BRPI0802688C1 - processo de obtenção de extrato rico em ácido rosmarínico (ar) obtido da espécie vegetal origanum vulgare e uso do extrato obtido - Google Patents
processo de obtenção de extrato rico em ácido rosmarínico (ar) obtido da espécie vegetal origanum vulgare e uso do extrato obtidoInfo
- Publication number
- BRPI0802688C1 BRPI0802688C1 BRPI0802688A BRPI0802688A BRPI0802688C1 BR PI0802688 C1 BRPI0802688 C1 BR PI0802688C1 BR PI0802688 A BRPI0802688 A BR PI0802688A BR PI0802688 A BRPI0802688 A BR PI0802688A BR PI0802688 C1 BRPI0802688 C1 BR PI0802688C1
- Authority
- BR
- Brazil
- Prior art keywords
- rosmarinic acid
- extract
- plants
- origanum vulgare
- diabetes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
processo de obtenção de ácido rosmarínico (ar) e de derivados semi-sintéticos a partir da espécie vegetal origanum vulgare e formulações para o tratamento de diabetes contendo tais substâncias. o valor científico está nas extraordinárias descobertas sobre as plantas, contribuindo efetivamente para purificar as aplicações empíricas, fazendo com que a fitoterapia se torne digna de maior crédito popular. o diabetes é considerada como uma síndrome quanto a etiologia e patogênese, caracterizada por alterar a homeostase do organismo, por distúrbios metabólicos complexos e primários dos carboidratos, que envolvem secundariamente, porém de forma importante, lipídeos e proteínas. tem sido constatado que muitas substâncias extraídas de plantas reduzem o nível de glicose no sangue. a grande diversidade de classes químicas indica que uma variedade de mecanismos de ação deve estar envolvida na redução do nível de glicose no sangue. assim, a presente investigação buscou avaliar a atividade hipoglicemiante da infusão, extrato hidroalcoólico da espécie vegetal origanum vulgare, bem como da substância isolada - ácido rosmarínico frente ratos diabéticos induzidos por aloxana. apesar dos antidiabéticos orais e a insulina apresentarem efeitos eficazes na terapêutica do diabetes, estes possuem efeitos colaterais que dificultam seu uso, além de seu elevado custo. portanto, a busca por plantas ou compostos naturais que apresentam atividade hipoglicemiante vem suprir a necessidade com novos compostos ativos, menos tóxicos e possivelmente mais acessíveis à população.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0802688A BRPI0802688C1 (pt) | 2008-06-25 | 2008-06-25 | processo de obtenção de extrato rico em ácido rosmarínico (ar) obtido da espécie vegetal origanum vulgare e uso do extrato obtido |
| EP09768649A EP2303257A4 (en) | 2008-06-25 | 2009-06-25 | ROSMARINIC ACID FROM ORIGANUM VULGARE FOR THE TREATMENT OF DIABETES |
| PCT/BR2009/000183 WO2009155676A1 (en) | 2008-06-25 | 2009-06-25 | Rosmarinic acid from origanum vulgare for treatment of diabetes |
| US13/000,777 US20110166226A1 (en) | 2008-06-25 | 2009-06-25 | Process for obtaining an extract rich in rosmarinic acid (ra) from the plant origanum vulgare and its use for the treatment of diabetes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0802688A BRPI0802688C1 (pt) | 2008-06-25 | 2008-06-25 | processo de obtenção de extrato rico em ácido rosmarínico (ar) obtido da espécie vegetal origanum vulgare e uso do extrato obtido |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0802688A2 BRPI0802688A2 (pt) | 2011-03-22 |
| BRPI0802688B1 BRPI0802688B1 (pt) | 2020-06-02 |
| BRPI0802688B8 BRPI0802688B8 (pt) | 2020-06-23 |
| BRPI0802688C1 true BRPI0802688C1 (pt) | 2021-05-25 |
Family
ID=41443927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0802688A BRPI0802688C1 (pt) | 2008-06-25 | 2008-06-25 | processo de obtenção de extrato rico em ácido rosmarínico (ar) obtido da espécie vegetal origanum vulgare e uso do extrato obtido |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110166226A1 (pt) |
| EP (1) | EP2303257A4 (pt) |
| BR (1) | BRPI0802688C1 (pt) |
| WO (1) | WO2009155676A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2951085B1 (fr) * | 2009-10-09 | 2012-05-18 | Inst Substances Vegetales | Utilisation de composes phenoliques pour la deglycation des proteines |
| CN103037901B (zh) * | 2010-06-01 | 2018-04-27 | 康奈尔大学 | 抑制cd36以控制肥胖和胰岛素敏感性 |
| WO2019224393A1 (en) * | 2018-05-25 | 2019-11-28 | University Of Copenhagen | Fenofibrate for reducing hypoglycemia in type 1 diabetes/lada |
| CN111574376B (zh) * | 2020-06-11 | 2023-03-24 | 湖南绿蔓生物科技股份有限公司 | 一种牛至的综合提取方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69930619T2 (de) * | 1998-05-16 | 2006-12-28 | Mogam Biotechnology Research Institute, Yongin | Verwendung von rosmarinsäure und deren derivate als immunsuppressor oder als inhibitor von sh-2 vermittelten prozessen |
| JP2005053891A (ja) * | 2003-07-18 | 2005-03-03 | Seresu Corporation:Kk | リパーゼ阻害剤 |
| JP4581064B2 (ja) * | 2003-11-07 | 2010-11-17 | 独立行政法人産業技術総合研究所 | インスリン分泌促進剤 |
| JP2006151838A (ja) * | 2004-11-26 | 2006-06-15 | Seresu Corporation:Kk | 糖質消化酵素阻害剤 |
| JP2006273741A (ja) * | 2005-03-29 | 2006-10-12 | Meiji Seika Kaisha Ltd | ＰＰＡＲγリガンド活性を有する組成物 |
-
2008
- 2008-06-25 BR BRPI0802688A patent/BRPI0802688C1/pt active IP Right Grant
-
2009
- 2009-06-25 EP EP09768649A patent/EP2303257A4/en not_active Withdrawn
- 2009-06-25 WO PCT/BR2009/000183 patent/WO2009155676A1/en active Application Filing
- 2009-06-25 US US13/000,777 patent/US20110166226A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2303257A1 (en) | 2011-04-06 |
| BRPI0802688B8 (pt) | 2020-06-23 |
| BRPI0802688B1 (pt) | 2020-06-02 |
| US20110166226A1 (en) | 2011-07-07 |
| WO2009155676A1 (en) | 2009-12-30 |
| EP2303257A4 (en) | 2011-07-20 |
| BRPI0802688A2 (pt) | 2011-03-22 |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B06V | Preliminary requirement: patent application procedure suspended [chapter 6.22 patent gazette] | ||
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
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