CA2259724C - Anticorps monoclonal specifique du facteur v11 de la coagulation active et son utilisation - Google Patents

Anticorps monoclonal specifique du facteur v11 de la coagulation active et son utilisation Download PDF

Info

Publication number
CA2259724C
CA2259724C CA2259724A CA2259724A CA2259724C CA 2259724 C CA2259724 C CA 2259724C CA 2259724 A CA2259724 A CA 2259724A CA 2259724 A CA2259724 A CA 2259724A CA 2259724 C CA2259724 C CA 2259724C
Authority
CA
Canada
Prior art keywords
monoclonal antibody
factor vii
activated factor
activated
factor vll
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2259724A
Other languages
English (en)
Other versions
CA2259724A1 (fr
Inventor
Jurgen Romisch
Wiegand Lang
Annette Feussner
Joachim Roder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring GmbH Deutschland
Original Assignee
CSL Behring GmbH Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CSL Behring GmbH Deutschland filed Critical CSL Behring GmbH Deutschland
Publication of CA2259724A1 publication Critical patent/CA2259724A1/fr
Application granted granted Critical
Publication of CA2259724C publication Critical patent/CA2259724C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6437Coagulation factor VIIa (3.4.21.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21021Coagulation factor VIIa (3.4.21.21)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745Assays involving non-enzymic blood coagulation factors
    • G01N2333/755Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
CA2259724A 1998-01-22 1999-01-20 Anticorps monoclonal specifique du facteur v11 de la coagulation active et son utilisation Expired - Fee Related CA2259724C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19802139A DE19802139C1 (de) 1998-01-22 1998-01-22 Monoklonaler Antikörper spezifisch für aktivierten Gerinnungsfaktor VII und seine Verwendung
DEP19802139.9 1998-01-22

Publications (2)

Publication Number Publication Date
CA2259724A1 CA2259724A1 (fr) 1999-07-22
CA2259724C true CA2259724C (fr) 2010-07-13

Family

ID=7855234

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2259724A Expired - Fee Related CA2259724C (fr) 1998-01-22 1999-01-20 Anticorps monoclonal specifique du facteur v11 de la coagulation active et son utilisation

Country Status (9)

Country Link
US (2) US6479245B1 (fr)
EP (1) EP0931793B1 (fr)
JP (1) JP4422228B2 (fr)
KR (1) KR100583537B1 (fr)
AT (1) ATE261991T1 (fr)
AU (1) AU742631B2 (fr)
CA (1) CA2259724C (fr)
DE (2) DE19802139C1 (fr)
ES (1) ES2217492T3 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19802139C1 (de) * 1998-01-22 1999-09-23 Centeon Pharma Gmbh Monoklonaler Antikörper spezifisch für aktivierten Gerinnungsfaktor VII und seine Verwendung
JP4309656B2 (ja) * 2000-12-14 2009-08-05 ジェネンテック・インコーポレーテッド 原核生物で生成させた抗体とその用途
WO2003004694A1 (fr) * 2001-07-03 2003-01-16 Oklahoma Medical Research Foundation Analyse destinee a mesurer les complexes facteur viia-antithrombine
AU2020259982A1 (en) 2019-04-17 2021-10-28 Novo Nordisk A/S Bispecific antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843442A (en) * 1990-10-22 1998-12-01 Corvas International, Inc. Blood coagulation protein antagonists and uses therefor
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
MX9204374A (es) * 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
MA24512A1 (fr) * 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
DE19802139C1 (de) * 1998-01-22 1999-09-23 Centeon Pharma Gmbh Monoklonaler Antikörper spezifisch für aktivierten Gerinnungsfaktor VII und seine Verwendung

Also Published As

Publication number Publication date
JP4422228B2 (ja) 2010-02-24
DE19802139C1 (de) 1999-09-23
DE59810998D1 (de) 2004-04-22
AU1318599A (en) 1999-08-12
JPH11279199A (ja) 1999-10-12
ATE261991T1 (de) 2004-04-15
ES2217492T3 (es) 2004-11-01
US20030003096A1 (en) 2003-01-02
AU742631B2 (en) 2002-01-10
CA2259724A1 (fr) 1999-07-22
KR19990068047A (ko) 1999-08-25
US6835817B2 (en) 2004-12-28
EP0931793A1 (fr) 1999-07-28
EP0931793B1 (fr) 2004-03-17
KR100583537B1 (ko) 2006-05-26
US6479245B1 (en) 2002-11-12

Similar Documents

Publication Publication Date Title
US4902614A (en) Monoclonal antibody to human protein C
EP0528525B1 (fr) Procédé et compositions pour détecter des protéases sanguines, spécialement pour protéine C activée
KR940002033B1 (ko) 단백질 c에 대해 특이성이 있는 단클론성 항체 및 항체의 분리방법
EP0162078B1 (fr) Procede d'isolation d'une proteine d'un melange la contenant et un anticorps specifique de conformation
KR100202773B1 (ko) 프로트롬빈 활성화 펩타이드 및 그것의 분해생성물에 대한 모노클론 항체 및 면역 분석법
Kumar et al. Identification of molecular sites on factor VII which mediate its assembly and function in the extrinsic pathway activation complex.
CA2259724C (fr) Anticorps monoclonal specifique du facteur v11 de la coagulation active et son utilisation
AU621823B2 (en) Improvements relating to measurement of tissue plasminogen activator activity
JP4398648B2 (ja) 血液凝固第vii因子活性化プロテアーゼに対する抑制性モノクローナル抗体
EP0339302B1 (fr) Système de réactif pour essai immunologique du complexe de l'inhibiteur d'activeur plasminogène humain et de l'activeur plasminogène humain de tissu et trousse à cet effet
EP0192675B1 (fr) Anticorps monoclonal anti-urokinase; production et utilisation
EP0205046B1 (fr) Anticorps monoclonal contre la protéine C humaine
US6258938B1 (en) Method for the purification and isolation of blood clotting proteins using conformation specific antibodies
EP0169549A2 (fr) Détermination immunologique d'inhibiteur de plasmine/alpha-2-plasmine humain
CA1291424C (fr) Methode faisant appel a un immunosorbant-amidolytique pour la detection du precurseur de l'activateur du plasminogene urinaire (pro-upa) et de l'activateur du plasminogene urinaire (u-pa)
JPH03200066A (ja) 活性化ヒトプロテインcの測定方法
US20040161810A1 (en) Monoclonal antibodies specific for latent antithrombin III and the use thereof
JPH0260267B2 (fr)

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20170120