BRPI0615141A2 - inibidores pentacìclicos de quinase - Google Patents
inibidores pentacìclicos de quinaseInfo
- Publication number
- BRPI0615141A2 BRPI0615141A2 BRPI0615141-8A BRPI0615141A BRPI0615141A2 BR PI0615141 A2 BRPI0615141 A2 BR PI0615141A2 BR PI0615141 A BRPI0615141 A BR PI0615141A BR PI0615141 A2 BRPI0615141 A2 BR PI0615141A2
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- pentacyclic
- malignancies
- compounds
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
INIBIDORES PENTACìCLICOS DE QUINASE. A presente invenção refere-se a novos inibidores de quinase que são úteis como agentes terapêutiCOs, por exemplo, no tratamento de estados malignos, em que os comDos:zs apresentam a Fórmula geral (1) em que A, X, Y, Z, Ra, Rb, Rc, R2 12, R2 22, R2 32 e m são tais como definidos no presente documento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70790205P | 2005-08-12 | 2005-08-12 | |
PCT/US2006/031682 WO2007022102A2 (en) | 2005-08-12 | 2006-08-14 | Pentacyclic kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0615141A2 true BRPI0615141A2 (pt) | 2009-07-14 |
Family
ID=37607426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0615141-8A BRPI0615141A2 (pt) | 2005-08-12 | 2006-08-14 | inibidores pentacìclicos de quinase |
Country Status (14)
Country | Link |
---|---|
US (1) | US7749994B2 (pt) |
EP (1) | EP1919920B1 (pt) |
JP (1) | JP2009504680A (pt) |
KR (1) | KR20080035691A (pt) |
CN (1) | CN101287737A (pt) |
AT (1) | ATE509933T1 (pt) |
AU (1) | AU2006279659A1 (pt) |
BR (1) | BRPI0615141A2 (pt) |
CA (1) | CA2619276A1 (pt) |
IL (1) | IL189296A0 (pt) |
NO (1) | NO20081292L (pt) |
RU (1) | RU2008108903A (pt) |
WO (1) | WO2007022102A2 (pt) |
ZA (1) | ZA200801332B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2240481A1 (en) * | 2008-01-11 | 2010-10-20 | Albany Molecular Research, Inc. | (1-azinone) -substituted pyridoindoles as mch antagonists |
US8629158B2 (en) * | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
WO2011003012A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
US9073925B2 (en) * | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
US8637501B2 (en) * | 2009-07-01 | 2014-01-28 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof |
US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
WO2012088038A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof |
JP6653573B2 (ja) | 2012-05-22 | 2020-02-26 | トラスティーズ・オブ・ダートマウス・カレッジ | シクロアルカニル[b]インドール、シクロアルカニル[b]ベンゾフラン、シクロアルカニル[b]ベンゾチオフェンを合成するための方法、化合物および使用の方法 |
WO2017162661A1 (en) | 2016-03-22 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | 1h-benzo[de]isoquinoline-1,3(2h)-diones |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050032869A1 (en) * | 2003-07-08 | 2005-02-10 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
WO2006133885A1 (en) * | 2005-06-15 | 2006-12-21 | F. Hoffmann-La Roche Ag | Tricyclic fused indole derivatives and their use as aurora kinase inhibitors |
-
2006
- 2006-08-14 US US11/503,405 patent/US7749994B2/en not_active Expired - Fee Related
- 2006-08-14 AT AT06813425T patent/ATE509933T1/de not_active IP Right Cessation
- 2006-08-14 RU RU2008108903/04A patent/RU2008108903A/ru not_active Application Discontinuation
- 2006-08-14 CN CNA200680037951XA patent/CN101287737A/zh active Pending
- 2006-08-14 JP JP2008526286A patent/JP2009504680A/ja active Pending
- 2006-08-14 BR BRPI0615141-8A patent/BRPI0615141A2/pt not_active IP Right Cessation
- 2006-08-14 KR KR1020087005941A patent/KR20080035691A/ko not_active Application Discontinuation
- 2006-08-14 AU AU2006279659A patent/AU2006279659A1/en not_active Abandoned
- 2006-08-14 EP EP06813425A patent/EP1919920B1/en active Active
- 2006-08-14 WO PCT/US2006/031682 patent/WO2007022102A2/en active Application Filing
- 2006-08-14 CA CA002619276A patent/CA2619276A1/en not_active Abandoned
-
2008
- 2008-02-05 IL IL189296A patent/IL189296A0/en unknown
- 2008-02-07 ZA ZA200801332A patent/ZA200801332B/xx unknown
- 2008-03-11 NO NO20081292A patent/NO20081292L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101287737A (zh) | 2008-10-15 |
EP1919920A2 (en) | 2008-05-14 |
US7749994B2 (en) | 2010-07-06 |
CA2619276A1 (en) | 2007-02-22 |
ATE509933T1 (de) | 2011-06-15 |
NO20081292L (no) | 2008-05-13 |
EP1919920B1 (en) | 2011-05-18 |
RU2008108903A (ru) | 2009-09-20 |
IL189296A0 (en) | 2008-06-05 |
WO2007022102A3 (en) | 2007-05-10 |
ZA200801332B (en) | 2009-10-28 |
WO2007022102A2 (en) | 2007-02-22 |
KR20080035691A (ko) | 2008-04-23 |
US20070037791A1 (en) | 2007-02-15 |
JP2009504680A (ja) | 2009-02-05 |
AU2006279659A1 (en) | 2007-02-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007120333A3 (en) | Tetracyclic kinase inhibitors | |
TW200740815A (en) | P38 MAP kinase inhibitors and methods for using the same | |
NO20081292L (no) | Pentasykliske kinaseinhibitorer | |
NO20073783L (no) | Pyrrolidininhibitorer for IAP | |
MX2007005932A (es) | 1-alquinil-2-ariloxialquilamidas y su uso como fungicidas. | |
TW200800999A (en) | Novel compounds | |
ATE430747T1 (de) | 2-pyrimidinyl-pyrazolopyridin-erbb- kinaseinhibitoren | |
EA200801428A1 (ru) | Производные пиридиазинона для лечения опухолей | |
MX2009014247A (es) | Compuestos heterociclicos utiles como inhibidores de mk2. | |
SE0302811D0 (sv) | Novel compounds | |
WO2006028958A3 (en) | Pyridyl inhibitors of hedgehog signalling | |
EA200701396A1 (ru) | Триазолофталазины в качестве ингибиторов pde-2 | |
ATE479687T1 (de) | Kinaseinhibitoren | |
JO3134B1 (ar) | مثبطات نشاط akt | |
ATE432281T1 (de) | Pyrrolotriazin-kinasehemmer | |
UA85505C2 (en) | Kinase inhibitors | |
ATE553106T1 (de) | Heteroarylpyrrolopyridinone als kinaseinhibitoren | |
MX2008001538A (es) | Aril piridinas y metodos para su uso. | |
CY1109916T1 (el) | Βενζιμιδαζολο-θειοφαινικες ενωσεις ως plk αναστολεις | |
TW200600499A (en) | Novel amido-substituted hydroxy-6-phenylphenanthridines | |
EA200801199A1 (ru) | Ингибиторы киназы | |
WO2007097981A3 (en) | Alpha carbolines and uses thereof | |
TW200634013A (en) | Quinoline derivative, its use, production and pharmaceutical agents containing the derivative | |
SE0301650D0 (sv) | Novel compounds | |
TW200744612A (en) | New combination |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUI DADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2215 DE 18/06/2013. |