CA2258146A1 - Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents
Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenantInfo
- Publication number
- CA2258146A1 CA2258146A1 CA002258146A CA2258146A CA2258146A1 CA 2258146 A1 CA2258146 A1 CA 2258146A1 CA 002258146 A CA002258146 A CA 002258146A CA 2258146 A CA2258146 A CA 2258146A CA 2258146 A1 CA2258146 A1 CA 2258146A1
- Authority
- CA
- Canada
- Prior art keywords
- polysaccharides
- pharmaceutical compositions
- compositions containing
- preparing same
- synthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cephalosporin Compounds (AREA)
Abstract
L'invention concerne des polysaccharides de synthèse contenant de 8 à 24 unités monosaccharidiques formées par un enchaînement de disaccharides constitués d'un acide uronique et d'un hexose, ledit polysaccharide étant caractérisé en ce que tous ses groupes hydroxyles sont éthérifiés avec un groupe (C1-C6)alkyle ou estérifiés sous la forme de groupe sulfo, chaque disaccharide étant au moins monoéthérifié; ainsi que leurs sels.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9607457A FR2749849B1 (fr) | 1996-06-14 | 1996-06-14 | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR96/07457 | 1996-06-14 | ||
PCT/FR1997/001048 WO1997047659A1 (fr) | 1996-06-14 | 1997-06-11 | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2258146A1 true CA2258146A1 (fr) | 1997-12-18 |
CA2258146C CA2258146C (fr) | 2003-10-07 |
Family
ID=9493087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002258146A Expired - Lifetime CA2258146C (fr) | 1996-06-14 | 1997-06-11 | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
Country Status (15)
Country | Link |
---|---|
US (1) | US7919614B2 (fr) |
EP (1) | EP0904299B1 (fr) |
JP (1) | JP3501813B2 (fr) |
AT (1) | ATE204883T1 (fr) |
AU (1) | AU3266797A (fr) |
BR (1) | BR9709722B1 (fr) |
CA (1) | CA2258146C (fr) |
CY (1) | CY2281B1 (fr) |
DE (1) | DE69706418T2 (fr) |
DK (1) | DK0904299T3 (fr) |
ES (1) | ES2163171T3 (fr) |
FR (1) | FR2749849B1 (fr) |
NO (1) | NO319037B1 (fr) |
PT (1) | PT904299E (fr) |
WO (1) | WO1997047659A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751334B1 (fr) * | 1996-07-19 | 1998-10-16 | Sanofi Sa | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR2773804B1 (fr) * | 1998-01-19 | 2000-02-18 | Sanofi Sa | Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant |
EP1574516A1 (fr) * | 2004-03-05 | 2005-09-14 | Sanofi-Aventis | Composés antithrombotiques |
JP4796758B2 (ja) * | 2004-08-24 | 2011-10-19 | 学校法人 京都産業大学 | 組成物及びそれを含有する抗腫瘍剤 |
TWI403334B (zh) | 2004-12-23 | 2013-08-01 | Merck Sharp & Dohme | 包含生物素殘基之抗血栓雙重抑制劑 |
KR101529061B1 (ko) | 2008-05-30 | 2015-06-16 | 모멘타 파머슈티컬스 인코포레이티드 | 당류 구조물, 그리고 이러한 구조물의 제조 및 사용 방법 |
FR2949114B1 (fr) | 2009-08-14 | 2011-08-26 | Sanofi Aventis | OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
FR2949115B1 (fr) * | 2009-08-14 | 2012-11-02 | Sanofi Aventis | OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
FR2970969B1 (fr) * | 2011-01-27 | 2013-10-18 | Sanofi Aventis | Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique |
EP2578594A1 (fr) * | 2011-10-04 | 2013-04-10 | Sanofi | Procédé pour la préparation de l'acide L-iduronique par une réaction decarboxylation/cyclisation intramoléculaire en tandem |
WO2021211441A1 (fr) * | 2020-04-13 | 2021-10-21 | The Board Of Regents Of The University Of Oklahoma | Polymères du sucre modifiés à faible activité anticoagulante et activité thérapeutique |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5529985A (en) * | 1990-04-23 | 1996-06-25 | Akzo Nobel Nv | Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type |
US5382570A (en) * | 1990-04-23 | 1995-01-17 | Akzo, N.V. | Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type |
US5378829A (en) * | 1990-04-23 | 1995-01-03 | Akzo N.V. | Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type |
US5668274A (en) * | 1991-04-23 | 1997-09-16 | Akzo Nobel N.V. | Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type |
-
1996
- 1996-06-14 FR FR9607457A patent/FR2749849B1/fr not_active Expired - Fee Related
-
1997
- 1997-06-11 DK DK97928337T patent/DK0904299T3/da active
- 1997-06-11 AT AT97928337T patent/ATE204883T1/de active
- 1997-06-11 BR BRPI9709722-5A patent/BR9709722B1/pt not_active IP Right Cessation
- 1997-06-11 WO PCT/FR1997/001048 patent/WO1997047659A1/fr active IP Right Grant
- 1997-06-11 PT PT97928337T patent/PT904299E/pt unknown
- 1997-06-11 ES ES97928337T patent/ES2163171T3/es not_active Expired - Lifetime
- 1997-06-11 EP EP97928337A patent/EP0904299B1/fr not_active Expired - Lifetime
- 1997-06-11 CA CA002258146A patent/CA2258146C/fr not_active Expired - Lifetime
- 1997-06-11 DE DE69706418T patent/DE69706418T2/de not_active Expired - Lifetime
- 1997-06-11 JP JP50130798A patent/JP3501813B2/ja not_active Expired - Lifetime
- 1997-06-11 AU AU32667/97A patent/AU3266797A/en not_active Abandoned
-
1998
- 1998-12-11 NO NO19985831A patent/NO319037B1/no not_active IP Right Cessation
-
2002
- 2002-05-15 CY CY0200035A patent/CY2281B1/xx unknown
-
2003
- 2003-10-02 US US10/677,894 patent/US7919614B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
BR9709722A (pt) | 2000-01-25 |
DK0904299T3 (da) | 2001-12-17 |
ES2163171T3 (es) | 2002-01-16 |
NO985831L (no) | 1999-02-11 |
FR2749849A1 (fr) | 1997-12-19 |
AU3266797A (en) | 1998-01-07 |
CY2281B1 (en) | 2003-07-04 |
DE69706418T2 (de) | 2002-05-29 |
JPH11513061A (ja) | 1999-11-09 |
EP0904299B1 (fr) | 2001-08-29 |
DE69706418D1 (de) | 2001-10-04 |
NO319037B1 (no) | 2005-06-06 |
EP0904299A1 (fr) | 1999-03-31 |
NO985831D0 (no) | 1998-12-11 |
US7919614B2 (en) | 2011-04-05 |
PT904299E (pt) | 2002-02-28 |
US20040068108A1 (en) | 2004-04-08 |
ATE204883T1 (de) | 2001-09-15 |
JP3501813B2 (ja) | 2004-03-02 |
BR9709722B1 (pt) | 2010-12-14 |
WO1997047659A1 (fr) | 1997-12-18 |
CA2258146C (fr) | 2003-10-07 |
FR2749849B1 (fr) | 1998-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20170612 |