CA2170485A1 - Compositions Containing an Amino Acid Salt of Propionic Acid Non-Steroidal Anti-Inflammatory Agents and Caffeine - Google Patents
Compositions Containing an Amino Acid Salt of Propionic Acid Non-Steroidal Anti-Inflammatory Agents and CaffeineInfo
- Publication number
- CA2170485A1 CA2170485A1 CA2170485A CA2170485A CA2170485A1 CA 2170485 A1 CA2170485 A1 CA 2170485A1 CA 2170485 A CA2170485 A CA 2170485A CA 2170485 A CA2170485 A CA 2170485A CA 2170485 A1 CA2170485 A1 CA 2170485A1
- Authority
- CA
- Canada
- Prior art keywords
- caffeine
- amino acid
- inflammatory agents
- steroidal anti
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 title abstract 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- -1 Amino Acid Salt Chemical class 0.000 title abstract 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001948 caffeine Drugs 0.000 title abstract 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 title abstract 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 title abstract 2
- 235000019260 propionic acid Nutrition 0.000 title abstract 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compositions and methods for providing improved analgesic and/or anti-inflammatory effect by administering a safe and effective amount of a composition comprising certain amino acid salts of propionic acid non-steroidal anti-inflammatory agents along with an amount of caffeine sufficient to hasten the onset.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US117,389 | 1980-02-01 | ||
| US11738993A | 1993-09-07 | 1993-09-07 | |
| PCT/US1994/009582 WO1995007079A1 (en) | 1993-09-07 | 1994-08-24 | Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agents and caffeine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2170485A1 true CA2170485A1 (en) | 1995-03-16 |
| CA2170485C CA2170485C (en) | 2000-11-07 |
Family
ID=22372657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002170485A Expired - Fee Related CA2170485C (en) | 1993-09-07 | 1994-08-24 | Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agents and caffeine |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0717624A1 (en) |
| JP (1) | JPH09502202A (en) |
| AU (1) | AU7604194A (en) |
| BR (1) | BR9407415A (en) |
| CA (1) | CA2170485C (en) |
| WO (1) | WO1995007079A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| US5863902A (en) * | 1995-01-06 | 1999-01-26 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
| IL126998A (en) * | 1996-05-20 | 2003-12-10 | Searle & Co | Potassium, sodium or tris oxaprozin salt pharmaceutical formulations |
| CA2293605A1 (en) | 1998-04-11 | 1999-10-21 | Paolo Luca Maria Giorgetti | Pharmaceutical preparations containing hydrosoluble ketoprofen salts and their application |
| NZ508490A (en) * | 1998-07-09 | 2003-08-29 | Warner Lambert Co | Use of a combination of a GABA analog and caffeine as an analgesic |
| US6211246B1 (en) * | 1999-06-10 | 2001-04-03 | Mcneil-Ppc, Inc. | Rapidly absorbed liquid compositions |
| US20040115290A1 (en) | 2001-06-20 | 2004-06-17 | Tripp Matthew L. | Modulation of inflammation by hops fractions and derivatives |
| US8158160B2 (en) | 2001-11-13 | 2012-04-17 | Eric Hauser Kuhrts | Anti-inflammatory cyclooxygenase inhibitors |
| US7166641B2 (en) * | 2002-10-02 | 2007-01-23 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
| TWI313598B (en) * | 2002-12-18 | 2009-08-21 | Wyeth Corp | Compositions of non-steroidal anti-inflammatory drugs, decongestants and anti-histamines |
| US9149474B2 (en) * | 2011-11-23 | 2015-10-06 | Michael Leighton | Compositions and methods for treating symptoms of inflammatory related conditions using a combination of an antihistamine and a stimulant |
| US9629847B2 (en) | 2011-11-23 | 2017-04-25 | Michael Leighton | Compositions and methods for treating symptoms of inflammatory related conditions using a combination of an antihistamine and a stimulant |
| EP3406239B1 (en) * | 2017-05-22 | 2021-10-20 | Epifarma Srl | Palatable ketoprofen lysine salt solutions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4420483A (en) * | 1982-07-22 | 1983-12-13 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising ibuprofen and methods of using same |
| DE3328401A1 (en) * | 1983-08-05 | 1985-02-21 | Merckle GmbH, 7902 Blaubeuren | INJECTABLE SOLUTION FOR TREATING INFLAMMATION |
| WO1991006295A1 (en) * | 1989-11-06 | 1991-05-16 | Sepracor, Inc. | Analgesic composition containing optically pure s(+) flurbiprofen |
| US4994604A (en) * | 1990-01-10 | 1991-02-19 | Merck & Co., Inc. | Formation and resolution of ibuprofen lysinate |
| JPH08501796A (en) * | 1992-09-29 | 1996-02-27 | メルク エンド カンパニー インコーポレーテッド | Ibuprofen-caffeine formulation |
| WO1994014449A1 (en) * | 1992-12-21 | 1994-07-07 | The Procter & Gamble Company | Compositions containing caffeine and s(+)-ibuprofen or s(+)-flurbiprofen or s(+)-ketoprofen |
| AU5995094A (en) * | 1993-01-29 | 1994-08-15 | Merck & Co., Inc. | Ciclobenzaprine-caffeine combination as a muscle relaxant |
-
1994
- 1994-08-24 AU AU76041/94A patent/AU7604194A/en not_active Abandoned
- 1994-08-24 JP JP7508696A patent/JPH09502202A/en active Pending
- 1994-08-24 CA CA002170485A patent/CA2170485C/en not_active Expired - Fee Related
- 1994-08-24 EP EP94926021A patent/EP0717624A1/en not_active Withdrawn
- 1994-08-24 BR BR9407415A patent/BR9407415A/en not_active Application Discontinuation
- 1994-08-24 WO PCT/US1994/009582 patent/WO1995007079A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2170485C (en) | 2000-11-07 |
| JPH09502202A (en) | 1997-03-04 |
| EP0717624A1 (en) | 1996-06-26 |
| WO1995007079A1 (en) | 1995-03-16 |
| AU7604194A (en) | 1995-03-27 |
| BR9407415A (en) | 1996-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |