CA2330104A1 - Creation de tissus tridimensionnels - Google Patents

Creation de tissus tridimensionnels Download PDF

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Publication number
CA2330104A1
CA2330104A1 CA002330104A CA2330104A CA2330104A1 CA 2330104 A1 CA2330104 A1 CA 2330104A1 CA 002330104 A CA002330104 A CA 002330104A CA 2330104 A CA2330104 A CA 2330104A CA 2330104 A1 CA2330104 A1 CA 2330104A1
Authority
CA
Canada
Prior art keywords
cells
vascularized
providing
constructs
dimensional tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002330104A
Other languages
English (en)
Inventor
Craig R. Halberstadt
Walter D. Holder, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Charlotte Mecklenburg Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charlotte Mecklenburg Hospital filed Critical Charlotte Mecklenburg Hospital
Publication of CA2330104A1 publication Critical patent/CA2330104A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé d'apport d'un tissu tridimensionnel vascularisé dans un sujet vivant. Le procédé consiste à) à créer à partir d'une matière biocompatible capable de support l'adhésion, la croissance et la migration cellulaires, une construction poreuse contenant des cellules à transplanter et b) à administrer la construction dans une zone d'intérêt dans le sujet vivant pour former un tissu tridimensionnel vascularisé. La construction préférentielle présente une dimension dont la distance de la surface la plus externe au centre de la construction mesure entre environ 50 µm et environ 500 µm. La construction préférentielle présente aussi une structure poreuse interconnectée dont la granulométrie des pores est de l'ordre d'environ 10 µm ne dépassant pas 300µm. Les cellules contenues dans la construction préférentielle ne dépassent pas une distance de 250 µm à partir de la surface externe de la construction.
CA002330104A 1998-04-09 1999-04-09 Creation de tissus tridimensionnels Abandoned CA2330104A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5861998A 1998-04-09 1998-04-09
US09/058,619 1998-04-09
PCT/US1999/007816 WO1999052356A1 (fr) 1998-04-09 1999-04-09 Creation de tissus tridimensionnels

Publications (1)

Publication Number Publication Date
CA2330104A1 true CA2330104A1 (fr) 1999-10-21

Family

ID=22017933

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002330104A Abandoned CA2330104A1 (fr) 1998-04-09 1999-04-09 Creation de tissus tridimensionnels

Country Status (5)

Country Link
EP (1) EP1069822A1 (fr)
JP (1) JP2002511284A (fr)
AU (1) AU3552099A (fr)
CA (1) CA2330104A1 (fr)
WO (1) WO1999052356A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1187909B1 (fr) 1999-04-30 2005-02-02 Massachusetts General Hospital Fabrication de tissus vascularises a trois dimensions a l'aide de moules bidimensionnels microfabriques
AU2004201641B2 (en) * 1999-04-30 2007-04-19 The Charles Stark Draper Laboratory, Inc. Fabrication of Vascularized Tissue Using Microfabricated Two-Dimensional Molds
DE19952847B4 (de) * 1999-10-01 2006-03-23 Minuth, Will, Prof. Dr. Vorrichtung zum Kultivieren und/oder Differenzieren und/oder Halten von Zellen und/oder Geweben
WO2001041809A1 (fr) * 1999-12-08 2001-06-14 Dmitry Vladimirovich Zybin Utilisation d'un gel polyacrilamide pour former une capsule dans un tissu d'un mammalien, procede de culture de cellules et procede de traitement des maladies oncologiques et du diabete sucre
US7265199B2 (en) 2000-04-11 2007-09-04 Celonova Biosciences Germany Gmbh Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
DE10100961B4 (de) 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
EP1230939B2 (fr) * 2001-02-13 2011-01-19 corLife GbR Matrice tissulaire bioartificielle vascularisée et tissu bioartificiel vascularisé
WO2002078439A2 (fr) * 2001-03-30 2002-10-10 The Arizona Board Of Regents On Behalf Of The University Of Arizona Constructions prevascularisees d'implantation destinees a fournir une perfusion sanguine
AU2002331669A1 (en) 2001-08-23 2003-03-10 The Wistar Institute Of Anatomy And Biology An organotypic intestinal culture and methods of use thereof
WO2003082366A1 (fr) * 2002-03-28 2003-10-09 Japan As Represented By President Of National Cardiovascular Center Materiau support d'ingenierie tissulaire, vaisseau artificiel, element de manchette et revetement destine a des implants
ATE439039T1 (de) 2003-01-16 2009-08-15 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
JP4837553B2 (ja) * 2003-02-11 2011-12-14 ノースウエスタン ユニバーシティ ナノ結晶表面被膜の方法及び材料ならびにその上へのペプチド両親媒性物質ナノ繊維の付着物
WO2004112860A1 (fr) * 2003-06-18 2004-12-29 Hokkaido Technology Licensing Office Co., Ltd. Materiau pour l'adhesion et la proliferation cellulaire
KR20060130580A (ko) * 2003-12-10 2006-12-19 셀룰라 바이오엔지니어링 인코포레이티드 연조직 형태 복원을 위한 조성물 및 방법
EP1713903A2 (fr) * 2004-02-09 2006-10-25 Indiana University Research and Technology Corporation Isolement, expansion et utilisation de progeniteurs clonogenes de cellules endotheliales
WO2005099784A1 (fr) * 2004-04-12 2005-10-27 Dai Nippon Printing Co., Ltd. Tissu artificiel et procédé servant à produire celui-ci
JP4303643B2 (ja) 2004-06-01 2009-07-29 育男 森田 人工組織体およびその製造方法
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
ATE534415T1 (de) 2005-12-13 2011-12-15 Harvard College Gerüste zur zelltransplantation
EP1976972B1 (fr) 2006-01-24 2014-03-12 Brown University Dispositif et procédé d'agrégation et d'encapsulation cellulaires
CN101541354B (zh) 2006-10-10 2012-11-21 西洛诺瓦生物科学公司 含聚磷氮烯的生物人工心瓣膜
US8658851B2 (en) 2006-10-20 2014-02-25 Keracure, Inc. Devices with cells cultured on flexible supports
EP2084264A1 (fr) 2007-03-09 2009-08-05 Corning Incorporated Matrices de gomme tridimensionnelles pour une culture cellulaire, procédés de fabrication et procédés d'utilisation
JP5024823B2 (ja) * 2007-05-30 2012-09-12 独立行政法人産業技術総合研究所 細胞運動性評価セルチップ
US20110076316A1 (en) * 2007-10-08 2011-03-31 Sureshan Sivananthan Scalable matrix for the in vivo cultivation of bone and cartilage
JP5177774B2 (ja) * 2008-12-12 2013-04-10 国立大学法人 東京大学 細胞の３次元階層的共培養法
US8501476B2 (en) 2009-10-07 2013-08-06 Brown University Assays and methods for fusing cell aggregates to form proto-tissues
US9468680B2 (en) 2011-09-22 2016-10-18 Brown University Differential effects of drugs on transport in a multi-layer 3D spheroid model
US9243278B2 (en) 2011-09-22 2016-01-26 Brown University Mechanotransduction by the synergistic action of heterotypic cell interactions
US9937249B2 (en) 2012-04-16 2018-04-10 President And Fellows Of Harvard College Mesoporous silica compositions for modulating immune responses
CN107073090A (zh) 2014-04-30 2017-08-18 哈佛学院董事会 结合的疫苗装置和杀死癌细胞的方法
WO2016123573A1 (fr) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Matériaux péritumoraux et intratumoraux pour traitement anticancéreux
JP6510656B2 (ja) 2015-09-11 2019-05-08 富士フイルム株式会社 ゼラチン構造体製造方法、及びゼラチン構造体製造システム
CN115531609A (zh) 2016-02-06 2022-12-30 哈佛学院校长同事会 重塑造血巢以重建免疫
MA45738A (fr) 2016-07-13 2019-05-22 Harvard College Échafaudages mimétiques de cellules présentant l'antigène et procédés pour les préparer et les utiliser

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering

Also Published As

Publication number Publication date
WO1999052356A1 (fr) 1999-10-21
AU3552099A (en) 1999-11-01
EP1069822A1 (fr) 2001-01-24
JP2002511284A (ja) 2002-04-16

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