CA1098808A - Test composition and device for determining peroxidatively active substances - Google Patents

Test composition and device for determining peroxidatively active substances

Info

Publication number: CA1098808A
Authority: CA; Canada
Prior art keywords: borate; mixtures; hydroperoxide; diluent; dimethyl
Prior art date: 1977-03-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA295,641A

Other languages

English (en)

French (fr)

Inventor

Charles T. W. Lam

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Corp

Original Assignee

Miles Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-14

Filing date

1978-01-25

Publication date

1981-04-07

1977-03-14 Priority claimed from US05/777,001 external-priority patent/US4071321A/en

1977-03-14 Priority claimed from US05/777,005 external-priority patent/US4071318A/en

1977-03-14 Priority claimed from US05/777,002 external-priority patent/US4071317A/en

1978-01-25 Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc

1981-04-07 Application granted granted Critical

1981-04-07 Publication of CA1098808A publication Critical patent/CA1098808A/en

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 117
238000012360 testing method Methods 0.000 title claims abstract description 89
239000013543 active substance Substances 0.000 title claims abstract description 26
238000000034 method Methods 0.000 claims abstract description 46
239000003085 diluting agent Substances 0.000 claims abstract description 39
-1 borate ester Chemical class 0.000 claims abstract description 32
150000002432 hydroperoxides Chemical class 0.000 claims abstract description 20
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 11
230000004044 response Effects 0.000 claims abstract description 10
125000000217 alkyl group Chemical group 0.000 claims abstract description 8
125000003118 aryl group Chemical group 0.000 claims abstract description 7
125000003545 alkoxy group Chemical group 0.000 claims abstract description 6
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 6
229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
239000001257 hydrogen Substances 0.000 claims abstract 4
125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 4
HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims description 44
HJVAFZMYQQSPHF-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;boric acid Chemical compound OB(O)O.OCCN(CCO)CCO HJVAFZMYQQSPHF-UHFFFAOYSA-N 0.000 claims description 28
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 28
NUIURNJTPRWVAP-UHFFFAOYSA-N 3,3'-Dimethylbenzidine Chemical compound C1=C(N)C(C)=CC(C=2C=C(C)C(N)=CC=2)=C1 NUIURNJTPRWVAP-UHFFFAOYSA-N 0.000 claims description 23
FRIBMENBGGCKPD-UHFFFAOYSA-N 3-(2,3-dimethoxyphenyl)prop-2-enal Chemical compound COC1=CC=CC(C=CC=O)=C1OC FRIBMENBGGCKPD-UHFFFAOYSA-N 0.000 claims description 22
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 18
239000011159 matrix material Substances 0.000 claims description 17
230000008569 process Effects 0.000 claims description 16
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 14
ITBPIKUGMIZTJR-UHFFFAOYSA-N [bis(hydroxymethyl)amino]methanol Chemical compound OCN(CO)CO ITBPIKUGMIZTJR-UHFFFAOYSA-N 0.000 claims description 9
SNCJAJRILVFXAE-UHFFFAOYSA-N 9h-fluorene-2,7-diamine Chemical compound NC1=CC=C2C3=CC=C(N)C=C3CC2=C1 SNCJAJRILVFXAE-UHFFFAOYSA-N 0.000 claims description 8
AGLSQWBSHDEAHB-UHFFFAOYSA-N azane;boric acid Chemical compound N.OB(O)O AGLSQWBSHDEAHB-UHFFFAOYSA-N 0.000 claims description 8
UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 claims description 7
HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical group C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 claims description 7
GPAPPPVRLPGFEQ-UHFFFAOYSA-N 4,4'-dichlorodiphenyl sulfone Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC=C(Cl)C=C1 GPAPPPVRLPGFEQ-UHFFFAOYSA-N 0.000 claims description 5
CIYSQIBVUOZMOU-UHFFFAOYSA-N 4-morpholin-4-ylbenzenethiol Chemical compound C1=CC(S)=CC=C1N1CCOCC1 CIYSQIBVUOZMOU-UHFFFAOYSA-N 0.000 claims description 5
HTMQZWFSTJVJEQ-UHFFFAOYSA-N benzylsulfinylmethylbenzene Chemical compound C=1C=CC=CC=1CS(=O)CC1=CC=CC=C1 HTMQZWFSTJVJEQ-UHFFFAOYSA-N 0.000 claims description 5
QUPCNWFFTANZPX-UHFFFAOYSA-M paramenthane hydroperoxide Chemical compound [O-]O.CC(C)C1CCC(C)CC1 QUPCNWFFTANZPX-UHFFFAOYSA-M 0.000 claims description 5
CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical group CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 57
SPTHWAJJMLCAQF-UHFFFAOYSA-M ctk4f8481 Chemical compound [O-]O.CC(C)C1=CC=CC=C1C(C)C SPTHWAJJMLCAQF-UHFFFAOYSA-M 0.000 claims 4
JGBAASVQPMTVHO-UHFFFAOYSA-N 2,5-dihydroperoxy-2,5-dimethylhexane Chemical compound OOC(C)(C)CCC(C)(C)OO JGBAASVQPMTVHO-UHFFFAOYSA-N 0.000 claims 2
238000005065 mining Methods 0.000 claims 1
150000001875 compounds Chemical class 0.000 abstract description 10
239000000243 solution Substances 0.000 description 26
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
239000003153 chemical reaction reagent Substances 0.000 description 14
230000035945 sensitivity Effects 0.000 description 13
150000002500 ions Chemical class 0.000 description 11
210000004369 blood Anatomy 0.000 description 10
239000008280 blood Substances 0.000 description 10
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
150000002978 peroxides Chemical class 0.000 description 8
239000000126 substance Substances 0.000 description 8
210000002700 urine Anatomy 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
235000019333 sodium laurylsulphate Nutrition 0.000 description 5
238000003860 storage Methods 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 4
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
150000002148 esters Chemical class 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
239000000463 material Substances 0.000 description 4
239000004033 plastic Substances 0.000 description 4
229920003023 plastic Polymers 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000000654 additive Substances 0.000 description 3
230000008859 change Effects 0.000 description 3
RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 3
238000007654 immersion Methods 0.000 description 3
230000009257 reactivity Effects 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
239000001509 sodium citrate Substances 0.000 description 3
239000002904 solvent Substances 0.000 description 3
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 3
229940038773 trisodium citrate Drugs 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
229960000583 acetic acid Drugs 0.000 description 2
125000003368 amide group Chemical group 0.000 description 2
238000013459 approach Methods 0.000 description 2
230000008901 benefit Effects 0.000 description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
229910052796 boron Inorganic materials 0.000 description 2
150000001642 boronic acid derivatives Chemical class 0.000 description 2
239000000470 constituent Substances 0.000 description 2
YQHLDYVWEZKEOX-UHFFFAOYSA-N cumene hydroperoxide Chemical compound OOC(C)(C)C1=CC=CC=C1 YQHLDYVWEZKEOX-UHFFFAOYSA-N 0.000 description 2
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000003365 glass fiber Substances 0.000 description 2
230000006872 improvement Effects 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000725 suspension Substances 0.000 description 2
SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 2
RVNSAAIWCWTCTJ-ZPQYLTHOSA-N (2s,3s,4r)-2-(1,2-dihydroxyethyl)pyrrolidine-3,4-diol Chemical compound OCC(O)[C@@H]1NC[C@@H](O)[C@H]1O RVNSAAIWCWTCTJ-ZPQYLTHOSA-N 0.000 description 1
PYKLUAIDKVVEOS-RAXLEYEMSA-N (e)-n-(cyanomethoxy)benzenecarboximidoyl cyanide Chemical compound N#CCO\N=C(\C#N)C1=CC=CC=C1 PYKLUAIDKVVEOS-RAXLEYEMSA-N 0.000 description 1
FTTATHOUSOIFOQ-UHFFFAOYSA-N 1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2-a]pyrazine Chemical compound C1NCCN2CCCC21 FTTATHOUSOIFOQ-UHFFFAOYSA-N 0.000 description 1
HFDLDPJYCIEXJP-UHFFFAOYSA-N 6-methoxyquinoline Chemical compound N1=CC=CC2=CC(OC)=CC=C21 HFDLDPJYCIEXJP-UHFFFAOYSA-N 0.000 description 1
BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 description 1
101100515517 Arabidopsis thaliana XI-I gene Proteins 0.000 description 1
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
238000006066 Comins reaction Methods 0.000 description 1
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
241000252163 Elops Species 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
241001527806 Iti Species 0.000 description 1
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
102000036675 Myoglobin Human genes 0.000 description 1
108010062374 Myoglobin Proteins 0.000 description 1
BVMWIXWOIGJRGE-UHFFFAOYSA-N NP(O)=O Chemical class NP(O)=O BVMWIXWOIGJRGE-UHFFFAOYSA-N 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
102000003992 Peroxidases Human genes 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
240000001987 Pyrus communis Species 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
239000002390 adhesive tape Substances 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
125000002648 azanetriyl group Chemical group *N(*)* 0.000 description 1
FYABMGZBIRRBQY-UHFFFAOYSA-N benzene;hydrogen peroxide Chemical compound OO.C1=CC=CC=C1 FYABMGZBIRRBQY-UHFFFAOYSA-N 0.000 description 1
125000002619 bicyclic group Chemical group 0.000 description 1
238000009534 blood test Methods 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
238000006555 catalytic reaction Methods 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
238000001311 chemical methods and process Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical compound C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
NJSUFZNXBBXAAC-UHFFFAOYSA-N ethanol;toluene Chemical compound CCO.CC1=CC=CC=C1 NJSUFZNXBBXAAC-UHFFFAOYSA-N 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000004744 fabric Substances 0.000 description 1
230000002550 fecal effect Effects 0.000 description 1
239000000835 fiber Substances 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
238000002156 mixing Methods 0.000 description 1
KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
150000001451 organic peroxides Chemical class 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
230000003617 peroxidasic effect Effects 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000006479 redox reaction Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
238000012764 semi-quantitative analysis Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
150000003457 sulfones Chemical class 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
239000012085 test solution Substances 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
239000002699 waste material Substances 0.000 description 1
238000007704 wet chemistry method Methods 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/725—Haemoglobin using peroxidative activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
- C12Q2326/10—Benzidines
- C12Q2326/14—Ortho-Tolidine, i.e. 3,3'-dimethyl-(1,1'-biphenyl-4,4'-diamine)

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Hematology (AREA)
Organic Chemistry (AREA)
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Zoology (AREA)
Urology & Nephrology (AREA)
Microbiology (AREA)
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Biomedical Technology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pathology (AREA)
Biophysics (AREA)
General Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

CA295,641A 1977-03-14 1978-01-25 Test composition and device for determining peroxidatively active substances Expired CA1098808A (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US777,001		1977-03-14
US777,005		1977-03-14
US05/777,001 US4071321A (en)	1977-03-14	1977-03-14	Test composition and device for determining peroxidatively active substances
US05/777,005 US4071318A (en)	1977-03-14	1977-03-14	Test composition and device for determining peroxidatively active substances
US777,002		1977-03-14
US05/777,002 US4071317A (en)	1977-03-14	1977-03-14	Test composition and device for determining peroxidatively active substances and process for preparing same

Publications (1)

Publication Number	Publication Date
CA1098808A true CA1098808A (en)	1981-04-07

Family

ID=27419729

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA295,641A Expired CA1098808A (en)	1977-03-14	1978-01-25	Test composition and device for determining peroxidatively active substances

Country Status (12)

Country	Link
JP (1)	JPS53115288A (de)
AR (1)	AR220329A1 (de)
AU (1)	AU3279478A (de)
BR (1)	BR7800603A (de)
CA (1)	CA1098808A (de)
DE (2)	DE2857298C2 (de)
FR (1)	FR2384261A1 (de)
GB (1)	GB1552747A (de)
HU (1)	HU177004B (de)
IN (1)	IN148528B (de)
IT (1)	IT1104148B (de)
SE (1)	SE430104B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4318984A (en) *	1979-11-13	1982-03-09	Miles Laboratories, Inc.	Stabilized composition, test device, and method for detecting the presence of a sugar in a test sample
US4290773A (en) *	1979-11-13	1981-09-22	Miles Laboratories, Inc.	Stabilization of benzidine-type indicators with various enhancers
JPS56147066A (en) *	1980-04-17	1981-11-14	Terumo Corp	Specimen for detection of latent blood
DE3048662A1 (de) *	1980-12-23	1982-07-22	Boehringer Mannheim Gmbh, 6800 Mannheim	Stabilisierte zubereitung von tetrazoliumsalzen
US4340669A (en) *	1981-02-12	1982-07-20	Miles Laboratories, Inc.	System for the determination of glucose in fluids
DE3425118A1 (de) *	1984-07-07	1986-01-16	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue redox-indikatoren
JP2610460B2 (ja) *	1987-12-03	1997-05-14	大日本印刷株式会社	潜血検出用組成物およびそれを用いた検査体
EP3036541B1 (de) *	2013-08-16	2019-06-12	Hach Company	Testelement für die analyse von chlor, stabilisierte n,n-diethyl-p-phenylendiamin-lösung sowie verfahren zur herstllung des testelements

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1943580B2 (de) *	1969-08-27	1971-08-05		Reagens zur blutzuckerbestimmung
DE2235127C2 (de) *	1972-07-18	1974-08-08	Boehringer Mannheim Gmbh, 6800 Mannheim	Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten

1978
- 1978-01-25 CA CA295,641A patent/CA1098808A/en not_active Expired
- 1978-01-27 AU AU32794/78A patent/AU3279478A/en active Pending
- 1978-01-30 DE DE2857298A patent/DE2857298C2/de not_active Expired
- 1978-01-30 DE DE2803955A patent/DE2803955C3/de not_active Expired
- 1978-01-30 HU HU78MI629A patent/HU177004B/hu unknown
- 1978-01-31 AR AR270911A patent/AR220329A1/es active
- 1978-01-31 BR BR7800603A patent/BR7800603A/pt unknown
- 1978-01-31 FR FR7802592A patent/FR2384261A1/fr active Granted
- 1978-01-31 SE SE7801164A patent/SE430104B/sv not_active IP Right Cessation
- 1978-01-31 JP JP897778A patent/JPS53115288A/ja active Granted
- 1978-01-31 IT IT7847859A patent/IT1104148B/it active
- 1978-02-17 GB GB6419/78A patent/GB1552747A/en not_active Expired
- 1978-03-20 IN IN211/DEL/78A patent/IN148528B/en unknown

Also Published As

Publication number	Publication date
BR7800603A (pt)	1978-10-03
FR2384261A1 (fr)	1978-10-13
GB1552747A (en)	1979-09-19
DE2803955A1 (de)	1978-09-21
SE430104B (sv)	1983-10-17
DE2803955C3 (de)	1981-04-23
FR2384261B1 (de)	1984-06-29
JPS6122780B2 (de)	1986-06-03
DE2803955B2 (de)	1980-07-03
IT7847859A0 (it)	1978-01-31
HU177004B (hu)	1981-06-28
JPS53115288A (en)	1978-10-07
IN148528B (de)	1981-03-21
IT1104148B (it)	1985-10-14
AU3279478A (en)	1979-08-02
DE2857298C2 (de)	1984-03-22
SE7801164L (sv)	1978-09-15
AR220329A1 (es)	1980-10-31

Legal Events

Date	Code	Title	Description
1998-04-07	MKEX	Expiry
2023-05-26	MKEX	Expiry	Effective date: 19980407

Publication	Publication Date	Title
US4071317A (en)	1978-01-31	Test composition and device for determining peroxidatively active substances and process for preparing same
US4071321A (en)	1978-01-31	Test composition and device for determining peroxidatively active substances
US4071318A (en)	1978-01-31	Test composition and device for determining peroxidatively active substances
EP0123115B1 (de)	1987-07-01	Ascorbat-interferenzbeständige Zusammensetzung, Vorrichtung und Verfahren zur Bestimmung von peroxidatisch wirksamen Substanzen
US4556640A (en)	1985-12-03	Stabilized test composition, device and method for the determination of peroxidatively active substances
EP0444263B1 (de)	1995-09-13	Verbesserte Zusammensetzung, Vorrichtung und Verfahren zur Untersuchung einer peroxidativ aktiven Substanz
EP0230229B1 (de)	1991-09-25	Stabile Zusammensetzung zum Nachweis von Stoffen mit Peroxidase-Aktivität
JP2928649B2 (ja)	1999-08-03	過酸化活性物質の検定のための組成物、用具及び方法
EP0029917B1 (de)	1985-02-20	Indikator-Zusammensetzung und Aminoxid enthaltende Testvorrichtung
US4447542A (en)	1984-05-08	Analytical test composition, device and method for the determination of peroxidatively active substances
JPS5813398A (ja)	1983-01-25	過酸化水素もしくは過酸化水素を形成する基質またはペルオキシダ−ゼもしくはペルオキシダ−ゼのように作用する物質を検出するための剤および方法
CA1098808A (en)	1981-04-07	Test composition and device for determining peroxidatively active substances
US4855228A (en)	1989-08-08	Multiple oxidative indicator system for visual determination of hydrogen peroxide
EP0043469B1 (de)	1985-01-16	Interferenzbeständige Testvorrichtung zum Bestimmen einer Substanz mit peroxidativer Aktivität in einer Testprobe und Verfahren zu deren Herstellung
JPH0418630B2 (de)	1992-03-27
CS219888B2 (cs)	1983-03-25	Zkušební prostředek pro stanovení přítomnosti peroxidačně účinných látek
EP0121191A2 (de)	1984-10-10	Analytische Testzusammensetzung, Vorrichtung, Verfahren zu ihrer Herstellung und zur Bestimmung von peroxidatisch wirkenden Substanzen