CA2006322A1 - Molecules d'adn recombinant, hotes, procedes et polypeptides ressemblant aux proteines vecteurs de somatomedine humaine - Google Patents
Molecules d'adn recombinant, hotes, procedes et polypeptides ressemblant aux proteines vecteurs de somatomedine humaineInfo
- Publication number
- CA2006322A1 CA2006322A1 CA2006322A CA2006322A CA2006322A1 CA 2006322 A1 CA2006322 A1 CA 2006322A1 CA 2006322 A CA2006322 A CA 2006322A CA 2006322 A CA2006322 A CA 2006322A CA 2006322 A1 CA2006322 A1 CA 2006322A1
- Authority
- CA
- Canada
- Prior art keywords
- polypeptides
- carrier protein
- dna molecules
- human
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 6
- 102000013275 Somatomedins Human genes 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 6
- 108020004511 Recombinant DNA Proteins 0.000 title abstract 4
- 102000014914 Carrier Proteins Human genes 0.000 abstract 4
- 108010078791 Carrier Proteins Proteins 0.000 abstract 4
- 108020004414 DNA Proteins 0.000 abstract 4
- 230000004071 biological effect Effects 0.000 abstract 1
- 238000011210 chromatographic step Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nutrition Science (AREA)
- Ophthalmology & Optometry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29025088A | 1988-12-22 | 1988-12-22 | |
US290,250 | 1988-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2006322A1 true CA2006322A1 (fr) | 1990-06-22 |
CA2006322C CA2006322C (fr) | 2000-08-01 |
Family
ID=23115154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002006322A Expired - Fee Related CA2006322C (fr) | 1988-12-22 | 1989-12-21 | Molecules d'adn recombinant, hotes, procedes et polypeptides ressemblant aux proteines vecteurs de somatomedine humaine |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0451194B1 (fr) |
JP (2) | JPH04503352A (fr) |
KR (1) | KR910700261A (fr) |
AT (1) | ATE155793T1 (fr) |
AU (1) | AU4836890A (fr) |
CA (1) | CA2006322C (fr) |
DE (1) | DE68928203T2 (fr) |
DK (1) | DK95291A (fr) |
ES (1) | ES2107422T3 (fr) |
GR (1) | GR3025094T3 (fr) |
HK (1) | HK1000826A1 (fr) |
IL (1) | IL92816A0 (fr) |
WO (1) | WO1990006950A1 (fr) |
ZA (1) | ZA899832B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
US5198340A (en) * | 1991-01-17 | 1993-03-30 | Genentech, Inc. | Assay for free igf-i, igf-ii, and gh levels in body fluids |
US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
US5643867A (en) * | 1992-08-26 | 1997-07-01 | Celtrix Pharmaceuticals, Inc. | Method for treating catabolic conditions |
EP0800530A4 (fr) * | 1994-07-20 | 1998-12-02 | Celtrix Pharma | Complexe igf/igfbp destines a favoriser la formation osseuse et a reguler le remodelage osseux |
US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US20030069177A1 (en) | 2000-05-16 | 2003-04-10 | Genentech, Inc. | Method for treating cartilage disorders |
EP1141014B1 (fr) | 1999-01-06 | 2004-12-08 | Genentech, Inc. | Variant mutant du facteur de croissance insulinomimetique (igf) de type i |
IL143834A0 (en) | 1999-01-06 | 2002-04-21 | Genentech Inc | Insulin-like growth factor (igf) i mutant variants |
CA2702192A1 (fr) | 2001-03-14 | 2002-09-19 | Genentech, Inc. | Peptides antagonistes d'igf |
US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
PT2274978E (pt) | 2003-09-12 | 2015-07-09 | Ipsen Biopharmaceuticals Inc | Métodos para tratamento da deficiência do fator de crescimento de tipo insulina i (igf-i) |
CA2541015A1 (fr) | 2003-10-03 | 2005-04-14 | Genentech, Inc. | Proteines de liaison a l'igf |
CA2612449A1 (fr) | 2005-06-17 | 2006-12-28 | Imclone Systems Incorporated | Antagonistes de recepteur pour le traitement de cancer osseux metastatique |
CN101484587B (zh) | 2006-02-03 | 2014-02-12 | 英克隆有限责任公司 | Igf-ir拮抗剂作为辅药用于***癌的治疗 |
KR20200097679A (ko) | 2017-09-11 | 2020-08-19 | 샤이어 휴먼 지네틱 테라피즈 인크. | 만성 폐 질환 치료를 위한 방법 및 조성물 |
MX2023004426A (es) | 2020-10-19 | 2023-08-04 | Oak Hill Bio Ltd | Composiciones adecuadas para su uso en neonatos. |
WO2023139115A1 (fr) | 2022-01-19 | 2023-07-27 | Oak Hill Bio Limited | Compositions et procédés pour réduire l'oxydation d'igf‐1/igfbp |
WO2023242440A1 (fr) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Traitement des poumons chez les nourrissons |
WO2023242439A1 (fr) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Stabilisation vasculaire (nourrissons prématurés) |
WO2023242442A1 (fr) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Procédé de maturation/différenciation de neurones et/ou de modulation du nerf vague |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
CA1322714C (fr) * | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Cicatrisation et regeneration osseuse |
US4885163A (en) * | 1987-02-24 | 1989-12-05 | Eli Lilly And Company | Topical use of IGF-II for wound healing |
WO1989008666A1 (fr) * | 1988-03-17 | 1989-09-21 | Novo-Nordisk A/S | Proteines liant l'heparine, adn codant pour ces proteines, leurs procedes de production ainsi que des preparations therapeutiques les contenant |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
ATE132164T1 (de) * | 1988-04-12 | 1996-01-15 | Amgen Boulder Inc | Verfahren zur steigerung und zur hemmung der wirkung eines insulinähnlichen wachstumfaktors |
-
1989
- 1989-12-20 IL IL92816A patent/IL92816A0/xx unknown
- 1989-12-21 ES ES90901407T patent/ES2107422T3/es not_active Expired - Lifetime
- 1989-12-21 WO PCT/US1989/005791 patent/WO1990006950A1/fr not_active Application Discontinuation
- 1989-12-21 EP EP90901407A patent/EP0451194B1/fr not_active Revoked
- 1989-12-21 AT AT90901407T patent/ATE155793T1/de not_active IP Right Cessation
- 1989-12-21 JP JP2501912A patent/JPH04503352A/ja active Pending
- 1989-12-21 KR KR1019900701824A patent/KR910700261A/ko not_active Application Discontinuation
- 1989-12-21 CA CA002006322A patent/CA2006322C/fr not_active Expired - Fee Related
- 1989-12-21 AU AU48368/90A patent/AU4836890A/en not_active Abandoned
- 1989-12-21 DE DE68928203T patent/DE68928203T2/de not_active Revoked
- 1989-12-21 ZA ZA899832A patent/ZA899832B/xx unknown
- 1989-12-21 EP EP19890313463 patent/EP0375438A3/fr active Pending
-
1991
- 1991-05-21 DK DK095291A patent/DK95291A/da unknown
-
1997
- 1997-10-20 GR GR970402735T patent/GR3025094T3/el unknown
- 1997-12-10 HK HK97102385A patent/HK1000826A1/xx not_active IP Right Cessation
-
1998
- 1998-10-23 JP JP10303047A patent/JPH11236400A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
GR3025094T3 (en) | 1998-01-30 |
KR910700261A (ko) | 1991-03-14 |
AU4836890A (en) | 1990-07-10 |
IL92816A0 (en) | 1990-09-17 |
WO1990006950A1 (fr) | 1990-06-28 |
EP0375438A2 (fr) | 1990-06-27 |
EP0375438A3 (fr) | 1992-03-25 |
ATE155793T1 (de) | 1997-08-15 |
ES2107422T3 (es) | 1997-12-01 |
ZA899832B (en) | 1990-10-31 |
EP0451194B1 (fr) | 1997-07-23 |
DE68928203T2 (de) | 1998-01-15 |
EP0451194A1 (fr) | 1991-10-16 |
EP0451194A4 (en) | 1992-09-02 |
JPH11236400A (ja) | 1999-08-31 |
CA2006322C (fr) | 2000-08-01 |
DK95291A (da) | 1991-08-16 |
DK95291D0 (da) | 1991-05-21 |
JPH04503352A (ja) | 1992-06-18 |
HK1000826A1 (en) | 1998-05-01 |
DE68928203D1 (de) | 1997-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |