CA2220670A1 - Inhibiteur humain du gene 1 de l'apoptose - Google Patents

Inhibiteur humain du gene 1 de l'apoptose Download PDF

Info

Publication number
CA2220670A1
CA2220670A1 CA002220670A CA2220670A CA2220670A1 CA 2220670 A1 CA2220670 A1 CA 2220670A1 CA 002220670 A CA002220670 A CA 002220670A CA 2220670 A CA2220670 A CA 2220670A CA 2220670 A1 CA2220670 A1 CA 2220670A1
Authority
CA
Canada
Prior art keywords
polypeptide
polynucleotide
dna
hiap
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002220670A
Other languages
English (en)
Inventor
Peter L. Hudson
Craig A. Rosen
Wei Wu He
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002220670A priority Critical patent/CA2220670A1/fr
Priority to AU25480/95A priority patent/AU2548095A/en
Priority to EP95919804A priority patent/EP0830375A4/fr
Priority to PCT/US1995/005922 priority patent/WO1996035703A1/fr
Publication of CA2220670A1 publication Critical patent/CA2220670A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un inhibiteur humain du polypeptide de l'apoptose et l'ADN (ARN) codant pour un tel polypeptide, ainsi qu'un procédé pour produire ce polypeptide, par des techniques de recombinaison. L'invention concerne, en outre, des procédés pour utiliser de tels polypeptides pour le traitement de maladies dégénératives, de la polyarthrite rhumatoïde, des chocs septiques, comme mécanisme de défense antiviral et pour empêcher la mort de cellules en cas de traumatisme ou d'attaque. L'invention concerne également des antagonistes de tels polypeptides et leur utilisation thérapeutique pour favoriser le développement cellulaire, empêcher les infections virales, favoriser la différentiation cellulaire, favoriser et maintenir l'homéostasie tissulaire (tumeurs). L'invention concerne enfin des méthodes de diagnostic pour détecter les mutations dans la séquence des acides nucléiques codant pour la protéine hIAP-1.
CA002220670A 1995-05-11 1995-05-11 Inhibiteur humain du gene 1 de l'apoptose Abandoned CA2220670A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002220670A CA2220670A1 (fr) 1995-05-11 1995-05-11 Inhibiteur humain du gene 1 de l'apoptose
AU25480/95A AU2548095A (en) 1995-05-11 1995-05-11 Human inhibitor of apoptosis gene 1
EP95919804A EP0830375A4 (fr) 1995-05-11 1995-05-11 Inhibiteur humain du gene 1 de l'apoptose
PCT/US1995/005922 WO1996035703A1 (fr) 1995-05-11 1995-05-11 Inhibiteur humain du gene 1 de l'apoptose

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002220670A CA2220670A1 (fr) 1995-05-11 1995-05-11 Inhibiteur humain du gene 1 de l'apoptose
PCT/US1995/005922 WO1996035703A1 (fr) 1995-05-11 1995-05-11 Inhibiteur humain du gene 1 de l'apoptose

Publications (1)

Publication Number Publication Date
CA2220670A1 true CA2220670A1 (fr) 1996-11-14

Family

ID=25679809

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002220670A Abandoned CA2220670A1 (fr) 1995-05-11 1995-05-11 Inhibiteur humain du gene 1 de l'apoptose

Country Status (4)

Country Link
EP (1) EP0830375A4 (fr)
AU (1) AU2548095A (fr)
CA (1) CA2220670A1 (fr)
WO (1) WO1996035703A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156535A (en) 1995-08-04 2000-12-05 University Of Ottawa Mammalian IAP gene family, primers, probes, and detection methods
AUPN727595A0 (en) * 1995-12-22 1996-01-18 Walter And Eliza Hall Institute Of Medical Research, The Therapeutic compositions
US6133437A (en) * 1997-02-13 2000-10-17 Apoptogen, Inc. Modulation of IAPs for the treatment of proliferative diseases
AU5065098A (en) * 1996-11-15 1998-06-10 University Of Ottawa Modulators of ovarial apoptosis related to iap
US6472172B1 (en) * 1998-07-31 2002-10-29 Schering Aktiengesellschaft DNA encoding a novel human inhibitor-of-apoptosis protein
MXPA01004318A (es) * 1998-10-30 2003-06-06 Univ Nebraska Lincoln Transferencia de especies trans de genes apopticos y plantas transgenicas asi desarrolladas.
WO2000077201A1 (fr) 1999-06-15 2000-12-21 Astrazeneca Ab Proteine-3 inhibiteur d'apoptose (iap-3), designee sous le nom de livine
ATE431410T1 (de) 2002-03-27 2009-05-15 Aegera Therapeutics Inc Gegen iap gerichtete antisense-nukleobasen und deren verwendungen
US8012944B2 (en) 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent

Also Published As

Publication number Publication date
EP0830375A1 (fr) 1998-03-25
WO1996035703A1 (fr) 1996-11-14
EP0830375A4 (fr) 2001-11-21
AU2548095A (en) 1996-11-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued