CA2330104A1 - Creation de tissus tridimensionnels - Google Patents
Creation de tissus tridimensionnels Download PDFInfo
- Publication number
- CA2330104A1 CA2330104A1 CA002330104A CA2330104A CA2330104A1 CA 2330104 A1 CA2330104 A1 CA 2330104A1 CA 002330104 A CA002330104 A CA 002330104A CA 2330104 A CA2330104 A CA 2330104A CA 2330104 A1 CA2330104 A1 CA 2330104A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- vascularized
- providing
- constructs
- dimensional tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/74—Alginate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne un procédé d'apport d'un tissu tridimensionnel vascularisé dans un sujet vivant. Le procédé consiste à) à créer à partir d'une matière biocompatible capable de support l'adhésion, la croissance et la migration cellulaires, une construction poreuse contenant des cellules à transplanter et b) à administrer la construction dans une zone d'intérêt dans le sujet vivant pour former un tissu tridimensionnel vascularisé. La construction préférentielle présente une dimension dont la distance de la surface la plus externe au centre de la construction mesure entre environ 50 µm et environ 500 µm. La construction préférentielle présente aussi une structure poreuse interconnectée dont la granulométrie des pores est de l'ordre d'environ 10 µm ne dépassant pas 300µm. Les cellules contenues dans la construction préférentielle ne dépassent pas une distance de 250 µm à partir de la surface externe de la construction.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5861998A | 1998-04-09 | 1998-04-09 | |
US09/058,619 | 1998-04-09 | ||
PCT/US1999/007816 WO1999052356A1 (fr) | 1998-04-09 | 1999-04-09 | Creation de tissus tridimensionnels |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2330104A1 true CA2330104A1 (fr) | 1999-10-21 |
Family
ID=22017933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002330104A Abandoned CA2330104A1 (fr) | 1998-04-09 | 1999-04-09 | Creation de tissus tridimensionnels |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1069822A1 (fr) |
JP (1) | JP2002511284A (fr) |
AU (1) | AU3552099A (fr) |
CA (1) | CA2330104A1 (fr) |
WO (1) | WO1999052356A1 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1187909B1 (fr) | 1999-04-30 | 2005-02-02 | Massachusetts General Hospital | Fabrication de tissus vascularises a trois dimensions a l'aide de moules bidimensionnels microfabriques |
AU2004201641B2 (en) * | 1999-04-30 | 2007-04-19 | The Charles Stark Draper Laboratory, Inc. | Fabrication of Vascularized Tissue Using Microfabricated Two-Dimensional Molds |
DE19952847B4 (de) * | 1999-10-01 | 2006-03-23 | Minuth, Will, Prof. Dr. | Vorrichtung zum Kultivieren und/oder Differenzieren und/oder Halten von Zellen und/oder Geweben |
WO2001041809A1 (fr) * | 1999-12-08 | 2001-06-14 | Dmitry Vladimirovich Zybin | Utilisation d'un gel polyacrilamide pour former une capsule dans un tissu d'un mammalien, procede de culture de cellules et procede de traitement des maladies oncologiques et du diabete sucre |
US7265199B2 (en) | 2000-04-11 | 2007-09-04 | Celonova Biosciences Germany Gmbh | Poly-tri-fluoro-ethoxypolyphosphazene coverings and films |
US7776021B2 (en) | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
US9080146B2 (en) | 2001-01-11 | 2015-07-14 | Celonova Biosciences, Inc. | Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface |
DE10100961B4 (de) | 2001-01-11 | 2005-08-04 | Polyzenix Gmbh | Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten |
EP1230939B2 (fr) * | 2001-02-13 | 2011-01-19 | corLife GbR | Matrice tissulaire bioartificielle vascularisée et tissu bioartificiel vascularisé |
WO2002078439A2 (fr) * | 2001-03-30 | 2002-10-10 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Constructions prevascularisees d'implantation destinees a fournir une perfusion sanguine |
AU2002331669A1 (en) | 2001-08-23 | 2003-03-10 | The Wistar Institute Of Anatomy And Biology | An organotypic intestinal culture and methods of use thereof |
WO2003082366A1 (fr) * | 2002-03-28 | 2003-10-09 | Japan As Represented By President Of National Cardiovascular Center | Materiau support d'ingenierie tissulaire, vaisseau artificiel, element de manchette et revetement destine a des implants |
