BRPI0720114A8 - Uso de um antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados, método para tratar caquexia, e, antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados - Google Patents

Uso de um antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados, método para tratar caquexia, e, antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados

Info

Publication number
BRPI0720114A8
BRPI0720114A8 BRPI0720114A BRPI0720114A BRPI0720114A8 BR PI0720114 A8 BRPI0720114 A8 BR PI0720114A8 BR PI0720114 A BRPI0720114 A BR PI0720114A BR PI0720114 A BRPI0720114 A BR PI0720114A BR PI0720114 A8 BRPI0720114 A8 BR PI0720114A8
Authority
BR
Brazil
Prior art keywords
antagonist
ht1a
partial agonist
adrenergic
combined beta
Prior art date
Application number
BRPI0720114A
Other languages
English (en)
Inventor
Cavalla David
Original Assignee
Actimed Therapeutics Ltd
Myotec Therapeutics Ltd
Psixus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actimed Therapeutics Ltd, Myotec Therapeutics Ltd, Psixus Therapeutics Ltd filed Critical Actimed Therapeutics Ltd
Publication of BRPI0720114A2 publication Critical patent/BRPI0720114A2/pt
Publication of BRPI0720114A8 publication Critical patent/BRPI0720114A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Orthopedic Medicine & Surgery (AREA)
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  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)

Abstract

USO DE UM ANTAGONISTA BETA-ADRENÉRGICO E ANTAGONISTA OU AGONISTA PARCIAL DE 5-HT1A COMBINADOS, E, ANTAGONISTA BETA-ADRENÉRGICO E ANTAGONISTA OU AGONISTA PARCIAL DE 5-HT1A COMBINADOS A presente invenção diz respeito a meios para a prevenção e tratamento de caquexia e outras enfermidades crônicas incluindo, mas sem limitações, a promoção de ganho de peso, redução ou prevenção de perda de peso pela administração de uma substância que reduz a sensibilidade tanto de receptores beta-adrenérgicos quanto de receptores 5-HT1a. (S)-pindolol, (S)- propanolol, tertatolol ou bopindolol são usados para este propósito.
BRPI0720114A 2006-12-05 2007-12-05 Uso de um antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados, método para tratar caquexia, e, antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados BRPI0720114A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0624282.0A GB0624282D0 (en) 2006-12-05 2006-12-05 Treatment of cachexia
GB0624282.0 2006-12-05
PCT/GB2007/004644 WO2008068477A1 (en) 2006-12-05 2007-12-05 Treatment of cachexia

Publications (2)

Publication Number Publication Date
BRPI0720114A2 BRPI0720114A2 (pt) 2014-04-15
BRPI0720114A8 true BRPI0720114A8 (pt) 2016-01-19

Family

ID=37671884

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720114A BRPI0720114A8 (pt) 2006-12-05 2007-12-05 Uso de um antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados, método para tratar caquexia, e, antagonista beta-adrenérgico e antagonista ou agonista parcial de 5-ht1a combinados

Country Status (16)

Country Link
US (1) US8716325B2 (pt)
EP (2) EP2094254B1 (pt)
JP (1) JP5166437B2 (pt)
CN (1) CN101610760B (pt)
AT (1) ATE513543T1 (pt)
AU (1) AU2007330607B2 (pt)
BR (1) BRPI0720114A8 (pt)
CA (1) CA2671622C (pt)
DK (1) DK2094254T3 (pt)
ES (1) ES2395244T3 (pt)
GB (1) GB0624282D0 (pt)
PL (1) PL2094254T3 (pt)
PT (1) PT2094254E (pt)
RU (1) RU2485950C2 (pt)
WO (1) WO2008068477A1 (pt)
ZA (1) ZA200904704B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0907350D0 (en) * 2009-04-29 2009-06-10 Myotec Therapeutics Ltd Methods
CN104703654A (zh) * 2012-07-25 2015-06-10 普西奥克瑟斯医疗有限公司 S-吲哚洛尔对于治疗恶病质和肌肉衰减症的应用
TWI669113B (zh) * 2013-03-14 2019-08-21 英商愛迪美治療有限公司 用於治療癌症之氧烯洛爾（ｏｘｐｒｅｎｏｌｏｌ）組合物
WO2017144977A1 (en) 2016-02-26 2017-08-31 Act Ventures Ltd. S-enantiomerically enriched compositions of beta blockers for treating muscle weakness
GB2593902B (en) 2020-04-07 2022-04-13 Actimed Therapeutics Ltd Salt of a pharmaceutical compound
GB202114564D0 (en) 2021-10-12 2021-11-24 Actimed Therapeutics Ltd Oral formulation

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US5552442A (en) 1987-09-15 1996-09-03 The Rowett Research Institute Therapeutic applications of clenbuterol
US6545040B1 (en) 1988-03-23 2003-04-08 Janssen Pharmaceutica N.V. Method of lowering the blood pressure
CA1337432C (en) 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
CA2025398A1 (en) 1989-09-20 1992-03-15 Timothy Gerard Dinan Diagnosis and treatment of a disorder of the gastrointestinal tract
US5120791A (en) 1990-07-27 1992-06-09 Lisco, Inc. Golf ball cover compositions
DK1121111T3 (da) 1998-10-15 2010-05-31 Imp Innovations Ltd Forbindelser til behandling af vægttab
IL150641A0 (en) 2000-01-31 2003-02-12 Pfizer Prod Inc Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes
AR030414A1 (es) * 2000-04-03 2003-08-20 Astrazeneca Ab Combinacion farmaceutica que comprende un beta bloqueante y un inhibidor de hmg-coa reductasa , formulacion farmaceutica, equipo transportable de partes , uso de esta combinacion y de esta formulacion para preparar medicamentos
EP1383496B1 (en) * 2001-02-20 2008-10-01 Dinan, Timothy Gerard Treatment of fibromyalgia using pindolol
US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
AU2005283829A1 (en) * 2004-09-17 2006-03-23 Neurocure Ltd Pindolol for the treating premenstrual syndrome and premenstrual dysphoric disorder
CN101065014A (zh) 2004-09-23 2007-10-31 亚历山大·米哈洛 通过诱导逆适应调节神经递质***的方法
EP2374508A1 (en) 2005-03-21 2011-10-12 Vicus Therapeutics SPE 1, LLC Combination of angiotension receptor blockers (ARB) and NSAIDs for use in ameliorating cachexia
WO2008093148A2 (en) 2005-12-22 2008-08-07 Anaborex, Inc. Compositions and methods for prevention and treatment of cachexia
WO2007100775A2 (en) 2006-02-27 2007-09-07 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3037095A3 (en) 2006-11-09 2016-11-16 Boehringer Ingelheim International GmbH Combination therapy with sglt-2 inhibitors and their pharmaceutical compositions
AU2008240379B2 (en) 2007-04-24 2012-10-04 Acacia Pharma Limited Drug combination of beta 2 agonist and a progestin for the treatment of muscle loss
JP2011516412A (ja) 2008-03-05 2011-05-26 ビカス セラピューティクス，エルエルシー 癌および粘膜炎の治療のための組成物および方法

Also Published As

Publication number Publication date
EP2094254A1 (en) 2009-09-02
CA2671622C (en) 2015-01-27
RU2485950C2 (ru) 2013-06-27
RU2009125548A (ru) 2011-01-20
ATE513543T1 (de) 2011-07-15
WO2008068477A1 (en) 2008-06-12
ES2395244T3 (es) 2013-02-11
JP2010511685A (ja) 2010-04-15
US20100292270A1 (en) 2010-11-18
PT2094254E (pt) 2011-09-19
AU2007330607B2 (en) 2013-02-07
CN101610760B (zh) 2012-09-26
US8716325B2 (en) 2014-05-06
CA2671622A1 (en) 2008-06-12
ZA200904704B (en) 2010-05-26
PL2094254T3 (pl) 2011-12-30
AU2007330607A1 (en) 2008-06-12
EP2359822B1 (en) 2016-08-03
GB0624282D0 (en) 2007-01-10
CN101610760A (zh) 2009-12-23
EP2359822A1 (en) 2011-08-24
BRPI0720114A2 (pt) 2014-04-15
EP2094254B1 (en) 2011-06-22
JP5166437B2 (ja) 2013-03-21
DK2094254T3 (da) 2011-10-03

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25K Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication

Owner name: PSIXUS THERAPEUTICS LIMITED (GB)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2468 DE 24/04/2018 POR TER SIDO INDEVIDA.

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