CA2199614A1 - Derives d'indole et de quinoxaline condenses, leur preparation et leur utilisation - Google Patents

Derives d'indole et de quinoxaline condenses, leur preparation et leur utilisation

Info

Publication number
CA2199614A1
CA2199614A1 CA2199614A CA2199614A CA2199614A1 CA 2199614 A1 CA2199614 A1 CA 2199614A1 CA 2199614 A CA2199614 A CA 2199614A CA 2199614 A CA2199614 A CA 2199614A CA 2199614 A1 CA2199614 A1 CA 2199614A1
Authority
CA
Canada
Prior art keywords
alkyl
amino
hydrogen
alkoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2199614A
Other languages
English (en)
Other versions
CA2199614C (fr
Inventor
Peter Moldt
Frank Watjen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Peter Moldt
Frank Watjen
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter Moldt, Frank Watjen, Neurosearch A/S filed Critical Peter Moldt
Publication of CA2199614A1 publication Critical patent/CA2199614A1/fr
Application granted granted Critical
Publication of CA2199614C publication Critical patent/CA2199614C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
CA002199614A 1994-09-14 1995-09-12 Derives d'indole et de quinoxaline condenses, leur preparation et leur utilisation Expired - Fee Related CA2199614C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK1054/94 1994-09-14
DK105494 1994-09-14
PCT/EP1995/003594 WO1996008495A1 (fr) 1994-09-14 1995-09-12 Derives d'indole et de quinoxaline condenses, leur preparation et leur utilisation

Publications (2)

Publication Number Publication Date
CA2199614A1 true CA2199614A1 (fr) 1996-03-21
CA2199614C CA2199614C (fr) 2000-02-22

Family

ID=8100467

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002199614A Expired - Fee Related CA2199614C (fr) 1994-09-14 1995-09-12 Derives d'indole et de quinoxaline condenses, leur preparation et leur utilisation

Country Status (12)

Country Link
US (1) US5801174A (fr)
EP (1) EP0781285B1 (fr)
JP (1) JP3164372B2 (fr)
AT (1) ATE188701T1 (fr)
AU (1) AU686888B2 (fr)
CA (1) CA2199614C (fr)
DE (1) DE69514533T2 (fr)
EE (1) EE03772B1 (fr)
FI (1) FI112486B (fr)
NO (1) NO308851B1 (fr)
NZ (1) NZ293266A (fr)
WO (1) WO1996008495A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008144931A1 (fr) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions et procédés pour la modulation des canaux ioniques

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2781482B1 (fr) * 1998-07-27 2001-08-31 Adir Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK1183025T3 (da) * 1999-05-19 2009-05-04 Painceptor Pharma Corp Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser
ES2266214T3 (es) * 2000-01-24 2007-03-01 Neurosearch A/S Derivados de isatina con actividad neurotrofica.
CA2630617C (fr) 2005-11-23 2014-03-25 Painceptor Pharma Corporation Compositions et procedes de modulation des canaux ioniques
WO2007070506A2 (fr) 2005-12-14 2007-06-21 Amgen Inc. Derives diaza heterocycliques de sulfonamide et leurs utilisations
US20080004282A1 (en) * 2006-04-10 2008-01-03 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
CA2868238A1 (fr) 2012-04-18 2013-10-24 Ramot At Tel Aviv University Ltd. Particules de glycosaminoglycane lipide pour la liberation d'acides nucleiques
WO2016114655A1 (fr) * 2015-01-12 2016-07-21 Ry Pharma B.V. Traitement de maladie neuromusculaire ou neurologique par réduction de la surstimulation des neurotransmetteurs inhibiteurs gabaergiques et/ou glycinergique
WO2017065602A1 (fr) * 2015-10-13 2017-04-20 Ry Pharma B.V. Traitement de maladie neuromusculaire ou neurologique par réduction de la surstimulation des neurotransmetteurs inhibiteurs gabaergiques et/ou glycinergiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076948C (fr) * 1991-08-28 2002-04-16 Frank Watjen Derives d'isatineoxime; preparation et utilisation
ES2109516T3 (es) * 1992-10-13 1998-01-16 Warner Lambert Co Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008144931A1 (fr) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions et procédés pour la modulation des canaux ioniques

Also Published As

Publication number Publication date
EE9700051A (et) 1997-08-15
NO970903D0 (no) 1997-02-27
JP3164372B2 (ja) 2001-05-08
FI112486B (fi) 2003-12-15
NO308851B1 (no) 2000-11-06
AU686888B2 (en) 1998-02-12
WO1996008495A1 (fr) 1996-03-21
EP0781285B1 (fr) 2000-01-12
AU3566595A (en) 1996-03-29
FI970785A0 (fi) 1997-02-25
DE69514533D1 (de) 2000-02-17
ATE188701T1 (de) 2000-01-15
CA2199614C (fr) 2000-02-22
EE03772B1 (et) 2002-06-17
NZ293266A (en) 1998-01-26
NO970903L (no) 1997-05-07
JPH09511525A (ja) 1997-11-18
FI970785A (fi) 1997-03-13
EP0781285A1 (fr) 1997-07-02
US5801174A (en) 1998-09-01
DE69514533T2 (de) 2000-07-06

Similar Documents

Publication Publication Date Title
SG128491A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
CA2199614A1 (fr) Derives d'indole et de quinoxaline condenses, leur preparation et leur utilisation
MY114679A (en) Aroyl-piperidine derivatives
NO20014363L (no) 4-okso-4,7-dihydro-tieno[2,3-b]pyridin-5-karboksamider som antivirale midler
CA2236707A1 (fr) Derives tropane condenses en tant qu'inhibiteurs de recaptage des neurotransmetteurs
AU7927591A (en) Substituted aminoalkylbiphenyl derivatives
PL351878A1 (en) Amino compound derivatives
JO2321B1 (en) 4-phenyl-pyridine derivatives
NZ528997A (en) Sulfonamides
GR3026008T3 (en) Ampa antagonists and a method of treatment therewith
CA2356985A1 (fr) Antagonistes du recepteur 5ht1 pour therapie antidepressive
DE69524610D1 (de) 2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung
CO5011066A1 (es) Compuestos de triazina
ES2182509T3 (es) Derivados de n-ariloxietilamina para el tratamiento de la depresion.
DE69514532D1 (de) Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung
DK0629615T3 (da) Indolderivater som glutamatantagonister
FI922694A0 (fi) Tioxantenonderivat med antitumoer- effekt.
EP0875512A3 (fr) Dérivés de la naphthylpipérazine avec une activité antipsychotique
DE69932627D1 (de) Iminoguanidine derivate, ihre herstellung und verwendung als arzneimittel

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed