BRPI0907656A2 - composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio - Google Patents
composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio Download PDFInfo
- Publication number
- BRPI0907656A2 BRPI0907656A2 BRPI0907656A BRPI0907656A BRPI0907656A2 BR PI0907656 A2 BRPI0907656 A2 BR PI0907656A2 BR PI0907656 A BRPI0907656 A BR PI0907656A BR PI0907656 A BRPI0907656 A BR PI0907656A BR PI0907656 A2 BRPI0907656 A2 BR PI0907656A2
- Authority
- BR
- Brazil
- Prior art keywords
- cisatracurium
- purity
- test compound
- purity test
- testing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
"composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúr1o, uso de um composto para testar a pureza de cisatracürio e processo para preparar compostos para testar a pureza de cisatracúrio" a presente invenção provê compostos que são úteis, p.ex., como marcadores de referência para analisar a pureza de cisatracúrio e sais deste, um método para determinar a dita pureza e a processos para preparar marcadores de referência.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4962008P | 2008-05-01 | 2008-05-01 | |
PCT/IL2009/000452 WO2009133556A2 (en) | 2008-05-01 | 2009-04-28 | Cisatracurium derivatives, preparation and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0907656A2 true BRPI0907656A2 (pt) | 2019-08-27 |
Family
ID=41255503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0907656A BRPI0907656A2 (pt) | 2008-05-01 | 2009-04-28 | composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio |
Country Status (6)
Country | Link |
---|---|
US (1) | US20110185796A1 (pt) |
EP (1) | EP2283005A4 (pt) |
AU (1) | AU2009241211A1 (pt) |
BR (1) | BRPI0907656A2 (pt) |
CA (1) | CA2722651A1 (pt) |
WO (1) | WO2009133556A2 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008222298A1 (en) * | 2007-03-08 | 2008-09-12 | Chemagis Ltd. | (1R,1'R)-atracurium salts separation process |
US20100087650A1 (en) * | 2007-03-26 | 2010-04-08 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
CA2685491A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
CA2685488A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
CA2687157A1 (en) * | 2007-06-18 | 2008-12-24 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
WO2009057086A1 (en) | 2007-10-29 | 2009-05-07 | Chemagis Ltd. | Novel r,r'-atracurium salts |
CN104557703B (zh) * | 2015-01-27 | 2018-01-16 | 江苏嘉逸医药有限公司 | 一种苯磺顺阿曲库铵精制方法 |
CN111072563A (zh) * | 2019-12-20 | 2020-04-28 | 上药东英(江苏)药业有限公司 | 一种苯磺顺阿曲库铵中间体r,r`-顺酯的制备方法 |
CN112326809A (zh) * | 2020-09-24 | 2021-02-05 | 南京斯泰尔医药科技有限公司 | 一种苯磺顺阿曲库铵对映异构体的检测方法 |
CN112778200B (zh) * | 2021-01-20 | 2022-09-23 | 江苏诚信药业有限公司 | 一种苯磺顺阿曲库铵的制备方法及其应用 |
CN115947685A (zh) * | 2023-02-07 | 2023-04-11 | 山东铂源药业股份有限公司 | 苯磺顺阿曲库铵手性异构体杂质的制备方法 |
CN116429940A (zh) * | 2023-04-14 | 2023-07-14 | 江苏原创药物研发有限公司 | 一种苯磺酸阿曲库铵原料药中丙烯酸、丙烯酸甲酯及丙烯酸乙酯的检测方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU506657B2 (en) * | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
US4491665A (en) * | 1979-10-19 | 1985-01-01 | Burroughs Wellcome Co. | Method of preparing isomers of bis isoquinolinium compounds |
US4701460A (en) * | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
GB8418303D0 (en) * | 1984-07-18 | 1984-08-22 | Wellcome Found | Compounds |
JPS62265266A (ja) * | 1986-05-13 | 1987-11-18 | Takasago Corp | N−アシル−テトラヒドロイソキノリン類の製造法 |
US4988815A (en) * | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
US5453510A (en) * | 1990-07-13 | 1995-09-26 | Burroughs Wellcome Co. | Neuromuscular blocking agents |
US5240939A (en) * | 1991-10-31 | 1993-08-31 | Anaquest, Inc. | Nitrogen bridge tetrahydroisoquinolines |
DE19535762A1 (de) * | 1995-09-26 | 1997-03-27 | Basf Ag | Verfahren zur Racematspaltung |
US5684154A (en) * | 1996-02-16 | 1997-11-04 | Abbott Laboratories | Process for the preparation and isolation of atracurium besylate |
ATE254107T1 (de) * | 1997-03-25 | 2003-11-15 | Avera Pharmaceuticals Inc | Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker |
CN1241576C (zh) * | 1999-08-13 | 2006-02-15 | 阿克佐诺贝尔公司 | 化学螯合剂用于制备逆转临床使用的神经肌肉传导阻滞剂药物诱发的神经肌肉传导阻滞的药物的用途 |
GB2371862B (en) * | 2000-12-29 | 2004-07-14 | Bioorg Bv | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
US20060009485A1 (en) * | 2005-06-23 | 2006-01-12 | Chemagis Ltd | Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents |
US20090156562A1 (en) * | 2005-11-14 | 2009-06-18 | Winch Peter D | Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts |
US8148398B2 (en) * | 2006-12-06 | 2012-04-03 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
AU2008222298A1 (en) * | 2007-03-08 | 2008-09-12 | Chemagis Ltd. | (1R,1'R)-atracurium salts separation process |
US20100087650A1 (en) * | 2007-03-26 | 2010-04-08 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
CA2685488A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
CA2685491A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
CA2687157A1 (en) * | 2007-06-18 | 2008-12-24 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
US20100256381A1 (en) * | 2007-07-09 | 2010-10-07 | Chemagis Ltd. | Process for producing cisatracurium and associated intermediates |
WO2009057086A1 (en) * | 2007-10-29 | 2009-05-07 | Chemagis Ltd. | Novel r,r'-atracurium salts |
ITMI20080319A1 (it) * | 2008-02-28 | 2009-08-29 | Recordati Chem Pharm | Processo per la risoluzione di derivati isochinolinici |
IT1396543B1 (it) * | 2008-07-16 | 2012-12-14 | Farmabios Spa | Processo per la purificazione di bloccanti neuromuscolari |
-
2009
- 2009-04-28 AU AU2009241211A patent/AU2009241211A1/en not_active Abandoned
- 2009-04-28 BR BRPI0907656A patent/BRPI0907656A2/pt not_active IP Right Cessation
- 2009-04-28 WO PCT/IL2009/000452 patent/WO2009133556A2/en active Application Filing
- 2009-04-28 EP EP09738569A patent/EP2283005A4/en not_active Withdrawn
- 2009-04-28 US US12/990,428 patent/US20110185796A1/en not_active Abandoned
- 2009-04-28 CA CA2722651A patent/CA2722651A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2009133556A3 (en) | 2010-03-11 |
CA2722651A1 (en) | 2009-11-05 |
AU2009241211A1 (en) | 2009-11-05 |
EP2283005A4 (en) | 2011-08-31 |
US20110185796A1 (en) | 2011-08-04 |
WO2009133556A2 (en) | 2009-11-05 |
EP2283005A2 (en) | 2011-02-16 |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2539 DE 03-09-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] |