CA1056381A - 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES - Google Patents
5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINESInfo
- Publication number
- CA1056381A CA1056381A CA223,250A CA223250A CA1056381A CA 1056381 A CA1056381 A CA 1056381A CA 223250 A CA223250 A CA 223250A CA 1056381 A CA1056381 A CA 1056381A
- Authority
- CA
- Canada
- Prior art keywords
- fluoro
- process according
- hydrogen
- chloro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA314,650A CA1067497A (fr) | 1974-04-01 | 1978-10-27 | LES 5-PHENYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45664074A | 1974-04-01 | 1974-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1056381A true CA1056381A (fr) | 1979-06-12 |
Family
ID=23813560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA223,250A Expired CA1056381A (fr) | 1974-04-01 | 1975-03-27 | 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES |
Country Status (6)
| Country | Link |
|---|---|
| JP (3) | JPS5874682A (fr) |
| BE (1) | BE827451A (fr) |
| CA (1) | CA1056381A (fr) |
| GB (1) | GB1476087A (fr) |
| IE (1) | IE41352B1 (fr) |
| ZA (1) | ZA751990B (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004063818A (ja) | 2002-07-30 | 2004-02-26 | Oki Electric Ind Co Ltd | フレキシブルチューブを利用した半導体装置の製造方法 |
| JP5894574B2 (ja) | 2010-04-22 | 2016-03-30 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| ES2727815T3 (es) | 2012-04-14 | 2019-10-18 | Intra Cellular Therapies Inc | Tratamiento del TEPT y de trastornos del control de impulsos |
| EP2968320B1 (fr) | 2013-03-15 | 2020-11-11 | Intra-Cellular Therapies, Inc. | Composés organiques |
| KR102495941B1 (ko) | 2013-12-03 | 2023-02-06 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| BR112016023162B1 (pt) | 2014-04-04 | 2022-11-29 | Intra-Cellular Therapies, Inc | Compostos orgânicos gama-carbolinas, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento ou na profilaxia de transtornos de sistema nervoso central |
| MX2016013046A (es) | 2014-04-04 | 2017-02-15 | Intra-Cellular Therapies Inc | Compuestos organicos. |
| BR112018015283B1 (pt) | 2016-01-26 | 2023-09-26 | Intra-Cellular Therapies, Inc | Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central |
| EP3888656A1 (fr) | 2016-03-25 | 2021-10-06 | Intra-Cellular Therapies, Inc. | Composés gamma-carbolines deutérés hétérocycliques et leur utilisation pour le traitement ou la prévention d'un désordre du système nerveux central |
| WO2017172795A1 (fr) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| US11331316B2 (en) | 2016-10-12 | 2022-05-17 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| WO2018126143A1 (fr) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Composés organiques |
| US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| CA3054841A1 (fr) | 2017-03-24 | 2018-09-27 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et methodes |
| WO2019023063A1 (fr) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | Composés organiques |
| MX2020000968A (es) | 2017-07-26 | 2020-09-28 | Intra Cellular Therapies Inc | Compuestos organicos. |
| MX2020009668A (es) | 2018-03-16 | 2021-01-08 | Intra Cellular Therapies Inc | Métodos novedosos. |
| JP7483671B2 (ja) | 2018-06-11 | 2024-05-15 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 置換ヘテロ環縮合ガンマ－カルボリン類合成 |
| WO2020047408A1 (fr) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Nouvelles méthodes |
| EP3843738A4 (fr) | 2018-08-31 | 2022-06-01 | Intra-Cellular Therapies, Inc. | Nouvelles méthodes |
-
1975
- 1975-03-19 IE IE589/75A patent/IE41352B1/xx unknown
- 1975-03-26 GB GB1277375A patent/GB1476087A/en not_active Expired
- 1975-03-27 CA CA223,250A patent/CA1056381A/fr not_active Expired
- 1975-04-01 ZA ZA00751990A patent/ZA751990B/xx unknown
- 1975-04-01 BE BE1006567A patent/BE827451A/fr not_active IP Right Cessation
-
1982
- 1982-09-14 JP JP57160718A patent/JPS5874682A/ja active Pending
- 1982-09-14 JP JP57160717A patent/JPS5915911B2/ja not_active Expired
- 1982-09-14 JP JP57160719A patent/JPS5874683A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB1476087A (en) | 1977-06-10 |
| JPS5915911B2 (ja) | 1984-04-12 |
| JPS5874681A (ja) | 1983-05-06 |
| JPS5874683A (ja) | 1983-05-06 |
| BE827451A (fr) | 1975-10-01 |
| JPS5874682A (ja) | 1983-05-06 |
| IE41352L (en) | 1975-10-01 |
| ZA751990B (en) | 1976-02-25 |
| IE41352B1 (en) | 1979-12-19 |
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