CA2295375A1 - Fragments de liaison antigeniques designes par 4b5, qui detectent specifiquement les cellules cancereuses, nucleotides codant lesdits fragments et leur utilisation pour la prophylaxie et la detection des cancers - Google Patents

Fragments de liaison antigeniques designes par 4b5, qui detectent specifiquement les cellules cancereuses, nucleotides codant lesdits fragments et leur utilisation pour la prophylaxie et la detection des cancers Download PDF

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Publication number
CA2295375A1
CA2295375A1 CA002295375A CA2295375A CA2295375A1 CA 2295375 A1 CA2295375 A1 CA 2295375A1 CA 002295375 A CA002295375 A CA 002295375A CA 2295375 A CA2295375 A CA 2295375A CA 2295375 A1 CA2295375 A1 CA 2295375A1
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CA
Canada
Prior art keywords
polynucleotide
antibody
cells
polypeptide
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002295375A
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English (en)
Inventor
Michael D. Dan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viventia Bio Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2295375A1 publication Critical patent/CA2295375A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Anticorps monoclonal 4B5 et fragments de liaison antigéniques qui se lient spécifiquement aux anticorps spécifiques de GD2. Des dérivés de polynucléotides et de polypeptides basés sur 4B5, dont des molécules à région variable de chaîne unique et des protéines de fusion, ainsi que des compositions pharmaceutiques sont également décrites. Lorsqu'il est administré à un sujet, l'anticorps 4B5 est efficace pour le diagnostic et/ou le traitement de néoplasies. La présente invention concerne encore des méthodes de traitement d'une maladie néoplasique, en particulier le mélanome, le neuroblastome, le gliome, le sarcome des tissus mous et le cancer du poumon. Les patients qui sont en rémission résultant d'une thérapie classique contre le cancer peuvent être traités à l'aide d'une composition selon la présente invention dans l'espoir de réduire le risque de rechute. Les patients peuvent également être traités simultanément avec les anticorps selon la présente invention et des agents anti-néoplasiques classiques.
CA002295375A 1997-07-08 1998-07-08 Fragments de liaison antigeniques designes par 4b5, qui detectent specifiquement les cellules cancereuses, nucleotides codant lesdits fragments et leur utilisation pour la prophylaxie et la detection des cancers Abandoned CA2295375A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5194597P 1997-07-08 1997-07-08
US60/051,945 1997-07-08
PCT/IB1998/001046 WO1999002545A2 (fr) 1997-07-08 1998-07-08 Fragments de liaison antigeniques designes par 4b5, qui detectent specifiquement les cellules cancereuses, nucleotides codant lesdits fragments et leur utilisation pour la prophylaxie et la detection des cancers

Publications (1)

Publication Number Publication Date
CA2295375A1 true CA2295375A1 (fr) 1999-01-21

Family

ID=21974384

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002295375A Abandoned CA2295375A1 (fr) 1997-07-08 1998-07-08 Fragments de liaison antigeniques designes par 4b5, qui detectent specifiquement les cellules cancereuses, nucleotides codant lesdits fragments et leur utilisation pour la prophylaxie et la detection des cancers

Country Status (6)

Country Link
EP (1) EP1000082A2 (fr)
JP (1) JP2001509369A (fr)
AU (1) AU7927398A (fr)
CA (1) CA2295375A1 (fr)
NZ (1) NZ501990A (fr)
WO (1) WO1999002545A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE309360T1 (de) 1994-03-08 2005-11-15 Human Genome Sciences Inc Vaskularer endothelialer wachstumsfaktor 2
US7153827B1 (en) 1994-03-08 2006-12-26 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 and methods of use
US7186688B1 (en) 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
US6040157A (en) 1994-03-08 2000-03-21 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US7109308B1 (en) 1994-03-08 2006-09-19 Human Genome Sciences, Inc. Antibodies to human vascular endothelial growth factor 2
US5932540A (en) 1994-03-08 1999-08-03 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US6608182B1 (en) 1994-03-08 2003-08-19 Human Genome Sciences, Inc. Human vascular endothelial growth factor 2
US7223724B1 (en) 1999-02-08 2007-05-29 Human Genome Sciences, Inc. Use of vascular endothelial growth factor to treat photoreceptor cells
JP2003527116A (ja) * 2000-03-15 2003-09-16 インサイト・ゲノミックス・インコーポレイテッド ヒト免疫応答タンパク質
NZ518077A (en) 2000-08-04 2003-11-28 Human Genome Sciences Inc Biologically active fragments, analogues and derivatives of VEGF-2 for the treatment of peripheral artery diseases such as critical limb ischemia and coronary disease
DE10059930A1 (de) * 2000-11-23 2002-05-29 Fischer Peter Mittel humanen Ursprungs zur Vakzination gegen GD2-pos. Tumore
WO2002083704A1 (fr) 2001-04-13 2002-10-24 Human Genome Sciences, Inc. Facteur de croissance 2, endothelial, vasculaire
US7402312B2 (en) 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
EP1380290A1 (fr) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht La voie de la structure cross-béta et sa pertinence thérapeutique
US7473424B2 (en) * 2003-01-31 2009-01-06 The Scripps Research Institute Anti-dengue virus antibodies and compositions
TWI434855B (zh) * 2006-11-21 2014-04-21 Hoffmann La Roche 結合物及其在免疫分析中作為參考標準之用途
WO2015095002A1 (fr) * 2013-12-16 2015-06-25 Texas Tech University System Anticorps monoclonaux anti-ron en tant que système d'administration de médicaments cytotoxiques pour une thérapie anticancéreuse ciblée

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653977A (en) * 1993-09-09 1997-08-05 Uab Research Foundation Anti-idiotypic antibody that mimics the GD2 antigen
DK0796280T3 (da) * 1994-12-28 2003-04-22 Univ Kentucky Murint monoklonalt anti-idiotypisk antistof 3H1
US5612030A (en) * 1995-01-17 1997-03-18 University Of Kentucky Research Foundation Anti-idiotype monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma

Also Published As

Publication number Publication date
WO1999002545A2 (fr) 1999-01-21
EP1000082A2 (fr) 2000-05-17
JP2001509369A (ja) 2001-07-24
WO1999002545A3 (fr) 1999-04-01
NZ501990A (en) 2002-09-27
AU7927398A (en) 1999-02-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued