BRPI0808043A2 - Compostos tricíclicos úteis no tratamento de distúrbios de ferro. - Google Patents

Compostos tricíclicos úteis no tratamento de distúrbios de ferro.

Info

Publication number
BRPI0808043A2
BRPI0808043A2 BRPI0808043-7A2A BRPI0808043A BRPI0808043A2 BR PI0808043 A2 BRPI0808043 A2 BR PI0808043A2 BR PI0808043 A BRPI0808043 A BR PI0808043A BR PI0808043 A2 BRPI0808043 A2 BR PI0808043A2
Authority
BR
Brazil
Prior art keywords
treatment
compounds useful
tricyclic compounds
iron disorders
disorders
Prior art date
Application number
BRPI0808043-7A2A
Other languages
English (en)
Inventor
Mikhail Chafeev
Nagasree Chakka
Jean-Jacques Cadieux
Jianmin Fu
Rajender Kamboj
Vishnumurthy Kodumuru
Johnathan Langille
Shifeng Liu
Jianyu Sun
Serguei Sviridov
Zaihui Zhang
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of BRPI0808043A2 publication Critical patent/BRPI0808043A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D337/00Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02Seven-membered rings
    • C07D337/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30Isothioureas
    • C07C335/32Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91Dibenzofurans; Hydrogenated dibenzofurans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06Six-membered rings
    • C07D327/08[b,e]-condensed with two six-membered carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/08Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing three- or four-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0808043-7A2A 2007-03-07 2008-03-07 Compostos tricíclicos úteis no tratamento de distúrbios de ferro. BRPI0808043A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89358507P 2007-03-07 2007-03-07
PCT/US2008/056250 WO2008109840A1 (en) 2007-03-07 2008-03-07 Tricyclic compounds useful in treating iron disorders

Publications (1)

Publication Number Publication Date
BRPI0808043A2 true BRPI0808043A2 (pt) 2014-06-24

Family

ID=39512833

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808043-7A2A BRPI0808043A2 (pt) 2007-03-07 2008-03-07 Compostos tricíclicos úteis no tratamento de distúrbios de ferro.

Country Status (13)

Country Link
US (1) US20090069408A1 (pt)
EP (1) EP2061755A1 (pt)
JP (1) JP2010520884A (pt)
CN (1) CN101616892A (pt)
AR (1) AR065628A1 (pt)
AU (1) AU2008222666A1 (pt)
BR (1) BRPI0808043A2 (pt)
CA (1) CA2678895A1 (pt)
CL (1) CL2008000666A1 (pt)
MX (1) MX2009009466A (pt)
RU (1) RU2009136996A (pt)
TW (1) TW200845961A (pt)
WO (1) WO2008109840A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2068855A2 (en) * 2007-06-05 2009-06-17 Xenon Pharmaceuticals Inc. Aromatic and heteroaromatic compounds useful in treating iron disorders
CN102574805A (zh) 2009-08-20 2012-07-11 维福(国际)股份公司 新型喹啉铁调素拮抗剂
AR077958A1 (es) 2009-08-27 2011-10-05 Vifor Int Ag Quinoxalinonas antagonistas de la hepcidina
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
BR112012005119A2 (pt) 2009-09-07 2016-11-22 Vifor Int Ag novos antagonistas de hepcidina etanodiaminas
WO2011029832A1 (de) 2009-09-09 2011-03-17 Vifor (International) Ag Neue thiazol- und oxazol-hepcidin-antagonisten
US20120214803A1 (en) 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
MA44474A (fr) 2015-10-23 2019-01-30 Vifor Int Ag Nouveaux inhibiteurs de la ferroportine
JOP20180036A1 (ar) 2017-04-18 2019-01-30 Vifor Int Ag أملاح لمثبطات فروبورتين جديدة
TW202102478A (zh) 2019-04-01 2021-01-16 瑞士商威佛(國際)股份有限公司 新穎的鐵螯合物
CN114163417B (zh) * 2021-12-06 2023-08-04 郑州海阔光电材料有限公司 一种3-溴硫芴的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) * 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
EP0661284A1 (en) * 1992-09-18 1995-07-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compound and medicinal use thereof
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
US6080587A (en) * 1998-01-23 2000-06-27 Eli Lilly And Company Method for preparing and selecting pharmaceutically useful sulfur-bridged bi- and triaromatic ring compounds from a structurally diverse universal library
GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US20060269498A1 (en) * 2005-05-17 2006-11-30 Gerard Malle Hair shaping composition comprising at least one polyguanidine other than hydroxide
EP2068855A2 (en) * 2007-06-05 2009-06-17 Xenon Pharmaceuticals Inc. Aromatic and heteroaromatic compounds useful in treating iron disorders

Also Published As

Publication number Publication date
EP2061755A1 (en) 2009-05-27
MX2009009466A (es) 2009-09-15
CA2678895A1 (en) 2008-09-12
WO2008109840A1 (en) 2008-09-12
CN101616892A (zh) 2009-12-30
RU2009136996A (ru) 2011-04-20
US20090069408A1 (en) 2009-03-12
TW200845961A (en) 2008-12-01
CL2008000666A1 (es) 2008-06-13
JP2010520884A (ja) 2010-06-17
AU2008222666A1 (en) 2008-09-12
AR065628A1 (es) 2009-06-17

Similar Documents

Publication Publication Date Title
BRPI0808043A2 (pt) Compostos tricíclicos úteis no tratamento de distúrbios de ferro.
HUS1900005I1 (hu) Javított nanotestek (TM) aggregáció közvetítette rendellenességek kezelésére
BRPI0809272A2 (pt) Compostos de biaril e biheteroaril no tratamento de distúrbios do ferro
FR2932478B1 (fr) Composes utiles pour le traitement des cancers.
AP2011005672A0 (en) Pyrazolopyrimidines and their use for the treatment of CNS disorders.
WO2007095638A3 (en) Boron-containing small molecules as anti-inflammatory agents
SMP200900085B (it) 3-imidazolil-indoli per il trattamento di malattieproliferative.
DK3567035T3 (da) N-substituerede 2,5-dioxo-azolin-forbindelser til anvendelse ved behandling af cancer
IL191379A (en) sewage care
IT1397774B1 (it) Ferro da stiro.
BRPI0820440A2 (pt) Inibidores aldh-2 no tratamento de desordens psiquiátricas
BRPI0923048A2 (pt) "composto de aminopirazol".
BRPI0812058A2 (pt) Sistema de ferro de passar
IL205137A0 (en) 5-cyanothienopyridines for the treatment of tumours
GB0810364D0 (en) Improved effluent treatment
EP2207555A4 (en) NOVEL COMPOUNDS FOR THE TREATMENT OR MITIGATION OF OEDEMES, AND METHODS OF USE THEREOF
HK1146221A1 (en) Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders
EP2307011A4 (en) USE OF ISOINDOLENE FOR THE TREATMENT OF NEURO BEHAVIORAL DISORDERS
GB2442365B (en) Methods of determining compounds useful in the treatment of bipolar disorders
ZA201003115B (en) Use of immunomodulatory compounds for the treatment of disorders associated with endothelial dysfunction
FR2930727B1 (fr) Composition pour le traitement des etats seborrheiques.
EP1841457A4 (en) TARGET APHERESIS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
BRPI0720697A2 (pt) Produtos para o tratamento de clorose de ferro
GB0602857D0 (en) The treatment of sialorrhoea
TJ20050863A (en) The way of narcotism treatment

Legal Events

Date Code Title Description
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 5A E 6A ANUIDADES.

B08I Application fees: publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA.

B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A, 8A, 9A, 10A, 11A E 12A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.