CA2319652A1 - Sels de paroxetine - Google Patents
Sels de paroxetine Download PDFInfo
- Publication number
- CA2319652A1 CA2319652A1 CA002319652A CA2319652A CA2319652A1 CA 2319652 A1 CA2319652 A1 CA 2319652A1 CA 002319652 A CA002319652 A CA 002319652A CA 2319652 A CA2319652 A CA 2319652A CA 2319652 A1 CA2319652 A1 CA 2319652A1
- Authority
- CA
- Canada
- Prior art keywords
- paroxetine
- salt
- acid
- solution
- toluene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des sels de paroxétine avec un acide sélectionné dans le groupe constitué d'acides sulfurique, tartrique, oxalique, fumarique, propionique, formique, glutamique, succinique, benzoïque, nitrique, phosphorique, 4-méthylbenzène sulfonique, hypophosphoreux, lactique et mandélique ainsi que de glycine. Ce sel peut servir au traitement et à la prévention de certains troubles du système nerveux central.
Applications Claiming Priority (67)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9802654.5 | 1998-02-06 | ||
GB9802656.0 | 1998-02-06 | ||
GBGB9802698.2A GB9802698D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802646.1 | 1998-02-06 | ||
GBGB9802658.6A GB9802658D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802640.4 | 1998-02-06 | ||
GB9802698.2 | 1998-02-06 | ||
GB9802658.6 | 1998-02-06 | ||
GBGB9802656.0A GB9802656D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802646.1A GB9802646D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802659.4A GB9802659D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802664.4 | 1998-02-06 | ||
GBGB9802654.5A GB9802654D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802645.3 | 1998-02-06 | ||
GBGB9802655.2A GB9802655D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802657.8A GB9802657D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802638.8A GB9802638D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802665.1A GB9802665D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802638.8 | 1998-02-06 | ||
GB9802657.8 | 1998-02-06 | ||
GBGB9802639.6A GB9802639D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802659.4 | 1998-02-06 | ||
GBGB9802645.3A GB9802645D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802640.4A GB9802640D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802664.4A GB9802664D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GBGB9802661.0A GB9802661D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802661.0 | 1998-02-06 | ||
GBGB9802644.6A GB9802644D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802653.7 | 1998-02-06 | ||
GBGB9802653.7A GB9802653D0 (en) | 1998-02-06 | 1998-02-06 | Novel compounds |
GB9802644.6 | 1998-02-06 | ||
GB9802655.2 | 1998-02-06 | ||
GB9802665.1 | 1998-02-06 | ||
GB9802639.6 | 1998-02-06 | ||
GBGB9817317.2A GB9817317D0 (en) | 1998-08-08 | 1998-08-08 | Novel compounds |
GB9817309.9 | 1998-08-08 | ||
GB9817321.4 | 1998-08-08 | ||
GBGB9817340.4A GB9817340D0 (en) | 1998-08-08 | 1998-08-08 | Novel compounds |
GBGB9817360.2A GB9817360D0 (en) | 1998-08-08 | 1998-08-08 | Novel compounds |
GBGB9817307.3A GB9817307D0 (en) | 1998-08-08 | 1998-08-08 | Novel compound |
GB9817360.2 | 1998-08-08 | ||
GB9817359.4 | 1998-08-08 | ||
GBGB9817359.4A GB9817359D0 (en) | 1998-08-08 | 1998-08-08 | Novel compounds |
GB9817344.6 | 1998-08-08 | ||
GBGB9817321.4A GB9817321D0 (en) | 1998-08-08 | 1998-08-08 | Novel compound |
GBGB9817364.4A GB9817364D0 (en) | 1998-08-08 | 1998-08-08 | Novel compounds |
GB9817364.4 | 1998-08-08 | ||
GBGB9817344.6A GB9817344D0 (en) | 1998-08-08 | 1998-08-08 | Novel compounds |
GB9817317.2 | 1998-08-08 | ||
GB9817307.3 | 1998-08-08 | ||
GB9817340.4 | 1998-08-08 | ||
GBGB9817309.9A GB9817309D0 (en) | 1998-08-08 | 1998-08-08 | Novel compounds |
GB9817320.6 | 1998-08-10 | ||
GB9817322.2 | 1998-08-10 | ||
GBGB9817322.2A GB9817322D0 (en) | 1998-08-10 | 1998-08-10 | Novel compounds |
GBGB9817320.6A GB9817320D0 (en) | 1998-08-10 | 1998-08-10 | Novel compounds |
