CA1268767C - - Google Patents

Info

Publication number: CA1268767C
Authority: CA; Canada
Prior art keywords: isoindole; piperidinyl; oxoisoindole; substitutent; phenylalkyl
Prior art date: 1982-11-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA 440844

Other languages

English (en)

Other versions

CA1246081A (en

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-12

Filing date

1983-11-09

Publication date

1990-05-08

1983-11-09 Application filed filed Critical

1988-11-14 Priority to CA000583066A priority Critical patent/CA1268767A/en

1988-12-06 Publication of CA1246081A publication Critical patent/CA1246081A/en

1990-05-08 Application granted granted Critical

1990-05-08 Publication of CA1268767C publication Critical patent/CA1268767C/xx

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical group 0.000 abstract 2
OIXLFMOEDWMDMT-UHFFFAOYSA-N 2-(1-benzylpiperidin-4-yl)-6-chloro-3-oxo-1h-isoindole-5-sulfonamide Chemical compound C1C=2C=C(Cl)C(S(=O)(=O)N)=CC=2C(=O)N1C(CC1)CCN1CC1=CC=CC=C1 OIXLFMOEDWMDMT-UHFFFAOYSA-N 0.000 abstract 1
VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical compound C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Suspension Of Electric Lines Or Cables (AREA)
Liquid Developers In Electrophotography (AREA)
Transformer Cooling (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA000440844A 1982-11-12 1983-11-09 1-PHENYL-4-AMINOPYRIMIDINE SUBSTITUTION DERIVATIVES Expired CA1246081A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000583066A CA1268767A (en)	1982-11-12	1988-11-14	1-phenyl-containing substituent-4-animo-pyrimidinyl substituted isoindole sulfonimide compounds exhibiting diuretic and antihypertensive properties

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/441,204 US4495194A (en)	1982-11-12	1982-11-12	Antihypertensive isoindole derivatives

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000583066A Division CA1268767A (en)	1982-11-12	1988-11-14	1-phenyl-containing substituent-4-animo-pyrimidinyl substituted isoindole sulfonimide compounds exhibiting diuretic and antihypertensive properties

Publications (2)

Publication Number	Publication Date
CA1246081A CA1246081A (en)	1988-12-06
CA1268767C true CA1268767C (ja)	1990-05-08

Family

ID=23751955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000440844A Expired CA1246081A (en)	1982-11-12	1983-11-09	1-PHENYL-4-AMINOPYRIMIDINE SUBSTITUTION DERIVATIVES

Country Status (15)

Country	Link
US (1)	US4495194A (ja)
EP (1)	EP0111397B1 (ja)
JP (2)	JPS59101483A (ja)
KR (1)	KR870001168B1 (ja)
AT (1)	ATE40999T1 (ja)
AU (2)	AU566900B2 (ja)
CA (1)	CA1246081A (ja)
DE (1)	DE3379267D1 (ja)
DK (2)	DK165116C (ja)
ES (5)	ES527146A0 (ja)
FI (1)	FI82691C (ja)
GR (1)	GR81279B (ja)
IE (1)	IE56231B1 (ja)
PT (1)	PT77651B (ja)
ZA (1)	ZA838361B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU636164B2 (en) *	1982-11-12	1993-04-22	Bristol-Myers Squibb Company	2,3-dihydro-1-hydroxy-3-oxo-2-(1-substituted-4-piperidinyl)- 1N-isoindole derivatives
EP0351283A1 (fr) *	1988-07-12	1990-01-17	Synthelabo	Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique
US5356906A (en) *	1989-10-27	1994-10-18	The Du Pont Merck Pharmaceutical Company	(N-phthalimidoalkyl) piperidines useful as treatments for psychosis
WO1991006297A1 (en) *	1989-10-27	1991-05-16	The Du Pont Merck Pharmaceutical Company	(n-phthalimidoalkyl) piperidines
JP2807577B2 (ja) *	1990-06-15	1998-10-08	エーザイ株式会社	環状アミド誘導体
ES2291293T3 (es) *	2000-02-29	2008-03-01	Mitsubishi Pharma Corporation	Nuevos derivados amida ciclicos.
US8939859B2 (en)	2012-10-19	2015-01-27	Caterpillar Inc.	Torque converter with stator clutch

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3579524A (en) *	1968-06-05	1971-05-18	Miles Lab	2-aminoalkyl derivatives of phthalimidines
GB1486104A (en) *	1975-01-23	1977-09-21	Wyeth John & Brother Ltd	Phthalimidopiperidine derivatives
IL52413A (en) *	1977-06-29	1980-01-31	Teva Pharma	Process for the preparazione of 5-chloro-6-sulfamyl-isoindolinone derivatives
SE7907121L (sv) *	1979-08-27	1981-02-28	Astra Laekemedel Ab	Ftalimidinderivat

1982
- 1982-11-12 US US06/441,204 patent/US4495194A/en not_active Expired - Fee Related
1983
- 1983-11-09 CA CA000440844A patent/CA1246081A/en not_active Expired
- 1983-11-09 ZA ZA838361A patent/ZA838361B/xx unknown
- 1983-11-09 GR GR72928A patent/GR81279B/el unknown
- 1983-11-09 FI FI834112A patent/FI82691C/fi not_active IP Right Cessation
- 1983-11-10 ES ES527146A patent/ES527146A0/es active Granted
- 1983-11-11 JP JP58211113A patent/JPS59101483A/ja active Granted
- 1983-11-11 DE DE8383306911T patent/DE3379267D1/de not_active Expired
- 1983-11-11 AU AU21183/83A patent/AU566900B2/en not_active Ceased
- 1983-11-11 AT AT83306911T patent/ATE40999T1/de active
- 1983-11-11 PT PT77651A patent/PT77651B/pt not_active IP Right Cessation
- 1983-11-11 DK DK517383A patent/DK165116C/da not_active IP Right Cessation
- 1983-11-11 IE IE2638/83A patent/IE56231B1/en not_active IP Right Cessation
- 1983-11-11 EP EP83306911A patent/EP0111397B1/en not_active Expired
- 1983-11-12 KR KR1019830005375A patent/KR870001168B1/ko not_active IP Right Cessation
1984
- 1984-07-02 ES ES533939A patent/ES8600743A1/es not_active Expired
- 1984-07-02 ES ES533936A patent/ES8600740A1/es not_active Expired
- 1984-07-02 ES ES533937A patent/ES8600741A1/es not_active Expired
- 1984-07-02 ES ES533938A patent/ES533938A0/es active Granted
1987
- 1987-10-05 AU AU79369/87A patent/AU604756B2/en not_active Ceased
1990
- 1990-06-22 DK DK153690A patent/DK153690D0/da not_active IP Right Cessation
1991
- 1991-10-30 JP JP3310030A patent/JPH051058A/ja active Granted

Also Published As

Publication number	Publication date
ES8600742A1 (es)	1985-10-16
ES8504172A1 (es)	1985-04-16
JPH051058A (ja)	1993-01-08
ES533936A0 (es)	1985-10-16
EP0111397A1 (en)	1984-06-20
FI834112A (fi)	1984-05-13
CA1246081A (en)	1988-12-06
ATE40999T1 (de)	1989-03-15
DE3379267D1 (en)	1989-04-06
DK153690A (da)	1990-06-22
ES533938A0 (es)	1985-10-16
IE832638L (en)	1984-05-12
AU566900B2 (en)	1987-11-05
DK165116B (da)	1992-10-12
PT77651B (en)	1986-05-12
ES533939A0 (es)	1985-10-16
DK517383D0 (da)	1983-11-11
IE56231B1 (en)	1991-05-22
AU7936987A (en)	1988-01-14
FI82691C (fi)	1991-04-10
FI82691B (fi)	1990-12-31
JPH0450309B2 (ja)	1992-08-13
ES8600740A1 (es)	1985-10-16
JPS59101483A (ja)	1984-06-12
ES8600743A1 (es)	1985-10-16
AU2118383A (en)	1984-05-17
FI834112A0 (fi)	1983-11-09
PT77651A (en)	1983-12-01
AU604756B2 (en)	1991-01-03
ES533937A0 (es)	1985-10-16
KR840006643A (ko)	1984-12-01
DK165116C (da)	1993-03-01
ES527146A0 (es)	1985-04-16
JPH0545591B2 (ja)	1993-07-09
KR870001168B1 (ko)	1987-06-15
ES8600741A1 (es)	1985-10-16
EP0111397B1 (en)	1989-03-01
GR81279B (ja)	1984-12-11
DK153690D0 (da)	1990-06-22
US4495194A (en)	1985-01-22
ZA838361B (en)	1984-06-27
DK517383A (da)	1984-05-13

Legal Events

Date	Code	Title	Description
2005-12-06	MKEX	Expiry

Publication	Publication Date	Title
PH23325A (en)	1989-07-14	Phenyl carbamates
AU549449B2 (en)	1986-01-30	Substituted 2,4-diaminopyrimidines
DE3381909D1 (de)	1990-10-31	Phthalazin substituierte aminomethylbenzolabkoemmlinge, zusammensetzungen und verwendung.
AU2999684A (en)	1985-01-03	Substituted 2-(monoannelated (3,4-, 4,5- and 5,6-) pyridylalkylenesulfinyl)-benzimidazoles
CA1268767C (ja)	1990-05-08
ES8205218A1 (es)	1982-06-01	Un procedimiento para la preparacion de pirrolilpiperidinas utiles como agentes antidepresivo.
AU1870683A (en)	1984-03-15	Antihypertensive 4,5-diaryl-alpha-polyfluoroalkyl-ih- imidazole-2-methanamines
SU1202352A2 (ru)	1996-05-20	Маслоотделитель
ATE100452T1 (de)	1994-02-15	1-substituierte laktame enthaltende zusammensetzungen.
RO87212B1 (ro)	1985-07-31	Derivati de p-fluorbenzamida
ES1000316U (es)	1988-03-01	Soporte mejorado para cajas acusticas y similares