CA1198440A - Carbapenem antibiotiques - Google Patents

Carbapenem antibiotiques

Info

Publication number
CA1198440A
CA1198440A CA000424190A CA424190A CA1198440A CA 1198440 A CA1198440 A CA 1198440A CA 000424190 A CA000424190 A CA 000424190A CA 424190 A CA424190 A CA 424190A CA 1198440 A CA1198440 A CA 1198440A
Authority
CA
Canada
Prior art keywords
alkyl
carbon atoms
formula
group
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000424190A
Other languages
English (en)
Inventor
Choung U. Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Application granted granted Critical
Publication of CA1198440A publication Critical patent/CA1198440A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000424190A 1982-04-08 1983-03-22 Carbapenem antibiotiques Expired CA1198440A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36662782A 1982-04-08 1982-04-08
US366,627 1982-04-08

Publications (1)

Publication Number Publication Date
CA1198440A true CA1198440A (fr) 1985-12-24

Family

ID=23443823

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000424190A Expired CA1198440A (fr) 1982-04-08 1983-03-22 Carbapenem antibiotiques

Country Status (25)

Country Link
JP (1) JPS58188887A (fr)
KR (1) KR880001055B1 (fr)
AT (1) AT383126B (fr)
AU (1) AU567092B2 (fr)
BE (1) BE896407A (fr)
CA (1) CA1198440A (fr)
CH (1) CH661927A5 (fr)
DE (1) DE3312517A1 (fr)
DK (1) DK155983A (fr)
ES (1) ES8405399A1 (fr)
FI (1) FI74009C (fr)
FR (1) FR2524888B1 (fr)
GB (1) GB2118183B (fr)
GR (1) GR78822B (fr)
HU (1) HU190716B (fr)
IE (1) IE55225B1 (fr)
IL (1) IL68295A0 (fr)
IT (1) IT1168854B (fr)
LU (1) LU84739A1 (fr)
MY (1) MY8700945A (fr)
NL (1) NL8301193A (fr)
OA (1) OA07395A (fr)
PT (1) PT76518B (fr)
SE (1) SE460197B (fr)
ZA (1) ZA832411B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
AT396473B (de) * 1984-10-02 1993-09-27 Bristol Myers Squibb Co Verfahren zur herstellung von neuen carbapenemderivaten
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
EP0082133A3 (en) * 1979-04-19 1983-07-20 Merck & Co. Inc. A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
EP0038869A1 (fr) * 1980-04-30 1981-11-04 Merck & Co. Inc. Procédé de préparation de 1-carbapénèmes et intermédiaires pour leur préparation
HU185493B (en) * 1981-12-30 1985-02-28 Richter Gedeon Vegyeszet Process for producing new azabicyclo-bracket-3.2.0-bracket closedheptene derivatives
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics

Also Published As

Publication number Publication date
ES521224A0 (es) 1984-06-01
JPS58188887A (ja) 1983-11-04
IT8348061A0 (it) 1983-04-07
SE8301928L (sv) 1983-12-02
AU567092B2 (en) 1987-11-12
GB2118183A (en) 1983-10-26
GR78822B (fr) 1984-10-02
DK155983A (da) 1983-10-09
BE896407A (fr) 1983-10-07
KR840004429A (ko) 1984-10-15
DE3312517C2 (fr) 1991-10-31
AT383126B (de) 1987-05-25
MY8700945A (en) 1987-12-31
NL8301193A (nl) 1983-11-01
KR880001055B1 (ko) 1988-06-18
FI831135L (fi) 1983-10-09
LU84739A1 (fr) 1983-12-05
DE3312517A1 (de) 1983-10-20
FI74009B (fi) 1987-08-31
ES8405399A1 (es) 1984-06-01
SE8301928D0 (sv) 1983-04-07
CH661927A5 (de) 1987-08-31
IE830800L (en) 1983-10-08
FR2524888A1 (fr) 1983-10-14
AU1319883A (en) 1983-10-13
PT76518B (en) 1986-02-06
OA07395A (fr) 1984-06-30
GB8309505D0 (en) 1983-05-11
SE460197B (sv) 1989-09-18
ZA832411B (en) 1983-12-28
FR2524888B1 (fr) 1985-12-13
DK155983D0 (da) 1983-04-07
IL68295A0 (en) 1983-07-31
FI74009C (fi) 1987-12-10
IT1168854B (it) 1987-05-20
IE55225B1 (en) 1990-07-04
PT76518A (en) 1983-05-01
ATA125583A (de) 1986-10-15
FI831135A0 (fi) 1983-04-05
HU190716B (en) 1986-10-28
GB2118183B (en) 1985-11-27
JPH0524156B2 (fr) 1993-04-06

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Legal Events

Date Code Title Description
MKEX Expiry