BRPI0922760A2 - derivados de 6-ciclo amino -3-(1h-pirrolo [2,3-b] piridin -4-il) imidazo [1,2-b]- piridazina, o respectivo preparo e a respectiva aplicação em terapêutica - Google Patents
derivados de 6-ciclo amino -3-(1h-pirrolo [2,3-b] piridin -4-il) imidazo [1,2-b]- piridazina, o respectivo preparo e a respectiva aplicação em terapêuticaInfo
- Publication number
- BRPI0922760A2 BRPI0922760A2 BRPI0922760-1A BRPI0922760A BRPI0922760A2 BR PI0922760 A2 BRPI0922760 A2 BR PI0922760A2 BR PI0922760 A BRPI0922760 A BR PI0922760A BR PI0922760 A2 BRPI0922760 A2 BR PI0922760A2
- Authority
- BR
- Brazil
- Prior art keywords
- group
- cycloamino
- pyrrolo
- imidazo
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0806723A FR2939134A1 (fr) | 2008-12-01 | 2008-12-01 | Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
FR0806723 | 2008-12-01 | ||
PCT/FR2009/052336 WO2010063929A1 (fr) | 2008-12-01 | 2009-11-30 | DERIVES DE 6-CYCLOAMINO-3-(1H-PYRROLO[2,3-b]PYRIDIN-4-YL)IMIDAZO[1,2-b]-PYRIDAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0922760A2 true BRPI0922760A2 (pt) | 2018-11-06 |
Family
ID=40383902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0922760-1A BRPI0922760A2 (pt) | 2008-12-01 | 2009-11-30 | derivados de 6-ciclo amino -3-(1h-pirrolo [2,3-b] piridin -4-il) imidazo [1,2-b]- piridazina, o respectivo preparo e a respectiva aplicação em terapêutica |
Country Status (27)
Country | Link |
---|---|
US (1) | US8546395B2 (pt) |
EP (1) | EP2370446B1 (pt) |
JP (1) | JP5677309B2 (pt) |
KR (1) | KR20110082094A (pt) |
CN (1) | CN102232079A (pt) |
AR (1) | AR074237A1 (pt) |
AU (1) | AU2009323968A1 (pt) |
BR (1) | BRPI0922760A2 (pt) |
CA (1) | CA2743560A1 (pt) |
CY (1) | CY1117529T1 (pt) |
DK (1) | DK2370446T3 (pt) |
ES (1) | ES2563085T3 (pt) |
FR (1) | FR2939134A1 (pt) |
HR (1) | HRP20160173T1 (pt) |
HU (1) | HUE028525T2 (pt) |
IL (1) | IL213208A0 (pt) |
MX (1) | MX2011005808A (pt) |
PA (1) | PA8849801A1 (pt) |
PL (1) | PL2370446T3 (pt) |
PT (1) | PT2370446E (pt) |
RS (1) | RS54656B1 (pt) |
RU (1) | RU2011126981A (pt) |
SG (1) | SG172757A1 (pt) |
SI (1) | SI2370446T1 (pt) |
TW (1) | TW201033209A (pt) |
UY (1) | UY32280A (pt) |
WO (1) | WO2010063929A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5550352B2 (ja) * | 2007-03-15 | 2014-07-16 | ノバルティス アーゲー | 有機化合物およびその使用 |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
CN103764656A (zh) * | 2011-06-22 | 2014-04-30 | 拜耳知识产权有限责任公司 | 杂环基氨基咪唑并哒嗪 |
EP4126878A1 (en) * | 2020-03-27 | 2023-02-08 | Gritscience Biopharmaceuticals Co., Ltd. | Compounds as casein kinase inhibitors |
US11939328B2 (en) | 2021-10-14 | 2024-03-26 | Incyte Corporation | Quinoline compounds as inhibitors of KRAS |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100439367C (zh) | 2003-12-11 | 2008-12-03 | 安万特药物公司 | 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物 |
DE102005042742A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
US7750000B2 (en) * | 2005-09-02 | 2010-07-06 | Bayer Schering Pharma Ag | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments |
AR064420A1 (es) * | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
PE20090215A1 (es) * | 2007-05-09 | 2009-03-30 | Novartis Ag | Compuestos derivados de imidazopiridazinas como inhibidores de cinasa |
JP2010526823A (ja) * | 2007-05-10 | 2010-08-05 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Pi3キナーゼ阻害物質としてのキノキサリン誘導体 |
AR067326A1 (es) * | 2007-05-11 | 2009-10-07 | Novartis Ag | Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido |
FR2918061B1 (fr) * | 2007-06-28 | 2010-10-22 | Sanofi Aventis | Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique. |
FR2918986B1 (fr) * | 2007-07-19 | 2009-09-04 | Sanofi Aventis Sa | Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique |
-
2008
- 2008-12-01 FR FR0806723A patent/FR2939134A1/fr active Pending
-
2009
- 2009-11-25 PA PA20098849801A patent/PA8849801A1/es unknown
- 2009-11-30 BR BRPI0922760-1A patent/BRPI0922760A2/pt not_active IP Right Cessation
- 2009-11-30 HU HUE09797121A patent/HUE028525T2/hu unknown
- 2009-11-30 CA CA2743560A patent/CA2743560A1/fr not_active Abandoned
- 2009-11-30 AU AU2009323968A patent/AU2009323968A1/en not_active Abandoned
- 2009-11-30 AR ARP090104598A patent/AR074237A1/es unknown
- 2009-11-30 US US13/128,998 patent/US8546395B2/en not_active Expired - Fee Related
- 2009-11-30 ES ES09797121.2T patent/ES2563085T3/es active Active
- 2009-11-30 KR KR1020117015085A patent/KR20110082094A/ko not_active Application Discontinuation
- 2009-11-30 JP JP2011538042A patent/JP5677309B2/ja not_active Expired - Fee Related
- 2009-11-30 CN CN2009801481699A patent/CN102232079A/zh active Pending
- 2009-11-30 TW TW098140839A patent/TW201033209A/zh unknown
- 2009-11-30 MX MX2011005808A patent/MX2011005808A/es not_active Application Discontinuation
- 2009-11-30 RU RU2011126981/04A patent/RU2011126981A/ru unknown
- 2009-11-30 RS RS20160093A patent/RS54656B1/en unknown
- 2009-11-30 SI SI200931370T patent/SI2370446T1/sl unknown
- 2009-11-30 PL PL09797121T patent/PL2370446T3/pl unknown
- 2009-11-30 PT PT97971212T patent/PT2370446E/pt unknown
- 2009-11-30 WO PCT/FR2009/052336 patent/WO2010063929A1/fr active Application Filing
- 2009-11-30 DK DK09797121.2T patent/DK2370446T3/en active
- 2009-11-30 SG SG2011038361A patent/SG172757A1/en unknown
- 2009-11-30 EP EP09797121.2A patent/EP2370446B1/fr active Active
- 2009-12-01 UY UY0001032280A patent/UY32280A/es not_active Application Discontinuation
-
2011
- 2011-05-29 IL IL213208A patent/IL213208A0/en unknown
-
2016
- 2016-02-16 HR HRP20160173T patent/HRP20160173T1/hr unknown
- 2016-02-24 CY CY20161100152T patent/CY1117529T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20160173T1 (hr) | 2016-03-25 |
CN102232079A (zh) | 2011-11-02 |
AR074237A1 (es) | 2010-12-29 |
MX2011005808A (es) | 2011-10-11 |
FR2939134A1 (fr) | 2010-06-04 |
HUE028525T2 (hu) | 2016-12-28 |
ES2563085T3 (es) | 2016-03-10 |
CA2743560A1 (fr) | 2010-06-10 |
AU2009323968A1 (en) | 2010-06-10 |
EP2370446B1 (fr) | 2015-11-25 |
JP5677309B2 (ja) | 2015-02-25 |
UY32280A (es) | 2010-06-30 |
WO2010063929A1 (fr) | 2010-06-10 |
PL2370446T3 (pl) | 2016-05-31 |
RS54656B1 (en) | 2016-08-31 |
PT2370446E (pt) | 2016-03-22 |
US20120010208A1 (en) | 2012-01-12 |
SG172757A1 (en) | 2011-08-29 |
PA8849801A1 (es) | 2010-07-27 |
TW201033209A (en) | 2010-09-16 |
US8546395B2 (en) | 2013-10-01 |
SI2370446T1 (sl) | 2016-03-31 |
IL213208A0 (en) | 2011-07-31 |
EP2370446A1 (fr) | 2011-10-05 |
CY1117529T1 (el) | 2017-04-26 |
KR20110082094A (ko) | 2011-07-15 |
DK2370446T3 (en) | 2016-02-22 |
RU2011126981A (ru) | 2013-01-10 |
JP2012510453A (ja) | 2012-05-10 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A, 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2497 DE 13-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |