CA2319652A1 - Sels de paroxetine - Google Patents

Sels de paroxetine Download PDF

Info

Publication number
CA2319652A1
CA2319652A1 CA002319652A CA2319652A CA2319652A1 CA 2319652 A1 CA2319652 A1 CA 2319652A1 CA 002319652 A CA002319652 A CA 002319652A CA 2319652 A CA2319652 A CA 2319652A CA 2319652 A1 CA2319652 A1 CA 2319652A1
Authority
CA
Canada
Prior art keywords
paroxetine
salt
acid
solution
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002319652A
Other languages
English (en)
Inventor
Michael Urquhart
David Crowe
Deirdre O'keeffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802653.7A external-priority patent/GB9802653D0/en
Priority claimed from GBGB9802658.6A external-priority patent/GB9802658D0/en
Priority claimed from GBGB9802661.0A external-priority patent/GB9802661D0/en
Priority claimed from GBGB9802644.6A external-priority patent/GB9802644D0/en
Priority claimed from GBGB9802656.0A external-priority patent/GB9802656D0/en
Priority claimed from GBGB9802646.1A external-priority patent/GB9802646D0/en
Priority claimed from GBGB9802659.4A external-priority patent/GB9802659D0/en
Priority claimed from GBGB9802654.5A external-priority patent/GB9802654D0/en
Priority claimed from GBGB9802655.2A external-priority patent/GB9802655D0/en
Priority claimed from GBGB9802657.8A external-priority patent/GB9802657D0/en
Priority claimed from GBGB9802638.8A external-priority patent/GB9802638D0/en
Priority claimed from GBGB9802665.1A external-priority patent/GB9802665D0/en
Priority claimed from GBGB9802639.6A external-priority patent/GB9802639D0/en
Priority claimed from GBGB9802645.3A external-priority patent/GB9802645D0/en
Priority claimed from GBGB9802640.4A external-priority patent/GB9802640D0/en
Priority claimed from GBGB9802664.4A external-priority patent/GB9802664D0/en
Priority claimed from GBGB9802698.2A external-priority patent/GB9802698D0/en
Priority claimed from GBGB9817359.4A external-priority patent/GB9817359D0/en
Priority claimed from GBGB9817321.4A external-priority patent/GB9817321D0/en
Priority claimed from GBGB9817317.2A external-priority patent/GB9817317D0/en
Priority claimed from GBGB9817340.4A external-priority patent/GB9817340D0/en
Priority claimed from GBGB9817360.2A external-priority patent/GB9817360D0/en
Priority claimed from GBGB9817307.3A external-priority patent/GB9817307D0/en
Priority claimed from GBGB9817344.6A external-priority patent/GB9817344D0/en
Priority claimed from GBGB9817364.4A external-priority patent/GB9817364D0/en
Priority claimed from GBGB9817309.9A external-priority patent/GB9817309D0/en
Priority claimed from GBGB9817320.6A external-priority patent/GB9817320D0/en
Priority claimed from GBGB9817322.2A external-priority patent/GB9817322D0/en
Priority claimed from GBGB9826173.8A external-priority patent/GB9826173D0/en
Priority claimed from GBGB9826172.0A external-priority patent/GB9826172D0/en
Priority claimed from GBGB9827341.0A external-priority patent/GB9827341D0/en
Priority claimed from GBGB9827277.6A external-priority patent/GB9827277D0/en
Priority claimed from GBGB9828775.8A external-priority patent/GB9828775D0/en
Application filed by Individual filed Critical Individual
Publication of CA2319652A1 publication Critical patent/CA2319652A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des sels de paroxétine avec un acide sélectionné dans le groupe constitué d'acides sulfurique, tartrique, oxalique, fumarique, propionique, formique, glutamique, succinique, benzoïque, nitrique, phosphorique, 4-méthylbenzène sulfonique, hypophosphoreux, lactique et mandélique ainsi que de glycine. Ce sel peut servir au traitement et à la prévention de certains troubles du système nerveux central.
CA002319652A 1998-02-06 1999-02-05 Sels de paroxetine Abandoned CA2319652A1 (fr)

Applications Claiming Priority (67)

Application Number Priority Date Filing Date Title
GB9802654.5 1998-02-06
GB9802656.0 1998-02-06
GBGB9802698.2A GB9802698D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802646.1 1998-02-06
GBGB9802658.6A GB9802658D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802640.4 1998-02-06
GB9802698.2 1998-02-06
GB9802658.6 1998-02-06
GBGB9802656.0A GB9802656D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802646.1A GB9802646D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802659.4A GB9802659D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802664.4 1998-02-06
GBGB9802654.5A GB9802654D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802645.3 1998-02-06
GBGB9802655.2A GB9802655D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802657.8A GB9802657D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802638.8A GB9802638D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802665.1A GB9802665D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802638.8 1998-02-06
GB9802657.8 1998-02-06
GBGB9802639.6A GB9802639D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802659.4 1998-02-06
GBGB9802645.3A GB9802645D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802640.4A GB9802640D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802664.4A GB9802664D0 (en) 1998-02-06 1998-02-06 Novel compounds
GBGB9802661.0A GB9802661D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802661.0 1998-02-06
GBGB9802644.6A GB9802644D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802653.7 1998-02-06
GBGB9802653.7A GB9802653D0 (en) 1998-02-06 1998-02-06 Novel compounds
GB9802644.6 1998-02-06
GB9802655.2 1998-02-06
GB9802665.1 1998-02-06
GB9802639.6 1998-02-06
GBGB9817317.2A GB9817317D0 (en) 1998-08-08 1998-08-08 Novel compounds
GB9817309.9 1998-08-08
GB9817321.4 1998-08-08
GBGB9817340.4A GB9817340D0 (en) 1998-08-08 1998-08-08 Novel compounds
GBGB9817360.2A GB9817360D0 (en) 1998-08-08 1998-08-08 Novel compounds
GBGB9817307.3A GB9817307D0 (en) 1998-08-08 1998-08-08 Novel compound
GB9817360.2 1998-08-08
GB9817359.4 1998-08-08
GBGB9817359.4A GB9817359D0 (en) 1998-08-08 1998-08-08 Novel compounds
GB9817344.6 1998-08-08
GBGB9817321.4A GB9817321D0 (en) 1998-08-08 1998-08-08 Novel compound
GBGB9817364.4A GB9817364D0 (en) 1998-08-08 1998-08-08 Novel compounds
GB9817364.4 1998-08-08
GBGB9817344.6A GB9817344D0 (en) 1998-08-08 1998-08-08 Novel compounds
GB9817317.2 1998-08-08
GB9817307.3 1998-08-08
GB9817340.4 1998-08-08
GBGB9817309.9A GB9817309D0 (en) 1998-08-08 1998-08-08 Novel compounds
GB9817320.6 1998-08-10
GB9817322.2 1998-08-10
GBGB9817322.2A GB9817322D0 (en) 1998-08-10 1998-08-10 Novel compounds
GBGB9817320.6A GB9817320D0 (en) 1998-08-10 1998-08-10 Novel compounds
GBGB9826173.8A GB9826173D0 (en) 1998-11-30 1998-11-30 Novel compounds
GBGB9826172.0A GB9826172D0 (en) 1998-11-30 1998-11-30 Novel compound
GB9826173.8 1998-11-30
GB9826172.0 1998-11-30
GBGB9827277.6A GB9827277D0 (en) 1998-12-11 1998-12-11 Novel compound
GB9827341.0 1998-12-11
GB9827277.6 1998-12-11
GBGB9827341.0A GB9827341D0 (en) 1998-12-11 1998-12-11 Novel compounds
GB9828775.8 1998-12-29
GBGB9828775.8A GB9828775D0 (en) 1998-12-29 1998-12-29 Novel compounds
PCT/GB1999/000380 WO1999040084A1 (fr) 1998-02-06 1999-02-05 Sels de paroxetine

Publications (1)

Publication Number Publication Date
CA2319652A1 true CA2319652A1 (fr) 1999-08-12

Family

ID=27586915

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002319652A Abandoned CA2319652A1 (fr) 1998-02-06 1999-02-05 Sels de paroxetine

Country Status (11)

Country Link
EP (1) EP1053234A1 (fr)
JP (1) JP2002505254A (fr)
KR (1) KR20010040711A (fr)
BG (1) BG104737A (fr)
CA (1) CA2319652A1 (fr)
EA (1) EA200000815A1 (fr)
IL (1) IL137684A0 (fr)
NO (1) NO20003960L (fr)
PL (1) PL342295A1 (fr)
SK (1) SK11812000A3 (fr)
WO (1) WO1999040084A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
GB9814316D0 (en) * 1998-07-02 1998-09-02 Smithkline Beecham Plc Novel compounds
EP1102764A1 (fr) * 1998-08-08 2001-05-30 Smithkline Beecham Plc Sels de paroxetine
GB9827431D0 (en) * 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
WO2000078290A2 (fr) * 1999-06-22 2000-12-28 Smithkline Beecham P.L.C. Nouvelle preparation
HU226912B1 (en) * 2000-04-07 2010-03-01 Richter Gedeon Nyrt New paroxetin salt and medicament containing it
EA200300770A1 (ru) * 2001-01-05 2003-10-30 Эли Лилли Энд Компани Антагонисты рецепторов возбуждающей аминокислоты
US20040225128A1 (en) * 2001-08-02 2004-11-11 Callewaert George Leo Paroxetine isethionate salt, process of preparation and use in the treatment of depression
KR100672184B1 (ko) 2004-09-21 2007-01-19 주식회사종근당 파록세틴의 콜린산 또는 콜린산 유도체 염
CN108218844B (zh) * 2018-03-08 2021-01-19 合肥科大生物技术有限公司 一种美金刚帕罗西汀共晶盐及其制备方法、药物组合物、应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
CA2206592A1 (fr) * 1996-05-30 1997-11-30 Shu-Zhong Wang Methode de preparation de chlorhydrate de paroxetine amorphe
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására

Also Published As

Publication number Publication date
PL342295A1 (en) 2001-06-04
BG104737A (en) 2001-07-31
SK11812000A3 (sk) 2001-08-06
WO1999040084A1 (fr) 1999-08-12
EA200000815A1 (ru) 2001-02-26
EP1053234A1 (fr) 2000-11-22
JP2002505254A (ja) 2002-02-19
NO20003960D0 (no) 2000-08-04
KR20010040711A (ko) 2001-05-15
IL137684A0 (en) 2001-10-31
NO20003960L (no) 2000-09-25

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Legal Events

Date Code Title Description
FZDE Discontinued