BRPI0716996B8 - processo para preparar um composto - Google Patents

processo para preparar um composto

Info

Publication number
BRPI0716996B8
BRPI0716996B8 BRPI0716996A BRPI0716996A BRPI0716996B8 BR PI0716996 B8 BRPI0716996 B8 BR PI0716996B8 BR PI0716996 A BRPI0716996 A BR PI0716996A BR PI0716996 A BRPI0716996 A BR PI0716996A BR PI0716996 B8 BRPI0716996 B8 BR PI0716996B8
Authority
BR
Brazil
Prior art keywords
processes
compost
prepare
preparing
useful
Prior art date
Application number
BRPI0716996A
Other languages
English (en)
Inventor
J Takasugi James
G Almstead Neil
Seongwoo Hwang Peter
Pines Seemon
Moon Young-Choon
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of BRPI0716996A2 publication Critical patent/BRPI0716996A2/pt
Publication of BRPI0716996B1 publication Critical patent/BRPI0716996B1/pt
Publication of BRPI0716996B8 publication Critical patent/BRPI0716996B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para preparar um composto. são fornecidos aqui processos para a preparação de compostos úteis para o tratamento, prevenção ou controle de doenças associadas com uma mutação sem sentido. mais especificamente, são fornecidos aqui processos para a síntese de 1,2,4-oxadiazóis. em particular, são fornecidos aqui processos úteis para a preparação de acido 3-[5-(2-fluorofenil)-[1,2,4]-oxadiazol-3-il]-benzóico.
BRPI0716996A 2006-09-08 2007-09-06 processo para preparar um composto BRPI0716996B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84359506P 2006-09-08 2006-09-08
US60/843,595 2006-09-08
US60/843595 2006-09-08
PCT/US2007/019561 WO2008030570A1 (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Publications (3)

Publication Number Publication Date
BRPI0716996A2 BRPI0716996A2 (pt) 2013-10-08
BRPI0716996B1 BRPI0716996B1 (pt) 2021-02-09
BRPI0716996B8 true BRPI0716996B8 (pt) 2021-05-25

Family

ID=38935880

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0716996A BRPI0716996B8 (pt) 2006-09-08 2007-09-06 processo para preparar um composto

Country Status (25)

Country Link
US (2) US7678922B2 (pt)
EP (1) EP2059513B1 (pt)
JP (2) JP5955494B2 (pt)
KR (1) KR101466368B1 (pt)
CN (1) CN101535284B (pt)
AR (3) AR062715A1 (pt)
AU (1) AU2007292915B2 (pt)
BR (1) BRPI0716996B8 (pt)
CA (2) CA2842625C (pt)
CL (1) CL2007002606A1 (pt)
DK (1) DK2059513T3 (pt)
ES (1) ES2404348T3 (pt)
HK (1) HK1134094A1 (pt)
IL (1) IL197445A (pt)
MX (1) MX2009002439A (pt)
MY (1) MY148598A (pt)
NZ (2) NZ575511A (pt)
PE (2) PE20120669A1 (pt)
PL (1) PL2059513T3 (pt)
PT (1) PT2059513E (pt)
RU (1) RU2495030C2 (pt)
TW (1) TWI482761B (pt)
UA (1) UA99265C2 (pt)
WO (1) WO2008030570A1 (pt)
ZA (1) ZA200901782B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3889142T1 (sl) 2003-04-11 2022-10-28 Ptc Therapeutics, Inc. Spojine 1,2,4-oksadiazol benzojske kisline in njihova uporaba za zatiranje nesmiselne ter zdravljenje bolezni
CN103720688A (zh) 2005-04-08 2014-04-16 Ptc医疗公司 用于无义突变抑制治疗的口服活性1,2,4-噁二唑组合物
SG170819A1 (en) 2006-03-30 2011-05-30 Ptc Therapeutics Inc Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
PL2059513T3 (pl) * 2006-09-08 2013-06-28 Ptc Therapeutics Inc Sposób wytwarzania pochodnych 1,2,4-oksadiazolowych kwasu benzoesowego
US8101641B2 (en) 2006-09-25 2012-01-24 Ptc Therapeutics, Inc. Hydroxylated 1,2,4-oxadiazole benzoic acid compounds and compositions thereof
JP5714228B2 (ja) 2006-09-25 2015-05-07 ピーティーシー セラピューティクス，インコーポレーテッド ３−［５−（２−フルオロフェニル）−［１，２，４］オキサジアゾール−３−イル］−安息香酸の結晶形
DK2073805T3 (da) 2006-10-12 2015-06-15 Ptc Therapeutics Inc Fremgangsmåder til dosering af en oralt aktiv 1,2,4-oxadiazol til terapi for suppression af nonsens-mutation
CN101714009A (zh) * 2009-05-14 2010-05-26 翁印嵩 集成通用电话功能的计算机
ES2610362T3 (es) 2011-01-25 2017-04-27 Viviabiotech, S.L. Derivados de 1,2,4-oxadiazol como fármacos moduladores del receptor para el péptido glp-1
EP2867230B1 (en) 2012-07-02 2020-02-12 Monsanto Technology LLC Process for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles
US9873677B2 (en) 2014-03-06 2018-01-23 Ptc Therapeutics, Inc. Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
CN105461650B (zh) * 2014-09-12 2018-04-13 杭州普晒医药科技有限公司 一种噁二唑化合物的溶剂化物及其制备方法
CN106316885B (zh) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法
CN108348527A (zh) 2015-10-30 2018-07-31 Ptc医疗公司 用于治疗癫痫的方法
TW201808922A (zh) 2016-06-20 2018-03-16 台灣神隆股份有限公司 製備阿塔魯仁及其中間體的方法
WO2020128816A2 (en) 2018-12-20 2020-06-25 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
CN113045510B (zh) * 2021-03-31 2022-05-27 北京大学生命科学华东产业研究院 一种阿塔鲁伦的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DE4425794A1 (de) * 1994-07-21 1996-01-25 Basf Ag Nitrofarbstoffe
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
MXPA03011196A (es) 2001-06-08 2004-10-28 Cytovia Inc 3-aril-5-aril-[1,2,4]-oxadiazoles sustituidos y analogos.
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
BR0313266A (pt) 2002-08-09 2005-06-21 Astrazeneca Ab Compostos, respectivos processos de preparação e uso, formulação farmacêutica e métodos de prevenção e/ou tratamento de um distúrbio mediado pelo receptor de mglur5 e de inibição da ativação de receptores de mglur5
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
SI3889142T1 (sl) * 2003-04-11 2022-10-28 Ptc Therapeutics, Inc. Spojine 1,2,4-oksadiazol benzojske kisline in njihova uporaba za zatiranje nesmiselne ter zdravljenje bolezni
US20050075375A1 (en) 2003-05-14 2005-04-07 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis C virus
CN103720688A (zh) 2005-04-08 2014-04-16 Ptc医疗公司 用于无义突变抑制治疗的口服活性1,2,4-噁二唑组合物
PL2059513T3 (pl) * 2006-09-08 2013-06-28 Ptc Therapeutics Inc Sposób wytwarzania pochodnych 1,2,4-oksadiazolowych kwasu benzoesowego

Also Published As

Publication number Publication date
EP2059513B1 (en) 2013-01-23
RU2495030C2 (ru) 2013-10-10
JP2010502715A (ja) 2010-01-28
CN101535284A (zh) 2009-09-16
UA99265C2 (ru) 2012-08-10
PT2059513E (pt) 2013-04-30
CN101535284B (zh) 2014-12-10
CA2842625A1 (en) 2008-03-13
AU2007292915B2 (en) 2012-07-26
JP5955494B2 (ja) 2016-07-20
US8367841B2 (en) 2013-02-05
RU2009113019A (ru) 2010-10-20
KR101466368B1 (ko) 2014-11-27
CA2662749A1 (en) 2008-03-13
CA2662749C (en) 2015-01-20
CL2007002606A1 (es) 2008-04-18
ZA200901782B (en) 2010-06-30
ES2404348T3 (es) 2013-05-27
US7678922B2 (en) 2010-03-16
HK1134094A1 (en) 2010-04-16
NZ575511A (en) 2012-02-24
TW200823180A (en) 2008-06-01
AR062715A1 (es) 2008-11-26
MX2009002439A (es) 2009-03-27
IL197445A (en) 2014-01-30
TWI482761B (zh) 2015-05-01
KR20090054464A (ko) 2009-05-29
NZ598012A (en) 2013-08-30
WO2008030570A1 (en) 2008-03-13
JP2014193896A (ja) 2014-10-09
AU2007292915A1 (en) 2008-03-13
AR118922A2 (es) 2021-11-10
US20100063297A1 (en) 2010-03-11
PE20080771A1 (es) 2008-06-13
PL2059513T3 (pl) 2013-06-28
DK2059513T3 (da) 2013-05-06
BRPI0716996A2 (pt) 2013-10-08
MY148598A (en) 2013-05-15
AR107474A2 (es) 2018-05-02
BRPI0716996B1 (pt) 2021-02-09
PE20120669A1 (es) 2012-06-01
US20080139818A1 (en) 2008-06-12
CA2842625C (en) 2016-07-12
IL197445A0 (en) 2009-12-24
EP2059513A1 (en) 2009-05-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/09/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF