CA2259145A1 - Hamster ef-1.alpha. transcriptional regulatory dna - Google Patents

Hamster ef-1.alpha. transcriptional regulatory dna

Info

Publication number
CA2259145A1
CA2259145A1 CA002259145A CA2259145A CA2259145A1 CA 2259145 A1 CA2259145 A1 CA 2259145A1 CA 002259145 A CA002259145 A CA 002259145A CA 2259145 A CA2259145 A CA 2259145A CA 2259145 A1 CA2259145 A1 CA 2259145A1
Authority
CA
Canada
Prior art keywords
regulatory dna
hamster
alpha
transcriptional regulatory
expression constructs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002259145A
Other languages
French (fr)
Other versions
CA2259145C (en
Inventor
Daniel S. Allison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CMC ICOS BIOLOGICS Inc
Original Assignee
Icos Corporation
Daniel S. Allison
Cmc Icos Biologics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/847,218 external-priority patent/US5888809A/en
Application filed by Icos Corporation, Daniel S. Allison, Cmc Icos Biologics, Inc. filed Critical Icos Corporation
Publication of CA2259145A1 publication Critical patent/CA2259145A1/en
Application granted granted Critical
Publication of CA2259145C publication Critical patent/CA2259145C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to regulatory DNA sequences derived from the hamster EF-1.alpha. gene. The invention further encompasses expression constructs comprising regulatory DNA of the invention, host cells transformed or transfected with the regulatory DNA and methods of increasing gene transcription utilizing the regulatory DNA.
Expression constructs comprising regulatory DNA of the invention operably linked to specific gene sequences are also comprehended.
CA002259145A 1997-05-01 1998-05-01 Hamster ef-1.alpha. transcriptional regulatory dna Expired - Lifetime CA2259145C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/847,218 1997-05-01
US08/847,218 US5888809A (en) 1997-05-01 1997-05-01 Hamster EF-1α transcriptional regulatory DNA
PCT/US1998/008906 WO1998049289A1 (en) 1997-05-01 1998-05-01 HAMSTER EF-1α TRANSCRIPTIONAL REGULATORY DNA

Publications (2)

Publication Number Publication Date
CA2259145A1 true CA2259145A1 (en) 1998-11-05
CA2259145C CA2259145C (en) 2007-08-21

Family

ID=38434644

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002259145A Expired - Lifetime CA2259145C (en) 1997-05-01 1998-05-01 Hamster ef-1.alpha. transcriptional regulatory dna

Country Status (1)

Country Link
CA (1) CA2259145C (en)

Also Published As

Publication number Publication date
CA2259145C (en) 2007-08-21

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Effective date: 20180501