CA2092074A1 - Rapidly disintegratable multiparticulate tablet - Google Patents

Rapidly disintegratable multiparticulate tablet

Info

Publication number
CA2092074A1
CA2092074A1 CA2092074A CA2092074A CA2092074A1 CA 2092074 A1 CA2092074 A1 CA 2092074A1 CA 2092074 A CA2092074 A CA 2092074A CA 2092074 A CA2092074 A CA 2092074A CA 2092074 A1 CA2092074 A1 CA 2092074A1
Authority
CA
Canada
Prior art keywords
tablet
rapidly disintegratable
multiparticulate tablet
disintegratable multiparticulate
rapidly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2092074A
Other languages
French (fr)
Other versions
CA2092074C (en
Inventor
Gerard Cousin
Etienne Bruna
Edouard Gendrot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9415391&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2092074(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2092074A1 publication Critical patent/CA2092074A1/en
Application granted granted Critical
Publication of CA2092074C publication Critical patent/CA2092074C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A rapidly disintegratable multiparticulate tablet having a mixture of excipients which is suitable for imparting a disintegration rate such that the tablet disintegrates in the mouth in an extremely short time, particularly in less than sixty seconds. The tablet is characterized in that the active substance is present in the form of coated microcrystals or optionally coated microgranules.
CA002092074A 1991-07-22 1992-07-21 Rapidly disintegratable multiparticulate tablet Expired - Lifetime CA2092074C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR919109245A FR2679451B1 (en) 1991-07-22 1991-07-22 MULTIPARTICLE TABLET WITH RAPID DELIVERY.
FR9109245 1991-07-22

Publications (2)

Publication Number Publication Date
CA2092074A1 true CA2092074A1 (en) 1993-01-23
CA2092074C CA2092074C (en) 1998-05-19

Family

ID=9415391

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002092074A Expired - Lifetime CA2092074C (en) 1991-07-22 1992-07-21 Rapidly disintegratable multiparticulate tablet

Country Status (12)

Country Link
EP (1) EP0548356B1 (en)
JP (1) JP2820319B2 (en)
KR (1) KR100197465B1 (en)
AT (1) ATE148339T1 (en)
CA (1) CA2092074C (en)
DE (1) DE69217191T2 (en)
DK (1) DK0548356T3 (en)
ES (1) ES2099275T3 (en)
FR (1) FR2679451B1 (en)
GR (1) GR3023281T3 (en)
HK (1) HK1007414A1 (en)
WO (1) WO1993001805A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8609641B2 (en) 2003-12-18 2013-12-17 Ucb Pharma Gmbh (S)-2-N-propylamino-5-hydroxytetralin as a D3-agonist
US10111832B2 (en) 2012-12-17 2018-10-30 Ethypharm Orodispersible tablets obtained by compression molding

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4318577A1 (en) * 1993-06-04 1994-12-08 Merck Patent Gmbh Lubricant-free, medicament-containing tablets
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
DE4333190C2 (en) * 1993-09-29 1996-05-30 Korsatko Werner Univ Prof Dr E Bite-coated tablet with delayed release of active ingredient
US5807577A (en) * 1995-11-22 1998-09-15 Lab Pharmaceutical Research International Inc. Fast-melt tablet and method of making same
US5807578A (en) * 1995-11-22 1998-09-15 Lab Pharmaceutical Research International Inc. Fast-melt tablet and method of making same
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
FR2766089B1 (en) * 1997-07-21 2000-06-02 Prographarm Lab IMPROVED MULTIPARTICULAR TABLET WITH RAPID DELIVERY
TW527195B (en) 1997-10-09 2003-04-11 Ssp Co Ltd Fast-soluble solid pharmaceutical combinations
FR2771291B1 (en) * 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques SPHEROIDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS
AU741992B2 (en) * 1998-03-06 2001-12-13 Adare Pharmaceuticals S.R.L. Fast disintegrating tablets
ES2274625T3 (en) 1998-05-18 2007-05-16 Takeda Pharmaceutical Company Limited REMOVABLE TABLETS IN THE MOUTH THAT INCLUDE A BENCIMIDAZOL.
FR2781793B1 (en) * 1998-08-03 2001-07-20 Prographarm Lab PROCESS FOR PRODUCING COATED GABAPENTINE GRANULES
FR2785538B1 (en) * 1998-11-06 2004-04-09 Prographarm Laboratoires PERFECTED QUICK DELIVERY TABLET
FR2785539B1 (en) 1998-11-06 2004-04-09 Prographarm Laboratoires PARTICLES COATED WITH GRANULATED CRYSTALLINE IBUPROFENE
FR2790387B1 (en) 1999-03-01 2001-05-18 Prographarm Laboratoires ORODISPERSIBLE TABLET HAVING LOW FRIABILITY AND PROCESS FOR THE PREPARATION THEREOF
GB9908014D0 (en) 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
DE19931708A1 (en) 1999-07-08 2001-01-18 Bayer Ag Process for the preparation of rapidly disintegrating solid pharmaceutical preparations
FR2795962B1 (en) * 1999-07-08 2003-05-09 Prographarm Laboratoires PROCESS FOR THE MANUFACTURE OF MASK TASTE COATED GRANULES AND IMMEDIATE RELEASE OF THE ACTIVE INGREDIENT
ATE508725T1 (en) 2001-06-20 2011-05-15 Takeda Pharmaceutical METHOD FOR PRODUCING TABLETS
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2831820B1 (en) * 2001-11-05 2004-08-20 Ethypharm Sa ORODISPERSIBLE TABLET HAVING HIGH HOMOGENEITY AND PREPARATION METHOD THEREOF
GB0204771D0 (en) * 2002-02-28 2002-04-17 Phoqus Ltd Fast disintegrating tablets
FR2837100B1 (en) 2002-03-18 2004-07-23 Flamel Tech Sa MODIFIED RELEASE MICROCAPSULE-BASED TABLETS
CN100553625C (en) 2002-04-09 2009-10-28 弗拉梅技术公司 The oral administration mixed suspension of active principle microcapsules
US20040005362A1 (en) * 2002-07-03 2004-01-08 Rajneesh Taneja Liquid dosage forms of acid labile drugs
DE10232020A1 (en) 2002-07-04 2004-02-26 Friedrich-Alexander-Universität Erlangen-Nürnberg Neuroreceptor-active heteroarenecarboxamides
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
FR2861990B1 (en) 2003-11-10 2006-02-10 Nouveaux Produits Pharma LOW DOSAGE TABLETS WITH POLYMER NETWORK
US8545881B2 (en) 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ709754A (en) 2004-10-21 2017-02-24 Adare Pharmaceuticals Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
WO2006085497A1 (en) * 2005-02-09 2006-08-17 Kissei Pharmaceutical Co., Ltd. Tablet disintegrating in the oral cavity
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US20070082048A1 (en) * 2005-06-08 2007-04-12 Ronald Warner Sleep aid formulations
ES2667944T3 (en) 2006-08-04 2018-05-16 Ethypharm Orodispersible granules and tablets containing oxycodone
ATE462416T1 (en) 2006-08-04 2010-04-15 Ethypharm Sa MULTI-LAYER OROUGH DISSOLVING TABLET
US9486446B2 (en) 2006-12-28 2016-11-08 Takeda Pharmaceutical Company Limited Orally disintegrating solid preparation
JP5228359B2 (en) * 2007-04-12 2013-07-03 ニプロ株式会社 Active ingredient particles, process for producing the same and orally disintegrating tablets
FR2920311B1 (en) * 2007-08-31 2010-06-18 Galenix Innovations SOLID COMPOSITION, ORODISPERSIBLE AND / OR DISPERSIBLE, WITHOUT A KNOWLEDGE EXCIPIENT AND PROCESS FOR PREPARING THE SAME
KR101626873B1 (en) 2007-10-01 2016-06-02 라보라토리오스 레스비, 에스.엘. orodispersible tablet
TWI441658B (en) 2008-03-11 2014-06-21 Takeda Pharmaceutical Orally-disintegrating solid preparation
FR2933299B1 (en) 2008-07-04 2012-02-03 Roquette Freres MANNITOL ORODISPERSIBLE
MX2012006240A (en) 2009-12-02 2012-10-03 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them.
FR2962331B1 (en) 2010-07-06 2020-04-24 Ethypharm PHARMACEUTICAL FORM FOR COMBATING CHEMICAL SUBMISSION, METHOD USING THE SAME
FR2962550B1 (en) 2010-07-06 2013-06-14 Ethypharm Sa METHOD FOR CONTROLLING CHEMICAL SUBMISSION, USE OF COLORING AGENT FOR COMBATING CHEMICAL SUBMISSION AND PHARMACEUTICAL COMPOSITION FOR THE IMPLEMENTATION OF THE METHOD
KR20140007364A (en) 2010-12-27 2014-01-17 다케다 야쿠힌 고교 가부시키가이샤 Orally disintegrating tablet
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
EP3449912B1 (en) 2016-06-16 2024-03-06 Towa Pharmaceutical Co., Ltd. Orally disintegrating tablet

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200178B (en) * 1986-07-23 1989-01-05 Alfa Farmaceutici Spa GALENIC FORMULATIONS WITH SCHEDULED SALE CONTAINING DRUGS WITH ANTI-FLOGISTIC ACTIVITY
EP0281200B1 (en) * 1987-03-02 1994-01-19 Yamanouchi Europe B.V. Pharmaceutical composition, pharmaceutical granulate and process for their preparation
CA2019324C (en) * 1989-07-10 1996-08-20 Robert L. Jerzewski Fosinopril tablet formulations

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8609641B2 (en) 2003-12-18 2013-12-17 Ucb Pharma Gmbh (S)-2-N-propylamino-5-hydroxytetralin as a D3-agonist
US9108900B2 (en) 2003-12-18 2015-08-18 Ucb Pharma Gmbh Method of treating diseases that respond to therapy by dopamine or dopamine agonists
US10111832B2 (en) 2012-12-17 2018-10-30 Ethypharm Orodispersible tablets obtained by compression molding

Also Published As

Publication number Publication date
DE69217191D1 (en) 1997-03-13
AU666666B2 (en) 1996-02-22
AU2417192A (en) 1993-02-23
HK1007414A1 (en) 1999-04-09
FR2679451B1 (en) 1994-09-09
ES2099275T3 (en) 1997-05-16
DK0548356T3 (en) 1997-08-11
FR2679451A1 (en) 1993-01-29
EP0548356A1 (en) 1993-06-30
KR100197465B1 (en) 1999-06-15
DE69217191T2 (en) 1997-08-28
GR3023281T3 (en) 1997-07-30
WO1993001805A1 (en) 1993-02-04
ATE148339T1 (en) 1997-02-15
EP0548356B1 (en) 1997-01-29
JP2820319B2 (en) 1998-11-05
CA2092074C (en) 1998-05-19
JPH06502194A (en) 1994-03-10

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Legal Events

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EEER Examination request
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