ATE439039T1 (de) | 2003-01-16 | 2009-08-15 | Gen Hospital Corp | Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen |
JP4837553B2 (ja) * | 2003-02-11 | 2011-12-14 | ノースウエスタン ユニバーシティ | ナノ結晶表面被膜の方法及び材料ならびにその上へのペプチド両親媒性物質ナノ繊維の付着物 |
WO2004112860A1 (fr) * | 2003-06-18 | 2004-12-29 | Hokkaido Technology Licensing Office Co., Ltd. | Materiau pour l'adhesion et la proliferation cellulaire |
KR20060130580A (ko) * | 2003-12-10 | 2006-12-19 | 셀룰라 바이오엔지니어링 인코포레이티드 | 연조직 형태 복원을 위한 조성물 및 방법 |
EP1713903A2 (fr) * | 2004-02-09 | 2006-10-25 | Indiana University Research and Technology Corporation | Isolement, expansion et utilisation de progeniteurs clonogenes de cellules endotheliales |
WO2005099784A1 (fr) * | 2004-04-12 | 2005-10-27 | Dai Nippon Printing Co., Ltd. | Tissu artificiel et procédé servant à produire celui-ci |
JP4303643B2 (ja) | 2004-06-01 | 2009-07-29 | 育男 森田 | 人工組織体およびその製造方法 |
US20210299056A9 (en) | 2004-10-25 | 2021-09-30 | Varian Medical Systems, Inc. | Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods |
US9114162B2 (en) | 2004-10-25 | 2015-08-25 | Celonova Biosciences, Inc. | Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same |
US9107850B2 (en) | 2004-10-25 | 2015-08-18 | Celonova Biosciences, Inc. | Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
ATE534415T1 (de) | 2005-12-13 | 2011-12-15 | Harvard College | Gerüste zur zelltransplantation |
EP1976972B1 (fr) | 2006-01-24 | 2014-03-12 | Brown University | Dispositif et procédé d'agrégation et d'encapsulation cellulaires |
CN101541354B (zh) | 2006-10-10 | 2012-11-21 | 西洛诺瓦生物科学公司 | 含聚磷氮烯的生物人工心瓣膜 |
US8658851B2 (en) | 2006-10-20 | 2014-02-25 | Keracure, Inc. | Devices with cells cultured on flexible supports |
EP2084264A1 (fr) | 2007-03-09 | 2009-08-05 | Corning Incorporated | Matrices de gomme tridimensionnelles pour une culture cellulaire, procédés de fabrication et procédés d'utilisation |
JP5024823B2 (ja) * | 2007-05-30 | 2012-09-12 | 独立行政法人産業技術総合研究所 | 細胞運動性評価セルチップ |
US20110076316A1 (en) * | 2007-10-08 | 2011-03-31 | Sureshan Sivananthan | Scalable matrix for the in vivo cultivation of bone and cartilage |
JP5177774B2 (ja) * | 2008-12-12 | 2013-04-10 | 国立大学法人 東京大学 | 細胞の3次元階層的共培養法 |
US8501476B2 (en) | 2009-10-07 | 2013-08-06 | Brown University | Assays and methods for fusing cell aggregates to form proto-tissues |
US9468680B2 (en) | 2011-09-22 | 2016-10-18 | Brown University | Differential effects of drugs on transport in a multi-layer 3D spheroid model |
US9243278B2 (en) | 2011-09-22 | 2016-01-26 | Brown University | Mechanotransduction by the synergistic action of heterotypic cell interactions |
US9937249B2 (en) | 2012-04-16 | 2018-04-10 | President And Fellows Of Harvard College | Mesoporous silica compositions for modulating immune responses |
CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
WO2016123573A1 (fr) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Matériaux péritumoraux et intratumoraux pour traitement anticancéreux |
JP6510656B2 (ja) | 2015-09-11 | 2019-05-08 | 富士フイルム株式会社 | ゼラチン構造体製造方法、及びゼラチン構造体製造システム |
CN115531609A (zh) | 2016-02-06 | 2022-12-30 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
MA45738A (fr) | 2016-07-13 | 2019-05-22 | Harvard College | Échafaudages mimétiques de cellules présentant l'antigène et procédés pour les préparer et les utiliser |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5716404A (en) * | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
-
1999
- 1999-04-09 CA CA002330104A patent/CA2330104A1/fr not_active Abandoned
- 1999-04-09 EP EP99917384A patent/EP1069822A1/fr not_active Withdrawn
- 1999-04-09 AU AU35520/99A patent/AU3552099A/en not_active Abandoned
- 1999-04-09 JP JP2000542979A patent/JP2002511284A/ja active Pending
- 1999-04-09 WO PCT/US1999/007816 patent/WO1999052356A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999052356A1 (fr) | 1999-10-21 |
AU3552099A (en) | 1999-11-01 |
EP1069822A1 (fr) | 2001-01-24 |
JP2002511284A (ja) | 2002-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |