CA1064798A - Germicidal cleansening compositions - Google Patents
Germicidal cleansening compositionsInfo
- Publication number
- CA1064798A CA1064798A CA235,368A CA235368A CA1064798A CA 1064798 A CA1064798 A CA 1064798A CA 235368 A CA235368 A CA 235368A CA 1064798 A CA1064798 A CA 1064798A
- Authority
- CA
- Canada
- Prior art keywords
- iodine
- weight
- fatty alcohols
- germicidal
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
- C11D3/485—Halophors, e.g. iodophors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
A germicidal cleansening composition of matter, in semi-solid form, comprising in combination:
a. at least 20 weight-% of one or two members of the group consisting of sulfated fatty alcohols (C14 to C26) and of sulfosuccinates of fatty alcohols (C12 to C24);
b, between i weight-% and 20 weight-% of an organic iodine complex or of solubilized inorganic iodine;
c. a quantity of not exceeding about 10 weight-% of water;
d. at least about 20-weight-% of one or more members of the group consisting of saturated fatty alcohols (C14 to C26), saturated fatty acids (C14 to C20) and succinates or maleates of fatty alcohols (C10 to C24).
Preferred iodine compounds are iodophors, such as PVP-iodine, undecoylum-chloride iodine, imidazoline iodine;
or inorganic iodine compounds such as iodine and an alkali metal iodine.
A germicidal cleansening composition of matter, in semi-solid form, comprising in combination:
a. at least 20 weight-% of one or two members of the group consisting of sulfated fatty alcohols (C14 to C26) and of sulfosuccinates of fatty alcohols (C12 to C24);
b, between i weight-% and 20 weight-% of an organic iodine complex or of solubilized inorganic iodine;
c. a quantity of not exceeding about 10 weight-% of water;
d. at least about 20-weight-% of one or more members of the group consisting of saturated fatty alcohols (C14 to C26), saturated fatty acids (C14 to C20) and succinates or maleates of fatty alcohols (C10 to C24).
Preferred iodine compounds are iodophors, such as PVP-iodine, undecoylum-chloride iodine, imidazoline iodine;
or inorganic iodine compounds such as iodine and an alkali metal iodine.
Description
The present invention relates to novel germicidal cleansening compositions of matter, in semi-solid form, the ger-micidal action of which is based on the combined effect of iodo-phors or on inorganic iodine and iodine compounds, in combination with constituents giving a detergent effect. The novel composi-tions of matter are of special use for disinfecting various items in hospitals and the like, for use before surgery and the like.
The novel products according to the present invention are substan-tially non-hygroscopic, non-corrosive and they have a long-lasting germicidal or germistatic effect and they are enhanced by outstand-ing detergent properties. The term "semi-solid form" defines a form like that of soap bars or of solid detergent sticks or the like.
The novel compositions according to the present inven tion comprise essentially in combination:
a) at least 20 weight-% of one or two of the group consisting of sulfated fatty alcohols (C14 to C26) and of sulfosuccinates of fatty alcohols (C12 to C24);
b) between l weight-% and 20 weight-% of an organic iodine com-plex or of solubilized inorganic iodine;c) a quantity of not exceeding about 10 weight-% of water;
d) at least about 20 weight-% of one or more members of the group consisting of saturated fatty alcohols ~C14 to C26), saturated fatty acids (C14 to C20) and succinates or maleates of fatty al-cohols (C10 to C24). Preferred iodine compounds are iodophors, such as PVP-iodine, undecoylum-chloride iodine, imidazoline iodine;
or inorganic iodine compounds such as iodine and an alkali metal iodide.
Other and further more detailed aspects of the invention will become apparent hereinafter.
There are known various germicidal preparations based on iodophors, such as, for example, those described in U.S. Patent 3~
No. 3,687,855 and in German Patents 2,123,551 and 2,166,215 These contain considerable quantities of extenders, such as poly-ethylene glycol and other polyhydroxy compounds. The inclusion of these was considered imperatiYe according to these patents.
According to the present invention there is provided a no~el composition of matter devoid of such extenders. The novel composition of matter comprises a sulfosuccinate and/or succinate of fatty alcohols and this obviates the necessity for the inclu-sion of bulky extenders which are inert and non-active. The pre-sence of the sulfosuccinates and/or succinates enhances the deter-gent properties of the novel composition o~ ma~ter and increases the germicidal properties of same due to the synergistic proper-ties of this mixture.
As set out above, the novel germicidal cleansening com-positions in semi-solid form according to the present invention comprise at least 20 weight-% and up to about 70 weight-% of one or two members of the group consisting of sulfated fatty alcohols and sulfosuccinates of fatty alcohols; between about 1 weight-%
and 20 weight-% of an organic iodine complex or of solubilized inorganic iodine; a quantity of up to about 10 weight-% of water;
at least about 20 weight-% of one or more of: saturated fatty alcohols, saturated fatty acids and succinates or maleates of fatty alcohols. In these, the carbon-atom range is as defined aboveO The saturated fatty alcohols are preferably of the R-OH
type, where R designates alkyl of about 14 to 26 carbon atoms.
The sulfated fatty alcohols are of the R'-O-S02-ONa type, where Rl designates alkyl of 10 to about 26 carbon atoms. The fatty acids are of the type R"-COOH where R~' is alkyl of about 14 to 20 carbon atoms. The sulfosuccinates are mono- and/or di-sulfo-succi-nates of fatty alcohols of the respective formulas:
//o ~ o CH - -; C CH2 OR
H2 ~ C ~ ~H2- ~ C ~
ONa \ OR2 ~nd Nn ~0 CH - C ~ N SO C~ _ C ~ORl / ONa ~ OR2 H2C -- C H2-- C ~ o wherein Rl and R2, which may be identical or different, ea~h re-presents an alkyl group or an alkoxylated alkyl group.
Suitable active iodine compounds are those generally known as "iodophors" i.e. products wherein a surface active agent serves as carrier and solubili7ing aglent for iodine, compounds such as PVP-I iodine-polyvinylpyrrolidone complex; undecoylum-chloride iodine, imidazoline iodine and the like or inorganic iodine such as iodine in combination with an alkali metal iodide such as potassium iodide or sodium iodide. These constitute about 1 to 20 per cent by weight of the compositions of the invention, ~` the preferred range being about 2 to 10 weight-%. Various of the different active iodine complexes and compounds were tested and satisfactory results were obtained. It is evident that the com-bination of such active iodine complexes or compounds with the other constituents of the novel compositions result in a syner-gistic germicidal effect.
- The iodine content of the compositions can be varied according to the desired use and degree of germicidal activity.
It is known that concentrations as low as about 10 ppm of iodophor in aqueous systems exhibit a pronounced batceriostatic effect.
The two components sulfated fatty alcohols and sulfosuc-cinates (as defined above) of fatty alcohols are substantially 7a31 3 interchangeable, and these impart the main detergent properties to the novel compositions. The novel compositions contain gene-rally not less than about 20 weight-% of these two or of one of these.
The saturated fatty alcohols, saturated fatty acids and also the succinate of fatty alcohols impart advantageous derma-tological characteristics to the compositions of the invention.
These two are interchangeable to a large extent. The choice of the relative quantities depends to a large extent on the desired quantity of lather desixed. A part or all of the succinate used in the compositions of the present invention may be replaced by corresponding quantities of maleates.
Satisfactory results can be achieved with various com-binations of the 3 ingredients: saturated fatty alcohols, satu-rated fatty acids and succinates (or partially maleates) of fatty alcohols, which comprise about up to 70 to 80 parts by weight of the compositions of the present invention. These (or any of these) three in~redients ought to constitute at least about 20 parts by weight o~ the compositions of the invention. When such low quan-tities o~ these are used, the other components such as sul~atPdfatty alcohols and/or sulfosuccinates of fatty alcohols will cons-titute a correspondingly higher percentage of the composition.
Such compositions have a high lathering actîvity.
The sulfosuccinates have a pH in the desired acid range, and the succinate has also a pH in the desired acid range. These serve also as bu~fering agents in this range.
The novel germicidal semi-solid preparations are advan-tageously prepared by heating the various ingredients together at an elevated temperature, to obtain an intimate fluid or semi-fluid mixture, cooling the mixture to a lower temperature at which it is still in a semi-fluid extrudable state, adding thereto the iodine-complex, or inorganic iodine, and extruding, casting or 7~
shaping by other means the product in a desired shape, such as bar, stick or the like Some of the preparations were initially heated to about 70-85C., cooled to about 50-65C., the iodine complex or inor-ganic iodine was added and the desired shape of the final product was prepared.
The pH of the preparation is advantageously adjusted -to a pH in the acid range, which ought to be in the range suited for dermal applications. The best pH is about pH 5, and this can be attained by the addition of suitable physiologically acceptable acids. Various organic acids are suited for this purpose; so is phosphoric acid. The fatty acids are advantageously part of the compositions of the present invention, but these do not form an imperative part thereof.
Example 1 70 parts by weight lauryl alcohol sulfate (90% active ingredient, 10% water) was heated to ,B0C. and mixed with 20 parts acetyl/steary alcohol and 5 parts stearic acid. The pH was ad-justed by the addition of lactic acid (about 1% by weight) to pH
5.0 and 4 parts P V P.-Iodine was added at a temperature of 55C.
` The product was cast in the form of soap-bars.
Example 2 A preparation was prepared from 45 per cent by weight fatty alcohol sulfates (60% lauryl, 30% myristyl and 10% cetyl alcohol) and this was mixed with 20% myristyl sulfosuccinate.
; After heating to 80C. the mixture was admixed with 24% of itæ
weight of technical grade cetyl/stearyl alcohol. The pH was ad-justed by addition of phosphoric acid to pH 5, cooled to 60C.
and 10% by weight of polyvinyl pyrrolidone iodine was added. The mixture was extruded in the form of soap bars.
The following preparations, given in the form of a Table illustrate the composition of a number of variations ac-cording to the present invention. It ought to be clearly under-stood that the percentages of the ingredients are not critical, and that these may be varied within certain limits without depart-ing from the scope and spirit of the present invention. The various percentages are to be adjusted mutually, and these depend also to a certain extent on the desired degree oF hardness of the product.
The following preparations were made as set out above, parts are by weight:
I II III IV V VI VII ~III
Sulfated fatty alcohols (C10-C26): 20 30 35 40 30 30 20 Saturated fatty alcohols (C14-C26): 25 18 15 5 7 20 15 35 Saturated fatty acidS (C14 C20) 8 - 5 10 - 10 46 15 Sulfosuccinate of fatty alcohols (~12 C24) 35 36 18 18 40 0 17 10 Succinate of fatty alcohols (C10 C24): 5 9 14 _ 24 10 10 Iodophor (PVP-I or non-ionic detergent-I complex): 7 10 10 5 15 10 2 0 Iodine and KI: 0 0 0 0 0 0 0 5 Water: - 5 8 8 8 6 5 5 Instead of the organic iodine complexes there may be used inorganic iodine preparations, such as for example, compo-sitions containing iodine and an alkali metal iodide, such as potassium iodide, dissolved in a suitable quantity of water. For example, 20 wt-% iodine, 40 wt-% potassium iodide and 40 wt-%
water give a suitable solution. A quantity of 4 g. of this solu-tion incorporated in 96 g. of detergent mixture according to the invention ~with no organic iodine complex) gave satisfactory de-tergent and antiseptic results.
Similar compositions were prepared, containing a quantity of an organic acid such as citric or lactic acid, adapted to adjust the pH to a value of about 5-5.5.
Stability:
The stability of the novel germicidal preparations according to the present invention was tested The tests carried out have shown that, for example, a preparation according to the present invention containing 10 per cent by weight Povidone Iodine (pH 5.3) lost only 6 per cent of the available iodine during a period of storage of 50 days at 50C. A liquid detergent preparation, available commercially, containing the same initial percentage of iodine lost 27 per cent available iodine at 50C during 30 days. Comparative tests have shown the superiority of preparations according to the present invention as regards storage, compared with other commercial pre-parations containing Povidone Iodine.
The pH of the preparations according to the present invention is an optimum as regards the activity of the iodine.
It is known that the bactericidal efflcacy of iodine and of orga-nic iodine preparations is increased when the pH is lowered. A
pH of below 6 is generally suggested, the activity being still better at a pH of about 5 or below this value.
; The preparation according to the present invention has a pH in the optimal range, while the advantageous detergent pro-perties o~ a good soap are maintained. The preparations according to the present invention are not detrimentally effected by hard water No "ring" is formed in the bathtub and no precipitates are formed with hard water or with salts such as magnesium or calcium salts.
The pH of the preparation according to the present invention can be adjusted to the desired value by the addition of various physiologically acceptable acids such as lactic acid, citric acid, phosphoric acid, fumaric acid, tartaric acid and the like.
The novel preparations according to the present inven-tion have a further advantage, namely the enhanced effect of the detergent and o~ the organic iodine compounds. In soaps contain-ing organic iodine compounds, hard water causes the formation of a precipitate and this impairs the antibacterial ef~ectivity. The novel compositions are not adversely affected by hard waterJ and the detergent effect and the bacteriacidal effect of the organic iodine compound complement each other and a certain synergism is obtained.
Conventional soaps used in places like hospitals are often the source of cross-infections due to the fact that bacte-ria may survive on the surface of such solid soap bars and infect subsequent users.
The bactericidal effect of the novel preparations is so strong that practically no patogenic microorganism will sur-vive on the surface of a preparation according to the invention.
This property is of special importance for use in hospitals, in the case o~ epidemics, in military medicine, nurseries and other publi~ places.
Bacteriological Tests:
A bar was prepared according to Example 4, ænd a sus-pension of 6.10 stphylococci was applied onto the surface of the bar, which had been wetted with tap water 3 minutes before. Sixty seconds after the application of the bacteria, a swab was taken and cultured. No bacteria survived.
A control was carried out with conventional toilet soap, and over 1000 bacteria were counted.
A suspension of about 10 pseudomonas aeruginosa was applied to the palm of a human hand and spread thereon. The hand was washed with soap during two minutes of scrubbing and rinsed with water. About 680 microorganisms were counted.
4~98 A parallel test with a bar o~ the novel preparation according to Example 4 resulted in zero survival of microorga-nisms.
A slurry was prepared comprising 10 g. of a composition according to preparation No. III in 20 ml. of water. A quantity of Pseudomonas Aeroginosa was introduced into the slurry so as to obtain a final concentration of 105 microorganisms per ml, After 30 minutes, a sample was taken and examined.
No bacteria survived alive.
A similar experiment was carried out with regular soap at similar concentrations in water and of bacteria. After 30 minutes the bacteria survived. Even after 2 hours they were 3still alive.
Similar results were obtained with analogous prepara-tions containing inorganic iodine in combination with sodium iodide or potassium iodide.
The novel products according to the present invention are substan-tially non-hygroscopic, non-corrosive and they have a long-lasting germicidal or germistatic effect and they are enhanced by outstand-ing detergent properties. The term "semi-solid form" defines a form like that of soap bars or of solid detergent sticks or the like.
The novel compositions according to the present inven tion comprise essentially in combination:
a) at least 20 weight-% of one or two of the group consisting of sulfated fatty alcohols (C14 to C26) and of sulfosuccinates of fatty alcohols (C12 to C24);
b) between l weight-% and 20 weight-% of an organic iodine com-plex or of solubilized inorganic iodine;c) a quantity of not exceeding about 10 weight-% of water;
d) at least about 20 weight-% of one or more members of the group consisting of saturated fatty alcohols ~C14 to C26), saturated fatty acids (C14 to C20) and succinates or maleates of fatty al-cohols (C10 to C24). Preferred iodine compounds are iodophors, such as PVP-iodine, undecoylum-chloride iodine, imidazoline iodine;
or inorganic iodine compounds such as iodine and an alkali metal iodide.
Other and further more detailed aspects of the invention will become apparent hereinafter.
There are known various germicidal preparations based on iodophors, such as, for example, those described in U.S. Patent 3~
No. 3,687,855 and in German Patents 2,123,551 and 2,166,215 These contain considerable quantities of extenders, such as poly-ethylene glycol and other polyhydroxy compounds. The inclusion of these was considered imperatiYe according to these patents.
According to the present invention there is provided a no~el composition of matter devoid of such extenders. The novel composition of matter comprises a sulfosuccinate and/or succinate of fatty alcohols and this obviates the necessity for the inclu-sion of bulky extenders which are inert and non-active. The pre-sence of the sulfosuccinates and/or succinates enhances the deter-gent properties of the novel composition o~ ma~ter and increases the germicidal properties of same due to the synergistic proper-ties of this mixture.
As set out above, the novel germicidal cleansening com-positions in semi-solid form according to the present invention comprise at least 20 weight-% and up to about 70 weight-% of one or two members of the group consisting of sulfated fatty alcohols and sulfosuccinates of fatty alcohols; between about 1 weight-%
and 20 weight-% of an organic iodine complex or of solubilized inorganic iodine; a quantity of up to about 10 weight-% of water;
at least about 20 weight-% of one or more of: saturated fatty alcohols, saturated fatty acids and succinates or maleates of fatty alcohols. In these, the carbon-atom range is as defined aboveO The saturated fatty alcohols are preferably of the R-OH
type, where R designates alkyl of about 14 to 26 carbon atoms.
The sulfated fatty alcohols are of the R'-O-S02-ONa type, where Rl designates alkyl of 10 to about 26 carbon atoms. The fatty acids are of the type R"-COOH where R~' is alkyl of about 14 to 20 carbon atoms. The sulfosuccinates are mono- and/or di-sulfo-succi-nates of fatty alcohols of the respective formulas:
//o ~ o CH - -; C CH2 OR
H2 ~ C ~ ~H2- ~ C ~
ONa \ OR2 ~nd Nn ~0 CH - C ~ N SO C~ _ C ~ORl / ONa ~ OR2 H2C -- C H2-- C ~ o wherein Rl and R2, which may be identical or different, ea~h re-presents an alkyl group or an alkoxylated alkyl group.
Suitable active iodine compounds are those generally known as "iodophors" i.e. products wherein a surface active agent serves as carrier and solubili7ing aglent for iodine, compounds such as PVP-I iodine-polyvinylpyrrolidone complex; undecoylum-chloride iodine, imidazoline iodine and the like or inorganic iodine such as iodine in combination with an alkali metal iodide such as potassium iodide or sodium iodide. These constitute about 1 to 20 per cent by weight of the compositions of the invention, ~` the preferred range being about 2 to 10 weight-%. Various of the different active iodine complexes and compounds were tested and satisfactory results were obtained. It is evident that the com-bination of such active iodine complexes or compounds with the other constituents of the novel compositions result in a syner-gistic germicidal effect.
- The iodine content of the compositions can be varied according to the desired use and degree of germicidal activity.
It is known that concentrations as low as about 10 ppm of iodophor in aqueous systems exhibit a pronounced batceriostatic effect.
The two components sulfated fatty alcohols and sulfosuc-cinates (as defined above) of fatty alcohols are substantially 7a31 3 interchangeable, and these impart the main detergent properties to the novel compositions. The novel compositions contain gene-rally not less than about 20 weight-% of these two or of one of these.
The saturated fatty alcohols, saturated fatty acids and also the succinate of fatty alcohols impart advantageous derma-tological characteristics to the compositions of the invention.
These two are interchangeable to a large extent. The choice of the relative quantities depends to a large extent on the desired quantity of lather desixed. A part or all of the succinate used in the compositions of the present invention may be replaced by corresponding quantities of maleates.
Satisfactory results can be achieved with various com-binations of the 3 ingredients: saturated fatty alcohols, satu-rated fatty acids and succinates (or partially maleates) of fatty alcohols, which comprise about up to 70 to 80 parts by weight of the compositions of the present invention. These (or any of these) three in~redients ought to constitute at least about 20 parts by weight o~ the compositions of the invention. When such low quan-tities o~ these are used, the other components such as sul~atPdfatty alcohols and/or sulfosuccinates of fatty alcohols will cons-titute a correspondingly higher percentage of the composition.
Such compositions have a high lathering actîvity.
The sulfosuccinates have a pH in the desired acid range, and the succinate has also a pH in the desired acid range. These serve also as bu~fering agents in this range.
The novel germicidal semi-solid preparations are advan-tageously prepared by heating the various ingredients together at an elevated temperature, to obtain an intimate fluid or semi-fluid mixture, cooling the mixture to a lower temperature at which it is still in a semi-fluid extrudable state, adding thereto the iodine-complex, or inorganic iodine, and extruding, casting or 7~
shaping by other means the product in a desired shape, such as bar, stick or the like Some of the preparations were initially heated to about 70-85C., cooled to about 50-65C., the iodine complex or inor-ganic iodine was added and the desired shape of the final product was prepared.
The pH of the preparation is advantageously adjusted -to a pH in the acid range, which ought to be in the range suited for dermal applications. The best pH is about pH 5, and this can be attained by the addition of suitable physiologically acceptable acids. Various organic acids are suited for this purpose; so is phosphoric acid. The fatty acids are advantageously part of the compositions of the present invention, but these do not form an imperative part thereof.
Example 1 70 parts by weight lauryl alcohol sulfate (90% active ingredient, 10% water) was heated to ,B0C. and mixed with 20 parts acetyl/steary alcohol and 5 parts stearic acid. The pH was ad-justed by the addition of lactic acid (about 1% by weight) to pH
5.0 and 4 parts P V P.-Iodine was added at a temperature of 55C.
` The product was cast in the form of soap-bars.
Example 2 A preparation was prepared from 45 per cent by weight fatty alcohol sulfates (60% lauryl, 30% myristyl and 10% cetyl alcohol) and this was mixed with 20% myristyl sulfosuccinate.
; After heating to 80C. the mixture was admixed with 24% of itæ
weight of technical grade cetyl/stearyl alcohol. The pH was ad-justed by addition of phosphoric acid to pH 5, cooled to 60C.
and 10% by weight of polyvinyl pyrrolidone iodine was added. The mixture was extruded in the form of soap bars.
The following preparations, given in the form of a Table illustrate the composition of a number of variations ac-cording to the present invention. It ought to be clearly under-stood that the percentages of the ingredients are not critical, and that these may be varied within certain limits without depart-ing from the scope and spirit of the present invention. The various percentages are to be adjusted mutually, and these depend also to a certain extent on the desired degree oF hardness of the product.
The following preparations were made as set out above, parts are by weight:
I II III IV V VI VII ~III
Sulfated fatty alcohols (C10-C26): 20 30 35 40 30 30 20 Saturated fatty alcohols (C14-C26): 25 18 15 5 7 20 15 35 Saturated fatty acidS (C14 C20) 8 - 5 10 - 10 46 15 Sulfosuccinate of fatty alcohols (~12 C24) 35 36 18 18 40 0 17 10 Succinate of fatty alcohols (C10 C24): 5 9 14 _ 24 10 10 Iodophor (PVP-I or non-ionic detergent-I complex): 7 10 10 5 15 10 2 0 Iodine and KI: 0 0 0 0 0 0 0 5 Water: - 5 8 8 8 6 5 5 Instead of the organic iodine complexes there may be used inorganic iodine preparations, such as for example, compo-sitions containing iodine and an alkali metal iodide, such as potassium iodide, dissolved in a suitable quantity of water. For example, 20 wt-% iodine, 40 wt-% potassium iodide and 40 wt-%
water give a suitable solution. A quantity of 4 g. of this solu-tion incorporated in 96 g. of detergent mixture according to the invention ~with no organic iodine complex) gave satisfactory de-tergent and antiseptic results.
Similar compositions were prepared, containing a quantity of an organic acid such as citric or lactic acid, adapted to adjust the pH to a value of about 5-5.5.
Stability:
The stability of the novel germicidal preparations according to the present invention was tested The tests carried out have shown that, for example, a preparation according to the present invention containing 10 per cent by weight Povidone Iodine (pH 5.3) lost only 6 per cent of the available iodine during a period of storage of 50 days at 50C. A liquid detergent preparation, available commercially, containing the same initial percentage of iodine lost 27 per cent available iodine at 50C during 30 days. Comparative tests have shown the superiority of preparations according to the present invention as regards storage, compared with other commercial pre-parations containing Povidone Iodine.
The pH of the preparations according to the present invention is an optimum as regards the activity of the iodine.
It is known that the bactericidal efflcacy of iodine and of orga-nic iodine preparations is increased when the pH is lowered. A
pH of below 6 is generally suggested, the activity being still better at a pH of about 5 or below this value.
; The preparation according to the present invention has a pH in the optimal range, while the advantageous detergent pro-perties o~ a good soap are maintained. The preparations according to the present invention are not detrimentally effected by hard water No "ring" is formed in the bathtub and no precipitates are formed with hard water or with salts such as magnesium or calcium salts.
The pH of the preparation according to the present invention can be adjusted to the desired value by the addition of various physiologically acceptable acids such as lactic acid, citric acid, phosphoric acid, fumaric acid, tartaric acid and the like.
The novel preparations according to the present inven-tion have a further advantage, namely the enhanced effect of the detergent and o~ the organic iodine compounds. In soaps contain-ing organic iodine compounds, hard water causes the formation of a precipitate and this impairs the antibacterial ef~ectivity. The novel compositions are not adversely affected by hard waterJ and the detergent effect and the bacteriacidal effect of the organic iodine compound complement each other and a certain synergism is obtained.
Conventional soaps used in places like hospitals are often the source of cross-infections due to the fact that bacte-ria may survive on the surface of such solid soap bars and infect subsequent users.
The bactericidal effect of the novel preparations is so strong that practically no patogenic microorganism will sur-vive on the surface of a preparation according to the invention.
This property is of special importance for use in hospitals, in the case o~ epidemics, in military medicine, nurseries and other publi~ places.
Bacteriological Tests:
A bar was prepared according to Example 4, ænd a sus-pension of 6.10 stphylococci was applied onto the surface of the bar, which had been wetted with tap water 3 minutes before. Sixty seconds after the application of the bacteria, a swab was taken and cultured. No bacteria survived.
A control was carried out with conventional toilet soap, and over 1000 bacteria were counted.
A suspension of about 10 pseudomonas aeruginosa was applied to the palm of a human hand and spread thereon. The hand was washed with soap during two minutes of scrubbing and rinsed with water. About 680 microorganisms were counted.
4~98 A parallel test with a bar o~ the novel preparation according to Example 4 resulted in zero survival of microorga-nisms.
A slurry was prepared comprising 10 g. of a composition according to preparation No. III in 20 ml. of water. A quantity of Pseudomonas Aeroginosa was introduced into the slurry so as to obtain a final concentration of 105 microorganisms per ml, After 30 minutes, a sample was taken and examined.
No bacteria survived alive.
A similar experiment was carried out with regular soap at similar concentrations in water and of bacteria. After 30 minutes the bacteria survived. Even after 2 hours they were 3still alive.
Similar results were obtained with analogous prepara-tions containing inorganic iodine in combination with sodium iodide or potassium iodide.
Claims (9)
1. A germicidal cleansening composition of matter, in semi-solid form, comprising a combination:
a) at least 20 weight-% of one or two members of the group con-sisting of sulfated fatty alcohols (C14 to C26), and sulfosucci-nates of fatty alcohols (C12 to C24);
b) between 1 and 20 weight-% of an organic iodine complex, PVP-I
or an inorganic iodine compound;
c) a quantity not exceeding about 10 weight-% of water;
d) at least 20 weight-% of one or more members of the group con-sisting of saturated fatty alcohols (C14 to C26), saturated fatty acids (C14 to C20) and succinates or maleates of fatty alcohols (C10 to C24).
a) at least 20 weight-% of one or two members of the group con-sisting of sulfated fatty alcohols (C14 to C26), and sulfosucci-nates of fatty alcohols (C12 to C24);
b) between 1 and 20 weight-% of an organic iodine complex, PVP-I
or an inorganic iodine compound;
c) a quantity not exceeding about 10 weight-% of water;
d) at least 20 weight-% of one or more members of the group con-sisting of saturated fatty alcohols (C14 to C26), saturated fatty acids (C14 to C20) and succinates or maleates of fatty alcohols (C10 to C24).
2. A germicidal composition according to claim 1, where-in the sulfated fatty alcohol and/or sulfosuccinate of fatty al-cohols comprise between 25 and 50 weight-% of the composition.
3. A germicidal composition according to claim 1, where-in an organic acid is added to adjust the pH to about pH 5.
4. A germicidal composition according to claim 1, where-in the active iodine is PVP-I.
5. A germicidal composition according to claim 1, where-in the active iodine is iodine and potassium iodide or sodium iodide.
6. A composition of matter according to claim 4, wherein the active iodine compound comprises from 2 to 10 weight-%.
7. A germicidal composition of matter according to claim 1, wherein the saturated fatty alcohols comprise from 30 to 60 weight-% of the composition
8. A germicidal composition according to claim 1 in bar form.
9. A process for producing a germicidal composition of matter according to claim 1, which comprises melting together all the ingredients except for the iodine carrier, cooling down to a temperature not exceeding 65°C., adding the iodine complex or compound and shaping the product to the desired form
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL45639A IL45639A (en) | 1974-09-10 | 1974-09-10 | Germicidal cleaning preparation based on iodophors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1064798A true CA1064798A (en) | 1979-10-23 |
Family
ID=11047848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA235,368A Expired CA1064798A (en) | 1974-09-10 | 1975-09-09 | Germicidal cleansening compositions |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU503301B2 (en) |
| CA (1) | CA1064798A (en) |
| CH (1) | CH612851A5 (en) |
| DE (1) | DE2539462A1 (en) |
| GB (1) | GB1519012A (en) |
| IL (1) | IL45639A (en) |
| ZA (1) | ZA755734B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1178205A (en) * | 1980-08-01 | 1984-11-20 | Eberhard F. Gottwald | Topical composition containing polyvinyl- pyrrolidone-iodine complex |
| CN112806386B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Disinfectant containing iodine complex and preparation method thereof |
-
1974
- 1974-09-10 IL IL45639A patent/IL45639A/en unknown
-
1975
- 1975-09-05 DE DE19752539462 patent/DE2539462A1/en not_active Withdrawn
- 1975-09-05 CH CH1155175A patent/CH612851A5/en not_active IP Right Cessation
- 1975-09-09 ZA ZA00755734A patent/ZA755734B/en unknown
- 1975-09-09 CA CA235,368A patent/CA1064798A/en not_active Expired
- 1975-09-09 AU AU84656/75A patent/AU503301B2/en not_active Expired
- 1975-09-10 GB GB37172/75A patent/GB1519012A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL45639A (en) | 1977-03-31 |
| ZA755734B (en) | 1976-09-29 |
| DE2539462A1 (en) | 1976-03-18 |
| AU8465675A (en) | 1977-07-07 |
| GB1519012A (en) | 1978-07-26 |
| CH612851A5 (en) | 1979-08-31 |
| AU503301B2 (en) | 1979-08-30 |
| IL45639A0 (en) | 1974-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3281366A (en) | Synergistic antibacterial compositions | |
| US4518517A (en) | Non-antimicrobial deodorant cleansing composition | |
| US3944663A (en) | Mild light duty detergent containing homopolymers of ethylene oxide | |
| JPH06511189A (en) | Divalent silver alkaline fungicide composition | |
| US4118332A (en) | Synergistic antibacterial composition containing mixtures of certain halogenated diphenyl ethers and trichlorocarbanilides | |
| US3897357A (en) | Bacteriostatic toilet bowl cleaner compositions | |
| US4130640A (en) | Germicidal cleaning compositions | |
| DE1158216B (en) | Bactericidal agent | |
| DE3615787C2 (en) | ||
| US5006529A (en) | Soap compositions of enhanced antimicrobial effectiveness | |
| US5651974A (en) | Disinfectant-detergent composition | |
| US4954281A (en) | Soap compositions of enhanced antimicrobial effectiveness | |
| US4832861A (en) | Soap compositions of enhanced antimicrobial effectiveness | |
| US3576843A (en) | Halogenated 2-acyloxy-diphenylethers | |
| CA1064798A (en) | Germicidal cleansening compositions | |
| US5523324A (en) | Composition | |
| KR20000075713A (en) | Use of the antibacterial active substance triclocarban in liquid soaps | |
| DE1258006B (en) | Detergents and cleaning agents with antibacterial properties | |
| DE2321656A1 (en) | DETERGENT MIXTURES | |
| US3903007A (en) | Detergent composition containing halogenated 2-acyloxy-diphenylethers | |
| DE3519557A1 (en) | Disinfecting preparation and the process for preparing it | |
| US3084097A (en) | Antibacterial compositions | |
| US2948684A (en) | Disinfectant and deodorant soap composition | |
| US3338837A (en) | Iodinated detergent composition | |
| US3784694A (en) | Halogenated 2-acyloxy-diphenylethers as bactericides and fungicides |