CA2261273A1 - Procedes immunologiques de selection et d'extraction de composants - Google Patents
Procedes immunologiques de selection et d'extraction de composants Download PDFInfo
- Publication number
- CA2261273A1 CA2261273A1 CA 2261273 CA2261273A CA2261273A1 CA 2261273 A1 CA2261273 A1 CA 2261273A1 CA 2261273 CA2261273 CA 2261273 CA 2261273 A CA2261273 A CA 2261273A CA 2261273 A1 CA2261273 A1 CA 2261273A1
- Authority
- CA
- Canada
- Prior art keywords
- label
- antibody
- biotin
- avidin
- competitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 97
- 238000011084 recovery Methods 0.000 title claims description 9
- 230000001900 immune effect Effects 0.000 title abstract 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 126
- 230000027455 binding Effects 0.000 claims description 97
- 229960002685 biotin Drugs 0.000 claims description 65
- 239000011616 biotin Substances 0.000 claims description 65
- 235000020958 biotin Nutrition 0.000 claims description 63
- 108090001008 Avidin Proteins 0.000 claims description 62
- 108010090804 Streptavidin Proteins 0.000 claims description 49
- 239000007787 solid Substances 0.000 claims description 49
- 230000001745 anti-biotin effect Effects 0.000 claims description 23
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 11
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- 230000009870 specific binding Effects 0.000 description 4
- YMXHPSHLTSZXKH-RVBZMBCESA-N (2,5-dioxopyrrolidin-1-yl) 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate Chemical compound C([C@H]1[C@H]2NC(=O)N[C@H]2CS1)CCCC(=O)ON1C(=O)CCC1=O YMXHPSHLTSZXKH-RVBZMBCESA-N 0.000 description 3
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 3
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- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 101710120037 Toxin CcdB Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
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- 238000007413 biotinylation Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 150000001720 carbohydrates Chemical group 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
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- 229940088597 hormone Drugs 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 230000016784 immunoglobulin production Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 210000003810 lymphokine-activated killer cell Anatomy 0.000 description 2
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- 229920001778 nylon Polymers 0.000 description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
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- 235000000346 sugar Nutrition 0.000 description 2
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- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
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- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
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- 108010035532 Collagen Proteins 0.000 description 1
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- 241000187747 Streptomyces Species 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 230000009830 antibody antigen interaction Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 150000001615 biotins Chemical class 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000004970 cd4 cell Anatomy 0.000 description 1
- 230000003196 chaotropic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
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- 238000009833 condensation Methods 0.000 description 1
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- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- 210000005104 human peripheral blood lymphocyte Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000007193 modulation by symbiont of host erythrocyte aggregation Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 125000006501 nitrophenyl group Chemical group 0.000 description 1
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- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
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- 239000012071 phase Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
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- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention se rapporte à un procédé immunologique de séparation de cellules ou de structures moléculaires, ciblées de manière spécifique, et présentes dans une population mélangée, ladite séparation ayant lieu dans des conditions qui minimisent les dégâts occasionnés à la structure cellulaire ou à l'intégrité moléculaire. Ledit procédé est fondé sur une interaction spécifique d'un marqueur et d'un anticorps dirigé contre ledit marqueur et sur la capacité d'un concurrent à inhiber l'interaction entre le marqueur et l'anticorps.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2261273 CA2261273A1 (fr) | 1996-05-17 | 1996-05-17 | Procedes immunologiques de selection et d'extraction de composants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2261273 CA2261273A1 (fr) | 1996-05-17 | 1996-05-17 | Procedes immunologiques de selection et d'extraction de composants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2261273A1 true CA2261273A1 (fr) | 1997-11-27 |
Family
ID=4163271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2261273 Abandoned CA2261273A1 (fr) | 1996-05-17 | 1996-05-17 | Procedes immunologiques de selection et d'extraction de composants |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2261273A1 (fr) |
-
1996
- 1996-05-17 CA CA 2261273 patent/CA2261273A1/fr not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |