BRPI0912988A2 - compostos bicíclicos tendo atividade no receptor cxcr4. - Google Patents
compostos bicíclicos tendo atividade no receptor cxcr4.Info
- Publication number
- BRPI0912988A2 BRPI0912988A2 BRPI0912988A BRPI0912988A BRPI0912988A2 BR PI0912988 A2 BRPI0912988 A2 BR PI0912988A2 BR PI0912988 A BRPI0912988 A BR PI0912988A BR PI0912988 A BRPI0912988 A BR PI0912988A BR PI0912988 A2 BRPI0912988 A2 BR PI0912988A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor activity
- bicyclic compounds
- cxcr4 receptor
- cxcr4
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5524808P | 2008-05-22 | 2008-05-22 | |
PCT/US2009/044347 WO2009143058A1 (en) | 2008-05-22 | 2009-05-18 | Bicyclic compounds having activity at the cxcr4 receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0912988A2 true BRPI0912988A2 (pt) | 2019-09-24 |
Family
ID=41059527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0912988A BRPI0912988A2 (pt) | 2008-05-22 | 2009-05-18 | compostos bicíclicos tendo atividade no receptor cxcr4. |
Country Status (11)
Country | Link |
---|---|
US (1) | US8193203B2 (pt) |
EP (1) | EP2300456A1 (pt) |
JP (1) | JP2011523420A (pt) |
KR (1) | KR20110018380A (pt) |
CN (1) | CN102105463A (pt) |
AU (1) | AU2009249246A1 (pt) |
BR (1) | BRPI0912988A2 (pt) |
CA (1) | CA2725066A1 (pt) |
IL (1) | IL209318A0 (pt) |
RU (1) | RU2010152290A (pt) |
WO (1) | WO2009143058A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011153310A1 (en) * | 2010-06-02 | 2011-12-08 | Trius Therapeutics | Dihydrofolate reductase inhibitors |
WO2013019966A1 (en) * | 2011-08-04 | 2013-02-07 | Allergan, Inc. | Aromatic bycyclic derivatives as cxcr4 receptor modulators |
AU2013237226A1 (en) | 2012-03-19 | 2014-10-09 | Emory University | Quinazoline compounds and their use in therapy |
WO2014105958A2 (en) | 2012-12-26 | 2014-07-03 | Medivation Technologies, Inc. | Fused pyrimidine compounds and use thereof |
MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
WO2016197027A1 (en) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
HUE061989T2 (hu) | 2016-03-16 | 2023-09-28 | Kura Oncology Inc | Szubsztituált tieno[2,3-D]pirimidin származékok mint menin-MLL inhibitorai és alkalmazási eljárások |
WO2017161002A1 (en) | 2016-03-16 | 2017-09-21 | Kura Oncology, Inc. | Bridged bicyclic inhibitors of menin-mll and methods of use |
JP2020514388A (ja) | 2017-03-24 | 2020-05-21 | クラ オンコロジー,インク. | 血液悪性腫瘍およびユーイング肉腫を処置するための方法 |
US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
EP3645006A4 (en) * | 2017-06-30 | 2020-12-16 | The University of North Carolina at Chapel Hill | HETEROCROMATIN GENE REPRESSION INHIBITORS |
TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
CN110669036B (zh) * | 2018-07-02 | 2022-02-11 | 盛世泰科生物医药技术(苏州)有限公司 | 一类具有cxcr4信号通路抑制活性的杂环化合物及其应用 |
CN115160294B (zh) * | 2022-06-27 | 2023-09-29 | 中山大学 | 一种G9a/GLP共价抑制剂及其制备方法及应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060074105A1 (en) | 2004-09-20 | 2006-04-06 | Serenex, Inc. | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 |
WO2006105056A2 (en) * | 2005-03-28 | 2006-10-05 | Fmc Corporation | Insecticidal 2,4-diaminoquinazolines and related derivatives |
FR2891829A1 (fr) | 2005-10-12 | 2007-04-13 | Sanofi Aventis Sa | Derives de la 4-amino-quinazoline, leur preparation et leur application en therapeutique |
KR20080089416A (ko) * | 2005-12-21 | 2008-10-06 | 페인셉터 파마 코포레이션 | 개폐 이온 통로를 조절하기 위한 조성물 및 방법 |
-
2009
- 2009-05-18 EP EP09751286A patent/EP2300456A1/en not_active Withdrawn
- 2009-05-18 BR BRPI0912988A patent/BRPI0912988A2/pt not_active IP Right Cessation
- 2009-05-18 CA CA2725066A patent/CA2725066A1/en not_active Abandoned
- 2009-05-18 WO PCT/US2009/044347 patent/WO2009143058A1/en active Application Filing
- 2009-05-18 CN CN2009801287044A patent/CN102105463A/zh active Pending
- 2009-05-18 RU RU2010152290/04A patent/RU2010152290A/ru unknown
- 2009-05-18 JP JP2011510620A patent/JP2011523420A/ja active Pending
- 2009-05-18 KR KR1020107028706A patent/KR20110018380A/ko not_active Application Discontinuation
- 2009-05-18 AU AU2009249246A patent/AU2009249246A1/en not_active Abandoned
- 2009-05-18 US US12/467,575 patent/US8193203B2/en active Active
-
2010
- 2010-11-15 IL IL209318A patent/IL209318A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20110018380A (ko) | 2011-02-23 |
IL209318A0 (en) | 2011-01-31 |
WO2009143058A1 (en) | 2009-11-26 |
US8193203B2 (en) | 2012-06-05 |
EP2300456A1 (en) | 2011-03-30 |
JP2011523420A (ja) | 2011-08-11 |
CN102105463A (zh) | 2011-06-22 |
AU2009249246A1 (en) | 2009-11-26 |
CA2725066A1 (en) | 2009-11-26 |
US20090312305A1 (en) | 2009-12-17 |
RU2010152290A (ru) | 2012-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |