CA2308029A1 - Reactifs et procedes utiles pour deceler les pathologies mammaires - Google Patents

Reactifs et procedes utiles pour deceler les pathologies mammaires Download PDF

Info

Publication number
CA2308029A1
CA2308029A1 CA002308029A CA2308029A CA2308029A1 CA 2308029 A1 CA2308029 A1 CA 2308029A1 CA 002308029 A CA002308029 A CA 002308029A CA 2308029 A CA2308029 A CA 2308029A CA 2308029 A1 CA2308029 A1 CA 2308029A1
Authority
CA
Canada
Prior art keywords
sequence
polypeptide
polynucleotide
fragments
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002308029A
Other languages
English (en)
Inventor
Patricia A. Billing-Medel
Maurice Cohen
Tracey L. Colpitts
Paula N. Friedman
Julian Gordon
Edward N. Granados
Steven C. Hodges
Michael R. Klass
Jon D. Kratochvil
Lisa Roberts-Rapp
John C. Russell
Stephen D. Stroupe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2308029A1 publication Critical patent/CA2308029A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne un ensemble de séquences d'ARN partiellement superposées et adjacentes et des polypeptides codés par celles-ci, appelés BS106 et transcrits à partir d'un tissu mammaire. Ces séquences sont utiles pour déceler, diagnostiquer, niveler, surveiller, pronostiquer, prévenir ou traiter, ou déterminer la prédisposition d'un individu à souffrir de pathologies et maladies mammaires, telles que le cancer du sein. Font aussi l'objet de cette invention des anticorps qui se lient spécifiquement au polypeptide ou à la protéine codé(e) par BS106 et des agonistes ou inhibiteurs qui préviennent l'action du polypeptide du tissu spécifique de BS106, dont les molécules sont utiles pour le traitement de maladies, de tumeurs ou de métastases mammaires.
CA002308029A 1997-10-31 1998-10-19 Reactifs et procedes utiles pour deceler les pathologies mammaires Abandoned CA2308029A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96209497A 1997-10-31 1997-10-31
US08/962,094 1997-10-31
PCT/US1998/022020 WO1999023230A1 (fr) 1997-10-31 1998-10-19 Reactifs et procedes utiles pour deceler les pathologies mammaires

Publications (1)

Publication Number Publication Date
CA2308029A1 true CA2308029A1 (fr) 1999-05-14

Family

ID=25505413

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002308029A Abandoned CA2308029A1 (fr) 1997-10-31 1998-10-19 Reactifs et procedes utiles pour deceler les pathologies mammaires

Country Status (4)

Country Link
EP (1) EP1027444A1 (fr)
JP (1) JP2001521744A (fr)
CA (1) CA2308029A1 (fr)
WO (1) WO1999023230A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US6365348B1 (en) 1997-12-24 2002-04-02 Corixa Corporation Compounds for diagnosis of Breast cancer and methods for their use
US6762020B1 (en) 1999-03-15 2004-07-13 Protein Design Labs, Inc. Methods of diagnosing breast cancer
US20040141983A1 (en) 1999-03-15 2004-07-22 Protein Design Labs, Inc. Compositions against cancer antigen LIV-1 and uses thereof
US6316272B1 (en) 1999-03-15 2001-11-13 Eos Biotechnology, Inc. Methods of diagnosis of colorectal cancer and methods of screening for colorectal cancer modulators
CA2368152A1 (fr) * 1999-03-15 2000-09-21 Eos Biotechnology, Inc. Nouvelles techniques permettant de traiter et de diagnostiquer le cancer du sein, compositions et techniques de criblage pour modulateurs de cancer du sein
US6649342B1 (en) 1999-03-15 2003-11-18 Eos Biotechnology, Inc. Methods of diagnosing breast cancer, compositions, and methods of screening for breast cancer modulators
AU1777201A (en) * 1999-11-16 2001-05-30 Eos Biotechnology, Inc. Novel methods of diagnosing and determining prognosis of breast cancer, compositions, and methods of screening for breast cancer modulators
US6780586B1 (en) 1999-11-29 2004-08-24 Protein Design Labs, Inc. Methods of diagnosing breast cancer
JP2004503208A (ja) * 2000-02-29 2004-02-05 アボット・ラボラトリーズ ***の疾患の検出に有用な試薬および方法
WO2004067564A2 (fr) 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions contre l'antgene cancereux liv-1 et leurs utilisations
EP3925533B1 (fr) 2009-04-30 2024-04-10 DexCom, Inc. Rapports de performances associés à des données de détecteur continues à partir de périodes multiples de temps d'analyse
HUE031726T2 (en) 2010-12-06 2017-07-28 Seattle Genetics Inc Humanized antibodies and anti-cancer antibodies against LIV-1 antibodies
US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby
MA45324A (fr) 2016-03-15 2019-01-23 Seattle Genetics Inc Polythérapie utilisant un adc-liv1 et un agent chimiothérapeutique
US10054485B2 (en) 2016-03-17 2018-08-21 Raytheon Company UV LED-phosphor based hyperspectral calibrator

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018945A1 (fr) * 1996-10-31 1998-05-07 Abbott Laboratories Reactifs et procedes pour le depistage de pathologies mammaires
JP2001522239A (ja) * 1997-03-21 2001-11-13 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド ８７個のヒト分泌タンパク質

Also Published As

Publication number Publication date
WO1999023230A1 (fr) 1999-05-14
JP2001521744A (ja) 2001-11-13
EP1027444A1 (fr) 2000-08-16

Similar Documents

Publication Publication Date Title
EP0939824B1 (fr) Reactifs et procedes pour le depistage de pathologies mammaires
CA2267128A1 (fr) Reactifs et procedes utiles pour detecter des maladies de la prostate
CA2308029A1 (fr) Reactifs et procedes utiles pour deceler les pathologies mammaires
CA2309758A1 (fr) Reactifs et procedes utiles pour detecter des maladies de la poitrine
CA2284686A1 (fr) Reactifs utilises aux fins de la detection de troubles du tractus digestif et methodes afferentes
CA2232237C (fr) Reactifs et procedes utiles a la detection de maladies du sein
WO1999002714A1 (fr) Reactifs et procedes utilises pour detecter les maladies du sein
US20050106614A1 (en) Reagents and methods useful for detecting diseases of the prostate
CA2285039A1 (fr) Reactifs et procedes utilises dans la detection de maladies du tractus gastro-intestinal
US6183952B1 (en) Reagents and methods useful for detecting diseases of the breast
US7122653B2 (en) Reagents and methods useful for detecting diseases of the prostate
US7479537B2 (en) Reagents and methods useful for detecting diseases of the breast
CA2292843A1 (fr) Reactifs et methodes utiles pour detecter des pathologies mammaires
CA2292788A1 (fr) Reactifs et procedes utiles dans la detection de maladies pulmonaires
US20030165906A1 (en) Reagents and methods useful for detecting diseases of the prostate
CA2293661A1 (fr) Reactifs et procedes destines a detecter des pathologies mammaires
EP0856010A1 (fr) Mammoglobines, anticorps contre celles-ci et leur utilisation pour la detection des maladies du sein
CA2279551A1 (fr) Reactifs et procedes utiles pour detecter des maladies du poumon
CA2309756A1 (fr) Reactifs et procedes utiles pour detecter les pathologies mammaires
US20050037379A1 (en) Reagents and methods useful for detecting diseases of the prostate
WO1999022027A1 (fr) Reactifs et procedes utiles pour detecter des maladies du sein
US20030165971A1 (en) Reagents and methods useful for detecting diseases of the breast
US20020042049A1 (en) Reagents and methods useful for detecting diseases of the breast
CA2303404A1 (fr) Reactifs et methodes servant a detecter les maladies de la prostate
US20020188115A1 (en) Reagents and methods useful for detecting diseases of the breast

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead