BRPI0812248A2 - agentes de ligação ao receptor fc de região constante de imunoglobulina - Google Patents

agentes de ligação ao receptor fc de região constante de imunoglobulina

Info

Publication number
BRPI0812248A2
BRPI0812248A2 BRPI0812248A BRPI0812248A BRPI0812248A2 BR PI0812248 A2 BRPI0812248 A2 BR PI0812248A2 BR PI0812248 A BRPI0812248 A BR PI0812248A BR PI0812248 A BRPI0812248 A BR PI0812248A BR PI0812248 A2 BRPI0812248 A2 BR PI0812248A2
Authority
BR
Brazil
Prior art keywords
constant region
receptor binding
binding agents
immunoglobulin constant
immunoglobulin
Prior art date
Application number
BRPI0812248A
Other languages
English (en)
Inventor
H Schulze Dan
S Block David
E Strome Scott
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Publication of BRPI0812248A2 publication Critical patent/BRPI0812248A2/pt
Publication of BRPI0812248B1 publication Critical patent/BRPI0812248B1/pt
Publication of BRPI0812248B8 publication Critical patent/BRPI0812248B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2318/00—Antibody mimetics or scaffolds
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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BRPI0812248A 2007-06-01 2008-05-30 estradômero agrupado BRPI0812248B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US94164407P 2007-06-01 2007-06-01
US60/941,644 2007-06-01
US1512707P 2007-12-19 2007-12-19
US61/015,127 2007-12-19
US1554707P 2007-12-20 2007-12-20
US61/015,547 2007-12-20
PCT/US2008/065428 WO2008151088A2 (en) 2007-06-01 2008-05-30 Immunoglobulin constant region fc receptor binding agents

Publications (3)

Publication Number Publication Date
BRPI0812248A2 true BRPI0812248A2 (pt) 2017-05-02
BRPI0812248B1 BRPI0812248B1 (pt) 2021-03-23
BRPI0812248B8 BRPI0812248B8 (pt) 2021-05-25

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BRPI0812248A BRPI0812248B8 (pt) 2007-06-01 2008-05-30 estradômero agrupado

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US (11) US8680237B2 (pt)
EP (3) EP2185589B1 (pt)
JP (3) JP5600588B2 (pt)
KR (2) KR101580938B1 (pt)
CN (3) CN101835802B (pt)
AU (1) AU2008259946B2 (pt)
BR (1) BRPI0812248B8 (pt)
CA (1) CA2688490C (pt)
DK (1) DK2185589T3 (pt)
ES (1) ES2565834T3 (pt)
HU (1) HUE026953T2 (pt)
IL (5) IL202409A (pt)
MX (3) MX2009013004A (pt)
PL (1) PL2185589T3 (pt)
RU (3) RU2729829C2 (pt)
SI (1) SI2185589T1 (pt)
WO (1) WO2008151088A2 (pt)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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RU2015107693A3 (pt) 2018-11-12
JP6215365B2 (ja) 2017-10-18
MX2019009211A (es) 2019-09-13
WO2008151088A3 (en) 2009-04-02
PL2185589T3 (pl) 2016-09-30
US20140335075A1 (en) 2014-11-13
EP2185589A2 (en) 2010-05-19
AU2008259946B2 (en) 2013-08-29
MX2009013004A (es) 2010-01-20
JP5600588B2 (ja) 2014-10-01
BRPI0812248B1 (pt) 2021-03-23
US9512208B2 (en) 2016-12-06
IL255334A0 (en) 2017-12-31
US20190218275A1 (en) 2019-07-18
IL290995A (en) 2022-05-01
US20160355570A1 (en) 2016-12-08
CN107011445B (zh) 2021-06-29
RU2009148295A (ru) 2011-07-20
WO2008151088A8 (en) 2009-07-02
US20100239633A1 (en) 2010-09-23
US9512210B2 (en) 2016-12-06
US9926362B2 (en) 2018-03-27
IL202409A (en) 2015-11-30
CN107011445A (zh) 2017-08-04
EP2185589A4 (en) 2010-06-23
ES2565834T3 (es) 2016-04-07
EP2185589B1 (en) 2016-01-06
SI2185589T1 (sl) 2016-04-29
IL202409A0 (en) 2011-08-01
JP5870134B2 (ja) 2016-02-24
RU2729829C2 (ru) 2020-08-12
RU2015107693A (ru) 2015-10-20
KR20100028599A (ko) 2010-03-12
US20170218049A1 (en) 2017-08-03
KR20140139619A (ko) 2014-12-05
US10208105B2 (en) 2019-02-19
WO2008151088A9 (en) 2010-03-04

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