CA2173830A1 - Process for Producing Simvastatin and Analogs Thereof - Google Patents

Process for Producing Simvastatin and Analogs Thereof

Info

Publication number
CA2173830A1
CA2173830A1 CA2173830A CA2173830A CA2173830A1 CA 2173830 A1 CA2173830 A1 CA 2173830A1 CA 2173830 A CA2173830 A CA 2173830A CA 2173830 A CA2173830 A CA 2173830A CA 2173830 A1 CA2173830 A1 CA 2173830A1
Authority
CA
Canada
Prior art keywords
analogs
producing simvastatin
simvastatin
producing
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2173830A
Other languages
French (fr)
Other versions
CA2173830C (en
Inventor
Rudolf Kubela
Jayaramaiyer Radhakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2173830A1 publication Critical patent/CA2173830A1/en
Application granted granted Critical
Publication of CA2173830C publication Critical patent/CA2173830C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

A process is disclosed for the preparation of simvastatin and its analogs through a novel intermediate (III), which enables a selective .alpha. carbon alkylation of the C-8 acyl side chain.
CA002173830A 1993-11-08 1994-11-03 Process for producing simvastatin and analogs thereof Expired - Fee Related CA2173830C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/148,517 US5393893A (en) 1993-11-08 1993-11-08 Process for producing simvastatin and analogs thereof
US08/148,517 1993-11-08

Publications (2)

Publication Number Publication Date
CA2173830A1 true CA2173830A1 (en) 1995-05-18
CA2173830C CA2173830C (en) 1998-04-07

Family

ID=22526110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002173830A Expired - Fee Related CA2173830C (en) 1993-11-08 1994-11-03 Process for producing simvastatin and analogs thereof

Country Status (6)

Country Link
US (1) US5393893A (en)
AU (1) AU8055594A (en)
CA (1) CA2173830C (en)
IL (1) IL111546A (en)
WO (1) WO1995013283A1 (en)
ZA (1) ZA948775B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763653A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Key intermediates in the manufacture of simvastatin
WO1998001116A1 (en) * 1996-07-09 1998-01-15 Merck & Co., Inc. Therapy for combined hyperlipidemia
CA2185961A1 (en) * 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US5763646A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
CN1102588C (en) * 1997-01-24 2003-03-05 兰贝克赛实验室有限公司 Process for manufacturing simvastatin from lovastatin or mevinolinic acid
DE69813538T2 (en) * 1997-01-28 2004-04-01 Plus Chemicals B.V. METHOD FOR PRODUCING SEMI-SYNTHETIC STATINES VIANEUE INTERMEDIATE PRODUCTS
EP0940395A1 (en) * 1998-03-05 1999-09-08 Synthon B.V. Process for producing simvastatin and/or its derivatives
NO991045L (en) † 1998-03-05 1999-09-06 Synthon Bv Process for the preparation of simvastatin and / or its derivatives
ZA9810764B (en) * 1998-04-22 1999-08-13 Ranbaxy Lab Ltd An improved process of lactonization in the preparation of statins.
CA2240983A1 (en) * 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
ATE283849T1 (en) * 1998-12-10 2004-12-15 Kaneka Corp METHOD FOR PRODUCING A SIMVASTATIN PRECURSOR
CO5140104A1 (en) * 1999-02-16 2002-03-22 Novartis Ag MEVINOLINE DERIVATIVES AND PHARMACEUTICAL PREPARATION CONTAINING THEM
US6573392B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
EP1268462B1 (en) 2000-03-30 2006-08-30 Cheil Jedang Corporation A process for producing simvastatin
EP1303268A4 (en) 2000-07-27 2006-08-09 Plus Chemicals Bv Highly purified simvastatin compositions
US6777552B2 (en) 2001-08-16 2004-08-17 Teva Pharmaceutical Industries, Ltd. Processes for preparing calcium salt forms of statins
NL1017548C2 (en) 2001-03-09 2002-09-10 Synthon Bv A lactonization process.
KR100407758B1 (en) * 2001-08-27 2003-12-01 씨제이 주식회사 Process of lactonization in the preparation of statins
SI21187A (en) * 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Process for preparation of 4-oxytetrahydropyran-2-ones
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
US20040254238A1 (en) * 2003-04-07 2004-12-16 Osteoscreen Bone growth stimulation with NO/statin and other NO modulating combinations
CN1754870A (en) * 2004-09-30 2006-04-05 淮北市辉克药业有限公司 Process for the preparation of simvastatin
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
US20070129437A1 (en) * 2005-12-06 2007-06-07 Ferenc Korodi Process for preparing simvastatin and intermediates thereof
SI2024341T1 (en) 2006-05-03 2016-04-29 Msn Laboratories Private Limited Novel process for statins and its pharmaceutically acceptable salts thereof
SI2086945T1 (en) * 2006-10-09 2016-05-31 Msn Laboratories Private Limited Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
ES2343049B1 (en) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. BIOSYNTHESIS OF DERIVATIVES OF MONACOLINA J.
US8487105B2 (en) 2009-01-19 2013-07-16 Msn Laboratories Limited Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
US8470805B2 (en) 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof
HUE046680T2 (en) 2009-09-30 2020-03-30 Codexis Inc Improved lov-d acyltransferase mediated acylation
IN2012DN03403A (en) 2009-10-08 2015-10-23 Univ California
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
TWI462739B (en) 2010-11-02 2014-12-01 Univ Kaohsiung Medical Processes for preparing piperazinium salts of sildenafil-analogues and use thereof
CN102532184B (en) * 2010-12-21 2015-04-29 北大方正集团有限公司 Dihydroxyl protection method of lovaamide and preparation method of simvastatin
EP2983711A4 (en) 2013-04-08 2016-11-23 Cytodyn Inc Felinized antibodies and methods of treating retroviral infections in felines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof

Also Published As

Publication number Publication date
IL111546A (en) 1999-12-31
US5393893A (en) 1995-02-28
ZA948775B (en) 1995-07-10
CA2173830C (en) 1998-04-07
WO1995013283A1 (en) 1995-05-18
AU8055594A (en) 1995-05-29
IL111546A0 (en) 1995-01-24

Similar Documents

Publication Publication Date Title
CA2173830A1 (en) Process for Producing Simvastatin and Analogs Thereof
EP0380848A3 (en) Production of demurcurized synthesis gas, reducing gas, or fuel gas
IL124645A0 (en) Process for the production of 1, 2-bis (acyloxylates)
HU907113D0 (en) Process for producing analogues of 2', 3'-didesoxy-2'-fluoro-arabino-nucleoside
HU9402794D0 (en) Process for the preparation of 1,4-disubstituted-5(4h)-tetrazolinones
AU5919990A (en) Steam cracking feed gas saturation
NZ229705A (en) Process for the production of 2,6-diethylnaphthalene
EP0362651A3 (en) Process for the production of 2,6-dimethylnaphthalene
HU9503959D0 (en) Process for the preparation of substituted 4,6-diamino-5-cyanopyrimidines
EP0430714A3 (en) Process for producing 2,6-dimethylnaphthalene
EP0432580A3 (en) Two-stage process for the preparation of polycarbonates based on particular dihydroxydiphenylalcanes
WO1990009956A1 (en) Process for producing hydrogen gas
HUT71953A (en) A process for the preparation of 2,3,5,6-tetrachloro-pyridine
AU630007B2 (en) Process for producing des(64,65)-proinsulin
IL91137A0 (en) Process for the enantiospecific synthesis of intermediates for hexahydro-benzo(d)-naphtho(2,1-b)azepines
AU7929791A (en) A process for the preparation of substituted acyclic nucleosides, and intermediates occurring therein
GB9307923D0 (en) Process for the purification of 1-chloro-2,2,2-trifluroethane
EP0347021A3 (en) Process for the preparation of 2,3-dimethoxy-5-methylbenzoquinone
PT83637A (en) Process for the preparation of antidepressant 5-heterocyclic-2,4-dialkyl-3h-1,2,4-triazole-3-thiones
AU5247090A (en) New process for the synthesis of the n-methyl-3,4- dimethoxyphenylethylamine
HU910994D0 (en) Process for the production of 2/3,4dialcoxi-benzyl/-pyrrolidines
EP0505183A3 (en) Process for the preparation of (8as,12as,13as)-decahydroisoquino(2,1-g)(1,6)-naphthyridin-8-one derivatives
IL102748A0 (en) Process for the preparation of 3a,6,6,9a-tetramethyl perhydronaphtho(2,1-b)furan
EP0413526A3 (en) Process for preparing 2-deoxy-2, 2-difluoroxylose analogs and intermediates therefor
NZ238886A (en) Process for the synthesis of intermediates for hexahydrobenzo(d)naphtho(2,1-b)azepines involving reductive and isomerisation steps

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed