CA1027293A - Polymeres greffes avec des molecules anti-inflammatoires - Google Patents

Polymeres greffes avec des molecules anti-inflammatoires

Info

Publication number
CA1027293A
CA1027293A CA175,363A CA175363A CA1027293A CA 1027293 A CA1027293 A CA 1027293A CA 175363 A CA175363 A CA 175363A CA 1027293 A CA1027293 A CA 1027293A
Authority
CA
Canada
Prior art keywords
dans
par
une
que
est
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA175,363A
Other languages
English (en)
Other versions
CA175363S (en
Inventor
Bernard Jacquet
Christos Papantoniou
Pierre Dufaure
Claude Mahieux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU65621A external-priority patent/LU65621A1/xx
Priority claimed from LU65622A external-priority patent/LU65622A1/xx
Application filed by LOreal SA filed Critical LOreal SA
Application granted granted Critical
Publication of CA1027293A publication Critical patent/CA1027293A/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F18/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F18/02—Esters of monocarboxylic acids
    • C08F18/04—Vinyl esters
    • C08F18/10—Vinyl esters of monocarboxylic acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PRECIS DE LA DIVULGATION:

Procédé de préparation de nouveaux polymères à activi-té anti-inflammatoire caractérisé par le fait que, dans un pre-mier stade, on polymérise en présence d'un catalyseur un monomè-re porteur d'une fonction réactive permettant de former avec les molécules anti-inflammatoires à fonction acide carboxylique ou ses dérivés des liaisons covalentes, ledit monomère étant poly-mérisé seul ou en présence d'autres monomères et que, dans un deuxième stade, on fait réagir le polymère formé avec une molé-cule anti-inflammatoire dans une proportion correspondant au po-lymère que l'on souhaite obtenir. Une variante consiste, dans un premier stade, à préparer un dérivé insaturé de la molécule anti-inflammatoire à fonction acide carboxylique et, dans un deuxième stade, à homopolymériser ou copolymériser en présence d'un catalyseur dé polymérisation ledit dérivé insaturé seul ou en présence d'autres monomères. L'invention a également pour ob-jet ces nouveaux polymères à activité anti-inflammatoire ainsi obtenus.
CA175,363A 1972-06-29 1973-06-29 Polymeres greffes avec des molecules anti-inflammatoires Expired CA1027293A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU65621A LU65621A1 (fr) 1972-06-29 1972-06-29
LU65622A LU65622A1 (fr) 1972-06-29 1972-06-29

Publications (1)

Publication Number Publication Date
CA1027293A true CA1027293A (fr) 1978-02-28

Family

ID=26640110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA175,363A Expired CA1027293A (fr) 1972-06-29 1973-06-29 Polymeres greffes avec des molecules anti-inflammatoires

Country Status (11)

Country Link
US (1) US3946035A (fr)
JP (1) JPS5415705B2 (fr)
AT (1) AT336269B (fr)
CA (1) CA1027293A (fr)
CH (2) CH579599A5 (fr)
DE (1) DE2333211A1 (fr)
ES (2) ES416403A1 (fr)
FR (1) FR2190454B1 (fr)
GB (1) GB1442640A (fr)
NL (1) NL7309151A (fr)
SE (2) SE419992B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107290A (en) * 1972-06-29 1978-08-15 L'oreal Anti-solar polymers, method of making the same and cosmetic compositions containing the same
US4701521A (en) * 1978-07-17 1987-10-20 The Trustees Of Boston University Method of effecting cellular uptake of molecules
JPS55500053A (fr) * 1978-01-16 1980-01-31
FR2629084B1 (fr) * 1988-03-28 1990-11-30 Essilor Int Polymeres supports de produits actifs relargables, de type hydrogel, compositions correspondantes et leur procede de preparation
US5753246A (en) * 1995-11-20 1998-05-19 Peters; Marlin W. Packaged germicidal towelette, sanitation kit and method for promoting hygiene
US5952392A (en) * 1996-09-17 1999-09-14 Avanir Pharmaceuticals Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
NZ526821A (en) * 2001-01-18 2005-02-25 Genzyme Corp Ionene polymers and their use as antimicrobial agents
EA200400535A1 (ru) * 2001-10-16 2005-06-30 Аванир Фармасютикалз ПОДАВЛЕНИЕ ВИРУСОВ n-ДОКОСАНОЛОМ
WO2004046109A2 (fr) * 2002-11-19 2004-06-03 Genzyme Corporation Oligomeres and polymeres d'ionene
WO2012134965A1 (fr) * 2011-03-25 2012-10-04 The Trustees Of Columbia University In The City Of New York Modulateurs de canaux chlorure et de transporteurs de chlorure pour thérapie dans les maladies des muscles lisses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2888380A (en) * 1954-11-05 1959-05-26 Merck & Co Inc S-ethyl cysteine compositions for combatting tubercle bacilli
FR92221E (fr) * 1965-03-03 1968-10-11 Oreal Nouveaux copolymères et applications de ces copolymères à la cosmétique
LU54202A1 (fr) * 1967-07-28 1969-03-24 Oreal Procédé de préparation de nouveaux copolymères et compositions cosmétiques contenant ces copolymères
US3535337A (en) * 1967-07-26 1970-10-20 Merck & Co Inc 1-p-chlorobenzoyl-2-methyl-3-metallo-methyl indoles
US3798235A (en) * 1967-12-09 1974-03-19 Sumitomo Chemical Co Novel method for producing 1-phenyl-3-indolylacetic acid derivatives
DE1930306A1 (de) * 1968-06-18 1970-01-02 Colgate Palmolive Co Substantive Lichtschutzmittel

Also Published As

Publication number Publication date
DE2333211A1 (de) 1974-04-04
DE2333211C2 (fr) 1988-09-08
CH579599A5 (fr) 1976-09-15
ES442306A1 (es) 1977-10-01
FR2190454B1 (fr) 1976-12-31
FR2190454A1 (fr) 1974-02-01
SE419992B (sv) 1981-09-07
ATA578673A (de) 1976-08-15
CH578021A5 (fr) 1976-07-30
JPS5415705B2 (fr) 1979-06-16
ES416403A1 (es) 1976-07-01
NL7309151A (fr) 1974-01-02
SE7708537L (sv) 1977-07-25
JPS4958195A (fr) 1974-06-05
AU5763373A (en) 1975-01-09
AT336269B (de) 1977-04-25
US3946035A (en) 1976-03-23
GB1442640A (en) 1976-07-14

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