CA2097801A1 - Method of producing collagen particles, and the use of such particles as substrates for active substances - Google Patents

Method of producing collagen particles, and the use of such particles as substrates for active substances

Info

Publication number
CA2097801A1
CA2097801A1 CA002097801A CA2097801A CA2097801A1 CA 2097801 A1 CA2097801 A1 CA 2097801A1 CA 002097801 A CA002097801 A CA 002097801A CA 2097801 A CA2097801 A CA 2097801A CA 2097801 A1 CA2097801 A1 CA 2097801A1
Authority
CA
Canada
Prior art keywords
particles
collagen
cross
substrates
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002097801A
Other languages
French (fr)
Other versions
CA2097801C (en
Inventor
Jorg Kreuter
Dieter Scherer
Walter Muller
Michael Roreger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2097801A1 publication Critical patent/CA2097801A1/en
Application granted granted Critical
Publication of CA2097801C publication Critical patent/CA2097801C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes

Abstract

The invention concerns a process for the production of cross-linked collagen particles whose size lies in the micro and nanometer range, in which a solution or disper-sion of collagen in water is distributed finely in discrete droplets in a waterimmiscible organic phase, whereby emul-sifying agents are added, a water-in-oil emulsion thereby being formed, the collagen being subsequently cross-linked in the interface of the droplets, using a cross-linking agent, and the collagen particles produced in this manner being purified and isolated by separating the organic phase and washing.
CA002097801A 1990-12-06 1991-11-21 Method of producing collagen particles, and the use of such particles as substrates for active substances Expired - Lifetime CA2097801C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4038887A DE4038887A1 (en) 1990-12-06 1990-12-06 METHOD FOR THE PRODUCTION OF COLLAGEN PARTICLES AND THEIR USE AS AN ACTIVE SUBSTANCE
DEP4038887.5 1990-12-06
PCT/EP1991/002195 WO1992010287A1 (en) 1990-12-06 1991-11-21 Method of producing collagen particles, and the use of such particles as substrates for active substances

Publications (2)

Publication Number Publication Date
CA2097801A1 true CA2097801A1 (en) 1992-06-07
CA2097801C CA2097801C (en) 2002-01-22

Family

ID=6419700

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002097801A Expired - Lifetime CA2097801C (en) 1990-12-06 1991-11-21 Method of producing collagen particles, and the use of such particles as substrates for active substances

Country Status (9)

Country Link
EP (1) EP0561821B1 (en)
JP (1) JP3233631B2 (en)
AT (1) ATE116158T1 (en)
CA (1) CA2097801C (en)
DE (2) DE4038887A1 (en)
DK (1) DK0561821T3 (en)
ES (1) ES2069316T3 (en)
GR (1) GR3015518T3 (en)
WO (1) WO1992010287A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201506B2 (en) 2013-03-12 2019-02-12 Cephalon, Inc. Nanoparticulate and macroparticulate formulations

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4414755C2 (en) * 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Collagen preparation for the controlled delivery of active ingredients, processes and use
DE19624332B4 (en) * 1996-06-19 2009-12-24 Namos Gmbh Metallic nanostructure based on highly ordered proteins and methods for their production
DE19739031A1 (en) * 1997-09-05 1999-03-11 Suwelack Nachf Dr Otto Oral administration agent, its preparation and use
DE19839515B4 (en) * 1998-08-29 2012-02-02 Nanohale Gmbh New pharmaceutical preparation containing colloidal polymer-drug associations, especially for mucosal drug administration
DE19934894A1 (en) * 1999-07-24 2001-02-01 Pharma Concepts Gmbh & Co Kg Collagen particles for use as drug carriers, e.g. for administration of proteins or peptides by injection, prepared from emulsion containing collagen solution or dispersion without using crosslinking agents
DE10010113B4 (en) * 2000-03-03 2009-05-07 Wolfgang Dr. Schatton Native sponge collagen, process for its isolation and its use, as well as native nanoparticulate sponge collagen, process for its preparation and its use
AU2002229434A1 (en) * 2001-01-29 2002-08-12 Bernard B. Fresco Controlled release microsphere system for administration of drug to the eye
WO2007041627A1 (en) * 2005-10-03 2007-04-12 Pinsky Mark A Compositions and methods for improved skin care
US20080175807A1 (en) 2007-01-24 2008-07-24 Fujifilm Corporation Composition for hair
JP2008201767A (en) * 2007-01-24 2008-09-04 Fujifilm Corp Composition for hair
JP2008255020A (en) * 2007-04-02 2008-10-23 Fujifilm Corp Antiaging skin care preparation
DE102008036576A1 (en) 2008-07-31 2010-02-04 Gelita Ag Particles of collagen material and method of manufacture
CN115350328A (en) * 2022-08-19 2022-11-18 江苏西宏生物医药有限公司 Long-acting particle III type collagen implant
CN115252898B (en) * 2022-08-19 2023-08-18 江苏西宏生物医药有限公司 Long-acting microparticle type I and type V collagen composite implant
CN115317668B (en) * 2022-08-19 2023-12-29 北京西宏润美医药科技有限公司 Long-acting microparticle type I collagen implant
CN115350329A (en) * 2022-08-19 2022-11-18 江苏西宏生物医药有限公司 Long-acting particle type I and type III collagen composite implant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
JPS60174725A (en) * 1984-02-22 1985-09-09 Koken:Kk Substrate containing regenerated collagen fibril and its preparation
SE459005B (en) * 1985-07-12 1989-05-29 Aake Rikard Lindahl SET TO MANUFACTURE SPHERICAL POLYMER PARTICLES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201506B2 (en) 2013-03-12 2019-02-12 Cephalon, Inc. Nanoparticulate and macroparticulate formulations

Also Published As

Publication number Publication date
DE59104102D1 (en) 1995-02-09
DE4038887A1 (en) 1992-07-02
EP0561821B1 (en) 1994-12-28
JP3233631B2 (en) 2001-11-26
JPH06503259A (en) 1994-04-14
GR3015518T3 (en) 1995-06-30
DE4038887C2 (en) 1992-10-08
CA2097801C (en) 2002-01-22
ES2069316T3 (en) 1995-05-01
DK0561821T3 (en) 1995-06-12
EP0561821A1 (en) 1993-09-29
ATE116158T1 (en) 1995-01-15
WO1992010287A1 (en) 1992-06-25

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