CA1030972A - Pharmacologically active benzo (b) thiophene compounds and process for their preparation - Google Patents

Pharmacologically active benzo (b) thiophene compounds and process for their preparation

Info

Publication number: CA1030972A
Authority: CA; Canada
Prior art keywords: preparation; pharmacologically active; thiophene compounds; active benzo; benzo
Prior art date: 1974-06-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA228,687A

Other languages

English (en)

French (fr)

Inventor

Jean Gubin

Marcel Descamps

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Labaz SA

Original Assignee

Labaz SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-06-06

Filing date

1975-06-06

Publication date

1978-05-09

1975-06-06 Application filed by Labaz SA filed Critical Labaz SA

1978-05-09 Application granted granted Critical

1978-05-09 Publication of CA1030972A publication Critical patent/CA1030972A/en

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

CA228,687A 1974-06-06 1975-06-06 Pharmacologically active benzo (b) thiophene compounds and process for their preparation Expired CA1030972A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2525674A GB1456323A (en)	1974-06-06	1974-06-06	Benzothiophenes process for preparing them and pharmaceutical compositions containing the same

Publications (1)

Publication Number	Publication Date
CA1030972A true CA1030972A (en)	1978-05-09

Family

ID=10224753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA228,687A Expired CA1030972A (en)	1974-06-06	1975-06-06	Pharmacologically active benzo (b) thiophene compounds and process for their preparation

Country Status (20)

Country	Link
US (1)	US4007204A (de)
JP (1)	JPS516958A (de)
AR (2)	AR207152A1 (de)
AT (1)	AT341517B (de)
BE (1)	BE829837A (de)
CA (1)	CA1030972A (de)
CH (1)	CH605910A5 (de)
DE (1)	DE2522655A1 (de)
DK (1)	DK135808B (de)
ES (1)	ES438303A1 (de)
FI (1)	FI751602A (de)
GB (1)	GB1456323A (de)
HU (1)	HU172820B (de)
IT (1)	IT1038094B (de)
NL (1)	NL7504921A (de)
NO (1)	NO751989L (de)
OA (1)	OA05022A (de)
SE (1)	SE7505482L (de)
SU (1)	SU578002A3 (de)
ZA (1)	ZA752871B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU509682B2 (en) *	1975-10-28	1980-05-22	Eli Lilly And Company	2-Aroyl-3-Phenylbenzothiophene Derivatives
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US5175184A (en) *	1982-10-19	1992-12-29	Kotobuki Seiyaku Company Limited	Benzothiophene derivatives and antihyperuricemia thereof
NO174506B (no) *	1984-10-30	1994-02-07	Usv Pharma Corp	Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4806663A (en) *	1987-04-06	1989-02-21	The University Of Tennessee Research Corporation	Certain 3-substituted 2-alkyl benzofuran derivatives
US4851554A (en) *	1987-04-06	1989-07-25	University Of Tennessee Research Corporation	Certain 3-substituted 2-alkyl benzofuran derivatives
US4912642A (en) *	1987-09-03	1990-03-27	The Boeing Company	Coordinated engine autothrottle
US4831156A (en) *	1987-09-30	1989-05-16	The University Of Tennessee Research Corp.	3-substituted 2-alkyl indole derivatives
AU2543388A (en) *	1987-09-30	1989-04-18	University Of Tennessee Research Corporation, The	Certain 3-substituted 2-alkyl benzothiophene derivatives
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体
CN1073563C (zh) *	1994-04-11	2001-10-24	中外制药株式会社	4,6－二叔丁基－2,3－二氢苯并噻吩衍生物
CO4410191A1 (es) *	1994-09-19	1997-01-09	Lilly Co Eli	SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US6653328B1 (en) *	1995-03-10	2003-11-25	Eli Lilly And Company	3-benzyl-benzothiophenes
US6417199B1 (en) *	1995-03-10	2002-07-09	Eli Lilly And Company	3-benzyl-benzothiophenes
ATE284690T1 (de) *	1995-10-31	2005-01-15	Lilly Co Eli	Antithrombotische diamine
WO1997034888A1 (en) *	1996-03-19	1997-09-25	Eli Lilly And Company	SYNTHESIS OF 3-[4-(2-AMINOETHOXY)-BENZOYL]-2-ARYL-6-HYDROXY-BENZO[b]THIOPHENES
US6391901B1 (en)	1997-04-30	2002-05-21	Eli Lilly And Company	Thrombin inhibitors
WO1998048792A1 (en) *	1997-04-30	1998-11-05	Eli Lilly And Company	A REGIOSELECTIVE ALKYLATION PROCESS FOR PREPARING SUBSTITUTED BENZO[b]THIOPHENES
ATE268768T1 (de)	1997-04-30	2004-06-15	Lilly Co Eli	Antithrombosemittel
JP2002513415A (ja)	1997-04-30	2002-05-08	イーライ・リリー・アンド・カンパニー	抗血栓剤
CA2288144A1 (en)	1997-04-30	1998-11-05	Eli Lilly And Company	Antithrombotic agents
US6284756B1 (en)	1998-04-30	2001-09-04	Eli Lilly And Company	Antithrombotic agents
ES2189355T3 (es) *	1998-10-28	2003-07-01	Lilly Co Eli	Compuestos de benzotiofeno como agentes antitromboticos e intermedios.
FR2864536B1 (fr) *	2003-12-24	2006-03-17	Clariant France Sa	Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
MY160768A (en) *	2010-08-06	2017-03-15	Tasly Pharmaceutical Group Co	Use of salvia miltiorrhiza composition in preparing drugs for secondary prevention of coronary heart disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3514465A (en) *	1966-12-30	1970-05-26	Degussa	Certain thiazolyl- and pyridinylaminoketones
US3706747A (en) *	1970-06-05	1972-12-19	Pfizer	Benzothieno(3,2-d)- and benzofuro(3,2-d)pyrimidines

1974
- 1974-06-06 GB GB2525674A patent/GB1456323A/en not_active Expired
1975
- 1975-01-01 AR AR258913A patent/AR207152A1/es active
- 1975-04-21 US US05/569,819 patent/US4007204A/en not_active Expired - Lifetime
- 1975-04-25 NL NL7504921A patent/NL7504921A/xx not_active Application Discontinuation
- 1975-05-02 ZA ZA00752871A patent/ZA752871B/xx unknown
- 1975-05-13 SE SE7505482A patent/SE7505482L/xx unknown
- 1975-05-14 IT IT23297/75A patent/IT1038094B/it active
- 1975-05-22 DE DE19752522655 patent/DE2522655A1/de active Pending
- 1975-05-30 FI FI751602A patent/FI751602A/fi not_active Application Discontinuation
- 1975-05-30 HU HU75LA00000867A patent/HU172820B/hu unknown
- 1975-06-04 DK DK251975AA patent/DK135808B/da unknown
- 1975-06-04 BE BE157003A patent/BE829837A/xx unknown
- 1975-06-05 SU SU7502143254A patent/SU578002A3/ru active
- 1975-06-05 NO NO751989A patent/NO751989L/no unknown
- 1975-06-06 CA CA228,687A patent/CA1030972A/en not_active Expired
- 1975-06-06 CH CH730375A patent/CH605910A5/xx not_active IP Right Cessation
- 1975-06-06 OA OA55520A patent/OA05022A/xx unknown
- 1975-06-06 ES ES438303A patent/ES438303A1/es not_active Expired
- 1975-06-06 AT AT431175A patent/AT341517B/de not_active IP Right Cessation
- 1975-06-06 JP JP50069021A patent/JPS516958A/ja active Pending
- 1975-11-07 AR AR261103A patent/AR210265A1/es active

Also Published As

Publication number	Publication date
JPS516958A (en)	1976-01-20
AR207152A1 (es)	1976-09-15
OA05022A (fr)	1980-12-31
CH605910A5 (de)	1978-10-13
GB1456323A (en)	1976-11-24
DK135808B (da)	1977-06-27
DE2522655A1 (de)	1975-12-18
NO751989L (de)	1975-12-09
IT1038094B (it)	1979-11-20
US4007204A (en)	1977-02-08
FI751602A (de)	1975-12-07
AT341517B (de)	1978-02-10
DK135808C (de)	1977-11-28
BE829837A (fr)	1975-12-04
DK251975A (de)	1975-12-07
HU172820B (hu)	1978-12-28
ZA752871B (en)	1976-04-28
ATA431175A (de)	1977-06-15
SU578002A3 (ru)	1977-10-25
SE7505482L (sv)	1975-12-08
NL7504921A (nl)	1975-12-09
AU8102275A (en)	1976-11-11
AR210265A1 (es)	1977-07-15
ES438303A1 (es)	1977-01-16

Publication	Publication Date	Title
CA1030972A (en)	1978-05-09	Pharmacologically active benzo (b) thiophene compounds and process for their preparation
ZA753455B (en)	1976-04-28	Pharmacologically active compounds
ZM14376A1 (en)	1977-08-22	Pharmacologically active compounds
ZM12176A1 (en)	1977-07-21	Pharmacologically active compounds
ZA764082B (en)	1977-06-29	Pharmacologically active compounds
ZA75180B (en)	1976-01-28	Pharmacologically active compounds
ZA765331B (en)	1977-08-31	Novel pharmaceutically active compounds
ZA7682B (en)	1976-12-29	Pharmacologically active compounds
ZA75870B (en)	1976-01-28	Pharmacologically active compounds
PT65377B (en)	1978-01-19	Pharmacologically active compounds
ZA761324B (en)	1977-02-23	Pharmaceutically active compounds
ZA763837B (en)	1977-05-25	Pharmacologically active compounds
ZA756708B (en)	1976-09-29	Pharmacologically active compounds
PT65839A (en)	1976-12-01	Pharmacologically active compounds
ZA762536B (en)	1977-04-27	Pharmacologically active compounds
AU499235B2 (en)	1979-04-12	Antimicorbial benzo [b] furans & benzo [b] thiophene derivatives
ZA753296B (en)	1976-04-28	New thiophene derivatives and process for their manufacture
AU8138275A (en)	1976-11-25	New thiophene derivatives and process for their manufacture
HU175418B (hu)	1980-07-28	Sposob poluchenija farmacevticheski aktivnykh proizvodnykh piridazina
AU500841B2 (en)	1979-05-31	Thiophene derivatives
CA1027561A (en)	1978-03-07	Pharmacologically active 1,4-benzodiazepins and process for their preparation
AU489242B2 (en)	1975-11-13	Pharmacologically active compounds
AU493469B2 (en)	1977-03-03	7-methoxy-7-ureido(thienyl & furyl) acetamidocephalosporins
GR60853B7 (en)	1978-08-31	Preparation process of pharmacologically active compounds
ZA743696B (en)	1975-06-25	Pharmacologically active compounds