3 are ligated with DNAS coding for the four variable domains of an F v antibody construct such that the peptide linkers link the variable domains with one another and the resulting DNA molecule is expressed in an expression plasmid.
13. Expression plasmid coding for the multivalent F v antibody construct according to any of claims 1 to 11.
14. The expression plasmid according to claim 13, namely pDISC3x19-LL.
15. The expression plasmid according to claim 13, namely pDISC3x19-SL.
16. The expression plasmid according to claim 13, namely pPIC-DISC-LL.
17. The expression plasmid according to claim 13, namely pPIC-DISC-SL.
18. The expression plasmid according to claim 13, namely pDISCS-LL.
19. The expression plasmid according to claim 13, namely pDISC6-SL.
20. Use of the multivalent F v antibody construct according to any of claims 1 to 11 for the diagnosis and/or treatment of diseases.
21. Use according to claim 20, wherein the diseases are viral, bacterial or tumoral diseases.
CA2331641A 1998-05-05 1999-05-05 Multivalent antibody constructs Expired - Lifetime CA2331641C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19819846.9A DE19819846B4 (en) 1998-05-05 1998-05-05 Multivalent antibody constructs
DE19819846.9 1998-05-05
PCT/DE1999/001350 WO1999057150A2 (en) 1998-05-05 1999-05-05 Multivalent antibody constructs

Publications (2)

Publication Number Publication Date
CA2331641A1 true CA2331641A1 (en) 1999-11-11
CA2331641C CA2331641C (en) 2011-06-28

Family

ID=7866613

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2331641A Expired - Lifetime CA2331641C (en) 1998-05-05 1999-05-05 Multivalent antibody constructs

Country Status (10)

Country Link
US (3) US7129330B1 (en)
EP (1) EP1078004B1 (en)
JP (1) JP4431277B2 (en)
AT (1) ATE377027T1 (en)
AU (1) AU4896099A (en)
CA (1) CA2331641C (en)
DE (2) DE19819846B4 (en)
DK (1) DK1078004T3 (en)
ES (1) ES2296395T3 (en)
WO (1) WO1999057150A2 (en)

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US7993642B2 (en) 2003-12-12 2011-08-09 Chugai Seiyaku Kabushiki Kaisha Anti-MPL antibodies
US8030461B2 (en) 2002-04-15 2011-10-04 Chugai Seiyaku Kabushiki Kaisha Methods for constructing scDb libraries
US8337841B2 (en) 2003-01-21 2012-12-25 Chugai Seiyaku Kabushiki Kaisha Methods of screening for antibody light chains
US8597911B2 (en) 2003-06-11 2013-12-03 Chugai Seiyaku Kabushiki Kaisha Process for producing antibodies
US8945543B2 (en) 2005-06-10 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
US9241994B2 (en) 2005-06-10 2016-01-26 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical compositions containing sc(Fv)2
US9334331B2 (en) 2010-11-17 2016-05-10 Chugai Seiyaku Kabushiki Kaisha Bispecific antibodies
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
US10011858B2 (en) 2005-03-31 2018-07-03 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
US11124576B2 (en) 2013-09-27 2021-09-21 Chungai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
US11649262B2 (en) 2015-12-28 2023-05-16 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of Fc region-containing polypeptide

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