CA2321171A1 - Conjugues convenant au traitement du cancer de la prostate - Google Patents

Conjugues convenant au traitement du cancer de la prostate Download PDF

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Publication number
CA2321171A1
CA2321171A1 CA002321171A CA2321171A CA2321171A1 CA 2321171 A1 CA2321171 A1 CA 2321171A1 CA 002321171 A CA002321171 A CA 002321171A CA 2321171 A CA2321171 A CA 2321171A CA 2321171 A1 CA2321171 A1 CA 2321171A1
Authority
CA
Canada
Prior art keywords
seq
ser
vin
hcap
dac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002321171A
Other languages
English (en)
Inventor
Dong-Mei Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815855.3A external-priority patent/GB9815855D0/en
Application filed by Individual filed Critical Individual
Publication of CA2321171A1 publication Critical patent/CA2321171A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des conjugués qui comprennent des oligopeptides portant des séquences d'acides aminés subissant sélectivement un clivage protéolytique sous l'effet d'un antigène libre spécifique de la prostate et d'agents cytotoxiques connus. Les conjugués de l'invention se caractérisent par une liaison hydroxylalkylamino entre l'oligopeptide et la vinblastine. De tels conjugués contiennent au traitement du cancer de la prostate et de l'hypertrophie prostatique bénigne. L'invention concerne également des agents cytotoxiques dérivés des alcaloïdes de la pervenche.
CA002321171A 1998-03-05 1999-03-04 Conjugues convenant au traitement du cancer de la prostate Abandoned CA2321171A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7686098P 1998-03-05 1998-03-05
US60/076,860 1998-03-05
GBGB9815855.3A GB9815855D0 (en) 1998-07-21 1998-07-21 Conjugates useful in the treatment of prostate cancer
GB9815855.3 1998-07-21
PCT/US1999/004882 WO1999044628A1 (fr) 1998-03-05 1999-03-04 Conjugues convenant au traitement du cancer de la prostate

Publications (1)

Publication Number Publication Date
CA2321171A1 true CA2321171A1 (fr) 1999-09-10

Family

ID=26314083

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002321171A Abandoned CA2321171A1 (fr) 1998-03-05 1999-03-04 Conjugues convenant au traitement du cancer de la prostate

Country Status (5)

Country Link
EP (1) EP1069906A1 (fr)
JP (1) JP2002505298A (fr)
AU (1) AU749063B2 (fr)
CA (1) CA2321171A1 (fr)
WO (1) WO1999044628A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924759D0 (en) * 1999-10-19 1999-12-22 Merck Sharp & Dohme Process for preparing peptide intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides

Also Published As

Publication number Publication date
AU749063B2 (en) 2002-06-20
WO1999044628A8 (fr) 1999-10-14
AU2985899A (en) 1999-09-20
EP1069906A1 (fr) 2001-01-24
WO1999044628A1 (fr) 1999-09-10
JP2002505298A (ja) 2002-02-19

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Legal Events

Date Code Title Description
FZDE Dead