GBGB9826173.8A GB9826173D0 (en) | 1998-11-30 | 1998-11-30 | Novel compounds |
GBGB9826172.0A GB9826172D0 (en) | 1998-11-30 | 1998-11-30 | Novel compound |
GB9826173.8 | 1998-11-30 | ||
GB9826172.0 | 1998-11-30 | ||
GBGB9827277.6A GB9827277D0 (en) | 1998-12-11 | 1998-12-11 | Novel compound |
GB9827341.0 | 1998-12-11 | ||
GB9827277.6 | 1998-12-11 | ||
GBGB9827341.0A GB9827341D0 (en) | 1998-12-11 | 1998-12-11 | Novel compounds |
GB9828775.8 | 1998-12-29 | ||
GBGB9828775.8A GB9828775D0 (en) | 1998-12-29 | 1998-12-29 | Novel compounds |
PCT/GB1999/000380 WO1999040084A1 (fr) | 1998-02-06 | 1999-02-05 | Sels de paroxetine |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2319652A1 true CA2319652A1 (fr) | 1999-08-12 |
Family
ID=27586915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002319652A Abandoned CA2319652A1 (fr) | 1998-02-06 | 1999-02-05 | Sels de paroxetine |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1053234A1 (fr) |
JP (1) | JP2002505254A (fr) |
KR (1) | KR20010040711A (fr) |
BG (1) | BG104737A (fr) |
CA (1) | CA2319652A1 (fr) |
EA (1) | EA200000815A1 (fr) |
IL (1) | IL137684A0 (fr) |
NO (1) | NO20003960L (fr) |
PL (1) | PL342295A1 (fr) |
SK (1) | SK11812000A3 (fr) |
WO (1) | WO1999040084A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
GB9814316D0 (en) * | 1998-07-02 | 1998-09-02 | Smithkline Beecham Plc | Novel compounds |
EP1102764A1 (fr) * | 1998-08-08 | 2001-05-30 | Smithkline Beecham Plc | Sels de paroxetine |
GB9827431D0 (en) * | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel compound |
WO2000078290A2 (fr) * | 1999-06-22 | 2000-12-28 | Smithkline Beecham P.L.C. | Nouvelle preparation |
HU226912B1 (en) * | 2000-04-07 | 2010-03-01 | Richter Gedeon Nyrt | New paroxetin salt and medicament containing it |
EA200300770A1 (ru) * | 2001-01-05 | 2003-10-30 | Эли Лилли Энд Компани | Антагонисты рецепторов возбуждающей аминокислоты |
US20040225128A1 (en) * | 2001-08-02 | 2004-11-11 | Callewaert George Leo | Paroxetine isethionate salt, process of preparation and use in the treatment of depression |
KR100672184B1 (ko) | 2004-09-21 | 2007-01-19 | 주식회사종근당 | 파록세틴의 콜린산 또는 콜린산 유도체 염 |
CN108218844B (zh) * | 2018-03-08 | 2021-01-19 | 合肥科大生物技术有限公司 | 一种美金刚帕罗西汀共晶盐及其制备方法、药物组合物、应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8430581D0 (en) * | 1984-12-04 | 1985-01-09 | Ferrosan As | Treatment |
ES2058061T3 (es) * | 1985-10-25 | 1994-11-01 | Beecham Group Plc | Derivado de piperidina, su preparacion y su uso como medicamento. |
CA2206592A1 (fr) * | 1996-05-30 | 1997-11-30 | Shu-Zhong Wang | Methode de preparation de chlorhydrate de paroxetine amorphe |
HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
-
1999
- 1999-02-05 WO PCT/GB1999/000380 patent/WO1999040084A1/fr not_active Application Discontinuation
- 1999-02-05 EP EP99904971A patent/EP1053234A1/fr not_active Withdrawn
- 1999-02-05 CA CA002319652A patent/CA2319652A1/fr not_active Abandoned
- 1999-02-05 KR KR1020007008591A patent/KR20010040711A/ko not_active Application Discontinuation
- 1999-02-05 JP JP2000530513A patent/JP2002505254A/ja active Pending
- 1999-02-05 PL PL99342295A patent/PL342295A1/xx not_active Application Discontinuation
- 1999-02-05 EA EA200000815A patent/EA200000815A1/ru unknown
- 1999-02-05 SK SK1181-2000A patent/SK11812000A3/sk unknown
- 1999-02-05 IL IL13768499A patent/IL137684A0/xx unknown
-
2000
- 2000-08-04 NO NO20003960A patent/NO20003960L/no not_active Application Discontinuation
- 2000-08-30 BG BG104737A patent/BG104737A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PL342295A1 (en) | 2001-06-04 |
BG104737A (en) | 2001-07-31 |
SK11812000A3 (sk) | 2001-08-06 |
WO1999040084A1 (fr) | 1999-08-12 |
EA200000815A1 (ru) | 2001-02-26 |
EP1053234A1 (fr) | 2000-11-22 |
JP2002505254A (ja) | 2002-02-19 |
NO20003960D0 (no) | 2000-08-04 |
KR20010040711A (ko) | 2001-05-15 |
IL137684A0 (en) | 2001-10-31 |
NO20003960L (no) | 2000-09-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |